Superfund Research Program

Leonidas G. Bachas

University of Miami
Room 227 Ashe Administration Building
1252 Memorial Drive
Coral Gables, Florida 33146-4620
Phone: 305-284-4021
Email: bachas@miami.edu

Projects

• University of Kentucky: Administrative Core (2000-2025)
• University of Kentucky: Chloro-Organic Degradation by Nanosized Metallic Systems and by Chelate-Modified Hydroxyl Radical Reaction (2000-2019)
• University of Kentucky: Research Support Core (2005-2025)
• University of Kentucky: Sensing Superfund Chemicals with Recombinant Systems (1997-2014)
• University of Kentucky: Superfund Inter-Disciplinary Training Core (2000-2025)

Publications

2013

• Zahran EM, Bhattacharyya D, Bachas LG. 2013. Reactivity of Pd/Fe bimetallic nantubes in dechlorination of coplanar polychlorinated biphenyls. Chemosphere 91:165-171. doi:10.1016/j.chemosphere.2012.12.037 PMID:23332879 PMCID:PMC4526161

2012

• Hamorsky KT, Ensor CM, Dikici E, Pasini P, Bachas LG, Daunert S. 2012. Bioluminescence inhibition assay for the detection of hydroxylated polychlorinated biphenyls. Anal Chem 84(18):7648-7655. doi:10.1021/ac301872u PMID:22908962 PMCID:PMC4127403
• Hennig B, Ormsbee LE, McClain CJ, Watkins BA, Blumberg B, Bachas LG, Sanderson W, Suk WA. 2012. Nutrition can modulate the toxicity of environmental pollutants: implications in risk assessment and human health. Environ Health Perspect 120(6):771-774. doi:10.1289/ehp.1104712 PMID:22357258 PMCID:PMC3385446

2011

• Lewis S, Datta S, Gui M, Coker EL, Huggins F, Daunert S, Bachas LG, Bhattacharyya D. 2011. Reactive nanostructured membranes for water purification. Proc Natl Acad Sci U S A 108(21):8577-8582. doi:10.1073/pnas.1101144108 PMID:21606340 PMCID:PMC3102394
• Zahran EM, Bhattacharyya D, Bachas LG. 2011. Development of reactive Pd/Fe bimetallic nanotubes for dechlorination reactions. J Mater Chem 21:10454-10462. doi:10.1039/C1JM11435B

2010

• Smuleac V, Bachas LG, Bhattacharyya D. 2010. Aqueous - phase synthesis of PAA in PVDF membrane pores for nanoparticle synthesis and dichlorobiphenyl degradation. J Memb Sci 346(2):310-317. doi:10.1016/j.memsci.2009.09.052 PMID:20161475 PMCID:PMC2794051

2009

• Lewis S, Lynch A, Bachas LG, Hampson S, Ormsbee LE, Bhattacharyya D. 2009. Chelate-modified fenton reaction for the degradation of trichloroethylene in aqueous and two-phase systems. Environ Eng Sci 26(4):849-859. doi:10.1089/ees.2008.0277 PMID:20418966 PMCID:PMC2858874
• Lewis S, Smuleac V, Montague A, Bachas LG, Bhattacharyya D. 2009. Iron-functionalized membranes for nanoparticle synthesis and reactions. Sep Sci Technol 44(14):3289-3311. doi:10.1080/01496390903212805 PMID:20556223 PMCID:PMC2885741
• Tee Y, Bachas LG, Bhattacharyya D. 2009. Degradation of trichloroethylene by iron-based bimetallic nanoparticles. Journal of Physical Chemistry C 113:9454-9464. doi:10.1021/jp905273a PMID:20161161 PMCID:PMC2736476

2008

• Lim EJ, Májková Z, Xu S, Bachas LG, Arzuaga X, Smart EJ, Tseng M, Toborek M, Hennig B. 2008. Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chem Biol Interact 176(2-3):71-78. doi:10.1016/j.cbi.2008.08.007 PMID:18786521 PMCID:PMC2603293
• Oesteriing E, Chopra N, Gavalas VG, Arzuaga X, Lim EJ, Sultana R, Butterfield DA, Bachas LG, Hennig B. 2008. Alumina nanoparticles induce expression of endothelial cell adhesion molecules. Toxicol Lett 178(3):160-166. doi:10.1016/j.toxlet.2008.03.011 PMID:18456438
• Venkatachalam K, Arzuaga X, Chopra N, Gavalas VG, Xu J, Bhattacharyya D, Hennig B, Bachas LG. 2008. Reductive dechlorination of 3,3',4,4'-tetrachlorobiphenyl (PCB77) using palladium or palladium/iron nanoparticles and assessment of the reduction in toxic potency in vascular endothelial cells. J Hazard Mater 159(2-3):483-491. doi:10.1016/j.jhazmat.2008.02.109 PMID:18423858 PMCID:PMC3247144
• Xu J, Bachas LG, Bhattacharyya D. 2008. Synthesis of Nanostructured Bimetallic Particles in Polyligand- Functionalized Membranes for Remediation Applications. In: Nanotechnology for Environmental Applications. John Wiley,

