Skip Navigation

Project Publications: University of California-Berkeley: Biomarkers of Chemical Exposure and Leukemia Risk

Superfund Research Program

Biomarkers of Chemical Exposure and Leukemia Risk

Project Leader: Martyn T. Smith
Co-Investigator: Patricia A. Buffler
Grant Number: P42ES004705
Funding Period: 1995 - 2011

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page Visit the grantee's Twitter page Visit the grantee's Facebook page View the grantee's Factsheet(491KB)




  • de Smith AJ, Walsh KM, Ladner MB, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL. 2014. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood 123:2497-2503. doi:10.1182/blood-2013-11-540625 PMID:24518758 PMCID:PMC3990912
  • Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler PA, Ward MH, Metayer C. 2014. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environ Res 133:388-395. doi:10.1016/j.envres.2014.04.033 PMID:24948546 PMCID:PMC4119528
  • Slusky DA, Does MB, Metayer C, Mezei G, Selvin S, Buffler PA. 2014. Potential role of selection bias in the association between childhood leukemia and residential magnetic fields exposure: a population-based assessment. Cancer Epidemiol 38(3):307-313. doi:10.1016/j.canep.2014.02.010 PMID:24679435 PMCID:PMC4140526
  • Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. 2014. Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect 122(10):1110-1116. doi:10.1289/ehp.1307602 PMID:24911217 PMCID:PMC4181922


  • Metayer C, Colt JS, Buffler PA, Reed HD, Selvin S, Crouse V, Ward MH. 2013. Exposure to herbicides in house dust and risk of childhood acute lymphoblastic leukemia. J Expo Sci Environ Epidemiol 23:363-370. doi:10.1038/jes.2012.115 PMID:23321862
  • Milne E, Greenop KR, Metayer C, Schuz J, Petridou E, Pombo-de-Oliveira MS, Infante-Rivard C, Roman E, Dockerty JD, Spector LG, Koifman S, Orsi L, Rudant J, Dessypris N, Simpson J, Lightfoot TJ, Kaatsch P, Baka M, Faro A, Armstrong BK, Clavel J, Buffler PA. 2013. Fetal growth and childhood acute lymphoblastic leukemia: findings from the childhood leukemia international consortium. Int J Cancer 133:2968-2979. doi:10.1002/ijc.28314 PMID:23754574 PMCID:PMC3797193



  • McHale CM, Zhang L, Lan Q, Vermeulen R, Li G, Hubbard AE, Porter KE, Thomas R, Portier CJ, Shen M, Rappaport SM, Yin S, Rothman N, Smith MT. 2011. Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect 119:628-634. doi:10.1289/ehp.1002546 PMID:21147609 PMCID:PMC3094412
  • Metayer C, Scelo G, Chokkalingam AP, Barcellos L, Aldrich MC, Chang JS, Guha N, Urayama KY, Hansen HM, Block G, Kiley VA, Wiencke JK, Wiemels JL, Buffler PA. 2011. Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control 22:1243-1258. doi:10.1007/s10552-011-9795-7 PMID:21748308 PMCID:PMC3744066
  • Novak R, Shuga J, Venugopalan G, Fletcher D, Smith MT, Mathies RA. 2011. Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions. Angew Chem Int Ed Engl 50:390-5. doi:10.1002/anie.201006089 PMID:21132688 PMCID:PMC3027204
  • Ren X, Lim S, Ji Z, Yuh J, Peng V, Smith MT, Zhang L. 2011. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546. doi:10.1371/journal.pone.0014546 PMID:21267443 PMCID:PMC3022623
  • Slusky DA, Mezei G, Metayer C, Selvin S, Von Behren J, Buffler PA. 2011. Comparison of racial differences in childhood cancer risk in case-control studies and population-based cancer registries. Cancer Epidemiol 36:36-44. doi:10.1016/j.canep.2011.05.005 PMID:22018954
  • Whitehead T, Metayer C, Gunier RB, Ward MH, Nishioka M, Buffler PA, Rappaport SM. 2011. Determinants of polycyclic aromatic hydrocarbon levels in house dust. J Expo Sci Environ Epidemiol 21(2):123-132. doi:10.1038/jes.2009.68 PMID:20040932 PMCID:PMC2891419
  • Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Vermeulen R, Yin S, Rothman N, Smith MT, Ji Z. 2011. Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene. Carcinogenesis 32:605-612. doi:10.1093/carcin/bgq286 PMID:21216845 PMCID:PMC3066415



