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Person Details: Praveen Sethupathy

Superfund Research Program

Praveen Sethupathy

Cornell University
618 Tower Road
T7006 Veterinary Research Tower
Ithaca, New York 27599-7412
Phone: 607-253-4375




  • Todero JE, Douillet C, Shumway AJ, Koller BH, Kanke M, Phuong DJ, Styblo M, Sethupathy P. 2023. Molecular and metabolic analysis of arsenic-exposed humanized AS3MT mice. Environ Health Perspect 131(12):127021. doi:10.1289/EHP12785 PMID:38150313 PMCID:PMC10752418


  • Todero JE, Koch-Laskowski K, Shi Q, Kanke M, Hung Y, Beck R, Styblo M, Sethupathy P. 2022. Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis. Arch Toxicol 96(6):1685-1699. doi:10.1007/s00204-022-03263-9 PMID:35314868 PMCID:PMC9095563


  • Hung Y, Huang S, Dame MK, Yu Q, Yu QC, Zeng Y, Camp JG, Spence JR, Sethupathy P. 2021. Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Nucleic Acids Res 49(2):726-744. doi:10.1093/nar/gkaa1204 PMID:33406262 PMCID:PMC7826262
  • Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, Sandoval DA. 2021. Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab 321(1):E11-E23. doi:10.1152/ajpendo.00060.2021 PMID:33998293 PMCID:PMC8321822
  • O'Connor S, Murphy EA, Szwed SK, Kanke M, Marchildon F, Sethupathy P, Darnell RB, Cohen P. 2021. AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity. Genes Dev 35(9-10):771-781. doi:10.1101/gad.345447.120 PMID:33832988 PMCID:PMC8091975
  • Oyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Fruh SP, McGinty JW, Churchill MJ, Cahoon JL, Sundaravaradan P, Flitter B, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt R, Gronert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait-Wojno ED. 2021. PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. J Exp Med 218(9):e20202178. doi:10.1084/jem.20202178 PMID:34283207 PMCID:PMC8294949
  • Shanahan MT, Kanke M, Oyesola OO, Hung Y, Koch-Laskowski K, Singh AP, Peck BC, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P. 2021. Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. Am J Physiol Gastrointest Liver Physiol 321:doi:10.1152/ajpgi.00222.2021 PMID:34643097 PMCID:PMC8887887
  • Smith GJ, Tovar A, Kanke M, Wang Y, Deshane J, Sethupathy P, Kelada SN. 2021. Ozone-induced changes in the murine lung extracellular vesicle small RNA landscape. Physiol Rep 9(18):doi:10.14814/phy2.15054 PMID:34558223 PMCID:PMC8461034
  • Swahari V, Nakamura A, Hollville E, Stroud H, Simon JM, Ptacek TS, Beck MV, Flowers C, Guo J, Plestant C, Liang J, Kurtz CL, Kanke M, Hammond SM, He Y, Anton E, Sethupathy P, Moy SS, Greenberg ME, Deshmukh M. 2021. MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation. Cell Rep 35(1):doi:10.1016/j.celrep.2021.108946 PMID:33826889 PMCID:PMC8103628
  • Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia MR, Guillem JG, Gulati AS, Sethupathy P, Furey TS, Ehre C, Sheikh SZ. 2021. Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease. Sci Rep 11(1):13533. doi:10.1038/s41598-021-92979-2 PMID:34188154 PMCID:PMC8241995
  • Wang X, Zhang W, Yang Y, Wang J, Qiu H, Liao L, Oikawa T, Wauthier E, Sethupathy P, Reid LM, Liu Z, He Z. 2021. A microRNA-based network provides potential predictive signatures and reveals the crucial role of PI3K/AKT signaling for hepatic lineage maturation. Front Cell Dev Biol 9:670059. doi:10.3389/fcell.2021.670059 PMID:34141708 PMCID:PMC8204022
  • Zhang W, Lanzoni G, Hani H, Overi D, Cardinale V, Simpson S, Pitman W, Allen A, Yi X, Wang X, Gerber D, Prestwich G, Lozoya O, Gaudio E, Alvaro D, Tokaz D, Dominguez-Bendala J, Adin C, Piedrahita JA, Mathews K, Sethupathy P, Carpino G, He Z, Wauthier E, Reid LM. 2021. Patch grafting, strategies for transplantation of organoids into solid organs such as liver. Biomaterials 277:121067. doi:10.1016/j.biomaterials.2021.121067 PMID:34517276


  • Beck R, Chandi M, Kanke M, Styblo M, Sethupathy P. 2019. Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape. Arch Toxicol doi:10.1007/s00204-019-02574-8 PMID:31555879



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