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Project Publications: University of California-Davis: Critical Role of Mitochondrial Oxidative Stress (MOS) in Chemical Induced Cardiac Toxicity

Superfund Research Program

Critical Role of Mitochondrial Oxidative Stress (MOS) in Chemical Induced Cardiac Toxicity

Project Leader: Nipavan Chiamvimonvat
Grant Number: P42ES004699
Funding Period: 2017-2023
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Publications

2023

  • Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad MJ, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2023. Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. Cardiovasc Drugs Ther 37(1):25-37. doi:10.1007/s10557-021-07253-4 PMID:34499283 PMCID:PMC8904649

2021

  • Lind L, Araujo JA, Barchowsky A, Belcher SM, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. 2021. Key characteristics of cardiovascular toxicants. Environ Health Perspect 129(9):95001. doi:10.1289/EHP9321 PMID:34558968 PMCID:PMC8462506
  • Tiwari S, Yang J, Morisseau C, Durbin-Johnson BP, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Sci Rep 11:7042. doi:10.1038/s41598-021-86284-1 PMID:33782432 PMCID:PMC8007717

2020

  • Carbonell T, Gomes AV. 2020. MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury. Redox Biol 36:14. doi:10.1016/j.redox.2020.101607 PMID:32593128 PMCID:PMC7322687
  • Sirish P, Thai PN, Lee JH, Yang J, Zhang X, Ren L, Li N, Timofeyev V, Lee KS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young JN, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. 2020. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med doi:10.1002/sctm.20-0143 PMID:32790136
  • Tiwari S, Mishra M, Salemi MR, Phinney BS, Newens J, Gomes AV. 2020. Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. Sci Rep
  • Wagner KM, Gomes AV, McReynolds C, Hammock BD. 2020. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics doi:10.1007/s13311-020-00916-4 PMID:32875445

2019

2017

2016

  • Sirish P, Li N, Timofeyev V, Zhang X, Wang L, Yang J, Lee KS, Bettaieb A, Ma S, Lee JH, Su D, Lau V, Myers R, Lieu DK, Lopez JE, Young JN, Yamoah EN, Haj FG, Ripplinger C, Hammock BD, Chiamvimonvat N. 2016. Molecular mechanisms and new treatment paradigm for atrial fibrillation. Circ Arrhythm Electrophysiol 9(5):e003721-e003740. doi:10.1161/CIRCEP.115.003721 PMID:27162031 PMCID:PMC4869994
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