Skip Navigation

Person Details: Chuanshu Huang

Superfund Research Program

Chuanshu Huang

New York University School of Medicine
Nelson Institute of Environmental Medicine
Tuxedo, New York 10987





  • Fang Y, Yu Y, Hou Q, Zheng X, Zhang M, Zhang D, Li J, Wu X, Huang C. 2012. The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP. J Biol Chem 287:35234-35243. doi:10.1074/jbc.M112.389494 PMID:22896709 PMCID:PMC3471739
  • Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, Zhu L, Gao J, Huang C. 2012. The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1 alpha mRNA stability. J Biol Chem 287:34361-34371. doi:10.1074/jbc.M112.365882 PMID:22910906 PMCID:PMC3464542
  • Zhang J, Ouyang W, Li J, Zhang D, Yu Y, Wang Y, Li X, Huang C. 2012. Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability. Toxicol Appl Pharmacol 263:218-224. doi:10.1016/j.taap.2012.06.012 PMID:22749963 PMCID:PMC3758130
  • Zuo Z, Cai T, Li J, Zhang D, Yu Y, Huang C. 2012. Hexavalent chromium Cr(VI) up-regulates COX-2 expression through an NFκB/c-Jun/AP-1–dependent pathway. Environ Health Perspect 120:547-553. doi:10.1289/ehp.1104179 PMID:22472290 PMCID:PMC3339461
  • Zuo Z, Ouyang W, Li J, Costa M, Huang C. 2012. Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal C141 cells. Curr Cancer Drug Targets 12(6):607-616. PMID:22463588 PMCID:PMC3782088


  • Cai T, Li X, Ding J, Luo W, Li J, Huang C. 2011. A cross-talk between NFAT and NF-κB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Curr Cancer Drug Targets 11(5):548-559. PMID:21486220 PMCID:PMC3759234 (Completed with ARRA Funds)
  • Guo W, Yang Z, Xia Q, Liu J, Yu Y, Li J, Zuo Z, Zhang D, Li X, Shi X, Huang C. 2011. Arsenite stabilizes HIF-1 alpha protein through p85 alpha-mediated up-regulation of inducible Hsp70 protein expression. Cellular and Molecular Life Sciences 68(3):475-488. doi:10.1007/s00018-010-0459-7 PMID:20835880 PMCID:PMC3758129 (Completed with ARRA Funds)
  • Liu J, Zhang D, Luo W, Yu Y, Li J, Zhang X, Zhang B, Chen J, Wu X, Rosas-Acosta G, Huang C. 2011. X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton. J Biol Chem 286:15630-15640. doi:10.1074/jbc.M110.176982 PMID:21402697 PMCID:PMC3091172 (Completed with ARRA Funds)
  • Song L, Gao M, Dong W, Hu M, Li J, Shi X, Hao Y, Li Y, Huang C. 2011. p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene 30(11):1360-1371. doi:10.1038/onc.2010.506 PMID:21057544 PMCID:PMC3761396 (Completed with ARRA Funds)


  • Liu J, Zhang D, Mi X, Xia Q, Yu Y, Zuo Z, Guo W, Zhao X, Cao J, Yang Q, Zhu AG, Yang W, Shi X, Huang C, Li J. 2010. p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways. J Biol Chem 285:26058-26065. doi:10.1074/jbc.M110.100271 PMID:20566634 PMCID:PMC2924005 (Completed with ARRA Funds)
  • Song L, Dong W, Gao M, Li J, Hu M, Guo N, Huang C. 2010. A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression. Biochim Biophys Acta 1803(2):323-332. doi:10.1016/j.bbamcr.2010.01.006 PMID:20080131 PMCID:PMC2850076 (Completed with ARRA Funds)
  • Zhang D, Li J, Costa M, Gao J, Huang C. 2010. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 70(2):813-823. doi:10.1158/0008-5472.CAN-09-0448 PMID:20068160 PMCID:PMC2939838 (Completed with ARRA Funds)



  • Li J, Chen H, Ke Q, Feng Z, Tang M, Liu B, Amin S, Costa M, Huang C. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappa B in mouse epidermal Cl41 cells. Mol Carcinog 40(2):104-115. PMID:15170815
  • Li J, Chen H, Tang M, Shi X, Amin S, Desai D, Costa M, Huang C. 2004. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165(1):77-86. PMID:15067018
  • Li J, Davidson G, Huang Y, Jiang B, Shi X, Costa M, Huang C. 2004. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res 64(1):94-101. PMID:14729612
  • Li J, Dokka S, Wang L, Shi X, Castranova V, Yan Y, Costa M, Huang C. 2004. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. Mol Cell Biochem 255(1-2):217-225. PMID:14971662
  • Li J, Tang M, Liu B, Shi X, Huang C. 2004. A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells. Oncogene 23(22):3932-3944. doi:10.1038/sj.onc.1207501 PMID:15021902


  • Huang C, Li J, Costa M, Zhang Z, Leonard SS, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res 61:8051-8057. PMID:11719426
  • Huang C, Li J, Ding M, Costa M, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Transactivation of RARE and GRE in the cellular response to arsenic. Mol Cell Biochem 222:119-125. PMID:11678593
  • Huang C, Li J, Ding M, Wang L, Shi X, Castranova V, Vallyathan V, Ju G, Costa M. 2001. Arsenic-induced NF kappa beta transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells. Mol Cell Biochem 222:29-34. PMID:11678607
  • Huang C, Zhang Q, Li J, Shi X, Castranova V, Ju G, Costa M, Dong Z. 2001. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo. Mol Cell Biochem 222(1-2):141-147. doi:10.1023/A:1017953927347 PMID:11678596
to Top