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Person Details: John K. Wiencke

Superfund Research Program

John K. Wiencke

University of California-San Francisco
Department of Neurological Surgery
500 Parnassus Avenue, MU-W 420
San Francisco, California 94143-0560
Phone: 415-476-3059
Fax: 415-476-6014
Email: wiencke@itsa.ucsf.edu

Projects

Publications

2015

  • Lee S, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith AJ, Martin-Subero JI, Heath S, Houseman EA, Roy R, Wrensch MR, Wiencke JK, Metayer C, Wiemels JL. 2015. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res 43(5):2590-2602. doi:10.1093/nar/gkv103 PMID:25690899 PMCID:PMC4357708

2014

  • Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT. 2014. Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics 9(6):884-895. doi:10.4161/epi.28575 PMID:24671036 PMCID:PMC4065186
  • Xiao J, Lee S, Xiao Y, Ma X, Houseman EA, Hsu L, Roy R, Wrensch MR, de Smith AJ, Chokkalingam AP, Buffler PA, Wiencke JK, Wiemels JL. 2014. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer 135(5):1101-1109. doi:10.1002/ijc.28759 PMID:24496747 PMCID:PMC4776754

2012

  • Nelson HH, Marsit CJ, Christensen BC, Houseman E, Kontic M, Wiemels JL, Karagas MR, Zheng S, Wiencke JK, Kelsey KT. 2012. Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling. Epigenetics 7(6):559-566. doi:10.4161/epi.20219 PMID:22522909 PMCID:PMC3398985

2011

  • Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 6:908-919. doi:10.4161/epi.6.7.16431 PMID:21617368 PMCID:PMC3154431 (Completed with ARRA Funds)
  • Metayer C, Scelo G, Chokkalingam AP, Barcellos L, Aldrich MC, Chang JS, Guha N, Urayama KY, Hansen HM, Block G, Kiley VA, Wiencke JK, Wiemels JL, Buffler PA. 2011. Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control 22:1243-1258. doi:10.1007/s10552-011-9795-7 PMID:21748308 PMCID:PMC3744066

2010

  • Christensen BC, Smith A, Zheng S, Koestler DC, Houseman E, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. 2010. DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst 103:143-153. doi:10.1093/jnci/djq497 PMID:21163902 PMCID:PMC3022619
  • Marsit CJ, Houseman EA, Christensen BC, Gagne LA, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. 2010. Identification of methylated genes associated with aggressive bladder cancer. PLoS One 5:e12334. doi:10.1371/journal.pone.0012334 PMID:20808801 PMCID:PMC2925945
  • Wilhelm-Benartzi C, Koestler DC, Houseman E, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis 31(11):1972-1976. doi:10.1093/carcin/bgq178 PMID:20802236 PMCID:PMC2966555 (Completed with ARRA Funds)

2009

  • Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury J, Bueno R, Sugarbaker DJ, Yeh R, Wiencke JK, Kelsey KT. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 5(8):e1000602. doi:10.1371/journal.pgen.1000602 PMID:19680444 PMCID:PMC2718614

2008

  • Chang JS, Yeh R, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR. 2008. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. Cancer Epidemiol Biomarkers Prev 17(6):1368-1373. doi:10.1158/1055-9965.EPI-07-2830 PMID:18559551
  • Houseman EA, Christensen BC, Yeh R, Marsit CJ, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT. 2008. Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochem 9:365. doi:10.1186/1471-2105-9-365 PMID:18782434 PMCID:PMC2553421

2007

  • Steinmaus CM, Moore LE, Shipp M, Kalman DA, Rey OA, Biggs ML, Hopenhayn-Rich C, Bates MN, Zheng S, Wiencke JK, Smith AH. 2007. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic. J Toxicol Environ Health A 70(2):159-170. doi:10.1080/15287390600755240 PMID:17365577
  • Urayama KY, Wiencke JK, Buffler PA, Selvin S, Wiemels JL. 2007. MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 16(6):1172-1177. doi:10.1158/1055-9965.EPI-07-0007 PMID:17548681

2005

  • Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
  • Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. 2005. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 19(3):415-419. PMID:15674422
  • Wiencke JK, Aldape K, McMillan A, Wiemels JL, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch MR. 2005. Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev 14(7):1774-1783. doi:10.1158/1055-9965.EPI-05-0089 PMID:16030116

