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Your Environment. Your Health.

Person Details

Superfund Research Program

Margaret R. Karagas

Dartmouth College
Geisel School of Medicine at Dartmouth Department of Epidemiology
7927 Rubin Building
One Medical Center Drive
Lebanon, NH 03756-1000
Phone: 603-653-9010
Fax: 603-653-9093
Email: margaret.karagas@dartmouth.edu

Projects

Research Briefs

Hazardous Waste Sites

18 SF sites in State of New Hampshire

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Elizabeth Mine

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Sites in Concord, New Hampshire

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Sites in Lebanon, New Hampshire and Surrounding Communities

  • Dartmouth College: Epidemiology, Biomarkers and Exposure Assessment of Metals

Publications

2016

  • Everson TM, Armstrong DA, Jackson BP, Green BB, Karagas MR, Marsit CJ. 2016. Maternal cadmium, placental PCDHAC1, and fetal development. Reprod Toxicol 65:263-271. doi:10.1016/j.reprotox.2016.08.011 PMID:27544570 PMCID:PMC5226342
  • Farzan SF, Gossai A, Chen Y, Chasan-Taber L, Baker E, Karagas MR. 2016. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Environ Health 64(5):1547-1558. PMID:27315352
  • Goossens ME, Isa F, Brinkman MT, Mak D, Reulen RC, Wesselius A, Benhamou S, Bosetti C, Bueno-de-Mesquita HB, Carta A, Allam MF, Golka K, Grant EJ, Jiang X, Johnson KC, Karagas MR, Kellen E, La Vecchia C, Lu C, Marshall J, Moysich KB, Pohlabeln H, Porru S, Steineck G, Stern MC, Tang L, Taylor JA, van den Brandt P, Villeneuve PJ, Wakai K, Weiderpass E, White E, Wolk A, Zhang Z, Buntinx F, Zeegers MP. 2016. International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics. Arch Public Health 74:30. doi:10.1186/s13690-016-0140-1 PMID:27386115 PMCID:PMC4933992
  • Punshon T, Li Z, Marsit CJ, Jackson BP, Baker E, Karagas MR. 2016. Placental Metal Concentrations in Relation to Maternal and Infant Toenails in a US Cohort. Environ Sci Technol 50(3):1587-1594. doi:10.1021/acs.est.5b05316 PMID:26727403 PMCID:PMC4873612

2015

  • Andrew AS, Gui J, Hu T, Wyszynski A, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Ekstrom RM, Li Z, Zens MS, Borsuk M, Moore JH, Karagas MR. 2015. Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. BJU Int 115(2):238-247. doi:10.1111/bju.12641 PMID:24666523 PMCID:PMC4533837
  • Andrew AS, Marsit CJ, Schned AR, Seigne JD, Kelsey KT, Moore JH, Perreard L, Karagas MR, Sempere LF. 2015. Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence. Int J Cancer 137(5):1158-1166. doi:10.1002/ijc.29413 PMID:25556547 PMCID:PMC4485975
  • Farzan S, Chen Y, Wu F, Jiang JY, Liu M, Baker E, Korrick SA, Karagas MR. 2015. Blood Pressure Changes in Relation to Arsenic Exposure in a US Pregnancy Cohort. Environ Health Perspect 123(10):999-1006. doi:10.1289/ehp.1408472 PMID:25793356 PMCID:PMC4590746
  • Farzan S, Karagas MR, Jiang JY, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Eunus M, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich VN, Graziano JH, Ahsan H, Chen Y, Scannell Bryan M, Islam T. 2015. Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 288(1):95-105. doi:10.1016/j.taap.2015.07.017 PMID:26220686 PMCID:PMC4606937
  • Gossai A, Lesseur C, Farzan S, Marsit CJ, Karagas MR, Gilbert-Diamond D. 2015. Association between maternal urinary arsenic species and infant cord blood leptin levels in a New Hampshire Pregnancy Cohort. Environ Res 136:180-186. doi:10.1016/j.envres.2014.10.005 PMID:25460635 PMCID:PMC4262605
  • Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel R, Gray K, Ha E, Junien C, Karagas MR, Kawamoto T, Lawrence BP, Perera F, Prins GS, Rosenfeld CS, Sherr DH, Sly PD, Suk WA, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ. 2015. Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives. Endocrinology 156(10):3408-3415. doi:10.1210/EN.2015-1350 PMID:26241067 PMCID:PMC4588822
  • Karagas MR, Gossai A, Pierce BL, Ahsan H. 2015. Drinking Water Arsenic Contamination, Skin Lesions, and Malignancies: A Systematic Review of the Global Evidence. Curr Environ Health Rep 2(1):52-68. doi:10.1007/s40572-014-0040-x PMID:26231242 PMCID:PMC4522704
  • Pearce N, Blair AE, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli A, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, Mannetje A, McMichael AJ, McLaughlin J, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer F, Monson RR, Nordby K, Olshan A, Parent M, Perera F, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart P, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger DD, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123(6):507-514. doi:10.1289/ehp.1409149 PMID:25712798 PMCID:PMC4455595
  • Punshon T, Chen S, Finney L, Howard L, Jackson BP, Karagas MR, Ornvold K. 2015. High-resolution elemental mapping of human placental chorionic villi using synchrotron X-ray fluorescence spectroscopy. Anal Bioanal Chem 407(22):6839-6850. doi:10.1007/s00216-015-8861-5 PMID:26138895 PMCID:PMC4663034
  • Punshon T, Davis MA, Marsit CJ, Theiler SK, Baker E, Jackson BP, Conway DC, Karagas MR. 2015. Placental arsenic concentrations in relation to both maternal and infant biomarkers of exposure in a US cohort. J Expo Sci Environ Epidemiol 25(6):599-603. doi:10.1038/jes.2015.16 PMID:25805251 PMCID:PMC4583336

