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Your Environment. Your Health.

Person Details: Gabriele Ludewig

Superfund Research Program

Gabriele Ludewig

University of Iowa
UI Research Park, #234 IREH
Iowa City, Iowa 52242-5000
Phone: 319-335-4650
Fax: 319-335-4290
Email: gabriele-ludewig@uiowa.edu

Projects

Publications

2019

  • Klenov V, Flor S, Adur M, Ganesan S, Eti N, Iqbal K, Soares M, Ludewig G, Ross J, Keating A, Robertson LW. 2019. Uterine toxicity following exposure to polychlorinated biphenyl 126 is mediated by the aryl hydrocarbon receptor. Fertil Steril 111(4):e4. doi:10.1016/j.fertnstert.2019.02.038
  • Liu B, Sun Y, Xu G, Snetselaar LG, Ludewig G, Wallace RB, Bao W. 2019. Association between Body Iron Status and Leukocyte Telomere Length, a Biomarker of Biological Aging, in a Nationally Representative Sample of US Adults. J Acad Nutr Diet 119(4):617-625. doi:10.1016/j.jand.2018.09.007 PMCID:PMC6548326

2018

2017

2016

2015

  • Agudo A, Aronson KJ, Bonefeld-Jørgensen EC, Cocco P, Cogliano VJ, Cravedi J, Esch HL, Fiedler H, Glauret HP, Guo YL, Herbert RA, Hopf NB, James MO, Johansson N, Le Bizec B, Ludewig G, Machala M, Merletti F, Narbonne J, Robertson LW, Ruder AM, Tryphonas H, Vermeulen R, Vorkamp K, Walker N. 2015. IARC monographs on the evaluation of carcinogenic risks to humans, volume 107, Polychlorinated biphenyls and polybrominated biphenyls. https://monographs.iarc.fr/ENG/Monographs/vol107/mono107.pdf
  • Gadupudi GS, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. 2015. PCB126 inhibits adipogenesis of human preadipocytes. Toxicol In Vitro 29(1):132-141. doi:10.1016/j.tiv.2014.09.015 PMID:25304490 PMCID:PMC4250299
  • Grimm FA, Hu D, Kania-Korwel I, Lehmler H, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW. 2015. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45(3):245-272. doi:10.3109/10408444.2014.999365 PMID:25629923 PMCID:PMC4383295

2014

2013

  • Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek-Hock WM, Wang K, Ludewig G, Robertson LW. 2013. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?. Chem Res Toxicol 26(5):634-644. doi:10.1021/tx400049s PMID:23527585 PMCID:PMC3660509
  • Ludewig G, Flor S. 2013. Harlequin Chromosomes. In: Brenner's Encyclopedia of Genetics (2nd ed). pp.399-401.
  • Ludewig G, Robertson LW. 2013. Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma. Cancer Lett 334(1):46-55. doi:10.1016/j.canlet.2012.11.041 PMID:23211541 PMCID:PMC3648605
  • Ludewig G, Robertson LW, Glauert HP. 2013. Carcinogenicity and Mechanisms of Persistent Organic Pollutants. In: Effects of Persistent and Bioactive Organic Pollutants on Human Health. pp.57-100.

2012

  • Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, Olivier AK. 2012. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology 302(1):25-33. doi:10.1016/j.tox.2012.07.007 PMID:22824115 PMCID:PMC3438370
  • Senthilkumar PK, Robertson LW, Ludewig G. 2012. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicol Appl Pharmacol 259(1):115-123. doi:10.1016/j.taap.2011.12.015 PMID:22210444 PMCID:PMC3288560
  • Shen H, Robertson LW, Ludewig G. 2012. Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats. Toxicol Lett 209(3):291-298. doi:10.1016/j.toxlet.2012.01.003 PMID:22266287 PMCID:PMC3288253
  • Xin X, Kuppusamy SP, Schnoor JL, Ludewig G. 2012. Downregulation of Telomerase Activity and Shortening of Telomere Length by Polychlorinated Biphenyls (PCBs) in HL-60 Cells. Environ Mol Mutagen 53:S66.

