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Person Details: John M. Essigmann

Superfund Research Program

John M. Essigmann

Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, Massachusetts 02139-4307
Phone: 617-253-6227




  • Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33(2):625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946 (in press)




  • Henderson PT, Neeley WL, Delaney JC, Gu F, Niles JC, Hah SS, Essigmann JM, Tannenbaum SR. 2005. Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations. Chem Res Toxicol 18(1):12-18. PMID:15651843


  • Neeley WL, Delaney JC, Henderson PT, Essigmann JM. 2004. In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole. J Biol Chem 279(42):43568-43573. doi:10.1074/jbc.M407117200 PMID:15299010
  • Neeley WL, Henderson PT, Essigmann JM. 2004. Efficient synthesis of DNA containing the guanine oxidation-nitration product 5-guanidino-4-nitroimidazole: generation by a postsynthetic substitution reaction. Org Lett 6(2):245-248. PMID:14723539


  • Henderson PT, Delaney JC, Muller JG, Neeley WL, Tannenbaum SR, Burrows CJ, Essigmann JM. 2003. The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry 42(31):9257-9262. doi:10.1021/bi0347252 PMID:12899611
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