2014

  • Davis MA, Li Z, Gilbert-Diamond D, MacKenzie TA, Cottingham KL, Jackson BP, Lee JS, Baker E, Marsit CJ, Karagas MR. 2014. Infant toenails as a biomarker of in utero arsenic exposure. J Expo Sci Environ Epidemiol 24(5):467-473. doi:10.1038/jes.2014.38 PMID:24896769 PMCID:PMC4141012
  • Koestler DC, Li J, Baron JA, Tsongalis GJ, Butterly LF, Goodrich M, Lesseur C, Karagas MR, Marsit CJ, Moore JH, Andrew AS, Srivastava A. 2014. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Modern Pathology 27:145-155. doi:10.1038/modpathol.2013.104 PMID:23868178 PMCID:PMC3880603
  • Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT. 2014. Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics 9(6):884-895. doi:10.4161/epi.28575 PMID:24671036 PMCID:PMC4065186
  • Nadeau KC, Li Z, Farzan S, Koestler DC, Robbins DJ, Fei DL, Malipatlolla M, Maecker H, Enelow RI, Korrick SA, Karagas MR. 2014. In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. Clin Immunol 155(2):188-197. doi:10.1016/j.clim.2014.09.004 PMID:25229165 PMCID:PMC4309995
  • Pan Q, Hu T, Malley JD, Andrew AS, Karagas MR, Moore JH. 2014. A system-level pathway-phenotype association analysis using synthetic feature random forest. Genet Epidemiol 38:209-219. doi:10.1002/gepi.21794 PMID:24535726 PMCID:PMC4327826
  • Sverrisson EF, Zens MS, Fei DL, Andrews A, Schned AR, Robbins DJ, Kelsey KT, Li H, DiRenzo J, Karagas MR, Seigne JD. 2014. Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. Urol Oncol 32(5):539-545. doi:10.1016/j.urolonc.2014.03.006 PMID:24856810 PMCID:PMC4243987