2011

  • Lai IK, Chai Y, Simmons DL, Watson WH, Tan R, Haschek-Hock WM, Wang K, Wang B, Ludewig G, Robertson LW. 2011. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci 124:202-214. doi:10.1093/toxsci/kfr215 PMID:21865291 PMCID:PMC3196656
  • Robertson LW, Ludewig G. 2011. Polychlorinated biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrst Reinhalt Luft 71(1-2):25-32. PMID:21686028 PMCID:PMC3113507
  • Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. 2011. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett 204:64-70. doi:10.1016/j.toxlet.2011.04.012 PMID:21530622 PMCID:PMC3109099
  • Wang B, Robertson LW, Wang K, Ludewig G. 2011. Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126. Xenobiotica 41:1031-1043. doi:10.3109/00498254.2011.603763 PMID:21970748 PMCID:PMC3564674

2010

2009

  • Yang-won S, Buettner GR, Venkataraman S, Treimer S, Robertson LW, Ludewig G. 2009. UVA/B-induced formation of free radicals from decabromodiphenyl ether. Environ Sci Technol 43(7):2581-2588. PMID:19452920 PMCID:PMC2685467

2008

  • Gregoraszczuk EL, Rak A, Ludewig G, Gasinska A. 2008. Effects of estradiol, PCBS, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environ Toxicol Pharmacol 25(2):227-233. PMID:21783862
  • Jacobus JA, Flor S, Klingelhutz AJ, Robertson LW, Ludewig G. 2008. 2-(4'-Chlorophenyl)-1,4-benxoquinone increases the frequency of micronuclei and shortens telomeres. Environ Toxicol Pharmacol 25(2):267-272. doi:10.1016/j.etap.2007.10.022 PMID:18438462 PMCID:PMC2346440
  • Ludewig G, Lehmann L, Esch HL, Robertson LW. 2008. Metabolic activation of PCBs to carcinogens in vivo - a review. Environ Toxicol Pharmacol 25(2):241-246. doi:10.1016/j.etap.2007.10.029 PMID:18452002 PMCID:PMC2364599
  • Luthe G, Boy R, Jacobus JA, Smith B, Rahaman A, Robertson LW, Ludewig G. 2008. Xenobiotic geometry and media pH determine cytotoxicity through solubility. Chem Res Toxicol 21(5):1017-1027. doi:10.1021/tx700214p PMID:18402468
  • Maddox C, Wang B, Kirby PA, Wang K, Ludewig G. 2008. Mutagenicity of 3-methylcholanthrene, pcb3, and 4-oh-pcb3 in the lung of transgenic bigblue rats. Environ Toxicol Pharmacol 25(2):260-266. doi:10.1016/j.etap.2007.10.021 PMID:18438460 PMCID:PMC2346436

2007

  • Lehmann L, Esch HL, Kirby PA, Robertson LW, Ludewig G. 2007. 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28(2):471-478. doi:10.1093/carcin/bgl157 PMID:16950798
  • Ludewig G, Esch HL, Robertson LW. 2007. Polyhalogenierte Bi- und Terphenyle. Chapter 20 in: Handbuch der Lebensmitteltoxikologie. Wiley-VCH Weinheim, Germany. pp.1031-1094.
  • Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. 2007. Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 Cells. Toxicol Sci 100:88-98. PMID:17686921

2006

  • Bender RP, Lehmler H, Robertson LW, Ludewig G, Osheroff N. 2006. Polychlorinated biphenyl quinone mtabolites Poison human topoisomerase II: Altering enzyme function by blocking the N-terminal protein gate. Biochemistry 45(33):10140-10152. PMID:16906772
  • Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler H, Robertson LW, Gregoraszczuk EL. 2006. Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicol Lett 166(3):200-211. PMID:16949219
  • Ptak A, Ludewig G, Robertson LW, Lehmler H, Gregoraszczuk EL. 2006. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: Effects on sex hormone levels and aromatase activity. Toxicol Lett 164(2):113-122. PMID:16412591

2005

  • Hennig B, Toborek M, Ramadass P, Ludewig G, Robertson LW, Arif JM. 2005. Polychlorinated biphenyls, oxidative stress and diet. Chapter Vol. 3 in: Reviews in Food and Nutrition Toxicity. CRC Press, Inc., Boca Raton, DE. pp.93-128.