2004

  • Moore LE, Wiencke JK, Bates MN, Zheng S, Rey OA, Smith AH. 2004. Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina. Cancer Lett 211(2):199-207. PMID:15219943
  • Ryan LM, Huang W, Thurston SW, Kelsey KT, Wiencke JK, Christiani DC. 2004. On the use of biomarkers for environmental health research. Stat Methods Med Res 13(3):207-225. PMID:15198487
  • Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch MR. 2004. Reduced immunoglobulin E and allergy among adults with glioma compared with controls. Cancer Res 64(22):8468-8473. PMID:15548720
  • Wiencke JK. 2004. Impact of race/ethnicity on molecular pathways in human cancer. Nature Reviews Cancer 4(1):79-84. PMID:14708028
  • Zhang L, Hayes RB, Guo W, McHale CM, Yin S, Wiencke JK, O'Neill JP, Rothman N, Li G, Smith MT. 2004. Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes. Mutat Res 558(1-2):63-74. PMID:15036120
  • Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. 2004. Hypermethylation of the 5 ' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 64(6):2000-2006. PMID:15026336

2003

  • Smith MT, Wiencke JK, Wiemels JL, Zhang L, Ma X, McHale CM, Buffler PA. 2003. Molecular epidemiology of childhood leukemia. Environ Mol Mutagen 41(3):206.
  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.
  • Zhang L, Zheng S, Ma X, Wiemels JL, Buffler PA, Smith MT, Wiencke JK. 2003. Molecular cytogenetic characterization of childhood acute lymphoblastic leukemia and its relation to FHIT gene methylation. Environ Mol Mutagen 41(3):215.
  • Zheng S, Ma X, Wiemels JL, Zhang L, Gunn L, Smith MT, Buffler PA, Wiencke JK. 2003. Hypermethylation of the 5'CpG island of the FHIT gene is associated with hyperdiploid and translocation negative subtypes of pediatric leukemia. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

2002

  • Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P. 2002. Daycare attendance and the risk of childhood acute lymphoblastic leukemia. Br J Cancer 86(9):1419-1424.
  • Urayama KY, Wiencke JK, Buffler PA, Wiemels JL. 2002. #21-S the role of MDR-1 gene polymorphisms in the genetic susceptibility to childhood leukemia. Ann Epidemiol 12(7):497.
  • Urayama KY, Wiencke JK, Buffler PA, Wiemels JL. 2002. The role of MDR-1 gene polymorphisms in the genetic susceptibility to childhood leukemia. In: The proceedings of the American College of Epidemiology Annual Scientific Session, September 22-24. Albuquerque, NM.
  • Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch MR. 2002. History of allergies among adults with glioma and controls. Int J Cancer 98(4):609-615. PMID:11920623
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4567.
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 99(10):3801-3805. PMID:11986239

2001

  • Caggana M, Kilgallen J, Conroy JM, Wiencke JK, Kelsey KT, Miike R, Chen P, Wrensch MR. 2001. Associations between ERCC2 polymorphisms and gliomas. Cancer Epidemiol Biomarkers Prev 10:355-360. PMID:11319176
  • Chen P, Aldape K, Wiencke JK, Kelsey KT, Miike R, Davis RL, Liu J, Kesler-Diaz A, Takahashi M, Wrensch MR. 2001. Ethnicity delineates different genetic pathways in malignant glioma. Cancer Res 61:3949-3954. PMID:11358811
  • Hirao T, Nelson HH, Devi-Ashok T, Wain JC, Mark EJ, Christiani DC, Wiencke JK, Kelsey KT. 2001. Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer. Cancer Res 61(2):612-615. PMID:11212258
  • Moore LE, Wiencke JK, Eng C, Zheng S, Smith AH. 2001. Evaluation of buccal cell collection protocols for genetic susceptibility studies. Biomarkers 6(6):448-454. PMID:23886316
  • Peters ES, Kelsey KT, Wiencke JK, Park S, Chen P, Miike R, Wrensch MR. 2001. NAT2 and NQO1 polymorphisms are not associated with adult glioma. Cancer Epidemiol Biomarkers Prev 10(2):151-152.
  • Wiencke JK, Kelsey KT, Zuo Z, Weinberg A, Wrensch MR. 2001. Genetic resistance factor for HIV-1 and immune response to varicella tester virus. Lancet 357(9253):360-361. PMID:11211001
  • Xiao Z, Greaves MF, Buffler PA, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL. 2001. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia 15:1906-1913. PMID:11753612
  • Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. 2001. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiol Biomarkers Prev 10:697-700. PMID:11401921

