Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Project Publications: University of California-Davis: Assessing the Adverse Effects of Environmental Hazards on Reproductive Health

Superfund Research Program

Assessing the Adverse Effects of Environmental Hazards on Reproductive Health

Project Leader: Bill L. Lasley
Grant Number: P42ES004699
Funding Period: 1995-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's Twitter page Visit the grantee's Facebook page



  • Moran-Messen FM, Chen J, Gee NA, Lohstroh PN, Lasley BL. 2013. Dehydroepiandrosterone sulfate levels reflect endogenous luteinizing hormone production and response to human chorionic gonadotropin challenge in older female macaque (Macaca fascicularis). Menopause 20(3):329-335. doi:10.1097/GME.0b013e3182698f80 PMID:23435031 PMCID:PMC3546135


  • Duleba AJ, Ahmed MI, Sun M, Gao AC, Villanueva J, Conley AJ, Turgeon JL, Benirschke K, Gee NA, Chen J, Green PG, Lasley BL. 2011. Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reprod Sci 18(2):119-127. doi:10.1177/1933719110382581 PMID:20889956 PMCID:PMC3031453


  • Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. 2008. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 101(2):294-309. PMID:17977901
  • Chen J, Ahn K, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. 2008. Triclocarban enhances testosterone action: a new type of endocrine disruptor?. Endocrinology 149(3):1173-1179. doi:10.1210/en.2007-1057 PMID:18048496 PMCID:PMC2275366


  • Ahn K, Lohstroh PN, Gee SJ, Gee NA, Lasley BL, Hammock BD. 2007. High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides. Anal Chem 79(23):8883-8890. doi:10.1021/ac070675l PMID:17983205
  • Chen J, Ahn K, Gee SJ, Gee NA, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284. doi:10.1016/j.taap.2007.03.015 PMID:17481686 PMCID:PMC1978490
  • Lemay DG, Neville MC, Rudolph MC, Pollard KS, German JB. 2007. Gene regulatory networks in lactation: identification of global principles using bioinformatics. BMC Syst Biol 1:56. PMID:18039394
  • Lohstroh PN, Laughlin LS, Lasley BL. 2007. Development, validation and application of a chemiluminescent immunoassay for the measurement of circulating chorionic gonadotropin levels in the laboratory macaque. Journal of Medical Primatology 36(3):164-169. PMID:17517091
  • Lohstroh PN, Overstreet JW, Stewart DR, Nakajima ST, Cragun JR, Boyers SP, Lasley BL. 2007. Hourly human chorionic gonadotropin secretion profiles during the peri-implantation period of successful pregnancies. Fertil Steril 87(6):1413-8. PMID:17261286
  • Phimister AJ, Lango J, Lee EH, Ernst-Russell M, Takeshima H, Ma J, Allen PD, Pessah IN. 2007. Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. J Biol Chem 282(12):8667-8677. doi:10.1074/jbc.M609936200 PMID:17237236


  • Chen J, Sowers MR, Moran-Messen FM, McConnell DS, Gee NA, Greendale GA, Whitehead C, Kasim-Karakas SE, Lasley BL. 2006. Circulating bioactive androgens in midlife women. J Clin Endocrinol Metab 92(11):4387-4394. PMID:16940455


  • Chen J, Qiu Q, Lohstroh PN. 2004. Hormonal characteristics in the early luteal phase of conceptive and nonconceptive menstrual cycles. J Soc Gynecol Investig 10(1):27-31. PMID:12517590
  • Chen J, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL, Douglas GC. 2004. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci 78(1):166-174. PMID:14691210
  • Moran-Messen FM, Hendrickx AG, Shideler SE, Watkins SM. 2004. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on fatty acid availability and neural tube formation in cynomolgus macaque, Macaca fascicularis. Birth Defects Research Part B: Developmental and Reproductive Toxicology 71(1):37-46. PMID:14991909


  • Chen J, Douglas GC, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL. 2003. Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. Toxicol Sci 76(1):75-82. PMID:12970577
  • Chen J, Laughlin LS, Hendrickx AG, Natarajan K, Overstreet JW, Lasley BL. 2003. The effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotrophin activity in pregnant macaques. Toxicology 186(1-2):21-31. PMID:12604168
  • Chen J, Thirkill TL, Overstreet JW, Lasley BL, Douglas GC. 2003. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotropin secretion by human trophoblasts. Reprod Toxicol 17(1):87-93. PMID:12507663
  • Lohstroh PN, Chen J, Ba J, Ryan LM, Xu X, Overstreet JW, Lasley BL. 2003. Bone resorption is affected by follicular phase length in female rotating shift workers. Environ Health Perspect 111(4):618-622. PMID:12676625
  • Shideler SE, Gee NA, Chen J, Laughlin LS, Rapp PR, Morrison JH, Roberts JA, Moran-Messen FM, Lasley BL. 2003. Contribution of ovarian steroid production to urinary estrone conjugate concentrations in Macaca mulatta. Am J Primatol 61(3):111-121. doi:10.1002/ajp.10114 PMID:14610729
  • Zhou Y, Zhong C, Kennedy IM, Pinkerton KE. 2003. Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats. Environ Toxicol Chem 18(4):227-235. PMID:12900941