2003

  • Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. Toxicol Sci 72(1):1771Suppl.S.
  • Ludewig G, Tampal N, Robertson LW. 2003. Comparative study of PCB, Pbb and PBDE mixtures on serum parameters in the rat. Presented at the 42nd Annual Meeting of the Cociety of Toxicology in Salt Lake City, Utan, March 9-13, 2003. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Tampal N, Robertson LW, Srinivasan C, Ludewig G. 2003. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicol Appl Pharmacol 187(3):168-177. PMID:12662900

2002

  • Fadhel ZA, Stafine N, Glauert HP, Robertson LW, Ludewig G. 2002. The effects of purified vs. unrefined diets on lipid peroxidation and antioxidant enzymes in tests of PCB-153 treated rats. Toxicol Sci 66:349.
  • Srinivasan A, Robertson LW, Ludewig G. 2002. Sulfhydryl binding and topoisomerase inhibition by PCB Metabolites. Chem Res Toxicol 15(4):497-505. PMID:11952335
  • Tampal N, Robertson LW, Ludewig G. 2002. In vivo MDR1 transport studies with PCB 77. Organohalogen Compounds 55:457-459.

2001

  • Festag M, Ludewig G, Srinivasan A, Robertson LW, Steinberg P. 2001. PCB-3, PCB-44 und verschiedene PCB Metabolite verursachen keine Einselstrangbruche in DNA in vitro und/oder in vivo. In: Proceedings of the German Society for Experimental and Clinical Pharmacology and Toxicology 42nd Spring Meeting. 13-15 March 2001. Mainz, Germany.
  • Festag M, Ludewig G, Srinivasan A, Robertson LW, Steinberg P. 2001. PCB-3, PCB-77 und verschiedene PCB Metabolite verursachen keine Einselstrangbruche in DNA in vitro und/oder in vivo. In: Proceedings of the 42nd Fruhjahrstagung of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 13-15, 2001. Mainz, Germany.
  • Festag M, Srinivasan A, Robertson LW, Ludewig G. 2001. Studies of the Effects of PCB-3, PCB-77, and Benzo(a)pyrene on Blood in Mice in vivo. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY.
  • Ludewig G. 2001. Cancer Initiation by PCBs. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY.
  • Ludewig G, Srinivasan A, McLean MR, Twaroski TP, Robertson LW. 2001. Oxidative Stess: Mechanisms of toxicity of persistent organic polllutants. In: Proceedings of the 44th Annual Meeting of the Polish Chemical Society, September 9-13, 2001. Katowice, Poland.
  • Ludewig G, Srinivasan A, McLean MR, Twaroski TP, Robertson LW. 2001. Oxidative stress: mechanisms of toxicity of persistent organic pollutants. Cent Eur J Public Health 111.
  • Ludewig G, Srinivasan A, Robertson LW. 2001. Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion. Cent Eur J Public Health 8:15-17. PMID:10943438
  • Ludewig G, Stemm DN, Tampal N. 2001. Interactions of pentamidine with the human multidrug resistance transporte (MDR). Environ Health Perspect 60(1):1798.
  • Srinivasan A, Espandiari P, Festag M, Robertson LW, Ludewig G. 2001. Analysis of DNA Strand Break Induction by PCB Metabolites in HL-60 Cells. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.395-398.
  • Srinivasan A, Espandiari P, Robertson LW, Ludewig G. 2001. Intracellular oxidative stress produced by PCB metabolites. Environ Health Perspect 60(1):1127.
  • Srinivasan A, Lehmler H, Robertson LW, Ludewig G. 2001. Production of DNA strand breaks in vitro and Reactive Oxygen Species in vitro and in HL-60 cells by PCB Metabolites. Toxicol Sci 60(1):92-102. PMID:11222876
  • Srinivasan A, Robertson LW, Ludewig G. 2001. Mechanisms of Toxicity of PCB Metabolites: Sulfhydryl Binding and ROS Generation. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.387-390.
  • Tampal N, Robertson LW, Lehmler H, Srinivasan C, Ludewig G. 2001. PCBs as Substrates for the MDR Transporter. In: Proceedings of the 40th Annual Meeting of the Society of Toxicology (SOT), March 25-29, 2001. San Franciso, CA.
  • Tampal N, Robertson LW, Lehmler H, Srinivasan C, Ludewig G. 2001. PCBs as Substrates for the MDR Transporter. Environ Health Perspect 60(1):1118.

