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Person Details: Angeline S. Andrew

Superfund Research Program

Angeline S. Andrew

Dartmouth College
Department of Community and Family Medicine
7927 Rubin Building, Room 860
One Medical Center Drive
Lebanon, New Hampshire 03756-1000
Phone: 603-653-9019
Fax: 603-653-9093
Email: Angeline.S.Andrew@Dartmouth.Edu




  • Andrew AS, O'Brien KM, Jackson BP, Sandler DP, Kaye WE, Wagner L, Stommel EW, Horton D, Mehta P, Weinberg CR. 2020. Keratinous biomarker of mercury exposure associated with amyotrophic lateral sclerosis risk in a nationwide US study. Amyotroph Lateral Scler Frontotemporal Degener 8:doi:10.1080/21678421.2020.1753777
  • Shee K, Marsit CJ, Schned AR, Pettus JR, Armstrong DA, Karagas MR, Miller TW, Seigne JD, Andrew AS. 2020. MicroRNA let-7f-5p is a novel biomarker of recurrence and a potential therapeutic opportunity in non-muscle invasive bladder cancer. J Urol 203:E226-E226.
  • Shee K, Seigne JD, Karagas MR, Marsit CJ, Hinds JW, Schned AR, Pettus JR, Armstrong DA, Miller TW, Andrew AS. 2020. Identification of Let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer. Cancer Biomark 29:101-110. doi:10.3233/cbm-191322 PMID:32623385
  • Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bosse Y, Lam S, Tsao M, Tardon A, Chen C, Doherty JA, Goodman G, Bojesen SE, Landi MT, Johansson M, Field JK, Bickeboller H, Wichmann H, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnstrom H, Le Marchand L, Liu G, Andrew AS, Duell EJ, Kiemeney LA, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Dawn Teare M, Scelo G, Hong Y, Yuan J, Lazarus P, Schabath MB, Aldrich MC, Albanes D, Mak R, Barbie D, Brennan P, Hung RJ, Amos CI, Christiani DC, Lin X. 2020. Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer. Genet Epidemiol doi:10.1002/gepi.22358 PMID:32924180



  • Andrew AS, Chen CY, Caller TA, Tandan R, Henegan PL, Jackson BP, Hall BP, Bradley WG, Stommel EW. 2018. Toenail mercury levels are associated with amyotrophic lateral sclerosis (ALS) risk. Muscle Nerve doi:10.1002/mus.26055 PMID:29314106 PMCID:PMC6034986


  • Andrew AS, Gui J, Hu T, Wyszynski A, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Ekstrom RM, Li Z, Zens MS, Borsuk M, Moore JH, Karagas MR. 2015. Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. BJU Int 115(2):238-247. doi:10.1111/bju.12641 PMID:24666523 PMCID:PMC4533837
  • Andrew AS, Marsit CJ, Schned AR, Seigne JD, Kelsey KT, Moore JH, Perreard L, Karagas MR, Sempere LF. 2015. Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence. Int J Cancer 137(5):1158-1166. doi:10.1002/ijc.29413 PMID:25556547 PMCID:PMC4485975


  • Koestler DC, Li J, Baron JA, Tsongalis GJ, Butterly LF, Goodrich M, Lesseur C, Karagas MR, Marsit CJ, Moore JH, Andrew AS, Srivastava A. 2014. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Mod Pathol 27:145-155. doi:10.1038/modpathol.2013.104 PMID:23868178 PMCID:PMC3880603
  • Pan Q, Hu T, Malley JD, Andrew AS, Karagas MR, Moore JH. 2014. A system-level pathway-phenotype association analysis using synthetic feature random forest. Genet Epidemiol 38:209-219. doi:10.1002/gepi.21794 PMID:24535726 PMCID:PMC4327826



