Superfund Research Program

Kelly M. Bakulski

University of Michigan
Epidemiology
M5511 SPH II
Ann Arbor, Michigan 48109-2029
Phone: 734-615-5899
Email: bakulski@umich.edu

Projects

• Northeastern University: Toxicant-Stimulated Disruption of Gestational Tissues with Implications for Adverse Pregnancy Outcomes (2010-2025)

Publications

2024

• Harris SM, Su AL, Dou JF, Loch-Caruso R, Elkin ER, Jaber S, Bakulski KM. 2024. Placental cell conditioned media modifies hematopoietic stem cell transcriptome in vitro. Placenta 145:117-125. doi:10.1016/j.placenta.2023.12.016 PMID:38128222

2023

• Campbell KA, Colacino JA, Puttabyatappa M, Dou JF, Elkin ER, Hammoud SS, Domino SE, Dolinoy DC, Goodrich JM, Loch-Caruso R, Padmanabhan V, Bakulski KM. 2023. Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences. Commun Biol 6(1):264. doi:10.1038/s42003-023-04623-6 PMID:36914823 PMCID:PMC1001142
• Elkin ER, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulski KM, Paquette AG. 2023. Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology. Mol Cell Endocrinol 578:112066. doi:10.1016/j.mce.2023.112066 PMID:37690473 PMCID:PMC10591899
• Elkin ER, Su AL, Dou JF, Colacino JA, Bridges D, Padmanabhan V, Harris SM, Boldenow E, Loch-Caruso R, Bakulski KM. 2023. Sexually concordant and dimorphic transcriptional responses to maternal trichloroethylene and/or N-acetyl cysteine exposure in Wistar rat placental tissue. Toxicology 483:153371. doi:10.1016/j.tox.2022.153371 PMID:36396003 PMCID:PMC10078828

2022

• Elkin ER, Su AL, Kilburn BA, Bakulski KM, Armant DR, Loch-Caruso R. 2022. Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models. Reprod Toxicol 109:109-120. doi:10.1016/j.reprotox.2022.03.003 PMID:35304307 PMCID:PMC9107309
• Harris S, Bakulski KM, Dou JF, Houskamp E, Scheeres EC, Schellenboom E, Harlow O, Loch-Caruso R, Boldenow E. 2022. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model. Toxicol Vitro 84:105429. doi:10.1016/j.tiv.2022.105429 PMID:35811015
• Harris SM, Colacino JA, Buxton MA, Croxton L, Nguyen VK, Loch-Caruso R, Bakulski KM. 2022. A data mining approach reveals chemicals detected at higher levels in non-Hispanic Black women target preterm birth genes and pathways. Reprod Sci doi:10.1007/s43032-022-00870-w PMID:35107823

2021

• Aung MT, Bakulski KM, Feinberg JI, Dou JF, Meeker JD, Mukherjee B, Loch-Caruso R, Ladd-Acosta C, Volk HE, Croen LA, Hertz-Picciotto I, Newschaffer CJ, Fallin MD. 2021. Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI). Epigenetics 1-16. doi:10.1080/15592294.2021.1897059 PMID:33794742
• Elkin ER, Bakulski KM, Colacino JA, Bridges D, Kilburn BA, Armant DR, Loch-Caruso R. 2021. Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine revealed activation of the eIF2a/ATF4 integrated stress response in two in vitro placental models. Arch Toxicol 95(5):1-25. doi:10.1007/s00204-021-03011-5 PMID:33725128 PMCID:PMC7961173 (ahead of print)

2020

• Aung MT, Meeker JD, Boss J, Bakulski KM, Mukherjee B, Cantonwine DE, McElrath TF, Ferguson KK. 2020. Manganese is associated with increased plasma interleukin-1B during pregnancy, within a mixtures analysis framework of urinary trace metals. Reprod Toxicol 93:43-53. doi:10.1016/j.reprotox.2019.12.004 PMID:31881266 PMCID:PMC7138746
• Campbell KA, Colacino JA, Park S, Bakulski KM. 2020. Cell Types in Environmental Epigenetic Studies: Biological and Epidemiological Frameworks. Curr Environ Health Rep 7:185-197. doi:10.1007/s40572-020-00287-0 PMID:32794033 PMCID:PMC7493967
• Harris SM, Jin Y, Loch-Caruso R, Padilla IY, Meeker JD, Bakulski KM. 2020. Identification of environmental chemicals targeting miscarriage genes and pathways using the comparative toxicogenomics database. Environ Res 184:doi:10.1016/j.envres.2020.109259 PMID:32143025 PMCID:PMC7103533

2019

• Aung MT, Ferguson KK, Cantonwine DE, Bakulski KM, Mukherjee B, Loch-Caruso R, McElrath TF, Meeker JD. 2019. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: a repeated measures study. Sci Total Environ 650(Pt1):1131-1140. doi:10.1016/j.scitotenv.2018.08.356 PMID:30308801 PMCID:PMC6236678
• Sikdar S, Joehanes R, Joubert BR, Xu C, Vives-Usano M, Rezwan F, Felix J, Ward JM, Guan W, Richmond RC, Brody JA, Kupers LK, Baiz N, Haberg SE, Smith JA, Reese SE, Aslibekyan S, Hoyo C, Dhingra R, Markunas CA, Xu T, Reynolds LM, Just AC, Mandaviya PR, Ghantous A, Bennett BD, Wang T, BIOS-Consortium, Bakulski KM, Melen E, Zhao S, Juin J, Herceg Z, van Meurs JB, Taylor JA, Baccarelli A, Murphy SK, Liu Y, Minthe-Kaas MC, Deary IJ, Nystad W, Waldenberger M, Annesi-Maesano I, Conneely K, Jaddoe VW, Arnett D, Snieder H, Kardia SL, Relton CL, Ong KK, Ewart S, Moreno-Macias H, Romieu I, Sotoodehnia N, Fornage M, Motsinger-Reif A, Koppelman GH, Bustamante M, Levy D, London SJ. 2019. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics 11(13):1487-1500. doi:10.2217/epi-2019-0066 PMID:31536415 PMCID:PMC6836223