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Your Environment. Your Health.

Project Publications: University of California-Berkeley: Exposomics and Arsenic Epidemiology

Superfund Research Program

Exposomics and Arsenic Epidemiology

Project Leader: Craig Murray Steinmaus
Co-Investigators: Martyn T. Smith, Allan H. Smith
Grant Number: P42ES004705
Funding Period: 1995-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Castriota F, Rieswijk L, Dahlberg S, La Merrill MA, Steinmaus CM, Smith MT, Wang J. 2020. A state-of-the-science review of arsenics effects on glucose homeostasis in experimental models. Environ Health Perspect 128(1):doi:10.1289/EHP4517 PMID:31898917 PMCID:PMC7015542
  • Eick SM, Steinmaus CM. 2020. Arsenic and Obesity: a Review of Causation and Interaction. Curr Environ Health Rep 7(3):343-351. doi:10.1007/s40572-020-00288-z PMID:32766950 PMCID:PMC7891850 (ahead of print)
  • Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev 29(10):doi:10.1158/1055-9965.EPI-19-1346 PMID:32152214 PMCID:PMC7483401




  • de la Rosa R, Steinmaus CM, Akers NK, Conde L, Ferreccio Readi C, Kalman DA, Zhang KR, Skibola CF, Smith AH, Zhang L, Smith MT. 2017. Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a Chilean population. Environ Mol Mutagen 58(6):411-422. doi:10.1002/em.22104 PMID:28640505 PMCID:PMC5515250
  • Hall EM, Acevedo J, Lopez FG, Cortes S, Ferreccio Readi C, Smith AH, Steinmaus CM. 2017. Hypertension among adults exposed to drinking water arsenic in Northern Chile. Environ Res 153:99-105. doi:10.1016/j.envres.2016.11.016 PMID:27918984 PMCID:PMC5534354
  • Nardone A, Ferreccio Readi C, Acevedo J, Enanoria W, Blair A, Smith AH, Balmes JR, Steinmaus CM. 2017. The impact of BMI on non-malignant respiratory symptoms and lung function in arsenic exposed adults of Northern Chile. Environ Res 158:710-719. doi:10.1016/j.envres.2017.06.024 PMID:28738299 PMCID:PMC5603214
  • Steinmaus CM, Smith MT. 2017. Steinmaus and Smith respond to Proximity to gasoline stations and childhood leukemia. Am J Epidemiol 185(1):5-7. doi:10.1093/aje/kww133 PMID:27923799 PMCID:PMC6267941


  • Bailey KA, Smith AH, Tokar EJ, Graziano JH, Kim KW, Navasumrit P, Ruchirawat K, Thiantanawat A, Suk WA, Fry RC. 2016. Mechanisms underlying latent disease risk associated with early-life arsenic exposure: current research trends and scientific gaps. Environ Health Perspect 124(2):170-175. doi:10.1289/ehp.1409360 PMID:26115410 PMCID:PMC4749078
  • Carlos-Wallace FM, Zhang L, Smith MT, Rader G, Steinmaus CM. 2016. Parental, in utero, and early-life exposure to benzene and the risk of childhood leukemia: a meta-analysis. Am J Epidemiol 183(1):1-14. doi:10.1093/aje/kwv120 PMID:26589707 PMCID:PMC4751231
  • Steinmaus CM. 2016. Perchlorate in water supplies: sources, exposures, and health effects. Curr Environ Health Rep 3(2):136-143. doi:10.1007/s40572-016-0087-y PMID:27026358 PMCID:PMC4834222
  • Steinmaus CM, Ferreccio Readi C, Acevedo J, Balmes JR, Liaw J, Troncoso P, Dauphine DC, Nardone A, Smith AH. 2016. High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile. Toxicol Appl Pharmacol 313:10-15. doi:10.1016/j.taap.2016.10.006 PMID:27725189 PMCID:PMC5247272