2000

  • Chen P, Wiencke JK, Aldape K, Kesler-Diaz A, Miike R, Kelsey KT, Lee M, Liu J, Wrensch MR. 2000. Association of an ERCC1 polymorphism with adult-onset glioma. Cancer Epidemiol Biomarkers Prev 9(8):843-847. PMID:10952103
  • Duell EJ, Wiencke JK, Cheng T, Varkonyi A, Zuo Z, Devi-Ashok T, Mark EJ, Wain JC, Christiani DC, Kelsey KT. 2000. Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis 21(5):965-971. PMID:10783319
  • Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke JK, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels JL, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis 21(1):55-62. PMID:10607734
  • Platz EA, Wiencke JK, Kelsey KT, Janower ML, Schottenfeld D, Travis LB, Goldman MB. 2000. Chromosomal aberrations and hprt mutant frequencies in long-term US Thorotrast survivors. Int J Radiat Biol 76(7):955-961. PMID:10923619
  • Thurston SW, Wand MP, Wiencke JK. 2000. Negative binomial additive models. Biometrics 56(1):139-144. PMID:10783788

1999

  • Ishibe N, Wiencke JK, Zuo Z, McMillan A, Spitz MR, Kelsey KT. 1999. Cytochrome P450 1A1 polymorphisms and lung cancer susceptibility in Mexican-Hispanic and African-American minority populations. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Nelson HH, Christiani DC, Mark EJ, Wiencke JK, Wain JC, Kelsey KT. 1999. Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. J Natl Cancer Inst 91(23):2032-2038. PMID:10580029
  • Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT. 1999. K-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. Cancer Res 59:4570-4573. PMID:10493509
  • Spitz MR, Wu X, Jiang HH, Kelsey KT, Wiencke JK, Hsu TC. 1999. Glutathione S-transferase (GSTM1 & GSTT1) genotypes, mutagen sensitivity, cigarette smoking and lung cancer risk. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Wang X, Christiani DC, Mark EJ, Nelson HH, Wiencke JK, Gunn L, Wain JC, Kelsey KT. 1999. Carcinogen exposure, p53 alteration and K-ras mutation in synchronous multiple primary lung carcinoma. Cancer 85(8):1734-1739. PMID:10223567
  • Wiemels JL, Wiencke JK, Varkonyi A, Smith MT. 1999. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 12(6):467-475. doi:10.1021/tx9800811 PMID:10368308
  • Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC. 1999. Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J Natl Cancer Inst 91(7):614-619. PMID:10451453
  • Wiencke JK, Varkonyi A, Kelsey KT, Wain JC, Mark EJ, Christiani DC. 1999. Polyphenol-related DNA adducts in blood mononuclear cells are increased in newly diagnosed patients with lung cancer. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Wiencke JK, Varkonyi A, Semey K, Levay G, Wain JC, Mark EJ, Kelsey KT, Christiani DC. 1999. Detection of benzene-related DNA adducts in human tissues and evidence of co-activation with polyaromatic hydrocarbons (PAHs). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.135.
  • Wiencke JK, Varkonyi A, Semey K, Levay G, Wain JC, Mark EJ, Kelsey KT, Christiani DC. 1999. Validation of blood mononuclear cell DNA-adducts as a marker of DNA damage in human lung. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.283.
  • Wiencke JK, Zheng S, Lafuente A, Lafuente MJ, Grudzen C, Wrensch MR, Miike R, Ballesta A, Trias M. 1999. Aberrant methylation of p16(INK4a) in anatomic and gender specific subtypes of sporadic colorectal cancer. Cancer Epidemiol Biomarkers Prev 8(6):501-506. PMID:10385139

