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Person Details: Richard H. Finnell

Superfund Research Program

Richard H. Finnell

Baylor College of Medicine
One Baylor Plaza
Alkek Building, BCM229
Suite N1317.00
Houston, Texas 77030-3411
Phone: 713-798-4363




  • Niedzwiecki M, Liu X, Zhu H, Hall MN, Slavkovich VN, Ilievski V, Levy D, Siddique AB, Kibriya MG, Parvez F, Islam T, Ahmed A, Navas-Acien A, Graziano JH, Finnell RH, Ahsan H, Gamble MV. 2018. Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study. Environ Int 113:133-142. doi:10.1016/j.envint.2018.01.015 PMID:29421402 PMCID:PMC5873983




  • Finnell RH. 2008. Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model. Birth Defects Research Part B: Developmental and Reproductive Toxicology 83(1):40-7. PMID:18186108


  • Lu W, Zhu H, Wen S, Laurent C, Shaw GM, Lammer EJ, Finnell RH. 2007. Screening for novel PAX3 polymorphisms and risks of spina bifida. Birth Defects Res A Clin Mol Teratol 79(1):45-49. PMID:17149730
  • Shaw GM, Jelliffe-Pawlowski L, Nelson V, Zhu H, Harris JA, Finnell RH. 2007. Infant C677T MTHFR polymorphism and severe mental retardation. Birth Defects Res A Clin Mol Teratol 79(1):24-26. PMID:17149733
  • Sobol E, Yagen B, Lamb JG, White HS, Wlodarczyk BJ, Finnell RH, Bialer M. 2007. Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide. Epilepsy Res 73(1):75-84. PMID:16997532


  • Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt RC, Liu S, Hill DS, Finnell RH, Wlodarczyk BJ, Jordan VC, Safe SH. 2006. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Res 66(4):2459-2467. doi:10.1158/0008-5472.CAN-05-3132 PMID:16489053
  • Blom HJ, Shaw GM, den Heijer M, Finnell RH. 2006. Neural tube defects and folate: case far from closed. Nat Rev Neurosci 7(9):724-731. PMID:16924261
  • Carmichael SL, Shaw GM, Iovannisci DM, Yang W, Finnell RH, Cheng S, Lammer EJ. 2006. Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. American Journal of Medical Genetics Part A 140A(22):2422-2440. PMID:17036337
  • Enaw JO, Zhu H, Yang W, Lu W, Shaw GM, Lammer EJ, Finnell RH. 2006. CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. BMC Med 4:36. PMID:17184542
  • Massa V, Wlodarczyk BJ, Giavini E, Finnell RH. 2006. Myo-inositol enhances teratogenicity of valproic acid in the mouse. Birth Defects Res A Clin Mol Teratol 76(3):200-204. PMID:16511884
  • Meador KJ, Baker G, Finnell RH, Kalayjian LA, Liporace JD, Loring DW, Mawer G, Pennell PB, Smith JC, Wolff MC. 2006. In utero antiepileptic drug exposure: fetal death and malformations. Neurology 67(3):407-412. PMID:16894099
  • Mitchell LE, Finnell RH, Whitehead A. 2006. Aetiology and Prevention of Spina Bifida. Chapter 9 in: Recent Advances in Pediatrics 23. Royal Society of Medicine Press, London, England. pp.12.
  • Pei L, Zhu H, Zhu J, Ren A, Finnell RH, Li Z. 2006. Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China. Ann Epidemiol 16(5):352-356. doi:10.1016/j.annepidem.2005.02.014 PMID:16019224
  • Sobol E, Yagen B, White HS, Wilcox KS, Lamb JG, Pappo O, Wlodarczyk BJ, Finnell RH, Bialer M. 2006. Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug. Neuropharmacology 51(4):933-946. doi:10.1016/j.neuropharm.2006.06.006 PMID:16890251
  • Wlodarczyk BJ, Cabrera RM, Hill DS, Bozinov D, Zhu H, Finnell RH. 2006. Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos. Neurotoxicology 27(4):547-557. PMID:16620997
  • Wlodarczyk BJ, Tang LS, Triplett A, Aleman F, Finnell RH. 2006. Spontaneous neural tube defects in Splotch mice supplemented with selected micronutrients. Toxicol Appl Pharmacol 213(1):55-63. PMID:16226775
  • Zhang J, Zhu H, Yang W, Shaw GM, Lammer EJ, Finnell RH. 2006. Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida. American Journal of Medical Genetics Part A 140(7):785-789. PMID:16523512
  • Zhu H, Yang W, Lu W, Zhang J, Shaw GM, Lammer EJ, Finnell RH. 2006. A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida. Mol Genet Metab 87(1):66-70. PMID:16256389
  • Zhu J, Ren A, Hao L, Pei L, Liu J, Zhu H, Li S, Finnell RH, Li Z. 2006. Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China. American Journal of Medical Genetics Part A 140(6):551-557. PMID:16470725