  • Kalman DA, Dills RL, Steinmaus CM, Yunus M, Khan A, Prodhan M, Yuan Y, Smith AH. 2014. Occurrence of trivalent monomethyl arsenic and other urinary arsenic species in a highly exposed juvenile population in Bangladesh. J Expo Sci Environ Epidemiol 24:113-120. doi:10.1038/jes.2013.14 PMID:23549402
  • Melak D, Ferreccio Readi C, Kalman DA, Parra RL, Acevedo J, Perez L, Cortes S, Smith AH, Yuan Y, Liaw J, Steinmaus CM. 2014. Arsenic methylation and lung and bladder cancer in a case-control study in Northern Chile. Toxicol Appl Pharmacol 274(2):225-231. doi:10.1016/j.taap.2013.11.014 PMID:24296302 PMCID:PMC4344188
  • Smith AH, Marshall G, Yuan Y, Steinmaus CM, Liaw J, Smith MT, Wood L, Heirich M, Fritzemeier R, Pegram M, Ferreccio Readi C. 2014. Rapid reduction in breast cancer mortality with inorganic arsenic in drinking water. EBioMedicine 1(1):58-63. doi:10.1016/j.ebiom.2014.10.005 PMID:25580451 PMCID:PMC4286879
  • Steinmaus CM, Ferreccio Readi C, Acevedo J, Yuan Y, Liaw J, Duran V, Cuevas S, Garcia J, Meza R, Valdes R, Valdes G, Benitez H, VanderLinde V, Villagra V, Cantor KP, Moore LE, Perez S, Steinmaus S, Smith AH. 2014. Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure. Cancer Epidemiol Biomarkers Prev 23(8):1529-1538. doi:10.1158/1055-9965.EPI-14-0059 PMID:24859871 PMCID:PMC4344186
  • Steinmaus CM, Ferreccio Readi C, Yuan Y, Acevedo J, Gonzalez F, Perez L, Cortes S, Balmes JR, Liaw J, Smith AH. 2014. Elevated lung cancer in younger adults and low concentrations of arsenic in water. Am J Epidemiol 180(11):1082-1087. doi:10.1093/aje/kwu238 PMID:25371173 PMCID:PMC4239797


  • Dangleben NL, Skibola CF, Smith MT. 2013. Arsenic immunotoxicity: a review. Environ Health 12(1):73. doi:10.1186/1476-069x-12-73 PMID:24004508 PMCID:PMC3848751
  • Ferreccio Readi C, Smith AH, Duran V, Barlaro T, Benitez H, Valdes R, Aguirre J, Moore LE, Acevedo J, Vasquez M, Perez L, Yuan Y, Liaw J, Cantor KP, Steinmaus CM. 2013. Case-control study of arsenic in drinking water and kidney cancer in uniquely exposed Northern Chile. Am J Epidemiol 178(5):813-818. doi:10.1093/aje/kwt059 PMID:23764934 PMCID:PMC3817454
  • Ferreccio Readi C, Yuan Y, Calle J, Benitez H, Parra RL, Acevedo J, Smith AH, Liaw J, Steinmaus CM. 2013. Arsenic, tobacco smoke, and occupation: associations of multiple agents with lung and bladder cancer. Epidemiology 24(6):898-905. doi:10.1097/EDE.0b013e31829e3e03 PMID:24036609
  • Moran-Messen FM, Chen J, Gee NA, Lohstroh PN, Lasley BL. 2013. Dehydroepiandrosterone sulfate levels reflect endogenous luteinizing hormone production and response to human chorionic gonadotropin challenge in older female macaque (Macaca fascicularis). Menopause 20(3):329-335. doi:10.1097/GME.0b013e3182698f80 PMID:23435031 PMCID:PMC3546135
  • Smith AH, Yunus M, Khan A, Ercumen A, Yuan Y, Smith M, Liaw J, Balmes JR, von Ehrenstein OS, Raqib R, Kalman DA, Alam DS, Streatfield PK, Steinmaus CM. 2013. Chronic respiratory symptoms in children following in utero and early life exposure to arsenic in drinking water in Bangladesh. Int J Epidemiol 42(4):1077-1086. doi:10.1093/ije/dyt120 PMID:24062297 PMCID:PMC3781005
  • Steinmaus CM, Ferreccio Readi C, Romo JA, Yuan Y, Cortes S, Marshall G, Moore LE, Balmes JR, Liaw J, Golden T, Smith AH. 2013. Drinking water arsenic in Northern Chile: high cancer risks 40 years after exposure cessation. Cancer Epidemiol Biomarkers Prev 22:623-630. doi:10.1158/1055-9965.epi-12-1190 PMID:23355602 PMCID:PMC3848421


