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Final Progress Reports: Columbia University: Consequences of Arsenic and Manganese Exposure on Children

Superfund Research Program

Consequences of Arsenic and Manganese Exposure on Children

Project Leader: Joseph H. Graziano
Grant Number: P42ES010349
Funding Period: 2000-2017
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Final Progress Reports

Year:   2016  2010  2005 

This project addresses several questions concerning the health effects of exposure to arsenic and manganese in water (WAs and WMn, respectively) among adolescents. First, does the arsenic-induced respiratory disease observed in adults also manifest itself in adolescents, and what are possible physiologic mechanisms? Second, to what extent do associations between WAs and both lung function brain function reflect the effects of exposure in utero and in infancy, periods of dramatic development for these systems? Third, are WAs and WMn associated with specific cognitive functions in addition to intelligence?

The research team has now completed all of the field work and laboratory analysis in 725 adolescents (14-17 years old) whose mothers are participants in the HEALS cohort study (another project under Columbia University SRP). Based on mothers' well arsenic, measured five times from 2000, researchers defined four groups with varying levels and patterns of exposure to arsenic: Group 1) consistently low (mean WAs = 3 ppb); Group 2) consistently moderate (mean WAs = 26 ppb); Group 3) consistently high (mean WAs = 146 ppb); and Group 4) high from conception through roughly age one (mean WAs = 201 ppb) but much lower thereafter (mean WAs =13 ppb).

Three specific aims target arsenic exposure and pulmonary function (FEV1 and FVC) as well as biomarkers of lung dysfunction in exhaled breath condensate. An additional three aims focus on neuropsychologic outcomes assessed via the Cambridge Neuropsychological Test Automated Battery (CANTAB), and the WISC-IV. Final analyses and manuscripts describing all of these outcomes are in progress.

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