2013

2012

  • Andrew AS, Hu T, Gu J, Gui J, Ye Y, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Mason RA, Morlock EV, Zens MS, Li Z, Moore JH, Wu X, Karagas MR. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One 7(12):e51301. doi:10.1371/journal.pone.0051301 PMID:23284679 PMCID:PMC3526593
  • Davis MA, MacKenzie TA, Cottingham KL, Gilbert-Diamond D, Punshon T, Karagas MR. 2012. Rice consumption and urinary arsenic concentrations in U.S. children. Environ Health Perspect 1290:1418-1424. doi:10.1289/ehp.1205014 PMID:23008276 PMCID:PMC3491944
  • Gruber JF, Karagas MR, Gilbert-Diamond D, Bagley PJ, Zens MS, Sayarath V, Punshon T, Morrissey JB, Cottingham KL. 2012. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutr J 11:45. doi:10.1186/1475-2891-11-45 PMID:22747713 PMCID:PMC3426470
  • Jackson BP, Taylor VF, Punshon T, Cottingham KL, Karagas MR. 2012. Arsenic, organic foods, and brown rice syrup. Environ Health Perspect 120:623-626. doi:10.1289/ehp.1104619 PMID:22336149 PMCID:PMC3346791
  • Karagas MR, Andrew AS, Nelson HH, Li Z, Punshon T, Schned AR, Marsit CJ, Morris J, Moore JH, Tyler AL, Gilbert-Diamond D, Guerinot ML, Kelsey KT. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Hum Genet 131:453-461. doi:10.1007/s00439-011-1090-x PMID:21947419 PMCID:PMC3278547
  • Karagas MR, Choi AL, Oken E, Horvat M, Schoeny R, Kamai E, Cowell W, Grandjean P, Korrick SA. 2012. Evidence on the Human Health Effects of Low-Level Methylmercury Exposure. Environ Health Perspect 120:799-806. doi:10.1289/ehp.1104494 PMID:22275730 PMCID:PMC3385440
  • Karagas MR, Sunderland EM, Amirbahman A, Burgess NM, Dalziel J, Harding G, Jones SH, Kamai E, Shi X, Chen CY. 2012. Mercury sources and fate in the Gulf of Maine. Environ Res 119:27-41. doi:10.1016/j.envres.2012.03.011 PMID:22572623 PMCID:PMC3442131
  • Lesseur C, Gilbert-Diamond D, Andrew AS, Ekstrom RM, Li Z, Kelsey KT, Marsit CJ, Karagas MR. 2012. A case-control study of polymorphisms in zenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicol Lett 210:100-106. doi:10.1016/j.toxlet.2012.01.015 PMID:22306368 PMCID:PMC3374400
  • Madan JC, Koestler DC, Stanton BA, Davidson L, Moulton LA, Housman ML, Moore JH, Guill MF, Morrison HG, Sogin ML, Hampton TH, Karagas MR, Palumbo PE, Foster JA, Hibberd PL, O'Toole GA. 2012. Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: Interactions between intestinal and respiratory tracts and impact of nutritional exposures. MBio 3(4):e00251-12. doi:10.1128/mBio.00251-12 PMID:22911969 PMCID:PMC3428694
  • Oken E, Choi AL, Karagas MR, Marien K, Rheinberger CM, Schoeny R, Sunderland EM, Korrick SA. 2012. Which Fish Should I Eat? Perspectives Influencing Fish Consumption Choices. Environ Health Perspect 120(6):790-798. doi:10.1289/ehp.1104500 PMID:22534056 PMCID:PMC3385441
  • Sloan CD, Andrew AS, Gruber JF, Mwenda KM, Moore JH, Onega T, Karagas MR, Shi X, Duell EJ. 2012. Indoor and outdoor air pollution and lung cancer in New Hampshire and Vermont. Toxicology and Environmental Chemistry 94:605-615. doi:10.1080/02772248.2012.659930 PMID:24273369 PMCID:PMC3834966