  • Grostern A, Sales CM, Zhuang WQ, Erbilgin O, Alvarez-Cohen L. 2012. Glyoxylate metabolism is a key feature of the metabolic degradation of 1,4-dioxane by Pseudonocardia dioxanivorans strain CB1190. Appl Environ Microbiol 78(9):3298-3308. doi:10.1128/AEM.00067-12 PMID:22327578 PMCID:PMC3346452
  • Smith AH, Liaw J, Steinmaus CM, Basu A, Mitra SR, Kalman DA. 2012. Relationship of creatinine and nutrition with arsenic metabolism: Smith et al. Respond. Environ Health Perspect 120(4):a146-a147. doi:10.1289/ehp.1104807R
  • Smith AH, Marshall G, Liaw J, Yuan Y, Ferreccio Readi C, Steinmaus CM. 2012. Mortality in young adults following in utero and childhood exposure to arsenic in drinking water. Environ Health Perspect 120:1527-1531. doi:10.1289/ehp.1104867 PMID:22949133 PMCID:PMC3556614


  • Basu A, Mitra SR, Chung JS, Guha-Mazumder DN, Ghosh N, Kalman DA, von Ehrenstein OS, Steinmaus CM, Liaw J, Smith AH. 2011. Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India. Environ Health Perspect 119(9):1308-1313. doi:10.1289/ehp.1003393 PMID:21652291 PMCID:PMC3230402
  • Dauphine DC, Ferreccio Readi C, Guntur S, Yuan Y, Hammond SK, Balmes JR, Smith AH, Steinmaus CM. 2011. Lung function in adults following in utero and childhood exposure to arsenic in drinking water: preliminary findings. Int Arch Occup Environ Health 84(6):591-600. doi:10.1007/s00420-010-0591-6 PMID:20972800 PMCID:PMC3141825
  • Novak R, Shuga J, Venugopalan G, Fletcher D, Smith MT, Mathies RA. 2011. Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions. Angew Chem Int Ed Engl 50:390-5. doi:10.1002/anie.201006089 PMID:21132688 PMCID:PMC3027204
  • Ren X, McHale CM, Skibola CF, Smith AH, Smith MT, Zhang L. 2011. An emerging role for epigenetic dysregulation in arsenic toxicity 
and carcinogenesis. Environ Health Perspect 119(1):11-19. doi:10.1289/ehp.1002114 PMID:20682481 PMCID:PMC3018488
  • Smith AH, Marshall G, Yuan Y, Liaw J, Ferreccio Readi C, Steinmaus CM. 2011. Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis. Am J Epidemiol 173(4):414-420. doi:10.1093/aje/kwq383 PMID:21190988 PMCID:PMC3032805


  • Ji Z, Zhang L, Peng V, Ren X, McHale CM, Smith MT. 2010. A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia 24(5):986-991. doi:10.1038/leu.2010.43 PMID:20339439 PMCID:PMC4353491
  • Lan Q, Zhang L, Tang X, Shen M, Smith MT, Qiu C, Ge Y, Ji Z, Xiong J, He J, Reiss B, Hao Z, Liu S, Xie Y, Guo W, Purdue MP, Galvan N, Xin KX, Hu W, Freeman LB, Blair AE, Li L, Rothman N, Vermeulen R, Huang H. 2010. Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers. Carcinogenesis 31(9):1592-1596. doi:10.1093/carcin/bgq121 PMID:20530238 PMCID:PMC2930801
  • Porter KE, Basu A, Hubbard AE, Bates MN, Kalman DA, Rey OA, Smith AH, Smith MT, Steinmaus CM, Skibola CF. 2010. Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Environ Res 110(6):580-587. doi:10.1016/j.envres.2010.05.001 PMID:20670920 PMCID:PMC2913479
  • Rappaport SM, Smith MT. 2010. Epidemiology. Environment and disease risks. Science 330:460-1. doi:10.1126/science.1192603 PMID:20966241 PMCID:PMC4841276
  • Shuga J, Zeng Y, Novak R, Mathies RA, Hainaut P, Smith MT. 2010. Selected technologies for measuring acquired genetic damage in humans. Environ Mol Mutagen 51:851-70. doi:10.1002/em.20630 PMID:20872848
  • Smith MT. 2010. Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health 31:133-48. doi:10.1146/annurev.publhealth.012809.103646 PMID:20070208 PMCID:PMC4360999
  • Steinmaus CM, Yuan Y, Kalman DA, Rey OA, Skibola CF, Dauphine DC, Basu A, Porter KE, Hubbard AE, Bates MN, Smith MT, Smith AH. 2010. Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicol Appl Pharmacol 247(2):138-145. doi:10.1016/j.taap.2010.06.006 PMID:20600216 PMCID:PMC3849353
  • Yuan Y, Marshall G, Ferreccio Readi C, Steinmaus CM, Liaw J, Bates MN, Smith AH. 2010. Kidney cancer mortality: fifty-year latency patterns related to arsenic exposure. Epidemiology 21(1):103-108. doi:10.1097/EDE.0b013e3181c21e46 PMID:20010213