  • Andrew AS, Hu T, Gu J, Gui J, Ye Y, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Mason RA, Morlock EV, Zens MS, Li Z, Moore JH, Wu X, Karagas MR. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One 7(12):e51301. doi:10.1371/journal.pone.0051301 PMID:23284679 PMCID:PMC3526593
  • Karagas MR, Andrew AS, Nelson HH, Li Z, Punshon T, Schned AR, Marsit CJ, Morris J, Moore JH, Tyler AL, Gilbert-Diamond D, Guerinot ML, Kelsey KT. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Hum Genet 131:453-461. doi:10.1007/s00439-011-1090-x PMID:21947419 PMCID:PMC3278547
  • Lesseur C, Gilbert-Diamond D, Andrew AS, Ekstrom RM, Li Z, Kelsey KT, Marsit CJ, Karagas MR. 2012. A case-control study of polymorphisms in zenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicol Lett 210:100-106. doi:10.1016/j.toxlet.2012.01.015 PMID:22306368 PMCID:PMC3374400
  • Sloan CD, Andrew AS, Gruber JF, Mwenda KM, Moore JH, Onega T, Karagas MR, Shi X, Duell EJ. 2012. Indoor and outdoor air pollution and lung cancer in New Hampshire and Vermont. Toxicol Environ Chem 94:605-615. doi:10.1080/02772248.2012.659930 PMID:24273369 PMCID:PMC3834966


  • Fan R, Zhong M, Wang S, Zhang Y, Andrew AS, Karagas MR, Chen H, Xiong M, Moore JH, Amos CI. 2011. Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases. Genet Epidemiol 35(7):706-721. doi:10.1002/gepi.20621 PMID:22009792 PMCID:PMC3384547
  • Gui J, Andrew AS, Andrews PC, Nelson HH, Kelsey KT, Karagas MR, Moore JH. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Annals of Human Genetics 75(1):20-28. doi:10.1111/j.1469-1809.2010.00624.x PMID:21091664 PMCID:PMC3057873 (Completed with ARRA Funds)
  • Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet 129(1):101-110. doi:10.1007/s00439-010-0905-5 PMID:20981448 PMCID:PMC3255326 (Completed with ARRA Funds)
  • Hu T, Sinnott-Armstrong NA, Kiralis JW, Andrew AS, Karagas MR, Moore JH. 2011. Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics 12:364. doi:10.1186/1471-2105-12-364 PMID:21910885 PMCID:PMC3215301 (Completed with ARRA Funds)



  • Andrew AS, Gui J, Sanderson A, Mason RA, Morlock EV, Schned AR, Kelsey KT, Marsit CJ, Moore JH, Karagas MR. 2009. Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet 125(5-6):527-539. doi:10.1007/s00439-009-0645-6 PMID:19252927 PMCID:PMC2763504
  • Andrew AS, Mason RA, Kelsey KT, Schned AR, Marsit CJ, Nelson HH, Karagas MR. 2009. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicol Lett 187(1):10-14. doi:10.1016/j.toxlet.2009.01.013 PMID:19429237 PMCID:PMC2680739
  • Baris D, Karagas MR, Verrill C, Johnson A, Andrew AS, Marsit CJ, Colt JS, Cherala S, Samanic C, Waddell R, Cantor KP, Schned AR, Rothman N, Lubin JH, Fraumeni JF, Hoover RN, Kelsey KT, Silverman DT, Schwenn M. 2009. A case-control study of smoking and bladder cancer risk: emergent patterns over time. J Natl Cancer Inst 101(22):1553-1561. doi:10.1093/jnci/djp361 PMID:19917915 PMCID:PMC2778671
  • Heck JE, Andrew AS, Onega T, Rigas JR, Jackson BP, Karagas MR, Duell EJ. 2009. Lung cancer in a US population with low to moderate arsenic exposure. Environ Health Perspect 117(11):1718-1723. doi:10.1289/ehp.0900566 PMID:20049123 PMCID:PMC2801179
  • Kelsey KT, Schned AR, Morris J, Andrew AS, Karagas MR, Wallace K. 2009. Selenium and risk of bladder cancer: a population-based case-control study. Cancer Prev Res (Phila) 2(1):70-73. doi:10.1158/1940-6207.CAPR-08-0046 PMID:19139020 PMCID:PMC2640833
  • Mason RA, Morlock EV, Karagas MR, Kelsey KT, Marsit CJ, Schned AR, Andrew AS. 2009. EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis. Carcinogenesis 30(7):1155-1160. doi:10.1093/carcin/bgp077 PMID:19372140 PMCID:PMC2704279
  • Sloan CD, Andrew AS, Duell EJ, Williams SM, Karagas MR, Moore JH. 2009. Genetic population structure analysis in New Hampshire reveals Eastern European ancestry. PLoS One 4(9):e6928. doi:10.1371/journal.pone.0006928 PMID:19738909 PMCID:PMC2734429
  • Stern MC, Lin J, Figueroa JD, Kelsey KT, Kiltie AE, Yuan J, Matullo G, Fletcher T, Benhamou S, Taylor JA, Placidi D, Zhang Z, Steineck G, Rothman N, Kogevinas M, Silverman DT, Malats N, Chanock SJ, Wu X, Karagas MR, Andrew AS, Nelson HH, Bishop DT, Sak S, Choudhury A, Barrett JH, Elliot F, Corral R, Joshi AD, Gago-Dominguez M, Cortessis VK, Gao Y, Xiang Y, Vineis P, Sacerdote C, Guarrera S, Polidoro S, Allione A, Gurzau ES, Koppova K, Kumar R, Rudnai P, Porru S, Carta A, Campagna M, Arici C, Park S, Garcia-Closas M. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Cancer Res 69(17):6857-6864. doi:10.1158/0008-5472.CAN-09-1091 PMID:19706757 PMCID:PMC2782435
  • Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang Z, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau ES, Koppova K, Mayordomo J, Sanchez M, Saez B, Lindblom A, de Verdier, P, Steineck G, Mills GB, Schned AR, Guarrera S, Polidoro S, Chang S, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes J, Stefansson K, Amos CI, Karagas MR, Gu J. 2009. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet 41(9):991-995. doi:10.1038/ng.421 PMID:19648920 PMCID:PMC3313685


