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Person Details: Bhagavatula Moorthy

Superfund Research Program

Bhagavatula Moorthy

Baylor College of Medicine
Texas Children's Hospital - Feigin Center
1102 Bates Ave
Suite C.530.04
Houston, Texas 77030
Phone: 832-824-3266




  • Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli XI, Lingappan K, Moorthy B. 2024. Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211:35-46. doi:10.1016/j.freeradbiomed.2023.12.001 PMID:38081439


  • Denison SB, Jin P, Dias Da Silva P, Chu C, Moorthy B, Senftle TP, Zygourakis K, Alvarez PJ. 2023. Pyro-catalytic degradation of pyrene by bentonite-supported transition metals: Mechanistic insights and trade-offs with low pyrolysis temperature. Environ Sci Technol 57(38):14373-14383. doi:10.1021/acs.est.3c04487 PMID:37683087
  • Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. 2023. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ 14(1):50. doi:10.1186/s13293-023-00535-6 PMID:37553579 PMCID:PMC10408139
  • Grimm SL, Stading R, Robertson M, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. 2023. Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation. Redox Biol 64:102790. doi:10.1016/j.redox.2023.102790 PMID:37348155 PMCID:PMC10271936
  • Suh J, Heo MJ, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim K. 2023. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab 72:101717. doi:10.1016/j.molmet.2023.101717 PMID:37004989 PMCID:PMC1010651


  • Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K. 2022. Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates. Pediatr Pulmonol doi:10.1002/ppul.26197 PMID:36205439
  • Ghosh S, Moorthy B, Haribabu B, Jala VR. 2022. Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis. Front Immunol 13:doi:10.3389/fimmu.2022.1004603 PMID:36159798 PMCID:PMC9493474


  • Burke R, Chu C, Zhou G, Putluri V, Putluri N, Stading R, Couroucli XI, Lingappan K, Moorthy B. 2021. Role of human NADPH quinone oxidoreductase (NQO1) in oxygen-mediated cellular injury and oxidative DNA damage in human pulmonary cells. Oxid Med Cell Longev 2021:5544600. doi:10.1155/2021/5544600 PMID:34691356 PMCID:PMC8536466
  • Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. 2021. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight 6(13):e146863. doi:10.1172/jci.insight.146863 PMID:34061778 PMCID:PMC8410054
  • Stading R, Gastelum G, Chu C, Jiang W, Moorthy B. 2021. Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. Semin Cancer Biol 76:3-16. doi:10.1016/j.semcancer.2021.07.001 PMID:34242741



  • Hassanin AA, Tavera-Garcia MA, Moorthy B, Zhou GD, Ramos KS. 2019. Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks. Am J Physiol Lung Cell Mol Physiol 317:L816-L822. doi:10.1152/ajplung.00304.2019 PMID:31596105 PMCID:PMC6962597 (accepted for publication)
  • Song W, Vidonish JE, Kamath R, Yu P, Chu C, Moorthy B, Gao B, Zygourakis K, Alvarez PJ. 2019. Pilot-scale pyrolytic remediation of crude-oil-contaminated soil in a continuously-fed reactor: treatment intensity trade-offs. Environ Sci Technol 53(4):2045-2053. doi:10.1021/acs.est.8b05825 PMID:30681845 PMCID:PMC8037193
  • Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou GD, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. 2019. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun 516(2):344-349. doi:10.1016/j.bbrc.2019.06.049 PMID:31208719 PMCID:PMC6637943




  • Randerath K, Sriram P, Moorthy B, Aston JP, Baan R, Van den Berg PT, Booth ED, Watson WP. 1998. Comparison of immunoaffinity chromatography enrichment and nuclease P1 procedures for 32P-postlabelling analysis of PAH-DNA adducts. Chem Biol Interact 110(1-2):85-102. PMID:9566727


  • Moorthy B, Sriram P, Randerath E, Randerath K. 1997. Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo. Biochem Pharmacol 53:663-669. PMID:9113085


  • Moorthy B, Randerath K. 1996. Pentachlorophenol enhances 9-hydroxybenzo(a)pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol. Arch Toxicol 70(11):696-703. PMID:8896715


  • Moorthy B, Liehr JG, Randerath E, Randerath K. 1995. Evidence from [32P]-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethyl stilbestrol and its dimethylether in mouse liver: likely " alpha-hydroxylation of ethyl group(s) followed by sulfate conjugation. Carcinogenesis 16(11):2643-2648.
  • Moorthy B, Sriram P, Randerath K. 1995. Effects of a single dose of the cytochrome P450 inducer, $-naphthoflavone, on hepatic and renal covalent DNA modifications (I-compounds). Toxicology 104:165-177. PMID:8560495
  • Vulimiri SV, Gupta MS, Smith CV, Moorthy B, Randerath K. 1995. Rapid decreases in indigenous covalent DNA modifications (I-compounds) in male Fischer 344 ra liver DNA by diquat treatment. Chem Biol Interact 95:1-16. PMID:7697743
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