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Your Environment. Your Health.

Person Details: Kim Boekelheide

Superfund Research Program

Kim Boekelheide

Brown University
Department of Pathology & Laboratory Medicine
70 Ship Street, Box G-E5
Providence, Rhode Island 02912
Phone: 401-863-1783
Fax: 401-863-9008
Email: kim_boekelheide@brown.edu

Projects

Research Briefs

Patents

Publications

2019

  • Bianchi E, Boekelheide K, Sigman M, Braun JM, Eliot M, Hall SJ, Dere E, Hwang K. 2019. Spermatozoal large RNA content is associated with semen characteristics, sociodemographic and lifestyle factors. PLoS One 14(5):doi:10.1371/journal.pone.0216584 PMID:31120914 PMCID:PMC6532849
  • Dent MP, Madnick SJ, Hall SJ, Vantangoli Policelli M, Bars C, Li H, Amin A, Carmichael PL, Martin FL, Boekelheide K. 2019. A human-derived prostate co-culture microtissue model using epithelial (RWPE-1) and stromal (WPMY-1) cell lines. Toxicol In Vitro 60:203-211. doi:10.1016/j.tiv.2019.05.023 PMID:31154061 PMCID:PMC6717042
  • Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN, Boekelheide K. 2019. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Toxicol Sci 167:546-558. doi:10.1093/toxsci/kfy260 PMID:30329139 PMCID:PMC6358251
  • Spade DJ, Hall SJ, Wortzel J, Reyes G, Boekelheide K. 2019. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Toxicol Sci 168(1):149-159. doi:10.1093/toxsci/kfy283 PMID:30476341 PMCID:PMC6390659
  • Stermer A, Klein D, Wilson S, Dalaijamts C, Bai CY, Hall SJ, Madnick SJ, Bianchi E, Chiu WA, Boekelheide K. 2019. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environ Toxicol Pharmacol 68:1-3. doi:10.1016/j.etap.2019.02.003 PMID:30836291 PMCID:PMC6594756
  • Stermer A, Reyes G, Hall SJ, Boekelheide K. 2019. Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol Sci 169(2):399-408. doi:10.1093/toxsci/kfz041 PMID:30768127 PMCID:PMC6934889
  • Stermer A, Wilson SK, Klein D, Hall SJ, Boekelheide K. 2019. Trichloroethylene exposure alters dimethylated histone three lysine four in protein kinase A signaling pathway chromatin of rat sperm. Biol Reprod 101(5):875-877. doi:10.1093/biolre/ioz155 PMID:31426087 PMCID:PMC730579

2018

2017

2016

  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888
  • Dere E, Huse SM, Hwang K, Sigman M, Boekelheide K. 2016. Intra- and inter-individual differences in human sperm DNA methylation. Andrology 4(5):832-842. doi:10.1111/andr.12170 PMID:27089098 PMCID:PMC4988918
  • Dere E, Wilson SK, Anderson LM, Boekelheide K. 2016. From the cover: sperm molecular biomarkers are sensitive indicators of testicular injury following subchronic model toxicant exposure. Toxicol Sci 153(2):327-340. doi:10.1093/toxsci/kfw137 PMID:27466211 PMCID:PMC5036622

2015

2014

  • Catlin NR, Huse SM, Boekelheide K. 2014. The stage-specific testicular germ cell apoptotic response to low-dose radiation and 2,5-hexanedione combined exposure II: qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. Toxicol Pathol 42(8):1229-1237. doi:10.1177/0192623314525689 PMID:24670816 PMCID:PMC4177022
  • Catlin NR, Huse SM, Boekelheide K. 2014. The stage-specific testicular germ cell apoptotic response to low-dose X-irradiation and 2,5-hexanedione combined exposure I: Validation of the laser capture microdissection method for qRT-PCR array application. Toxicol Pathol 42(8):1221-1228. doi:10.1177/0192623314526319 PMID:24717900 PMCID:PMC4192118
  • Rider CV, Boekelheide K, Catlin NR, Gordon CJ, Morata T, Selgrade MK, Sexton K, Simmons JE. 2014. Cumulative risk: toxicity and interactions of physical and chemical stressors. Toxicol Sci 137(1):3-11. doi:10.1093/toxsci/kft228 PMID:24154487 PMCID:PMC3871930
  • Thompson MR, Burdon A, Boekelheide K. 2014. Practice-based evidence informs environmental health policy and regulation: a case study of residential lead-soil contamination in Rhode Island. Sci Total Environ 468-469:514-522. doi:10.1016/j.scitotenv.2013.07.094 PMID:24055667 PMCID:PMC3858391