2011

  • Brinkman MT, Karagas MR, Zens MS, Schned AR, Reulen RC, Zeegers MP. 2011. Intake of alpha-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study. Br J Nutr 106(7):1070-1077. doi:10.1017/s0007114511001346 PMID:21736846 PMCID:PMC3321546 (Completed with ARRA Funds)
  • Cowper-Sallari R, Cole MD, Karagas MR, Lupien M, Moore JH. 2011. Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 3:513-526. doi:10.1002/wsbm.132 PMID:21197657 PMCID:PMC3062944
  • Dietrich K, Demidenko E, Schned AR, Zens MS, Heaney JA, Karagas MR. 2011. Parity, early menopause and the incidence of bladder cancer in women: A case-control study and meta-analysis. European Journal of Cancer 47(4):592-599. doi:10.1016/j.ejca.2010.10.007 PMID:21067913 PMCID:PMC3042804 (Completed with ARRA Funds)
  • Fan R, Zhong M, Wang S, Zhang Y, Andrew AS, Karagas MR, Chen H, Xiong M, Moore JH, Amos CI. 2011. Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases. Genet Epidemiol 35(7):706-721. doi:10.1002/gepi.20621 PMID:22009792 PMCID:PMC3384547
  • Gilbert-Diamond D, Cottingham KL, Gruber JF, Punshon T, Sayarath V, Gandolfi A, Baker E, Jackson BP, Folt CL, Karagas MR. 2011. Rice consumption contributes to arsenic exposure in US women. Proc Natl Acad Sci U S A 108(51):20656-20660. doi:10.1073/pnas.1109127108 PMID:22143778 PMCID:PMC3251121
  • Gui J, Andrew AS, Andrews PC, Nelson HH, Kelsey KT, Karagas MR, Moore JH. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Annals of Human Genetics 75(1):20-28. doi:10.1111/j.1469-1809.2010.00624.x PMID:21091664 PMCID:PMC3057873 (Completed with ARRA Funds)
  • Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet 129(1):101-110. doi:10.1007/s00439-010-0905-5 PMID:20981448 PMCID:PMC3255326 (Completed with ARRA Funds)
  • Hu T, Sinnott-Armstrong NA, Kiralis JW, Andrew AS, Karagas MR, Moore JH. 2011. Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics 12:364. doi:10.1186/1471-2105-12-364 PMID:21910885 PMCID:PMC3215301 (Completed with ARRA Funds)
  • Koutros S, Silverman DT, Baris D, Zahm SH, Morton LM, Colt JS, Hein DW, Moore LE, Johnson A, Schwenn M, Cherala S, Schned AR, Doll MA, Rothman N, Karagas MR. 2011. Hair dye use and risk of bladder cancer in the New England bladder cancer study. Int J Cancer 129(12):2894-2904. doi:10.1002/ijc.26245 PMID:21678399 PMCID:PMC3203248
  • Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 6:908-919. doi:10.4161/epi.6.7.16431 PMID:21617368 PMCID:PMC3154431 (Completed with ARRA Funds)
  • Linos A, Petralias A, Christophi CA, Christoforidou E, Kouroutou P, Stoltidis M, Veloudaki A, Tzala E, Makris K, Karagas MR. 2011. Oral ingestion of hexavalent chromium through drinking water and cancer mortality in an industrial area of Greece - An ecological study. Environ Health 10:50. doi:10.1186/1476-069X-10-50 PMID:21609468 PMCID:PMC3123268
  • MacKenzie TA, Zens MS, Ferrara A, Schned AR, Karagas MR. 2011. Diabetes and risk of bladder cancer: Evidence from a case-control study in New England. Cancer 117(7):1552-1556. doi:10.1002/cncr.25641 PMID:21425156 PMCID:PMC3117102 (Completed with ARRA Funds)
  • Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology 29(9):1133-1139. doi:10.1200/JCO.2010.31.3577 PMID:21343564 PMCID:PMC3083868 (Completed with ARRA Funds)
  • Moore LE, Baris D, Figueroa JD, Garcia-Closas M, Schwenn M, Johnson A, Lubin JH, Hein DW, Dagnall CL, Colt JS, Kida M, Jones MA, Schned AR, Cherala S, Chanock SJ, Cantor KP, Silverman DT, Rothman N, Karagas MR. 2011. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. Carcinogenesis 32(2):182-189. doi:10.1093/carcin/bgq223 PMID:21037224 PMCID:PMC3026839
  • Nuckols JR, Freeman LB, Lubin JH, Airola MS, Baris D, Ayotte JD, Taylor A, Paulu C, Karagas MR, Colt JS, Ward MH, Huang A, Bress W, Cherala S, Cantor KP. 2011. Estimating water supply arsenic levels in the new England bladder cancer study. Environ Health Perspect 199(9):doi:10.1289/ehp.1002345 PMID:21421449 PMCID:PMC3230387 (Completed with ARRA Funds)
  • Wilhelm-Benartzi C, Christensen BC, Koestler DC, Houseman EA, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes Control 22(8):1205-1213. doi:10.1007/s10552-011-9788-6 PMID:21660454 PMCID:PMC3140591 (Completed with ARRA Funds)

