Superfund Research Program
Critical Role of Mitochondrial Oxidative Stress (MOS) in Chemical Induced Cardiac Toxicity
Project Leader: Nipavan Chiamvimonvat
Grant Number: P42ES004699
Funding Period: 2017-2023
Project-Specific Links
- Project Summary
Publications
2023
- Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad MJ, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2023. Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. Cardiovasc Drugs Ther 37(1):25-37. doi:10.1007/s10557-021-07253-4 PMID:34499283 PMCID:PMC8904649
2021
- Lind L, Araujo JA, Barchowsky A, Belcher SM, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. 2021. Key characteristics of cardiovascular toxicants. Environ Health Perspect 129(9):95001. doi:10.1289/EHP9321 PMID:34558968 PMCID:PMC8462506
- Tiwari S, Yang J, Morisseau C, Durbin-Johnson BP, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Sci Rep 11:7042. doi:10.1038/s41598-021-86284-1 PMID:33782432 PMCID:PMC8007717
2020
- Carbonell T, Gomes AV. 2020. MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury. Redox Biol 36:14. doi:10.1016/j.redox.2020.101607 PMID:32593128 PMCID:PMC7322687
- Sirish P, Thai PN, Lee JH, Yang J, Zhang X, Ren L, Li N, Timofeyev V, Lee KS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young JN, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. 2020. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med doi:10.1002/sctm.20-0143 PMID:32790136
- Tiwari S, Mishra M, Salemi MR, Phinney BS, Newens J, Gomes AV. 2020. Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. Sci Rep
- Wagner KM, Gomes AV, McReynolds C, Hammock BD. 2020. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics doi:10.1007/s13311-020-00916-4 PMID:32875445
2019
- Bailey KA, Moreno E, Haj FG, Simon SI, Passerini AG. 2019. Mechanoregulation of p38 activity enhances endoplasmic reticulum stress-mediated inflammation by arterial endothelium. FASEB J 33:12888-12899. doi:10.1096/fj.201900236R PMID:31499005 PMCID:PMC6902662
- Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. 2019. Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis 40:1731-1739. doi:10.1002/elps.201900059 PMID:31021001 PMCID:PMC7036291
- Sander H, Wallace S, Plouse R, Tiwari S, Gomes AV. 2019. Ponceau S waste: Ponceau S staining for total protein normalization. Anal Biochem 575:44-53. doi:10.1016/j.ab.2019.03.010 PMID:30914243 PMCID:PMC6954006
2017
- Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe AJ, Lau V, Moshref M, Knowlton AA, Sirish P, Chiamvimonvat N. 2017. Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3 ' K pathways. Heart Rhythm 14:1685-1692. doi:10.1016/j.hrthm.2017.06.038 PMID:28668623 PMCID:PMC5671891
- Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. 2017. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat 133:68-78. doi:10.1016/j.prostaglandins.2017.08.003 PMID:28847566 PMCID:PMC5584617
- Mishra M, Tiwari S, Gomes AV. 2017. Protein purification and analysis: next generation Western blotting techniques. Expert Rev Proteomics 14(11):1037-1053. doi:10.1080/14789450.2017.1388167 PMID:28974114 PMCID:PMC6810642
- Wagner KM, Gilda JE, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. 2017. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res 326:69-76. doi:10.1016/j.bbr.2017.02.048 PMID:28259677 PMCID:PMC5409858
2016
- Sirish P, Li N, Timofeyev V, Zhang X, Wang L, Yang J, Lee KS, Bettaieb A, Ma S, Lee JH, Su D, Lau V, Myers R, Lieu DK, Lopez JE, Young JN, Yamoah EN, Haj FG, Ripplinger C, Hammock BD, Chiamvimonvat N. 2016. Molecular mechanisms and new treatment paradigm for atrial fibrillation. Circ Arrhythm Electrophysiol 9(5):e003721-e003740. doi:10.1161/CIRCEP.115.003721 PMID:27162031 PMCID:PMC4869994