2013

2012

  • Campion SN, Catlin NR, Houseman E, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K. 2012. Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure. Reprod Toxicol 33:382-389. doi:10.1016/j.reprotox.2012.01.014 PMID:22382377 PMCID:PMC3327768
  • Pacheco SE, Anderson LM, Boekelheide K. 2012. Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting. J Androl 33(5):811-816. doi:10.2164/jandrol.111.015131 PMID:22240558 PMCID:PMC3598013
  • Pacheco SE, Anderson LM, Sandrof MA, Vantangoli MM, Hall SJ, Boekelheide K. 2012. Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat. PLoS One 7:e44280. doi:10.1371/journal.pone.0044280 PMID:22952946 PMCID:PMC3432073
  • Saffarini CM, Heger NE, Yamasaki H, Liu T, Hall SJ, Boekelheide K. 2012. Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice. J Androl 33(3):505-513. doi:10.2164/jandrol.111.013706 PMID:21868749 PMCID:PMC3607946
  • Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K. 2012. Rodent thyroid, liver, and fatal testis toxicity of the monoester metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust. Environ Health Perspect 120:1711-1719. doi:10.1289/ehp.1204932 PMID:23014847 PMCID:PMC3548273

2011

  • Andersen ME, Clewell H, Carmichael PL, Boekelheide K. 2011. Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?". ALTEX 28(3):175-182. PMID:21993955 PMCID:PMC3943477 (Completed with ARRA Funds)
  • Bhattacharya S, Zhang Q, Carmichael PL, Boekelheide K, Andersen ME. 2011. Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One 6(6):doi:10.1371/journal.pone.0020887 PMID:21701582 PMCID:PMC3118802 (Completed with ARRA Funds)
  • Pacheco SE, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. 2011. Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS One 6:doi:10.1371/journal.pone.0020280 PMID:21674046 PMCID:PMC3107223 (Completed with ARRA Funds)

2010

  • Boekelheide K, Campion SN. 2010. Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol Sci 114(1):20-24. doi:10.1093/toxsci/kfp307 PMID:20026472 PMCID:PMC2902917
  • Campion SN, Sandrof MA, Hensley J, Sui Y, Gaido KW, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways. Toxicol Sci 117(2):457-465. doi:10.1093/toxsci/kfq204 PMID:20616210 PMCID:PMC2940405
  • Campion SN, Sandrof MA, Yamasaki H, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis. Toxicol Sci 117(2):466-474. doi:10.1093/toxsci/kfq205 PMID:20616204 PMCID:PMC2940406
  • Yamasaki H, Sandrof MA, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis. Toxicol Sci 117(2):449-456. doi:10.1093/toxsci/kfq203 PMID:20616207 PMCID:PMC2940404

2009

2008

  • Bryant BH, Yamasaki H, Sandrof MA, Boekelheide K. 2008. Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. Toxicol Pathol 36(4):552-559. doi:10.1177/0192623308317426 PMID:18467684 PMCID:PMC2574707
  • Klysik J, Theroux SJ, Sedivy JM, Moffit JS, Boekelheide K. 2008. Signaling crossroads: The function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal 20:1-9. PMID:17706925

2007

  • Boekelheide K. 2007. Mixed messages. Toxicol Sci 99(1):1-2. doi:10.1093/toxsci/kfm117
  • Bryant BH, Boekelheide K. 2007. Time-dependent changes in post-mortem testis histopathology in the rat. Toxicol Pathol 35:665-71. PMID:17676525
  • Moffit JS, Boekelheide K, Sedivy JM, Klysik J. 2007. Mice lacking Raf Kinase Inhibitor Protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. J Androl 28:883-90. PMID:17554109
  • Moffit JS, Bryant BH, Hall SJ, Boekelheide K. 2007. Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. Toxicol Pathol 35(5):719-727. doi:10.1080/01926230701481931 PMID:17763286
  • Rasoulpour RJ, Boekelheide K. 2007. NF-kB activation elicited by ionizing radiation is pro-apoptotic in testis. Biol Reprod 27(2):279-285. PMID:17123945

2006

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