2010

  • Brinkman MT, Karagas MR, Zens MS, Schned AR, Reulen RC, Zeegers MP. 2010. Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study. Cancer Causes Control 21(4):609-619. doi:10.1007/s10552-009-9490-0 PMID:20043202 PMCID:PMC2839516
  • Christensen BC, Smith A, Zheng S, Koestler DC, Houseman E, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. J Natl Cancer Inst 103:143-153. doi:10.1093/jnci/djq497 PMID:21163902 PMCID:PMC3022619
  • Fei DL, Li H, Kozul-Horvath CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ. 2010. Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res 70(5):1981-1988. doi:10.1158/0008-5472.CAN-09-2898 PMID:20179202 PMCID:PMC2831120
  • Greene CS, Himmelstein DS, Nelson HH, Kelsey KT, Williams SM, Andrew AS, Karagas MR, Moore JH. 2010. Enabling personal genomics with an explicit test of epistasis. Pac Symp Biocomput 327-36. doi:10.1142/9789814295291_0035 PMID:19908385 PMCID:PMC2916690
  • Gui J, Andrew AS, Andrews PC, Nelson HA, Kelsey KT, Karagas MR, Moore JH. 2010. A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis. Human Heredity 70:219-225. doi:10.1159/000319175 PMID:20924193 PMCID:PMC2982850
  • Karagas MR. 2010. Arsenic-related mortality in Bangladesh. Lancet 376(9737):213-214. doi:10.1016/S0140-6736(10)61002-1 PMID:20646757 PMCID:PMC2940271 (Completed with ARRA Funds)
  • Koestler DC, Marsit CJ, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Houseman EA. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics 26(20):2578-2585. doi:10.1093/bioinformatics/btq470 PMID:20834038 PMCID:PMC2951086 (Completed with ARRA Funds)
  • Kwong RC, Karagas MR, Kelsey KT, Mason RA, Tanyos SA, Schned AR, Marsit CJ, Andrew AS. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World J Urol 28(4):487-492. doi:10.1007/s00345-009-0477-y PMID:19834714 PMCID:PMC3296964 (Completed with ARRA Funds)
  • Marsit CJ, Houseman EA, Christensen BC, Gagne LA, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS One 5:e12334. doi:10.1371/journal.pone.0012334 PMID:20808801 PMCID:PMC2925945
  • Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu Y, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned AR, Andriole G, Grubb R, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan J, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes J, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau ES, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, Garcia-Prats MD, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF, Silverman DT, Chanock SJ. 2010. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet 42(11):978-984. doi:10.1038/ng.687 PMID:20972438 PMCID:PMC3049891
  • Wilhelm CS, Kelsey KT, Butler RA, Plaza S, Gagne LA, Zens MS, Andrew AS, Morris S, Nelson HH, Schned AR, Karagas MR, Marsit CJ. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clin Cancer Res 16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983 PMID:20179218 PMCID:PMC2831156
  • Wilhelm-Benartzi C, Koestler DC, Houseman E, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis 31(11):1972-1976. doi:10.1093/carcin/bgq178 PMID:20802236 PMCID:PMC2966555 (Completed with ARRA Funds)

2009

  • Andrew AS, Gui J, Sanderson A, Mason RA, Morlock EV, Schned AR, Kelsey KT, Marsit CJ, Moore JH, Karagas MR. 2009. Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet 125(5-6):527-539. doi:10.1007/s00439-009-0645-6 PMID:19252927 PMCID:PMC2763504
  • Andrew AS, Mason RA, Kelsey KT, Schned AR, Marsit CJ, Nelson HH, Karagas MR. 2009. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicol Lett 187(1):10-14. doi:10.1016/j.toxlet.2009.01.013 PMID:19429237 PMCID:PMC2680739
  • Baris D, Karagas MR, Verrill C, Johnson A, Andrew AS, Marsit CJ, Colt JS, Cherala S, Samanic C, Waddell R, Cantor KP, Schned AR, Rothman N, Lubin JH, Fraumeni JF, Hoover RN, Kelsey KT, Silverman DT, Schwenn M. 2009. A case-control study of smoking and bladder cancer risk: emergent patterns over time. J Natl Cancer Inst 101(22):1553-1561. doi:10.1093/jnci/djp361 PMID:19917915 PMCID:PMC2778671
  • Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury J, Bueno R, Sugarbaker DJ, Yeh R, Wiencke JK, Kelsey KT. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 5(8):e1000602. doi:10.1371/journal.pgen.1000602 PMID:19680444 PMCID:PMC2718614
  • Dietrich K, Schned AR, Fortuny J, Heaney JA, Marsit CJ, Kelsey KT, Karagas MR. 2009. Glucocorticoid therapy and risk of bladder cancer. Br J Cancer 101(8):1316-1320. doi:10.1038/sj.bjc.6605314 PMID:19773763 PMCID:PMC2768444
  • Heck JE, Andrew AS, Onega T, Rigas JR, Jackson BP, Karagas MR, Duell EJ. 2009. Lung cancer in a US population with low to moderate arsenic exposure. Environ Health Perspect 117(11):1718-1723. doi:10.1289/ehp.0900566 PMID:20049123 PMCID:PMC2801179
  • Kelsey KT, Schned AR, Morris J, Andrew AS, Karagas MR, Wallace K. 2009. Selenium and risk of bladder cancer: a population-based case-control study. Cancer Prev Res (Phila) 2(1):70-73. doi:10.1158/1940-6207.CAPR-08-0046 PMID:19139020 PMCID:PMC2640833
  • Mason RA, Morlock EV, Karagas MR, Kelsey KT, Marsit CJ, Schned AR, Andrew AS. 2009. EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis. Carcinogenesis 30(7):1155-1160. doi:10.1093/carcin/bgp077 PMID:19372140 PMCID:PMC2704279
  • Sloan CD, Andrew AS, Duell EJ, Williams SM, Karagas MR, Moore JH. 2009. Genetic population structure analysis in New Hampshire reveals Eastern European ancestry. PLoS One 4(9):e6928. doi:10.1371/journal.pone.0006928 PMID:19738909 PMCID:PMC2734429
  • Stern MC, Lin J, Figueroa JD, Kelsey KT, Kiltie AE, Yuan J, Matullo G, Fletcher T, Benhamou S, Taylor JA, Placidi D, Zhang Z, Steineck G, Rothman N, Kogevinas M, Silverman DT, Malats N, Chanock SJ, Wu X, Karagas MR, Andrew AS, Nelson HH, Bishop DT, Sak S, Choudhury A, Barrett JH, Elliot F, Corral R, Joshi AD, Gago-Dominguez M, Cortessis VK, Gao Y, Xiang Y, Vineis P, Sacerdote C, Guarrera S, Polidoro S, Allione A, Gurzau ES, Koppova K, Kumar R, Rudnai P, Porru S, Carta A, Campagna M, Arici C, Park S, Garcia-Closas M. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Cancer Res 69(17):6857-6864. doi:10.1158/0008-5472.CAN-09-1091 PMID:19706757 PMCID:PMC2782435
  • Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang Z, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau ES, Koppova K, Mayordomo J, Sanchez M, Saez B, Lindblom A, de Verdier, P, Steineck G, Mills GB, Schned AR, Guarrera S, Polidoro S, Chang S, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes J, Stefansson K, Amos CI, Karagas MR, Gu J. 2009. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet 41(9):991-995. doi:10.1038/ng.421 PMID:19648920 PMCID:PMC3313685

