Superfund Research Program

Seth W. Kullman

North Carolina State University
Toxicology Building 1232
Box 7633
Raleigh, North Carolina 27695
Phone: 919-515-4378
Email: swkullma@ncsu.edu

Projects

• Duke University: Altering the Balance of Adipogenic and Osteogenic Regulatory Pathways from Early Life Exposure to HPCs and AOPEs (2017-2022)
• Duke University: Functional Genomics Research Core (2005-2011)
• North Carolina State University: Uncovering the Mechanisms of PFAS-Induced Immunotoxicity: An Important Public Health Endpoint (2020-2025)

Publications

2024

• Hawkey AB, Shekey N, Dean C, Asrat H, Koburov R, Holloway Z, Kullman SW, Levin ED. 2024. Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish. Toxicol Sci doi:10.1093/toxsci/kfae001 PMID:38237923

2023

• Phelps D, Palekar AI, Conley HE, Ferrero G, Driggers JH, Linder KE, Kullman SW, Reif DM, Sheats MK, DeWitt JC, Yoder J. 2023. Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst. J Immunotoxicol 20(1):2176953. doi:10.1080/1547691X.2023.2176953 PMID:36788734 PMCID:PMC10361455

2020

• Baldwin WS, Bain LJ, Di Giulio RT, Kullman SW, Rice CD, Ringwood AH, van den Hurk P. 2020. 20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms. Aquat Toxicol 227:doi:10.1016/j.aquatox.2020.105620 PMID:32932042
• Kassotis CD, Herkert N, Hammel SC, Hoffman K, Xia Q, Kullman SW, Sosa JA, Stapleton HM. 2020. Thyroid receptor antagonism of chemicals extracted from personal silicone wristbands within a papillary thyroid cancer pilot study. Environ Sci Technol 54:15296-15312. doi:10.1021/acs.est.0c05972 PMID:33185092 PMCID:PMC7819617
• Knuth M, Mahapatra D, Jima DD, Wan D, Hammock BD, Law M, Kullman SW. 2020. Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Sci Rep 10:doi:10.1038/s41598-020-72622-2 PMID:32994480 PMCID:PMC7524799
• Oliveri A, Glazer L, Mahapatra D, Kullman SW, Levin ED. 2020. Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. Neurotoxicol Teratol 81:10. doi:10.1016/j.ntt.2020.106902 PMID:32473203 PMCID:PMC7483728
• Oliveri A, Knuth M, Glazer L, Bailey JM, Kullman SW, Levin ED. 2020. Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency. Physiol Behav 224:113016. doi:10.1016/j.physbeh.2020.113016 PMID:32561170 PMCID:PMC7737556 (ahead of print)

2019

• Watson AT, Nordberg RC, Loboa EG, Kullman SW. 2019. Evidence for aryl hydrocarbon receptor-mediated inhibition of osteoblast differentiation in human mesenchymal stem cells. Toxicol Sci 167(1):145-156. doi:10.1093/toxsci/kfy225 PMID:30203000 PMCID:PMC6317429

2017

• Macaulay LJ, Chernick M, Chen A, Hinton DE, Bailey JM, Kullman SW, Levin ED, Stapleton HM. 2017. Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environ Toxicol Chem 36(1):36-48. doi:10.1002/etc.3535 PMID:27329031

2013

• Van Wettere AJ, Hinton DE, Kullman SW, Law JM. 2013. Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury. Toxicol Pathol 41(5):744-760. doi:10.1177/0192623312464308 PMID:23197195 PMCID:PMC4096295

2012

• Miller HD, Clark BW, Hinton DE, Whitehead A, Martin S, Kwok KW, Kullman SW. 2012. Anchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the Medaka. PLoS One 7(12):e52479. doi:10.1371/journal.pone.0052479 PMID:23300682 PMCID:PMC3530452

2008

• Carney MW, Erwin K, Hardman R, Yuen B, Volz DC, Hinton DE, Kullman SW. 2008. Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. Mar Pollut Bull 57(6-12):255-266. doi:10.1016/j.marpolbul.2008.02.036 PMID:18433798 PMCID:PMC4299470

2007

• Hinton DE, Segner H, Au D, Kullman SW, Hardman R. 2007. Liver toxicity. In: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL.

2003

• Kullman SW, Matsumura F, Hinton DE. 2003. Estrogen signaling in trout liver: estrogen receptor and mitogenic mediated cellular responses. Environ Sci (Ruse) 10(4):223-237.
• Liu Z, Kullman SW, Bencic DC, Torten M, Hinton DE. 2003. ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish. Mutat Res 539(1-2):43-53. PMID:12948813

2001

• Arukwe A, Kullman SW, Hinton DE. 2001. Differential biomarker gene and protein expressions in nonylphenol and estradiol-17b treated juvenile rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol 129(1):1-10.