  • Andrew AS, Jewell DA, Mason RA, Whitfield ML, Moore JH, Karagas MR. 2008. Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a US population. Environ Health Perspect 116(4):524-531. doi:10.1289/ehp.10861 PMID:18414638 PMCID:PMC2290973
  • Andrew AS, Karagas MR, Nelson HH, Guarrera S, Polidoro S, Gamberini S, Sacerdote C, Moore JH, Kelsey KT, Demidenko E, Vineis P, Matullo G. 2008. DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. Cancer Epidemiol Biomarkers Prev 65(2):105-118. doi:10.1159/000108942 PMID:17898541 PMCID:PMC2857629
  • Andrew AS, Lantz RC, Rodgers, LS, Vaillancourt RR, Camenisch TD, Hays AM, Sollome JJ, Hamilton JW. 2008. Arsenic-induced decreases in the vascular matrix. Toxicol Pathol 36(6):805-817. doi:10.1177/0192623308323919 PMID:18812580 PMCID:PMC2875876
  • Moore JH, Karagas MR, Andrew AS. 2008. Analysis of Complex Datasets. Chapter 16 in: Molecular Epidemiology of Chronic Diseases. John Wiley & Sons Ltd, West Sussex, United Kingdom. pp.207-222.
  • Moore JH, Karagas MR, Andrew AS. 2008. Novel analytical methods for association studies. Chapter 12 in: Molecular Epidemiology: Applications in Cancer and Other Human Diseases. nforma Health Care, pp.169-187.
  • Schned AR, Andrew AS, Marsit CJ, Kelsey KT, Zens MS, Karagas MR. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scand J Urol Nephrol 42(3):237-42. PMID:18432530


  • Andrew AS, Bernardo V, Warnke L, Davey JC, Hampton TH, Mason RA, Thorpe JE, Ihnat MA, Hamilton JW. 2007. Exposure to arsenic at levels found inUS drinking water modifies expression in the mouse lung. Toxicol Sci 100(1):75-87. doi:10.1093/toxsci/kfm200 PMID:17682005


  • Andrew AS, Burgess JL, Meza MM, Demidenko E, Waugh MG, Hamilton JW, Karagas MR. 2006. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect 114(8):1193-1198. PMID:16882524 PMCID:PMC1552016
  • Andrew AS, Nelson HH, Kelsey KT, Moore JH, Meng AC, Casella DP, Tosteson TD, Schned AR, Karagas MR. 2006. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis 27(5):1030-1037. PMID:16311243
  • Marsit CJ, Karagas MR, Danaee H, Liu M, Andrew AS, Schned AR, Nelson HH, Kelsey KT. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112-116. PMID:15987713


