Superfund Research Program

Jamie C. DeWitt

Oregon State University
Department of Environmental & Molecular Toxicology
1007 Agriculture & Life Sciences Building
Corvallis, Oregon 97331
Phone: 5417377998
Email: jamie.dewitt@oregonstate.edu

Projects

• North Carolina State University: Administrative Core - Research Translation (2020-2025)
• North Carolina State University: Uncovering the Mechanisms of PFAS-Induced Immunotoxicity: An Important Public Health Endpoint (2020-2025)

Publications

2024

• Bline A, DeWitt JC, Kwiatkowski C, Pelch KE, Reade A, Varshavsky J. 2024. Public health risks of PFAS-related immunotoxicity are real. Curr Environ Health Rep doi:10.1007/s40572-024-00441-y PMID:38526771
• DeWitt JC, Gluge J, Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Trier X, Vierke L, Wang Z, Adu-Kumi S, Balan SA, Buser A, Fletcher T, Haug L, Heggelund A, Huang J, Kaserzon S, Leonel J, Sheriff I, Shi Y, Valsecchi S, Scheringer M. 2024. Zurich II statement on per- and polyfluoroalkyl substances (PFASs): scientific and regulatory needs. Environ Sci Technol Lett 11(8):786-797. doi:10.1021/acs.estlett.4c00147 PMID:39156923 PMCID:11325642
• Kirkwood-Donelson KI, Chappel JR, Dodds J, Reif DM, DeWitt JC, Baker ES, Tobin E. 2024. Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS). Chemosphere (354):doi:10.1016/j.chemosphere.2024.141654 PMID:38462188 PMCID:PMC10995748
• Kirkwood-Donelson KI, Chappel JR, Tobin E, Dodds J, Reif DM, DeWitt JC, Baker ES. 2024. Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS). Chemosphere 354:141654. doi:10.1016/j.chemosphere.2024.141654 PMID:38462188 PMCID:10995748
• Phelps D, Connors A, Ferrero G, DeWitt JC, Yoder J. 2024. Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps. J Immunotoxicol 21(1):doi:10.1080/1547691x.2024.2343362 PMID:38712868

2023

• Cuffney M, Wilkie AA, Kotlarz N, Knappe D, Lea CS, Collier D, DeWitt JC, Hoppin JA. 2023. Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study. Environ Res 237:117020. doi:10.1016/j.envres.2023.117020 PMID:37673120
• Phelps D, Palekar AI, Conley HE, Ferrero G, Driggers JH, Linder KE, Kullman SW, Reif DM, Sheats MK, DeWitt JC, Yoder J. 2023. Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst. J Immunotoxicol 20(1):2176953. doi:10.1080/1547691X.2023.2176953 PMID:36788734 PMCID:PMC10361455
• Wallis DJ, Kotlarz N, Knappe D, Collier D, Lea CS, Reif DM, McCord JP, Strynar M, DeWitt JC, Hoppin JA. 2023. Estimation of the half-lives of recently detected per- and polyfluorinated alkyl ethers in an exposed community. Environ Sci Technol 57(41):15348-15355. doi:10.1021/acs.est.2c08241 PMID:37801709

2022

• Ducatman A, LaPier J, Fuoco RE, DeWitt JC. 2022. Official health communications are failing PFAS-contaminated communities. Environmental Health doi:10.1186/s12940-022-00857-9 PMID:35538533 PMCID:PMC9092686
• Gluge J, London R, Cousins IT, DeWitt JC, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Trier X, Wang Z, Scheringer M. 2022. Information requirements under the essential-use concept: PFAS case studies. Environ Sci Technol doi:10.1021/acs.est.1c03732 PMID:34608797 PMCID:PMC8980108
• McDonough CA, Li W, Bischel HN, De Silva AO, DeWitt JC. 2022. Widening the lens on PFASs: Direct human exposure to perfluoroalkyl acid precursors (pre-PFAAs). Environ Sci Technol 56(10):6004-6013. doi:10.1021/acs.est.2c00254 PMID:35324171

2021

• Cousins IT, DeWitt JC, Gluge J, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Scheringer M, Trier X, Wang Z. 2021. Finding essentiality feasible: Common questions and misinterpretations concerning the 'essential-use' concept. Environ Sci Process Impacts 23(8):doi:10.1039/d1em00180a PMID:34190275 (ahead of print)
• Ng CA, Cousins IT, DeWitt JC, Gluge J, Goldenman G, Herzke D, Lohmann R, Miller M, Patton S, Scheringer M, Trier X, Wang Z. 2021. Addressing urgent questions for PFAS in the 21st century. Environ Sci Technol 55(19):12755-12765. doi:10.1021/acs.est.1c03386 PMID:34519210 PMCID:PMC8590733