1998

  • Kelsey KT, Wiencke JK. 1998. Growing pains for the environmental genetics of breast cancer: observations on a study of the glutathione s-transferases. J Natl Cancer Inst 90:484-485. PMID:9539238
  • Lee BW, Wain JC, Kelsey KT, Wiencke JK, Christiani DC. 1998. Association of cigarette smoking and asbestos exposure with location and histology of lung cancer. Am J Respir Crit Care Med 157:748-755. PMID:9517586
  • Nelson HH, Wiencke JK, Gunn L, Wain JC, Christiani DC, Kelsey KT. 1998. Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res 58(9):1804-1807. PMID:9581816
  • Wiencke JK, Mustacchi P. 1998. Styrene and Butadiene. In: Environmental and Occupational Medicine. Lippincott-Raven, Philadelphia, PA. pp.1129-1144.
  • Xu X, Wiencke JK, Niu T, Wang M, Watanabe H, Kelsey KT, Christiani DC. 1998. Benzene exposure, glutathione S-transferase theta homozygous deletion and sister chromatid exchanges. Am J Ind Med 33(2):157-163. PMID:9438048

1997

  • Ishibe N, Wiencke JK, Zuo Z, McMillan A, Spitz MR, Kelsey KT. 1997. Susceptibility to lung cancer in light smokers associated with Cyp1A1 polymorphisms and lung cancer in Mexican- and African-Americans. Cancer Epidemiol Biomarkers Prev 6(12):1075-1080. PMID:9419406
  • Kelsey KT, Ross D, Traver RD, Christiani DC, Zuo Z, Spitz MR, Wang M, Xu X, Lee BK, Schwartz BS, Wiencke JK. 1997. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Br J Cancer 76(7):852-854. doi:10.1038/bjc.1997.474 PMID:9328142
  • Kelsey KT, Spitz MR, Zuo Z, Wiencke JK. 1997. Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States). Cancer Causes Control 8(4):554-559. PMID:9242470
  • Wiencke JK, Spitz MR, McMillan A, Kelsey KT. 1997. Lung cancer in Mexican-Americans and African-Americans is associated with the wildtype genotype of the NAD(P)H:quinone oxidoreductase polymorphism. Cancer Epidemiol Biomarkers Prev 6(2):87-92. PMID:9037558
  • Wiencke JK, Wrensch MR, Miike R, Zuo Z, Kelsey KT. 1997. Population-based study of glutathione S-transferase mu gene deletion in adult glioma cases and controls. Carcinogenesis 18(7):1431-1433. PMID:9230293
  • Wiencke JK, Yager JW, Varkonyi A, Hultner M, Lutze LH. 1997. Study of arsenic mutagenesis using the plasmid shuttle vector pZ189 propagated in DNA repair proficient human cells. Mutat Res Rev Mutat Res 386:335-344. PMID:9219570
  • Yager JW, Wiencke JK. 1997. Inhibition of poly(ADP-ribose) polymerase by arsenite. Mutat Res Rev Mutat Res 386:345-351. PMID:9219571

1996

  • Wiencke JK, Spitz MR, McMillan A, Kelsey KT. 1996. Lung cancer in Mexican-American and African-Americans is associated with the wildtype genotype of the NAD(P)H:quinone oxidoreductase polymorphism. Am J Hum Genet 59:A294.

1995

  • Kelsey KT, Wiencke JK, Ward J, Bechtold WE, Fajen J. 1995. Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat Res 335(3):267-273. PMID:8524342
  • Nelson HH, Wiencke JK, Christiani DC, Cheng T, Zuo Z, Schwartz BS, Lee B, Spitz MR, Wang M, Xu X, Kelsey KT. 1995. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis 16(5):1243-1246. PMID:7767992
  • Wiencke JK, Kelsey KT, Varkonyi A, Semey K, Wain JC, Mark EJ, Christiani DC. 1995. Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung. Cancer Res 55(21):4910-4914. PMID:7585529
  • Wiencke JK, Pemble S, Ketterer B, Kelsey KT. 1995. Gene deletion in glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol Biomarkers Prev 4(3):253-259. PMID:7606200
  • Wiencke JK, Wiemels JL. 1995. Genotoxicity of 1,3,-bis(2-chloroethyl)-1- nitrosourea (BCNU). Mutat Res 339(2):91-119. PMID:7791804
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