2007

• Hennig B, Ormsbee LE, Bachas LG, Silverstone AE, Milner J, Carpenter DO, Thompson CL, Suk WA. 2007. Introductory comments: nutrition, environmental toxins and implications in prevention and intervention of human diseases. J Nutr Biochem 18(3):161-162. doi:10.1016/j.jnutbio.2006.12.004 PMID:17296487

2006

• Ahuja DK, Bachas LG, Bhattacharyya D. 2006. Modified fenton reaction for trichlorophenol dechlorination by enzymatically generated H2O2 and gluconic acid chelate. Chemosphere 66(11):2193-200. PMID:17166556
• Feliciano JS, Xu S, Guan X, Lehmler H, Bachas LG, Daunert S. 2006. ClcR-based biosensing system in the detection of cis-dihydroxylated (chloro-)biphenyls. Anal Bioanal Chem 385(5):807-813. PMID:16791559
• Oesterling EG, Arzuaga X, Lim EJ, Gavalas VG, Bachas LG, Toborek M, Hennig B. 2006. Manufactured nanosized alumina particle induced endothelial cell dysfunction: implication in vascular disease. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Venkatachalm K, Gavalas VG, Xu S, Leon AC, Bhattacharyya D, Bachas LG. 2006. Poly(amino acid)-facilitated electrochemical growth of metal nanoparticles. J Nanosci Nanotechnol 6(8):2408-12. PMID:17037848

2005

• Li Y, Bachas LG, Bhattacharyya D. 2005. Kinetics studies of trichlorophenol destruction by chelate-based fenton reaction. Environ Eng Sci 22(6):756-771.
• Meyer DE, Bhattacharyya D, Bachas LG, Ritchie SM. 2005. Membrane-based Nanostructured Metals for Reductive Degradation of Hazardous Organics. Chapter 890 in: ACS Symposium Series: Nanotechnology and the Environment: Applications and Implications. Clarendon Press, pp.256-267.

2004

• Ahuja DK, Gavalas VG, Bachas LG, Bhattacharyya D. 2004. Aqueous-phase dechlorination of toxic chloroethylenes by vitamin B-12 cobalt center: Conventional and polypyrrole film-based electrochemical studies. Ind Eng Chem Res 43(4):1049-1055.
• Hennig B, Toborek M, Bachas LG, Suk WA. 2004. Emerging issues: nutritional awareness in environmental toxicology. J Nutr Biochem 15(4):194-195. PMID:15068811
• Meyer DE, Wood K, Bachas LG, Bhattacharyya D. 2004. Degradation of chlorinated organics by membrane-immobilized nanosized metals. Environmental Progress 23(3):232-242.

2003

• Bhattacharyya D, Meyer DE, Bachas LG. 2003. Membrane-based nanostructured metals for reductive degradation of hazardous organics. In: Proceedings of the 225^th ACS (American Chemical Society) National Meeting - Spring 2003. New Orleans, LA.
• Feliciano JS, Guan X, Liu Y, D'Angelo E, van der Meer JR, Bachas LG, Daunert S. 2003. Bacterial sensing systems for monitoring superfund chemicals. In: Proceedings of the NAFF (North American Freedom Foundation) Symposium, 2003. Lexington, KY.
• Feliciano JS, Guan X, van der Meer JR, Bachas LG, Daunert S. 2003. Bacterial Biosensing Systems for Monitoring EnvironmentalPollutants:From The Laboratory to the Field. In: Proceedings of the International Symposium on Sensor Science, 2003. Paris, France.
• Tee Y, Grulke E, Bachas LG, Bhattacharyya D. 2003. Polyethyleneimine-based materials for the synthesis of nanosized metal and subsequent toxic organics degradation. In: Proceedings of the AlChE (American Institute of Chemical Engineers) Annual Meeting, November 16-21, 2003. San Franciso, CA.
• Xu J, Bachas LG, Bhattacharyya D. 2003. Synthesis of nanoscale metal particles for reductive transformation of halogenated compounds. In: Proceedings of the AlChE (American Institute of Chemical Engineers) Annual Meeting, November 16-21, 2003. San Franciso, CA.

2002

• Butterfield DA, Colvin J, Liu J, Wang J, Bachas LG, Bhattacharyya D. 2002. Electron paramagnetic resonance spin label titration: a novel method to investigate random and site-specific immobilization of enzymes onto polymeric membranes with different properties. Anal Chim Acta 470:29-36.

