Superfund Research Program

Biomarkers of Benzene Exposure and Leukemia Risk

Project Leader: Martyn T. Smith
Co-Investigator: Stephen M. Rappaport
Grant Number: P42ES004705
Funding Period: 2011-2017

Project-Specific Links

Publications

2019

• Brown AL, de Smith AJ, Gant VU, Yang W, Scheurer ME, Walsh KM, Chernus JM, Kallsen NA, Peyton SA, Davies GE, Ehli EA, Winick N, Heerema NA, Carroll AJ, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Feingold E, Devidas M, Barcellos L, Hansen HM, Morimoto L, Kang AY, Smirnov I, Healy J, Laverdiere C, Sinnett D, Taub JW, Birch JM, Thompson P, Spector LG, Pombo-de-Oliveira MS, DeWan AT, Mullighan CG, Hunger SP, Pui C, Loh ML, Zwick ME, Metayer C, Ma X, Mueller BA, Sherman SL, Wiemels JL, Relling MV, Yang J, Lupo PJ, Rabin KR. 2019. Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome. Blood 134:1227-1237. PMID:31350265
• de Smith AJ, Walsh KM, Morimoto L, Francis SS, Hansen HM, Jeon S, Gonseth S, Chen M, Sun H, Luna-Fineman S, Antillon F, Giron V, Kang AY, Smirnov I, Shao X, Whitehead TP, Barcellos L, Jolly KW, Healy J, Laverdiere C, Sinnett D, Taub JW, Birch JM, Thompson P, Pombo-de-Oliveira MS, Spector LG, DeWan AT, Mueller BA, Chiang C, Metayer C, Ma X, Wiemels JL. 2019. Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome. Leukemia doi:10.1038/s41375-019-0514-9 PMID:31296947 PMCID:PMC6858994
• Lee KM, Zhang L, Vermeulen R, Hu W, Bassig BA, Wong JJ, Qiu C, Purdue MP, Wen C, Walker DI, Jones DP, Li L, Huang Y, Rothman N, Smith MT, Lan Q. 2019. Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards. Occup Environ Med 76(6):376-381. doi:10.1136/oemed-2018-105583 PMID:30971425 PMCID:PMC6953904

2018

• Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. 2018. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun 9:8. doi:10.1038/s41467-017-02596-9 PMID:29348612 PMCID:PMC5773513

2017

• Petrick L, Edmands WM, Schiffman C, Grigoryan H, Perttula K, Yano Y, Dudoit S, Whitehead TP, Metayer C, Rappaport SM. 2017. An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies. Metabolomics 13:27. doi:10.1007/s11306-016-1153-z PMID:29706849 PMCID:PMC5918689
• Steinmaus CM, Smith MT. 2017. Steinmaus and Smith respond to Proximity to gasoline stations and childhood leukemia. Am J Epidemiol 185(1):5-7. doi:10.1093/aje/kww133 PMID:27923799 PMCID:PMC6267941
• Whitehead TP, Adhatamsoontra P, Wang Y, Arcolin E, Sender L, Selvin S, Metayer C. 2017. Home remodeling and risk of childhood leukemia. Ann Epidemiol 27(2):140-144. doi:10.1016/j.annepidem.2016.11.013 PMID:28065451 PMCID:PMC5313318