  • Chang W, Reddy SP, Di YP, Yoneda K, Harper R, Wu R. 2002. Regulation of thioredoxin gene expression by vitamin A in human airway epithelial cells. Am J Respir Cell Mol Biol 26(5):627-635. doi:10.1165/ajrcmb.26.5.4276 PMID:11970916
  • Cho S, Goldman MB, Ryan L, Damokosh AI, Christiani DC, Lasley BL, Wilcox AJ, Xu X. 2002. Reliability of serial urine HCG as a biomarker to detect early pregnancy loss. Hum Reprod 17(4):1060-1066. PMID:11925406
  • Li H, Chen J, Overstreet JW, Nakajima ST, Lasley BL. 2002. Urinary follicle-stimulating hormone peak as a biomarker for estimating the day of ovulation. Fertil Steril 77(5):961-966. PMID:12009351
  • Natarajan K, Overstreet JW, Rogers JM, Denison MS, Chen J, Lohstroh PN, McConnell DS, Lasley BL. 2002. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. Environ Health Perspect 110(8):791-795. PMID:12153760
  • Stanton B, Watkins SM, German JB, Lasley BL. 2002. Effect of estrogen and 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) on plasma fatty acids of immature male chickens (Gallus domesticus). Comp Biochem Physiol C Toxicol Pharmacol 132(2):129-142. PMID:12106890
  • Weissmann GS, Mount JF, Fogg GE. 2002. Glacially driven cycles in accumulation space and sequence stratigraphy of a stream-dominated alluvial fan, San Joaquin Valley, California, U.S.A. Journal of Sedimentary Research 72(2):240-251. doi:10.1306/062201720240
  • Wilken JA, Matsumoto K, Laughlin LS, Lasley BL, Bedows E. 2002. Comparison of chorionic gonadotropin expression in human and macaque (Macaca fascicularis) trophoblasts. Am J Primatol 56(2):89-97. doi:10.1002/ajp.1066 PMID:11793416


  • Li H, Nakajima ST, Chen J, Todd HE, Overstreet JW, Lasley BL. 2001. Differences in hormonal characteristics of conceptive versus nonconceptive menstrual cycles. Fertil Steril 75(3):549-553. PMID:11239540
  • Stanton B, El-Sabeawy F, Fang Yang X, Enan E, Lasley BL. 2001. Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in immature male chickens (Gallus domesticus). Comp Biochem Physiol C Toxicol Pharmacol 129(1):35-47. PMID:11369299
  • Stanton B, Watkins SM, German JB, Lasley BL. 2001. Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hepatic fatty acid synthesis and metabolism of male chickens (Gallus domesticus). Comp Biochem Physiol C Toxicol Pharmacol 129(2):137-150. PMID:11423386


  • Guo Y, Hendrickx AG, Overstreet JW, Dieter J, Stewart DR, Tarantal AF, Laughlin LS, Lasley BL. 1999. Endocrine biomarkers of early fetal loss in cynomolgus macaques (Macaca fascicularis) following exposure to dioxin. Biol Reprod 60(3):707-713. PMID:10026120
  • Stewart DR, VandeVoort CA. 1999. Relaxin secretion by human granulosa cell culture is predictive of in-vitro fertilization-embryo transfer success. Hum Reprod 14(2):338-344. PMID:10099975
  • Todd HE, Shideler SE, Laughlin LS, Overstreet JW, Pohl CR, Byrd W, Lasley BL. 1999. Application of an enzyme immunoassay for urinary follicle-stimulating hormone to describe the effects of an acute stressor at different stages of the menstrual cycle in female laboratory macaques. Am J Primatol 48(2):135-151. PMID:10333433
  • Wang X, Overstreet JW, Todd HE, Qiu Q, Yang J, Wang S, Xu X, Lasley BL. 1999. Urinary follicle stimulating hormone can be used as a biomarker to assess male reproductive function. Asian J Androl 1(1-2):67-72. PMID:11225907


  • Lasley BL, Overstreet JW. 1998. Biomarkers for assessing human female reproductive health, an interdisciplinary approach. Environ Health Perspect 106(Suppl.4):955-960. PMID:9703478
  • Qiu Q, Kuo A, Todd HE, Dias JA, Gould JE, Overstreet JW, Lasley BL. 1998. Enzyme immunoassay method for total urinary follicle stimulating hormone (FSH) beta subunit and its application for measurement of total urinary FSH. Fertil Steril 69(2):278-285. PMID:9496342


