Person Details: Pamela J. Lein

Superfund Research Program

Pamela J. Lein

University of California-Davis
Department of Molecular Biosciences
2161 Haring Hall
Davis, California 95616
Phone: 530-752-1970
Email: pjlein@ucdavis.edu

Projects

• University of California-Davis: Training Core (1995-2023)

Research Briefs

• 231 - Novel Pathway Involved in Neurodevelopmental Toxicity of PCBs

Publications

2023

• Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328

2022

• Chen H, Carty RK, Bautista AC, Hayakawa K, Lein PJ. 2022. Triiodothyronine or antioxidants block the inhibitory effects of BDE-47 and BDE-49 on axonal growth in rat hippocampal neuron-glia co-cultures. Toxics 10(2):doi:10.3390/toxics10020092 PMID:35202279 PMCID:PMC8879960
• Laufer BI, Neier K, Valenzuela A, Yasui DH, Schmidt RJ, Lein PJ, LaSalle J. 2022. Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure. Cell Rep 38(9):doi:10.1016/j.celrep.2022.110442 PMID:35235788 PMCID:PMC8941983
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920

2021

• Keil KP, Kennedy CL, Sethi S, Valenzuela A, Nunez A, Wang K, Wang Z, Wang P, Spiegelhoff A, Puschner B, Bjorling DE, Lein PJ. 2021. In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder. Curr Res Toxicol 2:1-18. doi:10.1016/j.crtox.2021.01.002 PMID:34337439 PMCID:PMC8317607
• Zhang C, Klocke CR, Lein PJ, Lehmler H. 2021. Disposition of PCB 11 in mice following acute oral exposure. Chem Res Toxicol 34:988-991. doi:10.1021/acs.chemrestox.1c00067 PMID:33734669 PMCID:PMC8058299

2019

• Pessah IN, Lein PJ, Seegal R, Sagiv SK. 2019. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol 138(3):363-387. doi:10.1007/s00401-019-01978-1 PMID:30976975 PMCID:PMC6708608
• Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. doi:10.1021/acs.est.9b00535 PMID:30821444 PMCID:PMC6457253
• Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308

2018

• Sethi S, Keil KP, Lein PJ. 2018. 3,3-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 1-9. doi:10.1007/s00204-018-2307-8 PMID:30225637 PMCID:PMC6196112
• Stamou M, Grodzki A, van Oostrum M, Wollscheid B, Lein PJ. 2018. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. J Neuroinflammation 15:7. doi:10.1186/s12974-017-1050-z PMID:29306331 PMCID:PMC5756609

2017

• Chapman CA, Wang L, Chen H, Garrison J, Lein PJ, Seker E. 2017. Nanoporous gold biointerfaces: modifying nanostructure to control neural cell coverage and enhance electrophysiological recording performance. Adv Funct Mate 27:doi:10.1002/adfm.201604631 PMID:28626362 PMCID:PMC5471629
• Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. 2017. Nanostructure introduces artifacts in quantitative immunofluorescence by influencing fluorophore intensity. Sci Rep 7(1):427. doi:10.1038/s41598-017-00447-7 PMID:28348397
• Chen H, Streifel KM, Singh V, Yang DR, Mangini L, Wulff H, Lein PJ. 2017. BDE-47 and BDE-49 inhibit axonal growth in primary hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci 156:375-386. doi:10.1093/toxsci/kfw259 PMID:28003438
• Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
• Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364

2016

• Chapman CA, Chen H, Stamou M, Lein PJ, Seker E. 2016. Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces. Cell Mol Bioeng 9(3):433-442. doi:10.1007/s12195-016-0449-4 PMID:27795742 PMCID:PMC5079442

2015

• Barnhart CD, Yang DR, Lein PJ. 2015. Using the Morris water maze to assess spatial learning and memory in weanling mice. PLoS One 10(4):e0124521. doi:10.1371/journal.pone.0124521 PMID:25886563 PMCID:PMC4401674
• Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. 2015. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Mol Pharmacol 87(4):595-605. doi:10.1124/mol.114.096701 PMID:25583085 PMCID:PMC4366799
• Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E. 2015. Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size. ACS Appl Mater Interfaces 7(13):7093-7100. doi:10.1021/acsami.5b00410 PMID:25706691 PMCID:PMC4517587
• Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. 2015. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol 47:36-45. doi:10.1016/j.ntt.2014.10.008 PMID:25446016 PMCID:PMC4291292
• Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
• Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler H, Lein PJ. 2015. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology 338:59-68. doi:10.1016/j.tox.2015.10.002 PMID:26463278 PMCID:PMC4658283
• Wu X, Barnhart CD, Lein PJ, Lehmler H. 2015. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol 49(1):616-625. doi:10.1021/es504766p PMID:25420130 PMCID:PMC4291784

2014

• Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. 2014. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3):717-725. doi:10.1523/jneurosci.2884-13.2014 PMID:24431430 PMCID:PMC3891953
• Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ. 2014. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos 42(2):239-244. doi:10.1124/dmd.113.054239 PMID:24255117 PMCID:PMC3912540
• Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107

2013

• Stamou M, Streifel KM, Goines PE, Lein PJ. 2013. Neuronal connectivity as a convergent target of gene X environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol 36:3-16. doi:10.1016/j.ntt.2012.12.001 PMID:23269408 PMCID:PMC3610799
• Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel MW, Lein PJ, Lehmler H. 2013. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica 43(11):933-947. doi:10.3109/00498254.2013.785626 PMID:23581876 PMCID:PMC3878182

2012

• Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244 PMID:22889812 PMCID:PMC3529644
• Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler H. 2012. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393-11401. doi:10.1021/es302810t PMID:22974126 PMCID:PMC3475189
• Wayman GA, Bose DD, Yang DR, Lesiak A, Bruun DA, Impey S, Ledoux V, Pessah IN, Lein PJ. 2012. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect 120:1003-1009. doi:10.1289/ehp.1104833 PMID:22534176 PMCID:PMC3404671
• Wayman GA, Yang DR, Bose DD, Lesiak A, Ledoux V, Bruun DA, Pessah IN, Lein PJ. 2012. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect 120:997-1002. doi:10.1289/ehp.1104832 PMID:22534141 PMCID:PMC3404670
• Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. 2012. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther 341(2):435-446. doi:10.1124/jpet.111.190579 PMID:22328574 PMCID:PMC3336809

2011

• Abdu E, Bruun DA, Yang DR, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. 2011. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem 117:632-642. doi:10.1111/j.1471-4159.2010.07139.x PMID:21155804 PMCID:PMC3081369
• Kim K, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. 2011. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward Ryanodine receptors and neurotoxicity. Environ Health Perspect 119:519-526. doi:10.1289/ehp.1002728 PMID:21106467 PMCID:PMC3080935

2008

• Dziennis S, Yang, D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. 2008. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environ Health Perspect 116(4):474-80. PMID:18414629
• Pessah IN, Seegal R, Lein PJ, LaSalle J, Yee BK, van de Water JG, Berman RF. 2008. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29(3):532-545. doi:10.1016/j.neuro.2008.02.006 PMID:18394707 PMCID:PMC2475601