2001

• Bhattacharyya D, Rodgers P, Meyer DE, Wood K, Bachas LG. 2001. Dehalogenation of chlorinated organics by chelate-based fenton reaction and by reductive nano-iron particle based systems. In: Proceedings of the AlChE (American Institute of Chemical Engineers) Annual Meeting, November 4-9, 2001. Rena, NV.
• Butterfield DA, Bhattacharyya D, Daunert S, Bachas LG. 2001. Catalytic biofunctional membranes containing site-specifically immobilized enzyme arrays: a review. J Memb Sci 181(1):29-37.
• Gavalas VG, Andrews R, Bhattacharyya D, Bachas LG. 2001. Carbon nanotube sol-gel composite materials. Nano Lett 1(12):719-721.
• Hestekin JA, Bachas LG, Bhattacharyya D. 2001. Poly(amino acid)-functionalized cellulosic membranes: metal sorption mechanisms and results. Ind Eng Chem Res 40(12):2668-2678.
• Liu J, Wang J, Bachas LG, Bhattacharyya D. 2001. Activity studies of immobilized subtilisin on functionalized pure cellulose-based membranes. Biotechnol Prog 17(5):866-871. PMID:11587576
• Ritchie SM, Kissick KE, Bachas LG, Sikdar SK, Parikh C, Bhattacharyya D. 2001. Polycysteine and other polyamino acid functionalized microfiltration membranes for heavy metal capture. Environ Sci Technol 35(15):3252-3258. PMID:11506016
• Rodgers P, Bhattacharyya D, Bachas LG, Grulke E. 2001. The effect of iron chelates on the oxidation of organic groudwater contaminants by Fenton's Reagent. In: Proceedings of the 2001 Kentucky Water Resources Symposium. University of Kentucky, KY.
• Wang J, Bhattacharyya D, Bachas LG. 2001. Improving the activity of immobilized subtilisin by site-directed attachment through a genetically engineered affinity tag. Fresenius J Anal Chem 369(3-4):280-285. PMID:11293705
• Wang J, Bhattacharyya D, Bachas LG. 2001. Orientation specific immobilization of organophosphorus hydrolase on magnetic particles through gene fusion. Biomacromolecules 2(3):700-705. PMID:11710024

2000

• Badr IH, Hestekin JA, Bhattacharyya D, Bachas LG. 2000. Electrochemical assay for highly charged polyamino acids: Application to polyamino acid functionalized microfiltration membranes. Electroanalysis 12(17):1368-1372.
• Bhattacharyya D, Ritchie SM, Hestekin JA, Bachas LG. 2000. Capture of metals by membranes containing multi-functional ligands. In: Proceedings of the 3^rd China-USA Joint Chemical Engineering Conference. Beijing, China.
• Guan X, Ramanathan S, Garris JP, Shetty RS, Ensor CM, Bachas LG, Daunert S. 2000. Chlorocatechol detection based on a clc operon/reporter gene system. Anal Chem 72(11):2423-2427. PMID:10857616

1998

• Bachas LG, Daunert S, Robertson LW. 1998. Information dissemination and outreach activities at the University of Kentucky. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.69.
• Bhattacharyya D, Hestekin JA, Brushaber P, Cullen L, Bachas LG, Sikdar SK. 1998. Novel poly-glutamic acid functionalized microfiltration membranes for sorption of heavy metals at high capacity. J Memb Sci 141(1):121-135.

1997

• Blair TL, Daunert S, Bachas LG. 1997. Host-Guest Chemistryin Fiber Optic Sensing. In: Biosensors, Current Topics in Biophysics.
• Palet C, Muñoz M, Valiente M, Cynkowski T, Daunert S, Bachas LG. 1997. Molecular recognition of dicarboxylic acids by neutral receptors: selective membrane transport. Anal Chim Acta 343(3):287-294.

1995

• Allen JR, Florido A, Young SD, Daunert S, Bachas LG. 1995. Nitrite-selective electrode based on an electropolymerized cobalt phthalocyanine. Electroanalysis 7(8):710-713.
• Daunert S, Bachas LG, Smith-Palmer T. 1995. Gas Sensing Probes. In: Encyclopedia of Analytical Science. Academic Press, pp.4118-4124.
• Hernandez EC, Witkowski A, Daunert S, Bachas LG. 1995. Potentiometric enzyme electrodes for urea based on electrochemically prepared polypyrrole membranes. Microchimica Acta 121:63-72.
• Witkowski A, Daunert S, Kindy MS, Bachas LG. 1995. Preparation of β-galactosidase conjugates for competitive binding assays by post-translational modification of recombinant proteins. Anal Chem 67:1301-1306.