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Your Environment. Your Health.

Person Details: John M. Essigmann

Superfund Research Program

John M. Essigmann

Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, Massachusetts 02139-4307
Phone: 617-253-6227
Email: jessig@mit.edu

Projects

Publications

2021

  • Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582
  • Tajai P, Suriyo T, Rangkadilok N, Fedeles BI, Essigmann JM, Satayavivad J. 2021. Andrographolide, an antioxidant, counteracts paraquat-induced mutagenesis in mammalian cells. Asian Pac. J. Cancer Prev 22:PMID:33576206

2020

  • Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33:625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946

2019

2018

2005

  • Henderson PT, Neeley WL, Delaney JC, Gu F, Niles JC, Hah SS, Essigmann JM, Tannenbaum SR. 2005. Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations. Chem Res Toxicol 18(1):12-18. PMID:15651843

2004

  • Neeley WL, Delaney JC, Henderson PT, Essigmann JM. 2004. In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole. J Biol Chem 279(42):43568-43573. doi:10.1074/jbc.M407117200 PMID:15299010
  • Neeley WL, Henderson PT, Essigmann JM. 2004. Efficient synthesis of DNA containing the guanine oxidation-nitration product 5-guanidino-4-nitroimidazole: generation by a postsynthetic substitution reaction. Org Lett 6(2):245-248. PMID:14723539

2003

  • Henderson PT, Delaney JC, Muller JG, Neeley WL, Tannenbaum SR, Burrows CJ, Essigmann JM. 2003. The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry 42(31):9257-9262. doi:10.1021/bi0347252 PMID:12899611
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