  • Chang JS, Buffler PA, Metayer C, Chokkalingam AP, Patoka J, Kronish D, Wiemels JL. 2009. Maternal immunoglobulin E and childhood leukemia. Cancer Epidemiol Biomarkers Prev 18(8):2221-2227. doi:10.1158/1055-9965.EPI-09-0212 PMID:19622720
  • Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame AL, Smith MT, Vulpe CD, Zhang L. 2009. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol 241(3):294-302. doi:10.1016/j.taap.2009.08.027 PMID:19732783 PMCID:PMC2784148
  • Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe CD, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet MS, Yin S, Chanock SJ, Smith MT, Rothman N. 2009. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30(1):50-58. doi:10.1093/carcin/bgn249 PMID:18978339 PMCID:PMC2639030
  • Scelo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. 2009. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117(1):133-139. PMID:19165400
  • Urayama KY, Von Behren J, Reynolds P, Hertz A, Does MB, Buffler PA. 2009. Factors associated with residential mobility in children with leukemia: implications for assigning exposures. Ann Epidemiol 19(11):834-840. doi:10.1016/j.annepidem.2009.03.001 PMID:19364662 PMCID:PMC2761989
  • Ward MH, Colt JS, Metayer C, Gunier RB, Lubin JH, Crouse V, Nishioka M, Reynolds P, Buffler PA. 2009. Residential exposure to polychlorinated biphenyls and organochlorine pesticides and risk of childhood leukemia. Environ Health Perspect 117(6):1007-13. doi:10.1289/ehp.0900583 PMID:19590698 PMCID:PMC2702395
  • Whitehead T, Metayer C, Ward MH, Nishioka M, Gunier RB, Colt JS, Reynolds P, Selvin S, Buffler PA, Rappaport SM. 2009. Is house-dust nicotine a good surrogate for household smoking?. Am J Epidemiol 169(9):1113-1123. doi:10.1093/aje/kwp021 PMID:19299402 PMCID:PMC2727236


  • Colt JS, Gunier RB, Metayer C, Nishioka M, Bell EM, Reynolds P, Buffler PA, Ward MH. 2008. Household vacuum cleaners vs the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children. Environ Health 7:6. doi:10.1186/1476-069X-7-6 PMID:18291036 PMCID:PMC2265689
  • Galvan N, Lim S, Zmugg S, Smith MT, Zhang L. 2008. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone. Mutat Res 649(1-2):54-61. doi:10.1016/j.mrgentox.2007.07.011 PMID:17875398 PMCID:PMC3461953
  • Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA. 2008. NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol 168(11):1221-1232. doi:10.1093/aje/kwn246 PMID:18945694 PMCID:PMC2727266
  • Metayer C, Buffler PA. 2008. Residential pesticides and childhood leukemia. Radiat Prot Dosimetry 132:212-9. PMID:18940823
  • Schiffenbauer J, Buffler PA, Wiemels JL, Vasconcelos GM, Kang M, Pombo-de-Oliveira MS, Lorey F. 2008. Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls. Br J Cancer 99(10):1668-1672. doi:10.1038/sj.bjc.6604714 PMID:19002185 PMCID:PMC2584954
  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307


