Superfund Research Program

Parkinsonism and Metal Exposures Among Welders

Project Leader: Harvey Checkoway (University of California-San Diego)
Grant Number: P42ES004696
Funding Period: 2009-2015

Project-Specific Links

Publications

2020

• Criswell SR, Searles Nielsen S, Warden MN, Perlmutter JS, Moerlein SM, Sheppard L, Lenox-Krug J, Checkoway H, Racette BA. 2020. [11C]dihydrotetrabenazine positron emission tomography in manganese-exposed workers. J Occup Environ Med 62:788-794. doi:10.1097/JOM.0000000000001915 PMID:32472844 PMCID:PMC7786890

2019

• Criswell SR, Nielsen SS, Warden MN, Flores HP, Lenox-Krug J, Racette S, Sheppard L, Checkoway H, Racette BA. 2019. MRI signal intensity and parkinsonism in manganese-exposed workers. J Occup Environ Med 61:641-645. doi:10.1097/JOM.0000000000001634 PMID:31348423

2018

• Criswell SR, Nielsen SS, Warden MN, Perlmutter JS, Huang J, Sheppard L, Seixas N, Checkoway H, Racette BA. 2018. F-18 FDOPA positron emission tomography in manganese-exposed workers. Neurotoxicology 64:43-49. doi:10.1016/j.neuro.2017.07.004 PMID:28694016 PMCID:PMC5758438
• Criswell SR, Warden MN, Searles Nielsen S, Perlmutter JS, Moerlein SM, Sheppard L, Lenox-Krug J, Checkoway H, Racette BA. 2018. Selective D2 receptor PET in manganese-exposed workers. Neurology 91(11):e1022-e1030. doi:10.1212/WNL.0000000000006163 PMID:30097475 PMCID:PMC6140373
• Racette BA, Gross A, Criswell SR, Checkoway H, Nielsen SS. 2018. A screening tool to detect clinical manganese neurotoxicity. Neurotoxicology 64:12-18. doi:10.1016/j.neuro.2017.02.009 PMID:28274800 PMCID:PMC5587364

2017

• Racette BA, Searles Nielsen S, Criswell SR, Sheppard L, Seixas N, Warden MN, Checkoway H. 2017. Dose-dependent progression of parkinsonism in manganese-exposed welders. Neurology 88(4):344-351. doi:10.1212/WNL.0000000000003533 PMID:28031394 PMCID:PMC5272970
• Searles Nielsen S, Al-Lozi A, Hershey T, Birke A, Checkoway H, Criswell SR, Racette BA. 2017. Cognitive control dysfunction in workers exposed to manganese-containing welding fume. Am J Ind Med 60(2):181-188. doi:10.1002/ajim.22675 PMID:27862095

2015

• Costa-Mallen P, Zabetian CP, Agarwal P, Hu S, Yearout D, Samii A, Leverenz JB, Roberts JW, Checkoway H. 2015. Haptoglobin phenotype modifies serum iron levels and the effect of smoking on Parkinson disease risk. Parkinsonism Relat Disord 21(9):1087-1092. doi:10.1016/j.parkreldis.2015.07.006 PMID:26228081 PMCID:PMC4554997
• Racette BA, Willis AW. 2015. Time to change the blind men and the elephant approach to Parkinson disease?. Neurology 85(2):190-196. doi:10.1212/WNL.0000000000001739 PMID:26070339 PMCID:PMC4515036
• Searles Nielsen S, Checkoway H, Criswell SR, Farin FM, Stapleton PL, Sheppard L, Racette BA. 2015. Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders. Parkinsonism Relat Disord 21(4):355-360. doi:10.1016/j.parkreldis.2015.01.007 PMID:25634431 PMCID:PMC4512640

2014

• Ahmed I, Lee P, Lill CM, Nielsen SS, Artaud F, Gallagher LG, Loriot M, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H, Ritz B, Elbaz A. 2014. Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. PLoS Genet 10(11):e1004788. doi:10.1371/journal.pgen.1004788 PMID:25412286 PMCID:PMC4238979
• Checkoway H, Searles Nielsen S, Racette BA. 2014. Epidemiological Studies of Parkinsonism in Welders. Chapter 20 in: Manganese in Health and Disease. Royal Society of Chemistry, Cambridge, United Kingdom.
• Gonzalez-Cuyar LF, Nelson G, Criswell SR, Ho P, Lonzanida JA, Checkoway H, Seixas N, Gelman BB, Evanoff BA, Murray J, Zhang J, Racette BA. 2014. Quantitative neuropathology associated with chronic manganese exposure in South African mine workers. Neurotoxicology 45:260-266. doi:10.1016/j.neuro.2013.12.008 PMID:24374477 PMCID:PMC4072755
• Lundin JI, Checkoway H, Criswell SR, Hobson AJ, Harris RC, Swisher LM, Evanoff BA, Racette BA. 2014. Screening for early detection of parkinsonism using a self-administered questionnaire: a cross-sectional epidemiologic study. Neurotoxicology 45:232-237. doi:10.1016/j.neuro.2013.08.010 PMID:24035927 PMCID:PMC3954448
• Lundin JI, Ton TG, LaCroix AZ, Longstreth WT, Swanson PD, Smith-Weller T, Racette BA, Checkoway H. 2014. Formulations of hormone therapy and risk of Parkinson's disease. Movement Disorders 29:1631-1636. doi:10.1002/mds.26037 PMID:25255692 PMCID:PMC4216612
• Racette BA. 2014. Manganism in the 21st century: the Hanninen lecture. Neurotoxicology 45:201-207. doi:10.1016/j.neuro.2013.09.007 PMID:24148923 PMCID:PMC3992192