  • Jo WJ, Loguinov AV, Wintz H, Chang M, Smith AH, Vulpe CD, Kalman DA, Zhang L, Smith MT. 2009. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci 111(2):424-436. doi:10.1093/toxsci/kfp162 PMID:19635755 PMCID:PMC2742584
  • Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe CD, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet MS, Yin S, Chanock SJ, Smith MT, Rothman N. 2009. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30(1):50-58. doi:10.1093/carcin/bgn249 PMID:18978339 PMCID:PMC2639030
  • Rahman A, Vahter M, Smith AH, Nermell B, Yunus M, El Arifeen S, Persson L, Ekstrom E. 2009. Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh. Am J Epidemiol 169(3):304-312. doi:10.1093/aje/kwn332 PMID:19037006
  • Scelo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. 2009. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117(1):133-139. PMID:19165400
  • Smith AH, Ercumen A, Yuan Y, Steinmaus CM. 2009. Increased lung cancer risks are similar whether arsenic is ingested or inhaled. J Expo Sci Environ Epidemiol 19(4):343-348. doi:10.1038/jes.2008.73 PMID:19190673 PMCID:PMC2682945
  • Smith AH, Steinmaus CM. 2009. Health effects of arsenic and chromium in drinking water: recent human findings. Annu Rev Public Health 30:107-122. doi:10.1146/annurev.publhealth.031308.100143 PMID:19012537 PMCID:PMC2762382
  • Steinmaus CM, Yuan Y, Liaw J, Smith AH. 2009. Low-level population exposure to inorganic arsenic in the United States and diabetes mellitus: a reanalysis. Epidemiology 20(6):807-815. doi:10.1097/EDE.0b013e3181b0fd29 PMID:19652600
  • Steinmaus CM, Yuan Y, Liaw J, Smith AH. 2009. On arsenic, diabetes, creatinine and multiple regression modeling: a response to the commentaries on our reanalysis. Epidemiology 20(6):1-2. doi:10.1097/EDE.0b013e3181ba360b