  • Chang JS, Metayer C, Fear NT, Reinier K, Yin X, Urayama KY, Russo C, Buffler PA. 2007. Parental social contact in the work place and the risk of childhood acute lymphoblastic leukaemia. Br J Cancer 97(9):1315-1321. doi:10.1038/sj.bjc.6604024 PMID:17923868 PMCID:PMC2360459
  • Chen J, van der Laan MJ, Smith MT, Hubbard AE. 2007. A comparison of methods to control type I errors in microarray studies. Stat Appl Genet Mol Biol 6:Article28. doi:10.2202/1544-6115.1310 PMID:18052911
  • Escobar PA, Smith MT, Vasishta A, Hubbard AE, Zhang L. 2007. Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH). Mutagenesis 22(5):321-327. doi:10.1093/mutage/gem020 PMID:17575318
  • Hegedus CM, Skibola CF, Bracci PM, Holly EA, Smith MT. 2007. Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism. Proteomics 7(4):548-557. doi:10.1002/pmic.200600366 PMID:17309100
  • Kim S, Lan Q, Waidyanatha S, Chanock SJ, Johnson BA, Vermeulen R, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. 2007. Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet Genomics 17(10):789-801. PMID:17885617
  • Smith MT, Hartge P. 2007. Environmental and behavioral factors and the risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):367-8. PMID:17344463
  • Smith MT, Jones RM, Smith AH. 2007. Benzene exposure and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):385-391. doi:10.1158/1055-9965.EPI-06-1057 PMID:17337645
  • Urayama KY, Wiencke JK, Buffler PA, Selvin S, Wiemels JL. 2007. MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 16(6):1172-1177. doi:10.1158/1055-9965.EPI-07-0007 PMID:17548681
  • Zhang L, Rothman N, Li G, Guo W, Yang W, Hubbard AE, Hayes RB, Yin S, Lu W, Smith MT. 2007. Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environ Mol Mutagen 48(6):467-74. PMID:17584886


  • Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. 2006. Cytogenetics of hispanic and white children with acute lymphoblastic leukemia in california. Cancer Epidemiol Biomarkers Prev 15(3):578-581. PMID:16537719
  • Chang JS, Selvin S, Metayer C, Crouse V, Golembesky A, Buffler PA. 2006. Parental smoking and the risk of childhood leukemia. Am J Epidemiol 163(12):1091-1100. doi:10.1093/aje/kwj143 PMID:16597704
  • Kwan ML, Metayer C, Crouse V, Buffler PA. 2006. Maternal illness and drug/medication use during the period surrounding pregnancy and risk of childhood leukemia among offspring. Am J Epidemiol 165(1):27-35. PMID:17035343
  • Paynter RA, Skibola DR, Skibola CF, Buffler PA, Wiemels JL, Smith MT. 2006. Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources. Cancer Epidemiol Biomarkers Prev 15(12):2533-2536. doi:10.1158/1055-9965.EPI-06-0219 PMID:17164381


  • Block G, Buffler PA, Ma X, Selvin S. 2004. Maternal intake of vegetables, protein sources and glutathione are associated with reduced risk of childhood leukemia. In: The American Public Health Association 131st Annual Meeting, November. San Francisco, CA.
  • Jensen CD, Block G, Buffler PA, Ma X, Selvin S, Month S. 2004. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 15(6):559-570. PMID:15280635
  • Kwan ML, Block G, Selvin S, Buffler PA. 2004. Early childhood nutrition and risk of childhood acute leukemia: Results from a case-control study. Am J Epidemiol 157(11):43Suppl.S.
  • Kwan ML, Block G, Selvin S, Buffler PA. 2004. Early childhood nutrition and risk of childhood acute leukemia: Results from a case-control study. In: The 36th Annual Meeting of the Society for Epidemiologic Research, June. Alanta, GA.
  • Kwan ML, Block G, Selvin S, Month S, Buffler PA. 2004. Food consumption by children and the risk of childhood acute leukemia. Am J Epidemiol 160(11):1098-1107. PMID:15561989
  • Kwan ML, Buffler PA, Abrams B, Kiley VA. 2004. Breastfeeding and the risk of childhood leukemia: a meta-analysis. Public Health Rep 119(6):521-535. PMID:15504444
  • Ma X, Buffler PA, Layefsky M, Does MB, Reynolds P. 2004. Control selection strategies in case-control studies of childhood diseases. Am J Epidemiol 159(10):915-921. PMID:15128601
  • Metayer C, Aldrich MC, Guha N, Does MB, Buffler PA. 2004. Childhood Leukemia and Environmental Exposures: the Northern and Central California Childhood Leukemia Study (NCCLS). In: The American Public Health Association 131st Annual Meeting, November. San Francisco, CA.
  • Reinier K, Hammond SK, Buffler PA, Gunier RB, Lea CS, Quinlan P, Kirsch J. 2004. Development and evaluation of parental occupational exposure questionnaires for a childhood leukemia study. Scand J Work Environ Health 30(6):450-458. PMID:15633596
  • Selvin S. 2004. Cytochrome P450 1A1 polymorphism and childhood leukemia: An analysis of matched pairs case-control genotype data. Cancer Epidemiol Biomarkers Prev 13(8):1371-1374. PMID:15298960
  • Selvin S, Ragland KE, Chien EY, Buffler PA. 2004. Spatial analysis of childhood leukemia in a case/control study. Int J Hyg Environ Health 207(6):555-562. PMID:15729836