  • Cooke JB. 1997. Effects of 17-beta-estradiol and beta- hexachlorocyclohexane on liver and gonad morphology and on liver tumorigenesis induced by diethylnitrosamine in medaka (Oryzias latipes). Ph.D. Thesis, University of California-Davis, Davis, CA.
  • Munro CJ, Laughlin LS, Illera JC, Dieter J, Hendrickx AG, Lasley BL. 1997. ELISA for the measurement of serum and urinary chorionic gonadotropin concentrations in the laboratory macaque. Am J Primatol 41(4):307-322. PMID:9093694
  • Qiu Q, Overstreet JW, Todd HE, Nakajima ST, Stewart DR, Lasley BL. 1997. Total urinary follicle stimulating hormone as a biomarker for detection of early pregnancy and periimplantation spontaneous abortion. Environ Health Perspect 105(8):862-866. PMID:9347902
  • Savage A, Shideler SE, Soto LH, Causado J, Giraldo LH, Lasley BL, Snowdon CT. 1997. Reproductive events of wild cotton-top tamarins (Saguinus oedipus) in Colombia. Am J Primatol 43(4):329-337. PMID:9403097
  • Stewart DR, Erikson MS, Erikson ME, Nakajima ST, Overstreet JW, Lasley BL, Amento EP, Seppala M. 1997. The role of relaxin in glycodelin secretion. J Clin Endocrinol Metab 82(3):839-846. PMID:9062493
  • Stewart DR, VandeVoort CA. 1997. Simulation of human luteal endocrine function with granulosa lutein cell culture. J Clin Endocrinol Metab 82(9):3078-3083. PMID:9284747


  • Duffy DM, Hutchison JS, Stewart DR, Stouffer RL. 1996. Stimulation of primate luteal function by recombinant human chorionic gonadotropin and modulation of steroid, but not relaxin, production by an inhibitor of 3-hydroxysteroid dehydrogenase during simulated early pregnancy. J Clin Endocrinol Metab 81(6):2307-2313. PMID:8964869
  • Kassam A, Overstreet JW, Snow-Harter C, De Souza MJ, Gold EB, Lasley BL. 1996. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ Health Perspect 104(4):408-413. PMID:8732951
  • Munro CJ, Laughlin LS, VonSchalscha T, Baldwin DM, Lasley BL. 1996. An enzyme immunoassay for serum and urinary levonorgestrel in human and non-human primates. Contraception 54(1):43-53. PMID:8804808
  • Winters KM, Adams WC, Meredith CN, Van Loan MD, Lasley BL. 1996. Bone density and cyclic ovarian function in trained runners and active controls. Medicine & Science in Sports & Exercise 28(7):776-785. PMID:8832529


  • Duffy DM, Stouffer RL, Stewart DR. 1995. Dissociation of relaxin and progesterone secretion from the primate corpus luteum by acute administration of a 3b-hydroxysteroid dehydrogenase inhibitor during the menstrual cycle. Biol Reprod 53(2):447-453. PMID:7492699
  • Eskenazi B, Gold EB, Lasley BL, Samuels S, Hammond SK, Wight S, Rasor MO, Hines CJ, Schenker MB. 1995. Prospective monitoring of early fetal loss and clinical spontaneous abortion among female semiconductor workers. Am J Ind Med 28(6):833-846. PMID:8588567
  • Eskenazi B, Gold EB, Samuels S, Wight S, Lasley BL, Hammond SK, Rasor MO, Schenker MB. 1995. Prospective assessment of fecundability of female semiconductor workers. Am J Ind Med 28(6):817-831. PMID:8588566
  • Gold EB, Eskenazi B, Hammond SK, Lasley BL, Samuels S, Rasor MO, Hines CJ, Overstreet JW, Schenker MB. 1995. Prospectively assessed menstrual cycle characteristics in female wafer-fabrication and nonfabrication semiconductor employees. Am J Ind Med 28(6):799-815. PMID:8588565
  • Gold EB, Eskenazi B, Lasley BL, Samuels S, Rasor MO, Overstreet JW, Schenker MB. 1995. Epidemiologic methods for prospective assessment of menstrual cycle and reproductive characteristics in female semiconductor workers. Am J Ind Med 28(6):783-797. PMID:8588564
  • Lasley BL, Lohstroh PN, Kuo A, Gold EB, Eskenazi B, Samuels S, Stewart DR, Overstreet JW. 1995. Laboratory methods for evaluating early pregnancy loss in an industry-based population. Am J Ind Med 28(6):771-781. PMID:8588563
  • Lee JV, Whaling CS, Lasley BL, Marler P. 1995. Validation of an enzyme immunoassay for measurement of excreted estrogen and testosterone metabolites in the white-crowned sparrow (Zonotrichia leucophrys oriantha). Zoo Biol 14(2):97-106.
  • Shideler SE, Munro CJ, Johl HK, Taylor HW, Lasley BL. 1995. Urine and fecal sample collection on filter paper for ovarian hormone evaluations. Am J Primatol 37(4):305-315.
  • Stewart DR, Nakajima ST, Overstreet JW, Boyers SP, Lasley BL. 1995. Relaxin as a biomarker for human pregnancy detection. In: Progress in Relaxin Research. World Scientific Publishing, Singapore. pp.214-224.
to Top