  • Bates MN, Hopenhayn-Rich C, Rey OA, Moore LE. 2007. Bladder cancer and mate consumption in Argentina: a case-control study. Cancer Lett 246(1-2):268-273. doi:10.1016/j.canlet.2006.03.005 PMID:16616809
  • Chen J, van der Laan MJ, Smith MT, Hubbard AE. 2007. A comparison of methods to control type I errors in microarray studies. Stat Appl Genet Mol Biol 6:Article28. doi:10.2202/1544-6115.1310 PMID:18052911
  • Escobar PA, Smith MT, Vasishta A, Hubbard AE, Zhang L. 2007. Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH). Mutagenesis 22(5):321-327. doi:10.1093/mutage/gem020 PMID:17575318
  • George CM, Smith AH, Kalman DA, Steinmaus CM. 2007. Reverse osmosis filter use and high arsenic levels in private well water. Arch Environ Occup Health 61(4):171-5. PMID:17867571
  • Hegedus CM, Skibola CF, Bracci PM, Holly EA, Smith MT. 2007. Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism. Proteomics 7(4):548-557. doi:10.1002/pmic.200600366 PMID:17309100
  • Kim S, Lan Q, Waidyanatha S, Chanock SJ, Johnson BA, Vermeulen R, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. 2007. Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet Genomics 17(10):789-801. PMID:17885617
  • Marshall G, Ferreccio Readi C, Yuan Y, Bates MN, Steinmaus CM, Selvin S, Liaw J, Smith AH. 2007. Fifty-year study of lung and bladder cancer mortality in Chile related to arsenic in drinking water. J Natl Cancer Inst 99(12):920-928. doi:10.1093/jnci/djm004 PMID:17565158
  • Smith MT, Jones RM, Smith AH. 2007. Benzene exposure and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):385-391. doi:10.1158/1055-9965.EPI-06-1057 PMID:17337645
  • Steinmaus CM, Moore LE, Shipp M, Kalman DA, Rey OA, Biggs ML, Hopenhayn-Rich C, Bates MN, Zheng S, Wiencke JK, Smith AH. 2007. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic. J Toxicol Environ Health A 70(2):159-170. doi:10.1080/15287390600755240 PMID:17365577
  • Thundiyil JG, Yuan Y, Smith AH, Steinmaus CM. 2007. Seasonal variation of arsenic concentration in wells in Nevada. Environ Res 104(3):367-73. PMID:17459366
  • von Ehrenstein OS, Poddar S, Yuan Y, Guha-Mazumder DN, Eskenazi B, Basu A, Hira Smith MM, Ghosh N, Lahiri S, Haque R, Ghosh A, Kalman DA, Das S, Smith AH. 2007. Children's intellectual function in relation to arsenic exposure. Epidemiology 18(1):44-51. PMID:17149142
  • Yuan Y, Marshall G, Ferreccio Readi C, Steinmaus CM, Selvin S, Liaw J, Bates MN, Smith AH. 2007. Acute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000. Am J Epidemiol 166(12):1381-1391. doi:10.1093/aje/kwm238 PMID:17875584


  • Chung JS, Haque R, Guha-Mazumder DN, Moore LE, Ghosh N, Samanta S, Mitra SR, Hira-Smith M, von Ehrenstein OS, Basu A, Liaw J, Smith AH. 2006. Blood concentrations of methionine, selenium, beta-carotene, and other micronutrients in a case-control study of arsenic-induced skin lesions in West Bengal, India. Environ Res 101(2):230-237. PMID:16332366
  • Hira Smith MM, Yuan Y, Savarimuthu X, Liaw J, Hira A, Green C, Hore T, Chakraborty P, von Ehrenstein OS, Smith AH. 2006. Arsenic concentrations and bacterial contamination in a pilot shallow dugwell program in West Bengal, India. J Environ Sci Health A Tox Hazard Subst Environ Eng 42(1):89-95. PMID:17129953
  • Savarimuthu X, Hira Smith MM, Yuan Y, von Ehrenstein OS, Das S, Ghosh N, Guha-Mazumder DN, Smith AH. 2006. Seasonal variation of arsenic concentrations in tubewells in West Bengal, India. J Health Popul Nutr 24(3):277-281. PMID:17366769
  • Smith AH, Marshall G, Yuan Y, Ferreccio Readi C, Liaw J, von Ehrenstein OS, Steinmaus CM, Bates MN, Selvin S. 2006. Increased mortality from lung cancer and bronchiectasis in young adults following exposure to arsenic in utero and early childhood. Environ Health Perspect 114(8):1293-1296.
  • Steinmaus CM, Bates MN, Yuan Y, Kalman DA, Atallah R, Rey OA, Biggs ML, Hopenhayn-Rich C, Moore LE, Hoang BK, Smith AH. 2006. Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States. J Occup Environ Med 48(5):478-488. PMID:16688004
  • Steinmaus CM, George CM, Kalman DA, Smith AH. 2006. Evaluation of two new arsenic field test kits capable of detecting arsenic water concentrations close to 10 ug/L. Environ Sci Technol 40(10):3362-3366. PMID:16749706
  • von Ehrenstein OS, Guha-Mazumder DN, Hira Smith MM, Ghosh N, Yuan Y, Windham GC, Ghosh A, Haque R, Lahiri S, Kalman DA, Das S, Smith AH. 2006. Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India. Am J Epidemiol 163(7):662-669. doi:10.1093/aje/kwj089 PMID:16524957
  • von Ehrenstein OS, Jenny AM, Basu A, Smith KR, Hira Smith MM, Smith AH. 2006. Capacity building in environmental health research in India and Nepal. Int J Occup Environ Health 12(4):300-306. PMID:17168216



