Superfund Research Program

Xinxin Ding

University of Arizona
PO Box 210207
Pharmacy, Rm. 341F
Tucson, Arizona 85721
Phone: 520-626-9906
Email: xding@pharmacy.arizona.edu

Projects

• University of Arizona: Role of CYP2A and Hmox1 in the Diabetogenic Effects of Arsenic in Mine Tailings (2020-2025)

Publications

2024

• Li H, Fan X, Ding X, Zhang Q. 2024. Tissue-, region-, and gene-specific induction of microsomal epoxide hydrolase expression and activity in the mouse intestine by arsenic in drinking water. Drug Metab Dispos 52(7):681-689. doi:10.1124/dmd.124.001720 PMID:38719743 PMCID:11185820

2023

• Ding X, Han J, Van Winkle LS, Zhang Q. 2023. Detection of transgene location in the CYP2A13/2B6/2F1-transgenic mouse model using optical genome mapping technology. Drug Metab Dispos 51(1):46-53. doi:10.1124/dmd.122.001090 PMID:36273825 PMCID:PMC983237
• Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128 PMID:37467352
• Shakya A, Dodson M, Artiola JF, Ramirez-Andreotta M, Root RA, Ding X, Chorover J, Maier RM. 2023. Arsenic in drinking water and diabetes. Water (Basel) 15(9):1751. doi:10.3390/w15091751
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328

2022

• Hannon SL, Ding X. 2022. Assessing cytochrome P450 function using genetically engineered mouse models. Adv Pharmacol 95:253-284. doi:10.1016/bs.apha.2022.05.008 PMID:35953157 PMCID:10544722
• Lai Y, Chu X, Di L, Gao W, Guo Y, Liu X, Lu C, Mao J, Shen H, Tang H, Xia CQ, Zhang L, Ding X. 2022. Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development. Acta Pharm Sin B 12(6):2751-2777. doi:10.1016/j.apsb.2022.03.009 PMID:35755285 PMCID:PMC921405
• Lehmler H, Uwimana E, Dean LE, Kovalchuk N, Zhang Q, Ding X. 2022. Probing the role of CYP2 enzymes in the atroposelective metabolism of polychlorinated biphenyls using liver microsomes from transgenic mouse models. Chem Res Toxicol 35(12):2310-2323. doi:10.1021/acs.chemrestox.2c00276 PMID:36473170
• Li H, Fan X, Wu X, Han W, Amistadi M, Liu P, Zhang DD, Chorover J, Ding X, Zhang Q. 2022. Differential effects of arsenic in drinking water on mouse hepatic and intestinal heme oxygenase-1 expression. Antioxidants (Basel) 11(9):1835. doi:10.3390/antiox11091835 PMID:36139908 PMCID:PMC9495312
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920

2021

• Liu P, Dodson M, Li H, Schmidlin C, Shakya A, Wei Y, Garcia JG, Chapman E, Kiela PR, Zhang Q, White E, Ding X, Ooi A, Zhang DD. 2021. Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism. Mol Metab 51:101243. doi:10.1016/j.molmet.2021.101243 PMID:33933676 PMCID:PMC8164084

2008

• Brusick D, Small MS, Cavalieri EL, Chakravarti D, Ding X, Longfellow DG, Nakamura J, Rogan EC, Swenberg JA. 2008. Possible genotoxic modes of action for naphthalene. Regul Toxicol Pharmacol 51(2Suppl):S43-S50. doi:10.1016/j.yrtph.2007.12.002 PMID:18194829

2000

• Spink DC, Spink BC, Zhuo X, Hussain MM, Gierthy JF, Ding X. 2000. NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol 74(1-2):11-18. doi:10.1016/s0960-0760(00)00083-2 PMID:11074351