  • Hirao S, Hirao T, Hirao Y, Marsit CJ, Schned AR, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR, Kelsey KT. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104(9):1918-1923. doi:10.1002/cncr.21423 PMID:16149093
  • Karagas MR, Park S, Nelson HH, Andrew AS, Mott LA, Schned AR, Kelsey KT. 2005. Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study. Int J Hyg Environ Health 208(5):321-327. PMID:16217917
  • Kelsey KT, Hirao T, Hirao S, Devi-Ashok T, Nelson HH, Andrew AS, Colt JS, Baris D, Morris J, Schned AR, Karagas MR. 2005. TP53 alterations and patterns of carcinogen exposure in a US population-based study of bladder cancer. Int J Cancer 117(3):370-375. doi:10.1002/ijc.21195 PMID:15906354
  • Marsit CJ, Karagas MR, Andrew AS, Liu M, Danaee H, Schned AR, Nelson HH, Kelsey KT. 2005. Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. Cancer Res 65(16):7081-7085. PMID:16103055


  • Andrew AS, Schned AR, Heaney JA, Karagas MR. 2004. Bladder cancer risk and personal hair dye use. Int J Cancer 109(4):581-586. PMID:14991581
  • Kelsey KT, Hirao T, Schned AR, Hirao S, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR. 2004. A population-based study of immunohistochemical detection of p53 alteration in bladder cancer. Br J Cancer 90(8):1572-1576. PMID:15083187


  • Andrew AS, Karagas MR, Hamilton JW. 2003. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer 104(3):263-268. PMID:12569548
  • Andrew AS, Karagas MR, Klei L, Hamilton JW. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. Toxicol Sci 72(S1):184.
  • Andrew AS, Warren AJ, Barchowsky A, Temple KA, Klei L, Soucy NV, O'Hara KA, Hamilton JW. 2003. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect 111(6):825-838. PMID:12760830


  • Andrew AS, Karagas MR, Schned AR, Hamilton JW. 2002. Decreased expression of DNA repair genes ERCC1, XPF, and XPB, but not XPG or XPA among individuals exposed to arsenic in drinking water. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Andrew AS, Mott LA, Heaney JA, Schned AR, Karagas MR. 2002. Bladder cancer risk and personal hair dye use in women. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Andrew AS, Warren AJ, Temple KA, Hamilton JW. 2002. Differential effects of arsenic, chromium, cadmium, nickel and mitomycin C on gene expression as measured by DNA microarray. Toxicol Sci 66(S1):116.
  • Barchowsky A, Soucy NV, O'Hara KA, Hwa J, Noreault-Conti TL, Andrew AS. 2002. A novel pathway for nickel-induced interleukin-8 expression. J Biol Chem 277(27):24225-24231. PMID:11978798


  • Andrew AS, Klei LR, Barchowsky A. 2001. AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. Am J Physiol 281(3):L616-L623. PMID:11504688
  • Andrew AS, Klei LR, Barchowsky A. 2001. Nickel requires hypoxia inducible factor-1a, not redox signaling to induce plasminogen activator inhibitor-1. Am J Physiol 281(3):L607-L615. PMID:11504687
  • Andrew AS, Klei LR, Barchowsky A. 2001. Role of oxidative, AP-1, and hypoxia-responsive signaling pathways in induction of plasminogen activator inhibitor-1 (PAI-1) by nickel. Environ Health Perspect 60:212.
  • Soucy NV, Andrew AS, Barchowsky A. 2001. Nickel induces IL-8 expression in human airway epithelial cells. Environ Health Perspect 60:317.


  • Andrew AS, Barchowsky A. 2000. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Toxicol Appl Pharmacol 168(1):50-57. PMID:11000099
  • Andrew AS, Klei LR, Barchowsky A. 2000. Role of oxidative, AP-1, and hypoxia-responsive signaling pathways in induction of plasminogen activator inhibitor-1 (PAI-1) by nickel. Free Radic Biol Med 29:S53.


  • Jacobs JM, Nichols C, Andrew AS, Marek D, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF. 1999. Effect of arsenite on induction of CYP1A, CYP2B and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 157(1):51-59. PMID:10329507
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