  • Lu W, Volcik K, Zhu H, Wen S, Shaw GM, Lammer EJ, Finnell RH. 2005. Genetic variation in the proto-oncogene SKI and risk for orofacial clefting. Mol Genet Metab 86(3):412-416. doi:10.1016/j.ymgme.2005.06.003 PMID:16054854
  • Massa V, Cabrera RM, Menegola E, Giavini E, Finnell RH. 2005. Valproic acid-induced skeletal malformations: associated gene expression cascades. Pharmacol Toxicol 15(11):787-800. PMID:16220111
  • Spiegelstein O, Cabrera RM, Finnell RH. 2005. Functional Genomics and Proteomics in Developmental and Reproductive Toxicology. In: Developmental and Reproductive Toxicology, A Practical Approach. Second Edition. pp.621-646.
  • Spiegelstein O, Gould A, Wlodarczyk BJ, Tsie M, Lu X, Le X, Troen A, Selhub J, Piedrahita JA, Salbaum JM, Kappen C, Melnyk SB, James S, Finnell RH. 2005. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Toxicol Appl Pharmacol 203(1):18-26. PMID:15694460
  • Spiegelstein O, Lu X, Le X, Troen A, Selhub J, Melnyk SB, James S, Finnell RH. 2005. Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice. Environ Toxicol Pharmacol 19(1):1-7. doi:10.1016/j.etap.2004.01.007 PMID:21783456
  • Tang LS, Santillano DR, Miranda RC, Finnell RH. 2005. Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 135C(1):48-58. PMID:15800851


  • Finnell RH, Shaw GM, Lammer EJ, Brandl KL, Carmichael SL, Rosenquist TH. 2004. Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis. Toxicol Appl Pharmacol 198(2):75-85. PMID:15236946
  • Spiegelstein O, Cabrera RM, Bozinov D, Wlodarczyk BJ, Finnell RH. 2004. Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos. Neurochem Res 29(6):1105-1112. PMID:15176467
  • Spiegelstein O, Mitchell LE, Merriweather MY, Wicker NJ, Zhang Q, Lammer EJ, Finnell RH. 2004. Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation. Dev Dyn 231(1):221-231. doi:10.1002/dvdy.20107 PMID:15305303
  • Tang LS, Santillano DR, Miranda RC, Finnell RH. 2004. Developmental consequences of abnormal folate transport during murine heart morphogenesis. Birth Defects Res A Clin Mol Teratol 70(7):449-458. PMID:15259034


  • Finnell RH, Gould A, Spiegelstein O. 2003. Pathobiology and genetics of neural tube defects. Epilepsia 44:14-23Suppl.3. PMID:12790882
  • Spiegelstein O, Lu X, Le X, Troen A, Selhub J, Melnyk SB, James S, Finnell RH. 2003. Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol Lett 145(2):167-174. doi:10.1016/S0378-4274(03)00307-2 PMID:14581169
  • Spiegelstein O, Lu X, Le X, Troen A, Selhub J, Melnyk SB, James S, Finnell RH. 2003. Urinary speciation of sodium arsenate in folate receptor knockout mice. In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.335-342.
  • Tang LS, Finnell RH. 2003. Neural and orofacial defects in Folbp1 knockout mice. Birth Defects Res A Clin Mol Teratol 67(4):209-218. PMID:12854656
  • Zhu H, Wicker NJ, Shaw GM, Lammer EJ, Hendricks K, Suarez L, Canfield M, Finnell RH. 2003. Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab 78(3):216-221. PMID:12649067


  • Finnell RH, Gelineau-van Waes J, Eudy JD, Rosenquist TH. 2002. Molecular basis of environmentally enduced birth defects. Annu Rev Pharmacol Toxicol 42:181-208. PMID:11807170
  • Finnell RH, Junker W, Wadman L, Cabrera RM. 2002. Gene expression profiling within the developing neural tube. Neurochem Res 27(10):1165-1180. PMID:12462415
  • Finnell RH, Spiegelstein O, Wlodarczyk BJ, Triplett A, Pogribny IP, Melnyk SB, James JS. 2002. DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr 132(8):2457S-2461SSuppl.S. PMID:12163711
  • Gefrides LA, Bennett GB, Finnell RH. 2002. Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice. Birth Defects Res A Clin Mol Teratol 65(2):63-69. doi:10.1002/tera.10019 PMID:11857507


  • Rosenquist TH, Finnell RH. 2001. Genes, folate and homocysteine in embryonic development. Proceedings of the Nutrition Society 60(1):53-61. PMID:11310424
  • Wlodarczyk BJ, Spiegelstein O, Gelineau-van Waes J, Vorce RL, Lu X, Le C, Finnell RH. 2001. Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol 177(3):238-246. PMID:11749123


  • Eudy JD, Spiegelstein O, Barber RC, Wlodarczyk BJ, Talbot J, Finnell RH. 2000. Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab 71(4):581-590. PMID:11136550
  • Gelineau-van Waes J, Bennett GD, Barber RC, Wlodarczyk BJ, Shaw GM, Lammer EJ, Piedrahita JA, Eberwine JH, Finnell RH. 2000. Genetic Basis of Susceptibility to Environmentally-Induced Birth Defects. In: Toxicology for the Next Millennium. New York Academy of Sciences, New York, NY. pp.261-277.
  • Ruan Y, Petersen MH, Wauson EM, Gelineau-van Waes J, Vorce RL, Finnell RH. 2000. Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity. Toxicol Lett 117:129-137. PMID:11087978
  • Spiegelstein O, Eudy JD, Finnell RH. 2000. Identification of two putative novel folate receptor genes in humans and mouse. Gene 258(1-2):117-125. PMID:11111049
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