2008

  • Andrew AS, Jewell DA, Mason RA, Whitfield ML, Moore JH, Karagas MR. 2008. Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a US population. Environ Health Perspect 116(4):524-531. doi:10.1289/ehp.10861 PMID:18414638 PMCID:PMC2290973
  • Andrew AS, Karagas MR, Nelson HH, Guarrera S, Polidoro S, Gamberini S, Sacerdote C, Moore JH, Kelsey KT, Demidenko E, Vineis P, Matullo G. 2008. DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. Cancer Epidemiol Biomarkers Prev 65(2):105-118. doi:10.1159/000108942 PMID:17898541 PMCID:PMC2857629
  • Houseman EA, Christensen BC, Yeh R, Marsit CJ, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT. 2008. Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics 9:365. doi:10.1186/1471-2105-9-365 PMID:18782434 PMCID:PMC2553421
  • Moore JH, Karagas MR, Andrew AS. 2008. Analysis of Complex Datasets. Chapter 16 in: Molecular Epidemiology of Chronic Diseases. John Wiley & Sons Ltd, West Sussex, pp.207-222.
  • Moore JH, Karagas MR, Andrew AS. 2008. Novel analytical methods for association studies. Chapter 12 in: Molecular Epidemiology: Applications in Cancer and Other Human Diseases. nforma Health Care, pp.169-187.
  • Schned AR, Andrew AS, Marsit CJ, Kelsey KT, Zens MS, Karagas MR. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scandinavian Journal of Urology and Nephrology 42(3):237-42. PMID:18432530

