Superfund Research Program

James Allen Ankrum

University of Iowa
5621 Seamans Center
103 S Capitol Street
Iowa City, Iowa 52242-1527
Phone: 617-335-7512
Email: james-ankrum@uiowa.edu

Projects

• University of Iowa: Research Experience & Training Coordination Core (2006-2025)
• University of Iowa: The Role of Airborne PCBs in Adipogenesis, Adipose Function, and Metabolic Syndrome (2020-2025)

Publications

2024

• Helm-Kwasny B, Bullert AJ, Wang H, Chimenti MS, Adamcakova-Dodd A, Jing X, Li X, Meyerholz D, Thorne PS, Lehmler H, Ankrum JA, Klingelhutz AJ. 2024. Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2',5,5'-tetrachlorobiphenyl). Environ Toxicol Pharmacol doi:10.1016/j.etap.2024.104520 PMID:39067718
• Liszewski JN, Klingelhutz A, Sander EA, Ankrum JA. 2024. Development and analysis of scaffold-free adipose spheroids. Adipocyte 13(1):doi:10.1080/21623945.2024.2347215 PMID:38864486 PMCID:11174133

2023

• Behan-Bush RM, Liszewski JN, Schrodt MV, Vats B, Li X, Lehmler H, Klingelhutz AJ, Ankrum JA. 2023. Toxicity impacts on human adipose mesenchymal stem/stronal cells acutely exposed to aroclor and non-aroclor mixtures of polychorinated biphenyl. Environ Sci Technol 57(4):1731-1742. doi:10.1021/acs.est.2c07281 PMID:36651682 PMCID:PMC9893815
• El-Hattab MY, Sinclair N, Liszewski JN, Schrodt MV, Herrmann J, Klingelhutz AJ, Sander EA, Ankrum JA. 2023. Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts. J R Soc Interface 20(202):20230004. doi:10.1098/rsif.2023.0004 PMID:37132228 PMCID:PMC1015492
• Gourronc FA, Chimenti MS, Lehmler H, Ankrum JA, Klingelhutz AJ. 2023. Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes. Toxicol Vitro 89:105568. doi:10.1016/j.tiv.2023.105568 PMID:36804509 PMCID:PMC10081964
• Gourronc FA, Chimenti MS, Lehmler H, Ankrum JA, Klingelhutz AJ. 2023. Updating Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) with additional data on exposure to 2,2',5,5'-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52). Data Brief 49:109415. doi:10.1016/j.dib.2023.109415 PMID:37520642 PMCID:PMC10375549
• Schrodt MV, Behan-Bush RM, Liszewski JN, Humpal-Pash ME, Boland L, Scroggins SM, Santillan DA, Ankrum JA. 2023. Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes. Stem Cell Res Ther 14(1):206. doi:10.1186/s13287-023-03443-z PMID:37592321 PMCID:PMC10433682
• Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum JA, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425

2022

• Boland L, Bitterlich LM, Hogan AE, Ankrum JA, English K. 2022. Translating MSC therapy in the age of obesity. Front Immunol 13:doi:10.3389/fimmu.2022.943333 PMID:35860241 PMCID:PMC9289617
• Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Joachim-Lehmler H, Ankrum JA, Klingelhutz AJ. 2022. Transcriptome sequencing of 3,3',4,4',5-Pentachlorobiphenyl (PCB126)-treated human preadipocytes demonstrates progressive changes in pathways associated with inflammation and diabetes. Toxicol Vitro 83:105396. doi:10.1016/j.tiv.2022.105396 PMID:35618242 PMCID:PMC9423686
• Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Lehmler H, Ankrum JA, Klingelhutz AJ. 2022. Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126). Data Brief 45:108571. doi:10.1016/j.dib.2022.108571 PMID:36131953 PMCID:PMC9483567