2016

• Bassig BA, Zhang L, Vermeulen R, Tang X, Li G, Hu W, Guo W, Purdue MP, Yin S, Rappaport SM, Shen M, Ji Z, Qiu C, Ge Y, Hosgood H, Reiss B, Wu B, Xie Y, Li L, Yue F, Freeman LB, Blair AE, Hayes RB, Huang H, Smith MT, Rothman N, Lan Q. 2016. Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene. Carcinogenesis 37(7):692-700. doi:10.1093/carcin/bgw053 PMID:27207665 PMCID:PMC4936387
• Carlos-Wallace FM, Zhang L, Smith MT, Rader G, Steinmaus CM. 2016. Parental, in utero, and early-life exposure to benzene and the risk of childhood leukemia: a meta-analysis. Am J Epidemiol 183(1):1-14. doi:10.1093/aje/kwv120 PMID:26589707 PMCID:PMC4751231
• Gunier RB, Nuckols JR, Colt JS, Whitehead TP, Deziel NC, Metayer C, Reynolds P, Ward MH. 2016. Temporal trends of insecticide concentrations in carpet dust in California from 2001 to 2006. Environ Sci Technol 50(14):7761-7769. doi:10.1021/acs.est.6b00252 PMID:27341453
• Metayer C, Scelo G, Kang AY, Gunier RB, Reinier K, Lea CS, Chang JS, Selvin S, Kirsch J, Crouse V, Does MB, Quinlan P, Hammond SK. 2016. A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California. Environ Res 151:174-183. doi:10.1016/j.envres.2016.06.047 PMID:27494537 PMCID:PMC5071154
• Perttula K, Edmands WM, Grigoryan H, Cai X, Iavarone A, Gunter MJ, Naccarati A, Polidoro S, Hubbard AE, Vineis P, Rappaport SM. 2016. Evaluating ultra-long-chain fatty acids as biomarkers of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 25(8):1216-1223. doi:10.1158/1055-9965.EPI-16-0204 PMID:27257090
• Rappaport SM. 2016. Genetic factors are not the major causes of chronic diseases. PLoS One 11(4):e0154387. doi:10.1371/journal.pone.0154387 PMID:27105432 PMCID:PMC4841510
• Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L. 2016. Identification of genes that modulate susceptibility to formaldehyde and imatinib by functional genomic screening in human haploid KBM7 cells. Toxicol Sci 151(1):10-22. doi:10.1093/toxsci/kfw032 PMID:27008852 PMCID:PMC4914802
• Singer AW, Carmichael SL, Selvin S, Fu C, Block G, Metayer C. 2016. Maternal diet quality before pregnancy and risk of childhood leukaemia. Br J Nutr 116(8):1469-1478. doi:10.1017/S0007114516003469 PMID:27725005
• Singer AW, Selvin S, Block G, Golden C, Carmichael SL, Metayer C. 2016. Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. Cancer Causes Control 27(7):929-940. doi:10.1007/s10552-016-0773-y PMID:27294727 PMCID:PMC4939072
• Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan R, Cogliano VJ, Straif K. 2016. Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environ Health Perspect 124(6):713-721. doi:10.1289/ehp.1509912 PMID:26600562 PMCID:PMC4892922
• Walker D, Uppal K, Zhang L, Vermeulen R, Smith MT, Hu W, Purdue MP, Tang X, Reiss B, Kim S, Li L, Huang H, Pennell KD, Jones DP, Rothman N, Lan Q. 2016. High-resolution metabolomics of occupational exposure to trichloroethylene. Int J Epidemiol 45(5):1517-1527. doi:10.1093/ije/dyw218 PMID:27707868 PMCID:PMC5100622

2015

• Lan Q, Smith MT, Tang X, Guo W, Vermeulen R, Ji Z, Hu W, Hubbard AE, Shen M, McHale CM, Qiu C, Liu S, Reiss B, Beane-Freeman L, Blair AE, Ge Y, Xiong J, Li L, Rappaport SM, Huang H, Rothman N, Zhang L. 2015. Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis 36(1):160-167. doi:10.1093/carcin/bgu229 PMID:25391402 PMCID:PMC4291049
• Shen H, McHale CM, Smith MT, Zhang L. 2015. Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9. Mutat Res Rev Mutat Res 764:31-42. doi:10.1016/j.mrrev.2015.01.002 PMID:26041264 PMCID:PMC4456615
• Vijai J, Wang Z, Berndt SI, Skibola CF, Slager SL, de Sanjose S, Melbye M, Glimelius B, Bracci PM, Birmann BM, Wang SS, Brooks-Wilson AR, Lan Q, de Bakker PI, Vermeulen R, Portlock CJ, Ansell SA, Link BK, Riby J, North KE, Gu J, Hjalgrim H, Cozen W, Becker N, Teras LR, Spinelli JJ, Turner J, Zhang Y, Purdue MP, Giles GG, Kelly RS, Zeleniuch-Jacquotte A, Ennas M, Monnereau A, Bertrand KA, Albanes D, Lightfoot TJ, Chung CC, Burdett L, Hutchinson A, Lawrence C, Montalvan R, Liang L, Huang J, Ma B, Villano DJ, Maria A, Corines M, Thomas T, Novak AJ, Dogan A, Liebow M, Thompson CA, Witzig TE, Habermann TM, Weiner GJ, Smith MT, Holly EA, Jackson RD, Tinker LF, Ye Y, Adami H, Smedby KE, De Roos AJ, Hartge P, Morton LM, Severson RK, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Diver WR, Vajdic CM, Armstrong BK, Kricker A, Zheng T, Holford TR, Severi G, Vineis P, Ferri GM, Ricco R, Clavel J, Giovannucci E, Kraft P, Virtamo J, Smith A, Kane E, Roman E, Chiu BC, Fraumeni JF, Wu X. 2015. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nat Commun 6:5751. doi:10.1038/ncomms6751 PMID:25569183 PMCID:PMC4287989
• Whitehead TP, Ward MH, Dahl G, Ducore J, Reinier K, Gunier RB, Hammond SK, Rappaport SM, Metayer C. 2015. Dust metal loadings and the risk of childhood acute lymphoblastic leukemia. J Expo Sci Environ Epidemiol 25(6):593-598. doi:10.1038/jes.2015.9 PMID:25736162 PMCID:PMC4560677
• Wild CP, Bucher JR, de Jong BW, Dillner J, von Gertten C, Groopman JD, Herceg Z, Holmes E, Holmila R, Olsen JH, Ringborg U, Scalbert A, Shibata T, Smith MT, Ulrich CM, Vineis P, McLaughlin J. 2015. Translational cancer research: balancing prevention and treatment to combat cancer globally. J Natl Cancer Inst 107(1):353. doi:10.1093/jnci/dju353 PMID:25515230 PMCID:PMC4334834
• Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C. 2015. Global characteristics of childhood acute promyelocytic leukemia. Blood Rev 29(2):101-125. doi:10.1016/j.blre.2014.09.013 PMID:25445717 PMCID:PMC4379131

