Superfund Research Program

Bhagavatula Moorthy

Baylor College of Medicine
Texas Children's Hospital - Feigin Center
1102 Bates Ave
Suite C.530.04
Houston, Texas 77030
Phone: 832-824-3266
Email: bmoorthy@bcm.edu

Projects

• Baylor College of Medicine: Administrative Core (2020-2025)
• Baylor College of Medicine: Role of Cytochrome P450 (CYP)1A/1B1 Enzymes in the Potentiation of Neonatal Lung Injury in Newborn Mice Exposed Prenatally to PAHs and Increased Risk of Premature Infants to Chronic Lung Disease (2020-2025)

Publications

2024

• Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli XI, Lingappan K, Moorthy B. 2024. Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211:35-46. doi:10.1016/j.freeradbiomed.2023.12.001 PMID:38081439

2023

• Denison SB, Jin P, Dias Da Silva P, Chu C, Moorthy B, Senftle TP, Zygourakis K, Alvarez PJ. 2023. Pyro-catalytic degradation of pyrene by bentonite-supported transition metals: Mechanistic insights and trade-offs with low pyrolysis temperature. Environ Sci Technol 57(38):14373-14383. doi:10.1021/acs.est.3c04487 PMID:37683087
• Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. 2023. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ 14(1):50. doi:10.1186/s13293-023-00535-6 PMID:37553579 PMCID:PMC10408139
• Grimm SL, Stading R, Robertson M, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. 2023. Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation. Redox Biol 64:102790. doi:10.1016/j.redox.2023.102790 PMID:37348155 PMCID:PMC10271936
• Suh J, Heo MJ, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim K. 2023. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab 72:101717. doi:10.1016/j.molmet.2023.101717 PMID:37004989 PMCID:PMC1010651

2022

• Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K. 2022. Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates. Pediatr Pulmonol doi:10.1002/ppul.26197 PMID:36205439
• Ghosh S, Moorthy B, Haribabu B, Jala VR. 2022. Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis. Front Immunol 13:doi:10.3389/fimmu.2022.1004603 PMID:36159798 PMCID:PMC9493474

2021

• Burke R, Chu C, Zhou G, Putluri V, Putluri N, Stading R, Couroucli XI, Lingappan K, Moorthy B. 2021. Role of human NADPH quinone oxidoreductase (NQO1) in oxygen-mediated cellular injury and oxidative DNA damage in human pulmonary cells. Oxid Med Cell Longev 2021:5544600. doi:10.1155/2021/5544600 PMID:34691356 PMCID:PMC8536466
• Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. 2021. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight 6(13):e146863. doi:10.1172/jci.insight.146863 PMID:34061778 PMCID:PMC8410054
• Stading R, Gastelum G, Chu C, Jiang W, Moorthy B. 2021. Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. Semin Cancer Biol 76:3-16. doi:10.1016/j.semcancer.2021.07.001 PMID:34242741

2020

• Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B. 2020. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med 160:208-218. doi:10.1016/j.freeradbiomed.2020.07.027 PMID:32791187 PMCID:PMC7704914
• Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker C, Moorthy B, Lingappan K. 2020. Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol 37:101718. doi:10.1016/j.redox.2020.101718 PMID:32961439 PMCID:PMC7509469
• Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. 2020. Polycyclic aromatic hydrocarbon-induced pulmonary carcinogenesis in cytochrome P450 (CYP)1A1-and 1A2-null mice: roles of CYP1A1 and CYP1A2. Toxicol Sci 177:347-361. doi:10.1093/toxsci/kfaa107 PMID:32726451
• Stading R, Chu C, Couroucli XI, Lingappan K, Moorthy B. 2020. Molecular role of cytochrome P4501A enzymes in oxidative stress. Curr Opin Toxicol 20-21:77-84. doi:10.1016/j.cotox.2020.07.001 PMID:33283080 PMCID:PMC7709944
• Stading R, Couroucli XI, Lingappan K, Moorthy B. 2020. The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert Opin Drug Metab Toxicol 8:doi:10.1080/17425255.2021.1853705 PMID:33215946
• Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose R. 2020. Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Expert Opin Drug Metab Toxicol 16:doi:10.1080/17425255.2020.1815705 PMID:32841068

2019

• Hassanin AA, Tavera-Garcia MA, Moorthy B, Zhou GD, Ramos KS. 2019. Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks. Am J Physiol Lung Cell Mol Physiol 317:L816-L822. doi:10.1152/ajplung.00304.2019 PMID:31596105 PMCID:PMC6962597 (accepted for publication)
• Song W, Vidonish JE, Kamath R, Yu P, Chu C, Moorthy B, Gao B, Zygourakis K, Alvarez PJ. 2019. Pilot-scale pyrolytic remediation of crude-oil-contaminated soil in a continuously-fed reactor: treatment intensity trade-offs. Environ Sci Technol 53(4):2045-2053. doi:10.1021/acs.est.8b05825 PMID:30681845 PMCID:PMC8037193
• Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou GD, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. 2019. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun 516(2):344-349. doi:10.1016/j.bbrc.2019.06.049 PMID:31208719 PMCID:PMC6637943

2015

• Moorthy B, Chu C, Carlin DJ. 2015. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci 145(1):5-15. doi:10.1093/toxsci/kfv040 PMID:25911656 PMCID:PMC4408964
• Phillips TD, Richardson MB, Cheng YL, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD. 2015. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89(6):967-977. doi:10.1007/s00204-014-1285-8 PMID:24888377 PMCID:PMC4254891

2011

• Zhou GD, Zhu H, Phillips TD, Wang J, Wang S, Wang F, Amendt BA, Couroucli XI, Donnelly KC, Moorthy B. 2011. Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One 6:doi:10.1371/journal.pone.0026589 PMID:22066002 PMCID:PMC3204992

1998

• Randerath K, Sriram P, Moorthy B, Aston JP, Baan R, Van den Berg PT, Booth ED, Watson WP. 1998. Comparison of immunoaffinity chromatography enrichment and nuclease P1 procedures for 32P-postlabelling analysis of PAH-DNA adducts. Chem Biol Interact 110(1-2):85-102. PMID:9566727

1997

• Moorthy B, Sriram P, Randerath E, Randerath K. 1997. Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo. Biochem Pharmacol 53:663-669. PMID:9113085

1996

• Moorthy B, Randerath K. 1996. Pentachlorophenol enhances 9-hydroxybenzo(a)pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol. Arch Toxicol 70(11):696-703. PMID:8896715

1995

• Moorthy B, Liehr JG, Randerath E, Randerath K. 1995. Evidence from [³²P]-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethyl stilbestrol and its dimethylether in mouse liver: likely " alpha-hydroxylation of ethyl group(s) followed by sulfate conjugation. Carcinogenesis 16(11):2643-2648.
• Moorthy B, Sriram P, Randerath K. 1995. Effects of a single dose of the cytochrome P450 inducer, $-naphthoflavone, on hepatic and renal covalent DNA modifications (I-compounds). Toxicology 104:165-177. PMID:8560495
• Vulimiri SV, Gupta MS, Smith CV, Moorthy B, Randerath K. 1995. Rapid decreases in indigenous covalent DNA modifications (I-compounds) in male Fischer 344 ra liver DNA by diquat treatment. Chem Biol Interact 95:1-16. PMID:7697743