  • Golembesky A, Ma X, Buffler PA. 2003. Paternal smoking and childhood leukemia: Preliminary results from the Northern California Childhood Leukemia Study and a meta-analysis. In: Proceedings of the 94th annual conference of the American Association for Cancer Research, July 11-14, 2003. Washington, DC.
  • Guha N, Reynolds P, Buffler PA. 2003. Home pesticide exposure assessment in the Northern California Childhood Leukemia Study. In: Proceedings of the NIEHS (National Institute of Environmental Health Sciences) Superfund Region 9 Conference, October 2003. Berkley, CA.


  • Ma X, Buffler PA, Gunier RB, Dahl GV, Smith MT, Reinier K, Reynolds P. 2002. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect 110(9):955-960. PMID:12204832
  • Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P. 2002. Daycare attendance and the risk of childhood acute lymphoblastic leukemia. Br J Cancer 86(9):1419-1424.
  • Segal MR, Wiemels JL. 2002. Clustering of translocation breakpoints. J Am Stat Assoc 97(457):66-76.
  • Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. 2002. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 99(23):15101-15106. PMID:12415113
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 99(10):3801-3805. PMID:11986239


  • Ma X, Buffler PA, Gunier RB, Reinier K, Reynolds P. 2001. Household pesticide exposure and childhood leukemia: results from a case-control study. Epidemiology 12(4):S42.
  • Reinier K, Buffler PA. 2001. The anatomy of participation rates in case-control studies. Am J Epidemiol 153(11):S258.
  • Reinier K, Does MB, Ragland D, Layefsky M, Buffler PA. 2001. Population-based controls in the Northern California Childhood Leukemia Study: an evaluation of possible selection bias. Epidemiology 12(4):S85.
  • Xiao Z, Greaves MF, Buffler PA, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL. 2001. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia 15:1906-1913. PMID:11753612
  • Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. 2001. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiol Biomarkers Prev 10:697-700. PMID:11401921


  • Wood S, Buffler PA, Burau K, Krivanek N. 1998. Mortality and morbidity experience of workers exposed to acrylonitrile in fiber production. Scand J Work Environ Health 24(2):54-62.


  • Croen LA, Shaw GM, Sanbonmatsu L, Selvin S, Buffler PA. 1997. Maternal residential proximity to hazardous waste sites and risk for selected congenital malformations. Epidemiology 8(4):347-354. PMID:9209846


  • Buffler PA, Reynolds P, Smith MT, Lea CS, Wood S. 1996. The molecular epidemiology of childhood leukemia with emphasis on chemical exposures. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia.


  • Smith MT, Lea CS, Buffler PA. 1995. Human population changes caused by hazardous waste. Eur J Public Health 2(3):77-79. PMID:7655408
to Top