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Your Environment. Your Health.

Person Details: Pamela J. Lein

Superfund Research Program

Pamela J. Lein

University of California-Davis
Department of Molecular Biosciences
2161 Haring Hall
Davis, California 95616
Phone: 530-752-1970
Email: pjlein@ucdavis.edu

Projects

Research Briefs

Publications

2019

  • Pessah IN, Lein PJ, Seegal R, Sagiv SK. 2019. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol 1-25. doi:10.1007/s00401-019-01978-1 PMID:30976975
  • Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. PMID:30821444 PMCID:PMC6457253

2018

2017

  • Chapman CA, Wang L, Chen H, Garrison J, Lein PJ, Seker E. 2017. Nanoporous gold biointerfaces: modifying nanostructure to control neural cell coverage and enhance electrophysiological recording performance. Adv Funct Mate 27:doi:10.1002/adfm.201604631 PMID:28626362 PMCID:PMC5471629
  • Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. 2017. Nanostructure introduces artifacts in quantitative immunofluorescence by influencing fluorophore intensity. Sci Rep 7(1):427. doi:10.1038/s41598-017-00447-7 PMID:28348397
  • Chen H, Streifel KM, Singh V, Yang DR, Mangini L, Wulff H, Lein PJ. 2017. BDE-47 and BDE-49 inhibit axonal growth in primary hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci 156:375-386. doi:10.1093/toxsci/kfw259 PMID:28003438
  • Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
  • Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364

2016

2015

2014

  • Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. 2014. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3):717-725. doi:10.1523/jneurosci.2884-13.2014 PMID:24431430 PMCID:PMC3891953
  • Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ. 2014. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos 42(2):239-244. doi:10.1124/dmd.113.054239 PMID:24255117 PMCID:PMC3912540
  • Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107

2013

  • Stamou M, Streifel KM, Goines PE, Lein PJ. 2013. Neuronal connectivity as a convergent target of gene X environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol 36:3-16. doi:10.1016/j.ntt.2012.12.001 PMID:23269408 PMCID:PMC3610799
  • Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel MW, Lein PJ, Lehmler H. 2013. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica 43(11):933-947. doi:10.3109/00498254.2013.785626 PMID:23581876 PMCID:PMC3878182

2012

  • Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244 PMID:22889812 PMCID:PMC3529644
  • Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler H. 2012. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393-11401. doi:10.1021/es302810t PMID:22974126 PMCID:PMC3475189
  • Wayman GA, Bose DD, Yang DR, Lesiak A, Bruun DA, Impey S, Ledoux V, Pessah IN, Lein PJ. 2012. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect 120:1003-1009. doi:10.1289/ehp.1104833 PMID:22534176 PMCID:PMC3404671
  • Wayman GA, Yang DR, Bose DD, Lesiak A, Ledoux V, Bruun DA, Pessah IN, Lein PJ. 2012. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect 120:997-1002. doi:10.1289/ehp.1104832 PMID:22534141 PMCID:PMC3404670
  • Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. 2012. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther 341(2):435-446. doi:10.1124/jpet.111.190579 PMID:22328574 PMCID:PMC3336809

2011

  • Abdu E, Bruun DA, Yang DR, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. 2011. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem 117:632-642. doi:10.1111/j.1471-4159.2010.07139.x PMID:21155804 PMCID:PMC3081369
  • Kim K, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. 2011. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward Ryanodine receptors and neurotoxicity. Environ Health Perspect 119:519-526. doi:10.1289/ehp.1002728 PMID:21106467 PMCID:PMC3080935

2008

  • Dziennis S, Yang, D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. 2008. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environ Health Perspect 116(4):474-80. PMID:18414629
  • Pessah IN, Seegal R, Lein PJ, LaSalle J, Yee BK, van de Water JG, Berman RF. 2008. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29(3):532-545. doi:10.1016/j.neuro.2008.02.006 PMID:18394707 PMCID:PMC2475601
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