2013

• Kwon E, Gallagher LG, Nielsen SS, Franklin GM, Littell CT, Longstreth WT, Swanson PD, Checkoway H. 2013. Parkinson's disease and history of outdoor occupation. Parkinsonism Relat Disord 19:1164-1166. doi:10.1016/j.parkreldis.2013.08.014 PMID:24044947 PMCID:PMC3927788
• Lock EA, Zhang J, Checkoway H. 2013. Solvents and Parkinson disease: a systematic review of toxicological and epidemiological evidence. Toxicol Appl Pharmacol 266(3):345-355. doi:10.1016/j.taap.2012.11.016 PMID:23220449 PMCID:PMC3621032
• Searles Nielsen S, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. 2013. Nicotine from edible Solanaceae and risk of Parkinson disease. Ann Neurol 74(3):472-477. doi:10.1002/ana.23884 PMID:23661325 PMCID:PMC4864980

2012

• Criswell SR, Perlmutter JS, Huang J, Golchin N, Flores HP, Hobson AJ, Aschner M, Erikson KM, Checkoway H, Racette BA. 2012. Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med 69(6):437-443. doi:10.1136/oemed-2011-100119 PMID:22447645 PMCID:PMC3651997
• Mata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim H, Alvarez V, Ribacoba R, Pastor P, Lorenzo-Betancor O, Infante J, Sierra M, Gomez-Garre P, Mir P, Ritz B, Rhodes SL, Colcher A, Van Deerlin V, Chung KA, Quinn JF, Yearout D, Martizez E, Farin FM, Wan JY, Edwards KL, Zabetian CP. 2012. Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Movement Disorders 27(14):1823-1826. doi:10.1002/mds.25226 PMID:23115130 PMCID:PMC3536918
• Nielsen SS, Checkoway H, Butler RA, Nelson HH, Farin FM, Longstreth WT, Franklin GM, Swanson PD, Kelsey KT. 2012. LINE-1 DNA methylation, smoking and risk of Parkinson's disease. J Parkinsons Dis 2(4):303-308. doi:10.3233/JPD-012129 PMID:23938260 PMCID:PMC3962286
• Nielsen SS, Gallagher LG, Lundin JI, Longstreth WT, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2012. Environmental tobacco smoke and Parkinson's disease. Movement Disorders 27(2):293-297. doi:10.1002/mds.24012 PMID:22095755 PMCID:PMC3289937
• Racette BA, Criswell SR, Lundin JI, Hobson AJ, Seixas N, Kotzbauer PT, Evanoff BA, Perlmutter JS, Zhang J, Sheppard L, Checkoway H. 2012. Increased risk of Parkinsonism associated with welding exposure. Neurotoxicology 33(5):1356-1361. doi:10.1016/j.neuro.2012.08.011 PMID:22975422 PMCID:PMC3651999

2011

• Criswell SR, Perlmutter JS, Videen TO, Morelein SM, Flores HP, Birke AM, Racette BA. 2011. Reduced uptake of [¹⁸F]FDOPA PET in asymptomatic welders with occupational manganese exposure. Neurology 76(15):1296-1301. doi:10.1212/WNL.0b013e3182152830 PMID:21471467 PMCID:PMC3090062
• Hobson AJ, Seixas N, Sterling DA, Racette BA. 2011. Estimation of particulate mass and manganese exposure levels among welders. Ann Occup Hyg 55(1):113-125. doi:10.1093/annhyg/meq069 PMID:20870928 PMCID:PMC3020674

2010

• Hofmann JN, Checkoway H, Borges O, Servin F, Fenske RA, Keifer M. 2010. Development of a computer-based survey instrument for organophosphate and N-methyl-carbamate exposure assessment among agricultural pesticide handlers. Ann Occup Hyg 54:640-650. doi:10.1093/annhyg/meq038 PMID:20413416 PMCID:PMC2918489
• Hofmann JN, Keifer M, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. 2010. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occup Environ Med 67(6):375-386. doi:10.1136/oem.2009.046391 PMID:19819864 PMCID:PMC2908529

2009

• Hobson AJ, Sterling DA, Emo B, Evanoff BA, Sterling CS, Good L, Seixas N, Checkoway H, Racette BA. 2009. Validity and reliability of an occupational exposure questionnaire for parkinsonism in welders. J Occup Environ Hyg 6(6):324-331. doi:10.1080/15459620902836856 PMID:19288335 PMCID:PMC2879629