Superfund Research Program

John M. Essigmann

Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, Massachusetts 02139-4307
Phone: 617-253-6227
Email: jessig@mit.edu

Projects

• Massachusetts Institute of Technology: Administrative Core (2017-2022)
• Massachusetts Institute of Technology: Assessment of Genotoxic Health Risks at Superfund Sites through Mutational Signatures (2017-2022)
• Massachusetts Institute of Technology: High Resolution Mutation Spectra and Multi-Omics for Deducing Etiology and Predicting Disease (2022-2027)
• Massachusetts Institute of Technology: Research Experience and Training Coordination Core (2022-2027)
• Massachusetts Institute of Technology: Training Core (2017-2022)

Publications

2024

• Wang J, Takyi N, Hsiao Y, Tang Q, Chen Y, Liu C, Ma JF, Qi R, Bian K, Peng Z, Essigmann JM, Lu K, Wetmore S, Li D. 2024. Stable interstrand cross-links generated from the repair of 1,N(6)-ethenoadenine in DNA by α-ketoglutarate/Fe(II)-dependent dioxygenase ALKBH2. J Am Chem Soc 146(15):10381-10392. doi:10.1021/jacs.3c12890 PMID:38573229

2023

• Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. 2023. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer 5(2):doi:10.1093/narcan/zcad015 PMID:36992846 PMCID:PMC1004153
• Feng H, Luo S, Croy RG, Essigmann JM, Swager TM. 2023. Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection. Dalton Trans 52(10):3219-3233. doi:10.1039/d2dt03848j PMID:36799554 PMCID:PMC9990372

2022

• Basu AK, Essigmann JM. 2022. Establishing linkages among DNA damage, mutagenesis, and genetic diseases. Chem Res Toxicol doi:10.1021/acs.chemrestox.2c00155 PMID:35881568

2021

• Fedeles BI, Essigmann JM. 2021. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease. DNA Damage, DNA Repair and Disease 15:214-253.
• Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582
• Lu R, Yuan W, Croy RG, Essigmann JM, Swager TM. 2021. Metallocalix[4]arene polymers for gravimetric detection of N-nitrosodialkylamines. J Am Chem Soc 143:doi:10.1021/jacs.1c08739 PMID:34793165 PMCID:PMC8811785
• Tajai P, Suriyo T, Rangkadilok N, Fedeles BI, Essigmann JM, Satayavivad J. 2021. Andrographolide, an antioxidant, counteracts paraquat-induced mutagenesis in mammalian cells. Asian Pac. J. Cancer Prev 22:PMID:33576206

2020

• Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33:625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946

2019

• He M, Croy RG, Essigmann JM, Swager TM. 2019. Chemiresistive carbon nanotube sensors for n-nitrosodialkylamines. ACS Sens 4(10):2819-2824. doi:10.1021/acssensors.9b01532 PMID:31573183 PMCID:PMC6939299

2018

• Fedeles BI, Essigmann JM. 2018. Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study. DNA Repair (Amst) 71:12-22. doi:10.1016/j.dnarep.2018.08.008 PMID:30309820 PMCID:PMC6340726

2005

• Henderson PT, Neeley WL, Delaney JC, Gu F, Niles JC, Hah SS, Essigmann JM, Tannenbaum SR. 2005. Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations. Chem Res Toxicol 18(1):12-18. PMID:15651843

2004

• Neeley WL, Delaney JC, Henderson PT, Essigmann JM. 2004. In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole. J Biol Chem 279(42):43568-43573. doi:10.1074/jbc.M407117200 PMID:15299010
• Neeley WL, Henderson PT, Essigmann JM. 2004. Efficient synthesis of DNA containing the guanine oxidation-nitration product 5-guanidino-4-nitroimidazole: generation by a postsynthetic substitution reaction. Org Lett 6(2):245-248. PMID:14723539

2003

• Henderson PT, Delaney JC, Muller JG, Neeley WL, Tannenbaum SR, Burrows CJ, Essigmann JM. 2003. The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry 42(31):9257-9262. doi:10.1021/bi0347252 PMID:12899611