2007

2006

  • Andrew AS, Burgess JL, Meza MM, Demidenko E, Waugh MG, Hamilton JW, Karagas MR. 2006. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect 114(8):1193-1198. PMID:16882524 PMCID:PMC1552016
  • Andrew AS, Nelson HH, Kelsey KT, Moore JH, Meng AC, Casella DP, Tosteson TD, Schned AR, Karagas MR. 2006. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis 27(5):1030-1037. PMID:16311243
  • Ayotte JD, Baris D, Cantor KP, Colt JS, Robinson GR, Lubin JH, Karagas MR, Hoover RN, Fraumeni JF, Silverman DT. 2006. Bladder cancer mortality and private well use in New England: an ecological study. J Epidemiol Community Health 60(2):168-172. doi:10.1136/jech.2005.038620 PMID:16415269 PMCID:PMC2566149
  • Ayotte JD, Nolan BT, Nuckols JR, Cantor KP, Robinson GR, Baris D, Hayes L, Karagas MR, Bress W, Silverman DT, Lubin JH. 2006. Modeling the probability of arsenic in groundwater in New England as a tool for exposure assessment. Environ Sci Technol 40(11):3578-85. doi:10.1021/es051972f PMID:16786697
  • Karagas MR, Weinstock MA, Nelson HH. 2006. Keratinocyte Carcinomas. Chapter 64 in: Cancer Epidemiology and Prevention. Oxford University Press, New York, NY.
  • Manuguerra M, Saletta F, Karagas MR, Berwick M, Veglia F, Vineis P, Matullo G. 2006. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Am J Epidemiol 164(4):297-302. PMID:16707649
  • Marsit CJ, Houseman EA, Eddy K, Bueno R, Sugarbaker DJ, Nelson HH, Karagas MR, Kelsey KT, Christensen BC. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res 66(21):10621-9. PMID:17079487
  • Marsit CJ, Karagas MR, Danaee H, Liu M, Andrew AS, Schned AR, Nelson HH, Kelsey KT. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112-116. PMID:15987713
  • Marsit CJ, Karagas MR, Schned AR, Kelsey KT. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Ann N Y Acad Sci 1076:810-21.

2005

  • Hirao S, Hirao T, Hirao Y, Marsit CJ, Schned AR, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR, Kelsey KT. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104(9):1918-1923.
  • Karagas MR, Park S, Nelson HH, Andrew AS, Mott LA, Schned AR, Kelsey KT. 2005. Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: A population-based case-control study. Int J Hyg Environ Health 208(5):321-327. PMID:16217917
  • Karagas MR, Park S, Warren AJ, Hamilton JW, Nelson HH, Mott LA, Kelsey KT. 2005. Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Lett 219(1):63-69. doi:10.1016/j.canlet.2004.10.006 PMID:15694665
  • Kelsey KT, Hirao T, Hirao S, Devi-Ashok T, Nelson HH, Andrew AS, Colt JS, Baris D, Morris J, Schned AR, Karagas MR. 2005. TP53 alterations and patterns of carcinogen exposure in a U.S. population-based study of bladder cancer. Int J Cancer 117(3):370-375.
  • Marsit CJ, Karagas MR, Andrew AS, Liu M, Danaee H, Schned AR, Nelson HH, Kelsey KT. 2005. Epigenetic Inactivation of SFRP Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder Cancer. Cancer Res 65(16):7081-7085. PMID:16103055

2004

  • Andrew AS, Schned AR, Heaney JA, Karagas MR. 2004. Bladder cancer risk and personal hair dye use. Int J Cancer 109(4):581-586. PMID:14991581
  • Carroll RJ, Ruppert D, Tosteson TD, Karagas MR. 2004. Nonlinear and nonparametric regression and instrumental variables. J Am Stat Assoc 99(467):736-750.
  • Colt JS, Baris D, Stewart P, Schned AR, Heaney JA, Mott LA, Silverman DT, Karagas MR. 2004. Occupation and bladder cancer risk in a population-based case-control study in New Hampshire. Cancer Causes Control 15(8):759-769. PMID:15456989
  • Karagas MR, Tosteson TD, Morris J, Demidenko E, Mott LA, Heaney JA, Schned AR. 2004. Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire. Cancer Causes Control 15(5):465-472. PMID:15286466
  • Kelsey KT, Hirao T, Schned AR, Hirao S, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR. 2004. A population-based study of immunohistochemical detection of p53 alteration in bladder cancer. Br J Cancer 90(8):1572-1576. PMID:15083187
  • Kelsey KT, Park S, Nelson HH, Karagas MR. 2004. A Population-Based Case-Control Study of the XRCC1 Arg399Gln Polymorphism and Susceptibility to Bladder Cancer. Cancer Epidemiol Biomarkers Prev 13(8):1337-1341. PMID:15298955
  • Wickre JB, Folt CL, Sturup S, Karagas MR. 2004. Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community. Archives of Environmental Health 59(8):400-409. PMID:16268116

2003

  • Andrew AS, Karagas MR, Hamilton JW. 2003. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer 104(3):263-268. PMID:12569548
  • Andrew AS, Karagas MR, Klei L, Hamilton JW. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. J Toxicol Sci 72(S1):184.
  • Tosteson TD, Buzas JS, Demidenko E, Karagas MR. 2003. Power and sample size calculations for generalized regression models with covariate measurement error. Stat Med 22(7):1069-1082. PMID:12652554