2020

• Cousins IT, DeWitt JC, Gluge J, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Scheringer M, Vierke L, Wang Z. 2020. Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health. Environ Sci Process Impacts 22:1444-1460. doi:10.1039/D0EM00147C PMID:32495786
• Cousins IT, DeWitt JC, Gluge J, Goldenman G, Herzke D, Lohmann R, Ng CA, Scheringer M, Wang Z. 2020. The high persistence of PFAS is sufficient for their management as a chemical class. Environ Sci Process Impacts doi:10.1039/d0em00355g PMID:33230514
• Gluge J, Scheringer M, Cousins IT, Goldenman G, Herzke D, Lohmann R, DeWitt JC, Ng CA, Trier X, Wang Z. 2020. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). Environ Sci Process Impacts 22:2345-2373. doi:10.1039/d0em00291g PMID:33125022 PMCID:PMC7784712
• Kwiatkowski C, Andrews DQ, Birnbaum LS, Bruton TA, DeWitt JC, Knappe D, Maffini MV, Miller M, Pelch KE, Reade A, Soehl A, Trier X, Venier M, Wagner CC, Wang Z, Blum A. 2020. Scientific basis for managing PFAS as a chemical class. Environ Sci Technol Lett 7:532-543. doi:10.1021/acs.estlett.0c00255
• Lohmann R, Cousins IT, DeWitt JC, Gluge J, Goldenman G, Herzke D, Lindstrom AB, Miller M, Ng CA, Patton S, Scheringer M, Trier X, Wang Z. 2020. Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS?. Environ Sci Technol 54(20):12820-12828. doi:10.1021/acs.est.0c03244 PMID:33043667 PMCID:PMC7700770

2019

• Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Scheringer M, Trier X, Vierke L, Wang Z, DeWitt JC. 2019. The concept of essential use for determining when uses of PFASs can be phased out. Environ Sci Process Impacts 21:1803-1815. doi:10.1039/c9em00163h PMID:31204421 PMCID:PMC6992415
• DeWitt JC, Blossom SJ, Schaider L. 2019. Exposure to per-fluoroalkyl and polyfluoroalkyl substances leads to immunotoxicity: epidemiological and toxicological evidence. J Expo Sci Environ Epidemiol 29:148-156. doi:10.1038/s41370-018-0097-y PMID:30482935 PMCID:PMC6380927

2016

• Portier CJ, Armstrong BK, Baguley B, Baur X, Belyaev I, Belle R, Belpoggi F, Biggeri A, Bosland MC, Bruzzi P, Budnik L, Bugge M, Burns K, Calaf GM, Carpenter DO, Carpenter H, Lopez-Carillo L, Clapp R, Cocco P, Consonni D, Comba P, Craft ES, Dalvie M, Davis D, Demers PA, De Roos AJ, DeWitt JC, Forastiere F, Freedman JH, Fritschi L, Gaus C, Gohlke J, Goldberg M, Greiser E, Hansen J, Hardell L, Hauptmann M, Huang W, Huff J, James MO, Jameson C, Kortenkamp A, Kopp-Schneider A, Kromhout H, Larramendy M, Landrigan PJ, Lash LH, Leszczynski D, Lynch CF, Magnani C, Mandrioli D, Martin FL, Merler E, Michelozzi P, Miligi L, Miller A, Mirabelli D, Mirer F, Naidoo S, Perry MJ, Petronio M, Pirastu R, Portier R, Ramos KS, Robertson LW, Rodriguez T, Roosli M, Ross M, Roy D, Rusyn I, Saldiva P, Sass J, Savolainen K, Scheepers P, Sergi C, Silbergeld EK, Smith MT, Stewart BW, Sutton P, Tateo F, Terracini B, Thielmann H, Thomas DB, Vainio H, Vena J, Vineis P, Weiderpass E, Weisenburger DD, Woodruff TJ, Yorifuji T, Yu I, Zambon P, Zeeb H, Zhou SF. 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health 70(8):741-745. doi:10.1136/jech-2015-207005 PMID:26941213 PMCID:PMC4975799