Superfund Research Program

Richard Seegal

University of Albany - SUNY
Empire State Plaza
Wadsworth Center
Albany, New York 12201
Phone: 518-473-4378
Email:

Projects

• University of Albany - SUNY: Neurochemical, Neurobehavioral, And Endocrine Effects of Developmental Exposure of Rats to Individual PCB Congeners (1995 - 2000)

Publications

2019

• Pessah IN, Lein PJ, Seegal R, Sagiv SK. 2019. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol 138(3):363-387. doi:10.1007/s00401-019-01978-1 PMID:30976975 PMCID:PMC6708608

2008

• Pessah IN, Seegal R, Lein PJ, LaSalle J, Yee BK, van de Water JG, Berman RF. 2008. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29(3):532-545. doi:10.1016/j.neuro.2008.02.006 PMID:18394707 PMCID:PMC2475601

2000

• Bemis JC, Seegal R. 2000. Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. Neurotoxicology 21(6):1123-1134. PMID:11233759
• Seegal R. 2000. Coplanar PCB congeners are uterotropic in prepubertal rats. Society of Toxicology
• Seegal R. 2000. Mechanisms of PCB-induced neurotoxicity. In: Proceedings of the 1^st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY.
• Seegal R, Okoniewski RJ, Bemis JC. 2000. Aroclor 1254 alters extra-cellular dopamine concentrations in adult rat striatum. In: Proceedings of the DIOXIN 2000 International Meeting. Monterey, CA.

1999

• Arcaro KF, Yi L, Seegal R, Vakharia D, Yang Y, Spink DC, Brosch KO, Gierthy JF. 1999. 2,2',6,6'-tetrachlorobiphenyl is estrogenic in vitro and in vivo. J Cell Biochem 72(1):94-102. PMID:10025670
• Bemis JC, Seegal R. 1999. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environ Health Perspect 107:879-885. PMID:10544155
• Seegal R. 1999. Polychlorinated biphenyls and methylmercury synergistically alter dopamine and intracellular calcium in vitro. In: Proceedings of the 17th International Neurotoxicology Conference. Little Rock, AR.
• Seegal R, Brosch KO. 1999. The uterotropic actions of 3,4,5,3',4'-PCB are mediated by the estrogen receptor. In: Proceedings of the 38^th Annual Meeting of the Society of Toxicology (SOT), March, 1999. New Orleans, LA.

1998

• Fischer L, Seegal R, Ganey PE, Pessah IN, Kodavanti PR. 1998. Symposium overview: toxicity of non-coplanar PCBs. Toxicol Sci 41(1):49-61. doi:10.1006/toxs.1997.2386 PMID:9520341
• Seegal R. 1998. Neurochemical effects of co-planar and non-coplanar polychlorinated biphenyls. In: Neurobehavioral Teratology Society Meeting. San Diego, CA.
• Seegal R, Bemis JC, Okoniewski RJ. 1998. Polychlorinated biphenyls interact with other Great Lakes fish-borne contaminants to alter dopamine function in vitro. In: Proceedings of the DIOXIN 1998 International Meeting. Stockholm, Sweden.
• Seegal R, Gierthy JF, Arcaro KF, Brosch KO. 1998. Neurochemical and neuroendocrine effects of non-coplanar and coplanar PCBs. Fundam Appl Toxicol 41:49-61.
• Seegal R, Pappas BA, Park GA. 1998. Neurochemical effects of consumption of Great Lakes salmon by rats. Regul Toxicol Pharmacol 27:S68-S75. PMID:9618335

1997

• Seegal R, Brosch KO, Okoniewski RJ. 1997. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2',4'- and 3,4,3',4'-tetrachlorobiphenyl on dopamine function. Toxicol Appl Pharmacol 146:95-103. PMID:9299601

1996

• Carpenter DO, Stoner CT, Lawrence DA, Niemi WD, Shain W, Seegal R. 1996. Multiple mechanisms of PCB neurotoxicity. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia. pp.404-418.
• Chishti MA, Fisher JP, Seegal R. 1996. Aroclors 1254 and 1260 reduce dopamine concentrations in rat striatal slices. Neurotoxicology 17:653-660. PMID:9086486
• Gierthy JF, Seegal R, Floyd M, Arcaro KF, Spink DC. 1996. Estrogenic activity of 2,2',6,6'-tetrachlorobiphenyl in MCF-7 human breast cancer cells. Environ Health Perspect 30:225-226.
• Seegal R. 1996. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit Rev Toxicol 26:709-737. PMID:8958469
• Seegal R. 1996. Neurochemical effects of PCBs: limitations in extrapolation of in vitro effects to whole animals. Organohalogen Compounds 29:137-142.
• Seegal R, Chishti MA, Gierthy JF. 1996. Uterotropic and neurochemical effects of 2,2',6,6'-tetrachlorobiphenyl in the prepubertal rat. Environ Health Perspect 30:227.

1995

• Seegal R. 1995. Dopaminergic bases of polychlorinated biphenyl-neurotoxicity. In: Neurotoxicology: Approaches and Methods. Academic Press, NY. pp.347-357.
• Seegal R. 1995. Neurochemical effects of PCBs are structure and recipient age-dependent. Organohalogen Compounds 25:425-430.
• Seegal R, Chishti MA. 1995. Polychlorinated biphenyls reduce dopamine content in striatal slices from immature and adult rats. Environ Health Perspect 15:146.
• Seegal R, Chishti MA, Battaglioli G. 1995. Polychlorinated biphenyls decrease dopamine and elevate GABA content in striatal slices from adult rats. In: Proceedings of the 5^th International Neurotoxicology Association Conference. Port Ludlow, WA. pp.18.
• Seegal R, Gierthy JF. 1995. Developmental exposure to individual PCB congeners - multiple mechanisms of action. Neurotoxicology 16:753.