  • Bates MN, Rey OA, Biggs ML, Hopenhayn-Rich C, Moore LE, Kalman DA, Steinmaus CM, Smith AH. 2004. Case-control study of bladder cancer and exposure to arsenic in Argentina. Am J Epidemiol 159:381-389. PMID:14769642
  • Mitra SR, Guha-Mazumder DN, Basu A, Block G, Haque R, Samanta S, Ghosh N, Hira Smith MM, von Ehrenstein OS, Smith AH. 2004. Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India. Environ Health Perspect 112(10):1104-1109. PMID:15238285
  • Moore LE, Wiencke JK, Bates MN, Zheng S, Rey OA, Smith AH. 2004. Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina. Cancer Lett 211(2):199-207. PMID:15219943
  • Smith AH, Hira Smith MM. 2004. Arsenic drinking water regulations in developing countries with extensive exposure. Toxicology 198(1-3):39-44. PMID:15138028
  • Steinmaus CM, Lu M, Todd RL, Smith AH. 2004. Probability estimates for the unique childhood leukemia cluster in Fallon, Nevada, and risks near other U.S. Military aviation facilities. Environ Health Perspect 112(6):766-71. PMID:15121523


  • Haque R, Guha-Mazumder DN, Samanta S, Ghosh N, Kalman DA, Hira Smith MM, Mitra SR, Santra A, Lahiri S, Das S, De BK, Smith AH. 2003. Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Epidemiology 14(2):174-182. PMID:12606883
  • Hira Smith MM, Hore T, Chakraborty P, Chakraborti DK, Savarimuthu X, Smith AH. 2003. A dugwell program to provide arsenic-safe water in West Bengal, India: preliminary results. J Environ Sci Health A Tox Hazard Subst Environ Eng A38(1):289-299. PMID:12635833
  • Moore LE, Smith AH, Eng C, DeVries S, Kalman DA, Bhargava V, Chew K, Ferreccio Readi C, Rey OA, Hopenhayn-Rich C, Biggs ML, Bates MN, Waldman FM. 2003. P53 alterations in bladder tumors from arsenic and tobacco exposed patients. Carcinogenesis 24(11):1785-1791. PMID:12919957
  • Steinmaus CM, Yuan Y, Bates MN, Smith AH. 2003. Case-control study of bladder cancer and drinking water arsenic in the Western United States. Am J Epidemiol 158(12):1193-1201. PMID:14652304


  • Chung JS, Kalman DA, Moore LE, Kosnett MJ, Arroyo AP, Beeris M, Guha-Mazumder DN, Hernandez AL, Smith AH. 2002. Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water. Environ Health Perspect 110(7):729-733. PMID:12117651
  • Moore LE, Smith AH, Eng C, Kalman DA, DeVries S, Bhargava V, Chew K, Moore DH, Ferreccio Readi C, Rey OA, Waldman FM. 2002. Arsenic-related chromosomal alterations in bladder cancer. J Natl Cancer Inst 94(22):1688-1696. PMID:12441324
  • Smith AH, Lopipero PA, Bates MN, Steinmaus CM. 2002. Public health Arsenic epidemiology and drinking water standards. Science 296(5576):2145-2146. doi:10.1126/science.1072896 PMID:12077388
  • Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch MR. 2002. History of allergies among adults with glioma and controls. Int J Cancer 98(4):609-615. PMID:11920623


  • Moore LE, Wiencke JK, Eng C, Zheng S, Smith AH. 2001. Evaluation of buccal cell collection protocols for genetic susceptibility studies. Biomarkers 6(6):448-454. PMID:23886316


