Superfund Research Program

Krithika Lingappan

University of Pennsylvania
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson Research Center, 415B
Philadelphia, Pennsylvania 19104
Phone: 215-590-1653
Email: lingappank@chop.edu

Projects

• Baylor College of Medicine: Role of Cytochrome P450 (CYP)1A/1B1 Enzymes in the Potentiation of Neonatal Lung Injury in Newborn Mice Exposed Prenatally to PAHs and Increased Risk of Premature Infants to Chronic Lung Disease (2020-2025)

Publications

2024

• Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli XI, Lingappan K, Moorthy B. 2024. Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211:35-46. doi:10.1016/j.freeradbiomed.2023.12.001 PMID:38081439

2023

• Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. 2023. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ 14(1):50. doi:10.1186/s13293-023-00535-6 PMID:37553579 PMCID:PMC10408139
• Grimm SL, Stading R, Robertson M, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. 2023. Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation. Redox Biol 64:102790. doi:10.1016/j.redox.2023.102790 PMID:37348155 PMCID:PMC10271936

2022

• Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K. 2022. Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates. Pediatr Pulmonol doi:10.1002/ppul.26197 PMID:36205439

2021

• Burke R, Chu C, Zhou G, Putluri V, Putluri N, Stading R, Couroucli XI, Lingappan K, Moorthy B. 2021. Role of human NADPH quinone oxidoreductase (NQO1) in oxygen-mediated cellular injury and oxidative DNA damage in human pulmonary cells. Oxid Med Cell Longev 2021:5544600. doi:10.1155/2021/5544600 PMID:34691356 PMCID:PMC8536466
• Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. 2021. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight 6(13):e146863. doi:10.1172/jci.insight.146863 PMID:34061778 PMCID:PMC8410054

2020

• Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B. 2020. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med 160:208-218. doi:10.1016/j.freeradbiomed.2020.07.027 PMID:32791187 PMCID:PMC7704914
• Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker C, Moorthy B, Lingappan K. 2020. Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol 37:101718. doi:10.1016/j.redox.2020.101718 PMID:32961439 PMCID:PMC7509469
• Stading R, Chu C, Couroucli XI, Lingappan K, Moorthy B. 2020. Molecular role of cytochrome P4501A enzymes in oxidative stress. Curr Opin Toxicol 20-21:77-84. doi:10.1016/j.cotox.2020.07.001 PMID:33283080 PMCID:PMC7709944
• Stading R, Couroucli XI, Lingappan K, Moorthy B. 2020. The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert Opin Drug Metab Toxicol 8:doi:10.1080/17425255.2021.1853705 PMID:33215946

2019

• Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou GD, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. 2019. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun 516(2):344-349. doi:10.1016/j.bbrc.2019.06.049 PMID:31208719 PMCID:PMC6637943