Superfund Research Program

P. Lee Ferguson

Duke University
Box 90287
Ciemas 2453
Dept. of Civil & Environmental Engineering
Durham, North Carolina 27708
Phone: 919-660-5460
Fax: 919-660-5219
Email: lee.ferguson@duke.edu

Projects

• Duke University: Altering the Balance of Adipogenic and Osteogenic Regulatory Pathways from Early Life Exposure to HPCs and AOPEs (2017-2022)
• Duke University: Analytical Chemistry Core (2011-2022)
• Duke University: Analytical Chemistry Core (ACC) (2022-2027)
• Duke University: Thyroid Metabolism Disruption Key in Toxicant-Induced Developmental Impairment (2011-2017)

Hazardous Waste Sites

Atlantic Wood Site, Elizabeth River

• Duke University: Analytical Chemistry Core

Publications

2023

• Camdzic D, Dickman RA, Joyce A, Wallace JS, Ferguson PL, Aga DS. 2023. Quantification of total PFAS including trifluoracetic acid with fluorine nuclear magnetic resonance spectroscopy. Anal Chem 95(13):5484-5488. doi:10.1021/acs.analchem.2c05354 PMID:36946571

2022

• Markovich Z, Hartman JH, Ryde IT, Hershberger KA, Joyce A, Ferguson PL, Meyer JN. 2022. Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Curr Res Toxicol 3:doi:10.1016/j.crtox.2022.100084 PMID:35957653 PMCID:PMC9361317

2021

• Ulrich JC, Ferguson PL. 2021. Development of a sensitive direct injection LC-MS/MS method for the detection of glyphosate and aminomethylphosphonic acid (AMPA) in hard waters. Anal Bioanal Chem 413(14):3763-3774. doi:10.1007/s00216-021-03324-5 PMID:33846826 PMCID:PMC8154743

2020

• Babich R, Ulrich JC, Dilini V. Ekanyake E, Massarsky A, De Silva PC, Manage PM, Jackson BP, Ferguson PL, Di Giulio RT, Drummond IA, Jayasundara N. 2020. Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology. Environ Int 144:doi:10.1016/j.envint.2020.106019
• Czaplicki LM, Redfern L, Cooper EM, Ferguson PL, Vilgalys R, Gunsch C. 2020. Investigating the mycobiome of the Holcomb Creosote Superfund Site. Chemosphere 252:9. doi:10.1016/j.chemosphere.2020.126208 PMID:32229362 PMCID:PMC7242165
• Phillips AL, Herkert N, Ulrich JC, Hartman JH, Ruis MT, Cooper EM, Ferguson PL, Stapleton HM. 2020. In vitro metabolism of isopropylated and tert-butylated triarylphosphate esters using human liver subcellular fractions. Chem Res Toxicol 33:1428-1441. doi:10.1021/acs.chemrestox.0c00002 PMID:32129605 PMCID:PMC7508416

2019

• Budarz JF, Cooper EM, Gardner CM, Hodzic E, Ferguson PL, Gunsch C, Wiesner MR. 2019. Chlorpyrifos degradation via photoreactive TiO2 nanoparticles: Assessing the impact of a multi-component degradation scenario. J Hazard Mater 372:61-68. doi:10.1016/j.jhazmat.2017.12.028 PMID:29254886 PMCID:PMC5995634 (in press)
• Redfern L, Gardner CM, Hodzic E, Ferguson PL, Hsu-Kim H, Gunsch C. 2019. A new framework for approaching precision bioremediation of PAH contaminated soils. J Hazard Mater 378:doi:10.1016/j.jhazmat.2019.120859 PMID:31327574 PMCID:PMC6833951

2018

• Czaplicki LM, Dharia M, Cooper EM, Ferguson PL, Vilgalys R, Gunsch C. 2018. Evaluating the mycostimulation potential of select carbon amendments for the degradation of a model PAH by an ascomycete strain enriched from a Superfund site. Biodegradation 29(5):463-471. doi:10.1007/s10532-018-9843-z PMID:30003496 PMCID:PMC6330244
• Kassotis CD, Kollitz EM, Ferguson PL, Stapleton HM. 2018. Nonionic ethoxylated surfactants induce adipogenesis in 3T3-L1 cells. Toxicol Sci 162(1):124-136. doi:10.1093/toxsci/kfx234 PMID:29106673 PMCID:PMC625695
• Kollitz EM, De Carbonnel L, Stapleton HM, Ferguson PL. 2018. The affinity of brominated phenolic compounds for human and zebrafish thyroid receptor beta: Influence of chemical structure. Toxicol Sci doi:10.1093/toxsci/kfy028 PMID:29409039
• Kollitz EM, Kassotis CD, Hoffman K, Ferguson PL, Sosa JA, Stapleton HM. 2018. Chemical mixtures isolated from house dust disrupt thyroid receptor beta signaling. Environ Sci Technol 52:11857-11864. doi:10.1021/acs.est.8b03283 PMID:30212187

