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Person Details: Jared V. Goldstone

Superfund Research Program

Jared V. Goldstone

Woods Hole Oceanographic Institution
Biology Department
Redfield 3-52, MS #32
Woods Hole, Massachusetts 02543
Phone: 508-289-4823




  • Brun NR, Panlilio JM, Zhang K, Zhao Y, Ivashkin E, Stegeman JJ, Goldstone JV. 2021. Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Commun Biol 4:doi:10.1038/s42003-021-02626-9 PMID:34561524 PMCID:PMC8463681
  • Brun NR, Salanga MC, Mora-Zamorano FX, Lamb DC, Goldstone JV, Stegeman JJ. 2021. Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish. Sci Rep 11:doi:10.1038/s41598-021-03068-3 PMID:34903767 PMCID:PMC8669017
  • Celander MC, Goldstone JV, Brun NR, Clark BW, Jayaraman S, Nacci DE, Stegeman JJ. 2021. Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environ Toxicol Pharmacol 83:103580. doi:10.1016/j.etap.2020.103580 PMID:33429071
  • Crespi E, Burnap R, Chen J, Das M, Gassman N, Rosa E, Simmons R, Wada H, Wang ZQ, Xiao J, Yang B, Yin J, Goldstone JV. 2021. Resolving the rules of robustness and resilience in biology across scales. Integr Comp Biol 61(6):doi:10.1093/icb/icab183 PMID:34427654 PMCID:PMC8825770
  • Eide M, Zhang X, Karlsen OA, Goldstone JV, Stegeman JJ, Jonassen I, Goksoyr A. 2021. The chemical defensome of five model teleost fish. Sci Rep doi:10.1038/s41598-021-89948-0 PMID:34006915 PMCID:PMC8131381



  • Eide M, Rydbeck H, Torresen OK, Lille-Langoy R, Puntervoll P, Goldstone JV, Jakobsen KS, Stegeman JJ, Goksoyr A, Karlsen OA. 2018. Independent losses of a xenobiotic receptor across teleost evolution. Sci Rep 8(1):10404. doi:10.1038/s41598-018-28498-4 PMID:29991818 PMCID:PMC6039460
  • Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees F, Hahn ME, Stegeman JJ. 2018. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta 1866:155-165. doi:10.1016/j.bbapap.2017.06.026 PMID:28694077 PMCID:PMC5693637
  • Lille-Langoy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksoyr A. 2018. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci 168:28-39. doi:10.1093/toxsci/kfy269 PMID:30371853 PMCID:PMC6390661
  • Ulin A, Henderson J, Pham MT, Meyo J, Chen Y, Karchner SI, Goldstone JV, Hahn ME, Williams LM. 2018. Developmental regulation of nuclear factor erythroid-2 related factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicol Sci 167(2):536-545. doi:10.1093/toxsci/kfy257 PMID:30321412 PMCID:PMC6358246


  • Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. 2017. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): a phylogenetic and population-based comparison. Aquat Toxicol 192:105-115. doi:10.1016/j.aquatox.2017.09.002 PMID:28942070 PMCID:PMC5662517
  • Leung MC, Procter AC, Goldstone JV, Foox J, DeSalle R, Mattingly CJ, Siddall ME, Timme-Laragy AR. 2017. Applying evolutionary genetics to developmental toxicology and risk assessment. Reprod Toxicol 69:174-186. doi:10.1016/j.reprotox.2017.03.003 PMID:28267574
  • Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy AR. 2017. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biol 13:207-218. doi:10.1016/j.redox.2017.05.023 PMID:28582729 PMCID:PMC5458767


  • Goldstone JV, Sundaramoorthy M, Zhao B, Waterman MR, Stegeman JJ, Lamb DC. 2016. Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. Mol Phylogenet Evol 94(PtB):676-687. doi:10.1016/j.ympev.2015.09.012 PMID:26432395 PMCID:PMC4801120
  • Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001 PMID:26853319 PMCID:PMC4807407
  • Maldonado A, Lavodo R, Knuston S, Slattery M, Ankisetty S, Goldstone JV, Watanabe K, Hoh E, Gadepalli RS, Rimoldi JM, Ostrander GK, Schlenk D. 2016. Biochemical mechanisms for geographical adaptations to novel toxin exposures in butterflyfish. PLoS One 11(5):e0154208. doi:10.1371/journal.pone.0154208 PMID:27136924 PMCID:PMC4854401


  • Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN. 2015. Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Aquat Toxicol 159:156-166. doi:10.1016/j.aquatox.2014.12.017 PMID:25546006 PMCID:PMC4300256
  • Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ. 2015. Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143(2):398-407. doi:10.1093/toxsci/kfu240 PMID:25424564 PMCID:PMC4306721
  • Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. 2015. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1):54-64. doi:10.1016/j.taap.2015.02.001 PMID:25680588 PMCID:PMC4387200
  • Stegeman JJ, Behrendt L, Woodin BR, Kubota A, Lemaire B, Pompon D, Goldstone JV, Urban P. 2015. Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta 1850(11):2340-2352. doi:10.1016/j.bbagen.2015.07.010 PMID:26231923 PMCID:PMC4587093


  • Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ. 2014. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase. Biochim Biophys Acta 1840(6):1825-1836. doi:10.1016/j.bbagen.2013.12.009 PMID:24361620 PMCID:PMC4118742




  • Gao K, Brandt I, Goldstone JV, Jonsson ME. 2011. Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comp Biochem Physiol 154:42-55. doi:10.1016/j.cbpc.2011.02.005 PMID:21354474 PMCID:PMC3560405
  • Jonsson ME, Berg C, Goldstone JV, Stegeman JJ. 2011. New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183. doi:10.1016/j.taap.2010.10.010 PMID:20965207 PMCID:PMC3014448
  • Kubota A, Stegeman JJ, Goldstone JV, Nelson DR, Kim EY, Tanabe S, Iwata H. 2011. Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression. Comp Biochem Physiol C Toxicol Pharmacol 153:280-289. doi:10.1016/j.cbpc.2010.11.006 PMID:21130899 PMCID:PMC3560406
  • Parente T, Rebelo MF, da-Silva ML, Woodin BR, Goldstone JV, Bisch PM, Paumgartten FJ, Stegeman JJ. 2011. Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp. Gene 489:111-118. doi:10.1016/j.gene.2011.07.023 PMID:21840383 PMCID:PMC3200446



  • Whalen KE, Morin D, Lin C, Tjeerdema RS, Goldstone JV, Hahn ME. 2008. Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum. Arch Biochem Biophys 478(1):7-17. doi:10.1016/ PMID:18671936


  • Goldstone JV, Handley-Goldstone HM, Morrison AM, Tarrant AM, Kern SE, Woodin BR, Stegeman JJ. 2007. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol Biol Evol 24(12):2619-31. doi:10.1093/molbev/msm200 PMID:17916789
  • Goldstone JV, Stegeman JJ. 2007. Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes). Mar Environ Res 66(1):19--20. PMID:18400289
  • Jonsson ME, Orrego R, Woodin BR, Goldstone JV, Stegeman JJ. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol 221(1):29-41. PMID:17445853
  • Prasad JC, Goldstone JV, Camacho CJ, Vajda S, Stegeman JJ. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologues. Biochemistry 46(10):2640-2654. PMID:17300179


  • Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. 2006. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol 300(1):366-384. doi:10.1016/j.ydbio.2006.08.066 PMID:17097629 PMCID:PMC3166225
  • Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol 77(4):422-432. PMID:16500718
  • Verslycke T, Goldstone JV, Stegeman JJ. 2006. Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp): a CYP3 line in early deuterostomes?. Mol Phylogenet Evol 40(3):760-771. doi:10.1016/j.ympev.2006.04.017 PMID:16777437


  • Godard-Codding CJ, Goldstone JV, Said MR, Dickerson RL, Woodin BR, Stegeman JJ. 2005. The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis. Biochem Biophys Res Commun 331(4):1016-1024. PMID:15882979


  • Goldstone JV, Stegeman JJ. 2003. Quantification of ROS Production and Enzyme Inactivation of CYP 1A by Polychlorinated Biphenyls and by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Prasad JC, Vajda S, Goldstone JV, Camacho CJ, Stegeman JJ. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
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