2002

  • Andrew AS, Karagas MR, Schned AR, Hamilton JW. 2002. Decreased expression of DNA repair genes ERCC1, XPF, and XPB, but not XPG or XPA among individuals exposed to arsenic in drinking water. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Andrew AS, Mott LA, Heaney JA, Schned AR, Karagas MR. 2002. Bladder cancer risk and personal hair dye use in women. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Colt JS, Baris D, Clark SF, Ayotte JD, Ward MH, Nuckols JR, Cantor KP, Silverman DT, Karagas MR. 2002. Sampling private wells at past homes to estimate arsenic exposure: a methodologic study in New England. J Expo Sci Environ Epidemiol 12(5):329-334. PMID:12198581
  • Danaee H, Nelson HH, Karagas MR, Schned AR, Devi-Ashok T, Hirao T, Perry AE, Kelsey KT. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. Oncogene 21(32):4894-4899. PMID:12118368
  • Danaee H, Nelson HH, Karagas MR, Schned AR, Devi-Ashok T, Hirao T, Perry AE, Kelsey KT. 2002. Microsatellite instability at tetranucleotide repeats in skin and bladder cancer. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA.
  • Karagas MR, Nelson HA, Kelsey KT, Morris S, Blum JD, Tosteson TD, Carey M, Le X. 2002. Urinary Arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. Chapter 17 in: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL.
  • Karagas MR, Nelson HA, Kelsey KT, Morris S, Blum JD, Tosteson TD, Carey M, Le X. 2002. Urinary arsenic species in relation to drinking water and toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire. Proceedings in Nucleic Research 17:251-261.
  • Karagas MR, Stukel TA, Tosteson TD. 2002. Assessment of cancer risk and environmental levels of arsenic in New Hampshire. Int J Hyg Environ Health 205(1-2):85-94. PMID:12018020
  • Schned AR, Karagas MR, Kelsey KT. 2002. Prevalence of bladder tumour types in a non-selected patient Population, classified according tothe World Health Organization/International Society of Urologic Pathologists(WHO/ISUP) System. Histopathology 41(S1):52-53.

2001

  • Karagas MR, Le X, Morris S, Blum JD, Lu X, Spate VL, Carey M, Stannard V, Klaue B, Tosteson TD. 2001. Markers of low level arsenic exposure for evaluating human cancer risks in a US population. Int J Occup Med Environ Health 14(2):171-175. PMID:11548067
  • Karagas MR, Stukel TA, Morris J, Tosteson TD, Spencer SK, Greenberg ER. 2001. Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study. Am J Epidemiol 153(6):559-565. PMID:11257063
  • Park S, Karagas MR, Nelson HH, Mott LA, Bronson KM, Kelsey KT. 2001. X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and the risk of bladder cancer. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2001.

2000

  • Karagas MR, Tosteson TD, Blum JD, Klaue B, Weiss JE, Stannard V, Spate VL, Morris J. 2000. Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. Am J Epidemiol 152(1):84-90.
  • Tosteson TD, Karagas MR. 2000. Designing an arsenic and bladder cancer case-control study. What sample size is needed to detect the beginning of dose-response?. Metal Ions in Biology and Medicine 6:28-30.

1999

  • Peters SC, Blum JD, Klaue B, Karagas MR. 1999. Arsenic occurrence in New Hampshire drinking water. Environ Sci Technol 33(9):1328-1333.

1998

  • Karagas MR, Tosteson TD, Blum JD, Morris J, Baron JA, Klaue B. 1998. Design of an epidemiological study of drinking water arsenic exposure and cancer risk in a US population. Environ Health Perspect 106Suppl.4:1047-1050.
  • Nichols TA, Morris J, Mason MM, Spate VL, Baskett CK, Cheng TP, Tharp CJ, Scott JA, Horsman TL, Tawson AE, Karagas MR, Stannard V, Colbert JW. 1998. The study of human nails as an intake monitor for arsenic using neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry 236(1-2):51-56. doi:10.1007/BF02386317

1996

  • Karagas MR, Morris J, Weiss JE, Spate VL, Baskett CK, Greenberg ER. 1996. Toenail samples as an indicator of drinking water arsenic exposure. Cancer Epidemiol Biomarkers Prev 5(10):849-852. PMID:8896897

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