2017

• Barzen-Hanson KA, Roberts SC, Choyke S, Oetjen K, McAlees A, Riddell N, McCrindle R, Ferguson PL, Higgins CP, Field JA. 2017. Discovery of 40 classes of per- and polyfluoroalkyl substances in historical aqueous film-forming foams (AFFFs) and AFFF-impacted groundwater. Environ Sci Technol 51(4):2047-2057. doi:10.1021/acs.est.6b05843 PMID:28098989
• Ferguson PL, Stapleton HM. 2017. Comment on: Mutagenic azo dyes, rather than flame retardants, are the predominant brominated compounds in house dust. Environ Sci Technol 51(6):3588-3590. doi:10.1021/acs.est.7b00372 PMID:28282131
• Hollender J, Schymanski EL, Singer HP, Ferguson PL. 2017. Nontarget screening with high resolution mass spectrometry in the environment: ready to go?. Environ Sci Technol 51(20):11505-11512. doi:10.1021/acs.est.7b02184 PMID:28877430

2016

• Cooper EM, Kroeger G, Davis K, Clark C, Ferguson PL, Stapleton HM. 2016. Results from screening polyurethane foam based consumer products for flame retardant chemicals: assessing impacts on the change in the furniture flammability standards. Environ Sci Technol 50(19):10653-10660. doi:10.1021/acs.est.6b01602 PMID:27552529 PMCID:PMC5052662
• Czaplicki LN, Cooper EM, Ferguson PL, Stapleton HM, Vilgalys R, Gunsch C. 2016. A new perspective on sustainable soil remediation-case study suggests novel fungal genera could facilitate in situ biodegradation of hazardous contaminants. Remediation (N Y) 26(2):59-72. doi:10.1002/rem.21458 PMID:27917031 PMCID:PMC5130160
• Holden PA, Gardea-Torresdey JL, Klaessig F, Turco RF, Mortimer M, Hund-Rinke K, Cohen Hubal EA, Avery D, Barcelo D, Behra R, Cohen Y, Deydier-Stephan L, Ferguson PL, Fernandes TF, Herr Harthorn B, Henderson WM, Hoke RA, Hristozov D, Johnston JM, Kane AB, Kapustka L, Keller AA, Lenihan HS, Lovell W, Murphy CJ, Nisbet RM, Petersen EJ, Salinas ER, Scheringer M, Sharma M, Speed DE, Sultan Y, Westerhoff P, White JC, Wiesner MR, Wong E, Xing B, Steele Horan M, Godwin H, Nel AE. 2016. Considerations of environmentally relevant test conditions for improved evaluation of ecological hazards of engineered nanomaterials. Environ Sci Technol 50(12):6124-6145. doi:10.1021/acs.est.6b00608 PMID:27177237 PMCID:PMC4967154

2015

• Fang M, Webster TF, Ferguson PL, Stapleton HM. 2015. Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environ Health Perspect 123(2):166-172. doi:10.1289/ehp.1408522 PMID:25314719 PMCID:PMC4314249

2014

• Dong W, Macaulay LJ, Kwok KW, Hinton DE, Ferguson PL, Stapleton HM. 2014. The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos. Endocr Disruptors (Austin) 2(1):doi:10.4161/23273739.2014.969072 PMID:25767823 PMCID:PMC4354867
• Fang M, Getzinger GJ, Cooper EM, Clark BW, Garner LV, Di Giulio RT, Ferguson PL, Stapleton HM. 2014. Effect-directed analysis of Elizabeth River porewater: developmental toxicity in zebrafish (Danio rerio). Environ Toxicol Chem 33(12):2767-2774. doi:10.1002/etc.2738 PMID:25196082 PMCID:PMC4393830
• Levin ED, Cauley M, Johnson JE, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. 2014. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol Teratol 41:35-42. doi:10.1016/j.ntt.2013.10.004 PMID:24177596 PMCID:PMC3943881

2011

• Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Toward identifying the next generation of superfund and hazardous waste site contaminants. Environ Health Perspect 119(1):6-10. doi:10.1289/ehp.1002497 PMID:21205582 PMCID:PMC3018501

2003

• Ferguson PL, Bopp RF, Chillrud SN, Aller RC, Brownawell B. 2003. Biogeochemistry of nonylphenol ethoxylates in urban estuarine sediments. Environ Sci Technol 37(16):3499-3506. PMID:12953858