  • Ferreccio Readi C, Gonzalez C, Milosavjlevic V, Marshall G, Sancha AM, Smith AH. 2000. Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiology 11(6):673-679. PMID:11055628
  • Guha-Mazumder DN, Haque R, Ghosh N, De BK, Santra A, Chakraborti DK, Smith AH. 2000. Arsenic in drinking water and the prevalence of respiratory effects in West Bengal, India. Int J Epidemiol 29(6):1047-1052. PMID:11101546
  • Smith AH, Arroyo AP, Guha-Mazumder DN, Kosnett MJ, Hernandez AL, Beeris M, Hira Smith MM, Moore LE. 2000. Arsenic-induced skin lesions among Atacameno people in northern Chile despite good nutrition and centuries of exposure. Environ Health Perspect 108(7):617-620. PMID:10903614
  • Steinmaus CM, Moore LE, Hopenhayn-Rich C, Biggs ML, Smith AH. 2000. Arsenic in drinking water and bladder cancer. Cancer Invest 18(2):174-182. PMID:10705880
  • Steinmaus CM, Nunez S, Smith AH. 2000. Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151(7):693-702. PMID:10752797


  • Biggs ML, Haque R, Moore LE, Smith AH. 1998. Arsenic-laced water in Chile (letter). Science 281:785. PMID:9714681
  • Guha-Mazumder DN, Haque R, Ghosh N, De BK, Santra A, Chakraborti DK, Smith AH. 1998. Arsenic levels in drinking water and the prevalence of skins lesions in West Bengal, India. Int J Epidemiol 27:871-877. PMID:9839746
  • Hopenhayn-Rich C, Biggs ML, Smith AH. 1998. Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina. Int J Epidemiol 27(4):561-569. PMID:9758107
  • Smith AH, Goycolea M, Haque R, Biggs ML. 1998. Marked increase in bladder and lung cancer mortality in a region of northern Chile due to arsenic in drinking water. Am J Epidemiol 147(7):660-669. PMID:9554605


  • Aposhian HV, Arroyo AP, Cebrian ME, Del Razo LM, Hurlbut KM, Dart RC, Gonzalez-Ramirez D, Kreppel H, Speisky H, Smith AH, Gonsebatt ME, Ostrosky-Wegman P, Aposhian MM. 1997. DMPS-Arsenic challenge test: I-increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sufolnate. J Pharmacol Exp Ther 282(1):192-200. PMID:9223554
  • Biggs ML, Kalman DA, Moore LE, Hopenhayn-Rich C, Smith MT, Smith AH. 1997. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei. Mutat Res Rev Mutat Res 386:185-195. PMID:9219557
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. 1997. Decrease in bladder cell micronucleus prevalance after intervention to lower the concentration of arsenic in drinking water. Cancer Epidemiol Biomarkers Prev 6(12):1051-1056. PMID:9419402


  • Hopenhayn-Rich C, Biggs ML, Fuchs A, Bergoglio R, Tello E, Nicolli H, Smith AH. 1996. Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology 7(2):117-124. PMID:8834549
  • Hopenhayn-Rich C, Biggs ML, Kalman DA, Moore LE, Smith AH. 1996. Arsenic methylation patterns before and after change from high to lower arsenic concentrations in drinking water. Environ Health Perspect 104(11):1200-1207. PMID:8959409
  • Moore LE, Warner M, Smith AH, Kalman DA, Smith MT. 1996. Use of the fluorescent micronucleus assay to detect the clastogenic effects of radiation and arsenic in human exfoliated epithelial cells. Environ Mol Mutagen 27:176-184. PMID:8625953
  • Smith AH, Hopenhayn-Rich C, Biggs ML, Moore LE, Kalman DA, Oyanguren C, Marchetti C. 1996. Marcadores biologicas de exposicion y efecto relacionados con el contenido arsenical del agua de beber en el Desierto de Atacama. In: Proceedings of Las Segundas Jornadas de Arcenicismo Laboral y Ambiental, Nov.22-25, Antofagasta, Chile. 1996. Antofagasta, Chile.


  • Bates MN, Smith AH, Cantor KP. 1995. Case-control study of bladder cancer and arsenic in drinking water. Am J Epidemiol 141(6):523-530. PMID:7900719
  • Smith AH, Biggs ML, Hopenhayn-Rich C, Kalman DA. 1995. Arsenic risk assessment [letter]. Environ Health Perspect 103:13-15. PMID:7628413
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