2000

  • Ludewig G, Espandiari P, Festag M, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Arif JM, Gupta RC, Robertson LW. 2000. Mechanisms of cancer induction by polychlorinated biphenyls (PCBs). In: Proceedings of the 2nd Department of Defense Breast Cancer Research Program, 2000. Alanta, GA. pp.325.
  • Ludewig G, Espandiari P, Festag M, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Arif JM, Gupta RC, Robertson LW. 2000. Mechanisms of cancer induction by polychlorinated biphenyls (PCBs). In: Proceedings of the "Era of Hope" Department of Defense Breast Cancer Research Program Meeting, June 8-11, 2000. Atlanta, GA.
  • Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. Toxicol Sci 54(1):76.
  • Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.
  • Robertson LW, Espandiari P, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Ludewig G, Glauert HP, Arif JM, Gupta RC. 2000. Metabolism and activation of polychlorinated biphenyls (PCBs). Cent Eur J Public Health 8Suppl:14-15. PMID:10943437
  • Srinivasan A, Robertson LW, Ludewig G. 2000. PCB metabolites: cytotoxicity, glutathione depletion and inhibition of topoisomerase II. Toxicol Sci 54(1):78.
  • Srinivasan A, Robertson LW, Ludewig G. 2000. PCB metabolites: cytotoxicity, glutathione depletion and inhibition of topoisomerase II. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.

1999

  • Espandiari P, Robertson LW, Ludewig G. 1999. Dihydroxybiphenyls: A structure-activity comparison. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.328.
  • Espandiari P, Srinivasan A, Robertson LW, Ludewig G. 1999. Structure activity relationships for strand break induction and toxicity of lower halogenated dihydroxy-biphenyls. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.2259.
  • Srinivasan A, Espandiari P, Robertson LW, Ludewig G. 1999. DNA strand break induction by the PCB metabolite 4-chloro-2',5'-dihydroxybiphenyl. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.2258.
  • Srinivasan A, Lehmler H, Shaw JR, Robertson LW, Ludewig G. 1999. Superoxide production and glutathione binding by hydroquinone and p-quinone metabolites of Polychlorinated Biphenyls (PCBs). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.4261.

1998

  • Espandiari P, Ludewig G, Glauert HP, Robertson LW. 1998. Activation of hepatic NF-ÇB by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats. J Biochem Mol Toxicol 12:339-344. PMID:9736482
  • Ludewig G, Espandiari P, Srinivasan A, Robertson LW. 1998. Reactive oxygen species (ROS) and genotoxicity associated with PCB metabolism. Pol J Pharmacol 50(83):
  • Ludewig G, Srinivasan A, Espandiari P, Robertson LW. 1998. Generation of reactive oxygen species (ROS) and genotoxicity by metabolites of polychlorinated biphenyls (PCBs). Organohalogen Compounds 37:143-146.

1997

  • Robertson LW, Amaro AR, Bauer U, Espandiari P, Ludewig G, McLean MR, Oakley GG, Twaroski TP, Gupta RC. 1997. Oxidative DNA Damage Induced by Polychlorinated Biphenyls (PCBs). New Activation Mechanisms. In: Proceedings of the DOD (Department of Defense ) Breast Cancer Research Program Meeting. Washington, DC. pp.211.

1996

  • Ludewig G, Oakley GG, Espandiari P, Robertson LW. 1996. Production of superoxide and DNA strand breaks by diol metabolites of lower chlorinated biphenyls (PCBs). In: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.989.
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