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Your Environment. Your Health.

Person Details: Alvaro Puga

Superfund Research Program

Alvaro Puga

University of Cincinnati
Department of Environmental Health and Center for Environmental Genetics
PO Box 670056
424 Kettering
Cincinnati, Ohio 45267-0056
Phone: 513-558-0916
Fax: 513-558-0925




  • Barouki R, Melen E, Herceg Z, Beckers J, Chen J, Karagas MR, Puga A, Xia Y, Chadwick LH, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K. 2018. Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int 114:77-86. doi:10.1016/j.envint.2018.02.014 PMID:29499450 PMCID:PMC5899930
  • Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X. 2018. Old receptor, new tricks the ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR Meeting, 29 31 August 2018 in Paris, France. Int J Mol Sci 19(11):3603. doi:10.3390/ijms19113603 PMID:30445691


  • Chen L, Ovesen JL, Puga A, Xia Y. 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environ Health Perspect 117(7):1124-30. PMID:19654923


  • Reichard JF, Schnekenburger M, Puga A. 2007. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun 352(1):188-92. PMID:17107663
  • Schnekenburger M, Talaska G, Puga A. 2007. Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol 27(20):7089-101. PMID:17682057


  • Kann S, Estes C, Reichard JF, Huang M, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A. 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87(2):365-384. PMID:16014739
  • Kann S, Huang M, Estes C, Reichard JF, Sartor MA, Xia Y, Puga A. 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Mol Pharmacol 68(2):336-346. doi:10.1124/mol.105.011841 PMID:15894712
  • Marlowe JL, Puga A. 2005. Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J Cell Biochem 96(6):1174-1184. doi:10.1002/jcb.20656 PMID:16211578
  • Puga A, Tomlinson CR, Xia Y. 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochem Pharmacol 69(2):199-207. PMID:15627472


  • Guo J, Sartor MA, Karyala S, Medvedovic M, Kann S, Puga A, Ryan P, Tomlinson CR. 2004. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol 194(1):79-89. PMID:14728982
  • Karyala S, Guo J, Sartor MA, Medvedovic M, Puga A, Ryan P, Tomlinson CR. 2004. Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. Cardiovasc Toxicol 4(1):47-73. PMID:15034205
  • Puga A, Sartor MA, Huang M, Kerzee JK, Wei Y, Tomlinson CR, Baxter CS, Medvedovic M. 2004. Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure. Cardiovasc Toxicol 4(4):385-404. PMID:15531781
  • Tan Z, Huang M, Puga A, Xia Y. 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicol Sci 82(1):80-87. doi:10.1093/toxsci/kfh228 PMID:15272135
  • Vonderheide AP, Meija J, Tepperman K, Puga A, Pinhas AR, States JC, Caruso JA. 2004. Retention of Cr(III) by high-performance chelation ion chromatography interfaced to inductively-coupled plasma mass spectrometric detection with collision cell. J Chromatogr A 1024(1-2):129-137. PMID:14753715
  • Wei Y, Tepperman K, Huang M, Sartor MA, Puga A. 2004. Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem 279(6):4110-4119. PMID:14625279


  • Maier A, Schumann BL, Chang X, Talaska G, Puga A. 2002. Arsenic coexposure potentiates benzo[a]pyrene genotoxicity. Mutat Res 517(1-2):101-111. PMID:12034312
  • Tan Z, Chang X, Puga A, Xia Y. 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol 64(5-6):771-780. PMID:12213569


  • Maier A, Dalton TP, Puga A. 2000. Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic. Mol Carcinog 28:225-235. PMID:10972992


  • Shertzer HG, Nebert DW, Puga A, Ary M, Sonntag DM, Dixon K, Robertson LJ, Cianciolo E, Dalton TP. 1998. Dioxin causes a sustained oxidative stress response in the mouse. Biochem Biophys Res Commun 253(1):44-48. PMID:9875217


  • Vasiliou V, Puga A, Tabor MW, Nebert DW. 1995. Role of the AP-1-like electrophile response element in the induction of murine phase II [Ah] battery gene expression. Biochem Pharmacol 50:2057-2068.


  • Liu R, Vasiliou V, Zhu H, Duh J, Tabor MW, Puga A, Nebert DW, Sainsbury M, Shertzer HG. 1994. Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines. Carcinogenesis 15(10):2347-2352. PMID:7955076
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