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Your Environment. Your Health.

Project Publications: University of Washington: Parkinsonism and Metal Exposures Among Welders

Superfund Research Program

Parkinsonism and Metal Exposures Among Welders

Project Leader: Harvey Checkoway (University of California-San Diego)
Grant Number: P42ES004696
Funding Period: 2009-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

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  • Criswell SR, Nielsen SS, Warden MN, Flores HP, Lenox-Krug J, Racette S, Sheppard L, Checkoway H, Racette BA. 2019. MRI signal intensity and parkinsonism in manganese-exposed workers. J Occup Environ Med 61:641-645. doi:10.1097/JOM.0000000000001634 PMID:31348423



  • Racette BA, Searles Nielsen S, Criswell SR, Sheppard L, Seixas N, Warden MN, Checkoway H. 2017. Dose-dependent progression of parkinsonism in manganese-exposed welders. Neurology 88(4):344-351. doi:10.1212/WNL.0000000000003533 PMID:28031394 PMCID:PMC5272970
  • Searles Nielsen S, Al-Lozi A, Hershey T, Birke A, Checkoway H, Criswell SR, Racette BA. 2017. Cognitive control dysfunction in workers exposed to manganese-containing welding fume. Am J Ind Med 60(2):181-188. doi:10.1002/ajim.22675 PMID:27862095



  • Ahmed I, Lee P, Lill CM, Nielsen SS, Artaud F, Gallagher LG, Loriot M, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H, Ritz B, Elbaz A. 2014. Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. PLoS Genet 10(11):e1004788. doi:10.1371/journal.pgen.1004788 PMID:25412286 PMCID:PMC4238979
  • Checkoway H, Searles Nielsen S, Racette BA. 2014. Epidemiological Studies of Parkinsonism in Welders. Chapter 20 in: Manganese in Health and Disease. Royal Society of Chemistry, Cambridge, United Kingdom.
  • Gonzalez-Cuyar LF, Nelson G, Criswell SR, Ho P, Lonzanida JA, Checkoway H, Seixas N, Gelman BB, Evanoff BA, Murray J, Zhang J, Racette BA. 2014. Quantitative neuropathology associated with chronic manganese exposure in South African mine workers. Neurotoxicology 45:260-266. doi:10.1016/j.neuro.2013.12.008 PMID:24374477 PMCID:PMC4072755
  • Lundin JI, Checkoway H, Criswell SR, Hobson AJ, Harris RC, Swisher LM, Evanoff BA, Racette BA. 2014. Screening for early detection of parkinsonism using a self-administered questionnaire: a cross-sectional epidemiologic study. Neurotoxicology 45:232-237. doi:10.1016/j.neuro.2013.08.010 PMID:24035927 PMCID:PMC3954448
  • Lundin JI, Ton TG, LaCroix AZ, Longstreth WT, Swanson PD, Smith-Weller T, Racette BA, Checkoway H. 2014. Formulations of hormone therapy and risk of Parkinson's disease. Movement Disorders 29:1631-1636. doi:10.1002/mds.26037 PMID:25255692 PMCID:PMC4216612
  • Racette BA. 2014. Manganism in the 21st century: the Hanninen lecture. Neurotoxicology 45:201-207. doi:10.1016/j.neuro.2013.09.007 PMID:24148923 PMCID:PMC3992192



  • Criswell SR, Perlmutter JS, Huang J, Golchin N, Flores HP, Hobson AJ, Aschner M, Erikson KM, Checkoway H, Racette BA. 2012. Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med 69(6):437-443. doi:10.1136/oemed-2011-100119 PMID:22447645 PMCID:PMC3651997
  • Mata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim H, Alvarez V, Ribacoba R, Pastor P, Lorenzo-Betancor O, Infante J, Sierra M, Gomez-Garre P, Mir P, Ritz B, Rhodes SL, Colcher A, Van Deerlin V, Chung KA, Quinn JF, Yearout D, Martizez E, Farin FM, Wan JY, Edwards KL, Zabetian CP. 2012. Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Movement Disorders 27(14):1823-1826. doi:10.1002/mds.25226 PMID:23115130 PMCID:PMC3536918
  • Nielsen SS, Checkoway H, Butler RA, Nelson HH, Farin FM, Longstreth WT, Franklin GM, Swanson PD, Kelsey KT. 2012. LINE-1 DNA methylation, smoking and risk of Parkinson's disease. J Parkinsons Dis 2(4):303-308. doi:10.3233/JPD-012129 PMID:23938260 PMCID:PMC3962286
  • Nielsen SS, Gallagher LG, Lundin JI, Longstreth WT, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2012. Environmental tobacco smoke and Parkinson's disease. Movement Disorders 27(2):293-297. doi:10.1002/mds.24012 PMID:22095755 PMCID:PMC3289937
  • Racette BA, Criswell SR, Lundin JI, Hobson AJ, Seixas N, Kotzbauer PT, Evanoff BA, Perlmutter JS, Zhang J, Sheppard L, Checkoway H. 2012. Increased risk of Parkinsonism associated with welding exposure. Neurotoxicology 33(5):1356-1361. doi:10.1016/j.neuro.2012.08.011 PMID:22975422 PMCID:PMC3651999



  • Hofmann JN, Checkoway H, Borges O, Servin F, Fenske RA, Keifer M. 2010. Development of a computer-based survey instrument for organophosphate and N-methyl-carbamate exposure assessment among agricultural pesticide handlers. Ann Occup Hyg 54:640-650. doi:10.1093/annhyg/meq038 PMID:20413416 PMCID:PMC2918489
  • Hofmann JN, Keifer M, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. 2010. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occup Environ Med 67(6):375-386. doi:10.1136/oem.2009.046391 PMID:19819864 PMCID:PMC2908529


  • Hobson AJ, Sterling DA, Emo B, Evanoff BA, Sterling CS, Good L, Seixas N, Checkoway H, Racette BA. 2009. Validity and reliability of an occupational exposure questionnaire for parkinsonism in welders. J Occup Environ Hyg 6(6):324-331. doi:10.1080/15459620902836856 PMID:19288335 PMCID:PMC2879629
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