2014

• Bassig BA, Zhang L, Cawthon RM, Smith MT, Yin S, Li G, Hu W, Shen M, Rappaport SM, Barone-Adesi F, Rothman N, Vermeulen R, Lan Q. 2014. Alterations in leukocyte telomere length in workers occupationally exposed to benzene. Environ Mol Mutagen 55(8):673-678. doi:10.1002/em.21880 PMID:24945723 PMCID:PMC4360990
• Cai X, Perttula K, Pajouh S, Hubbard AE, Nomura DK, Rappaport SM. 2014. Untargeted lipidomic profiling of human plasma reveals differences due to race, gender and smoking status. Metabolomics 4:131. doi:10.4172/2153-0769.1000131
• Cerhan JR, Berndt SI, Vijai J, Ghesquieres H, McKay J, Wang SS, Wang Z, Yeager M, Conde L, de Bakker PI, Nieters A, Cox DP, Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Lan Q, Severi G, Melbye M, Gu J, Jackson RD, Kane E, Teras LR, Purdue MP, Vajdic CM, Spinelli JJ, Giles GG, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SA, Witzig TE, Weiner GJ, Veron AS, Zelenika D, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami H, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot TJ, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Turner J, Southey M, Clavel J, Virtamo J, Weinstein SJ, Riboli E, Vineis P, Trichopoulos D, Vermeulen R, Boeing H, Tjonneland A, Angelucci E, Di Lollo S, Rais M, Birmann BM, Laden F, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Sampson J, Liang L, Park J, Chung CC, Weisenburger DD, Chatterjee N, Fraumeni JF, Slager SL, Wu X, de Sanjose S, Smedby KE, Salles G, Skibola CF, Rothman N, Chanock SJ. 2014. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet 46(11):1233-1238. doi:10.1038/ng.3105 PMID:25261932 PMCID:PMC4213349
• Daniels SI, Sille FC, Goldbaum A, Yee B, Key EF, Zhang L, Smith MT, Thomas R. 2014. Improving power to detect changes in blood miRNA expression by accounting for sources of variability in experimental designs. Cancer Epidemiol Biomarkers Prev 23(12):2658-2666. doi:10.1158/1055-9965.EPI-14-0623 PMID:25472674 PMCID:PMC4256675
• Lu SS, Sobus JR, Sallsten G, Albin M, Pleil JD, Gudmundsson A, Madden MC, Strandberg B, Wierzbicka A, Rappaport SM. 2014. Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?. Biomarkers 19(4):332-339. doi:10.3109/1354750X.2014.910553 PMID:24754404 PMCID:PMC4737554
• McHale CM, Smith MT, Zhang L. 2014. Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: From yeast to human. Ann N Y Acad Sci 1310:74-83. doi:10.1111/nyas.12382 PMID:24571325 PMCID:PMC3978411
• North M, Shuga J, Fromowitz M, Loguinov AV, Shannon K, Zhang L, Smith MT, Vulpe CD. 2014. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer 14:6. doi:10.1186/1471-2407-14-6 PMID:24386979 PMCID:PMC3898384
• Rappaport SM, Barupal D, Wishart D, Vineis P, Scalbert A. 2014. The blood exposome and its role in discovering causes of disease. Environ Health Perspect 122(8):769-774. doi:10.1289/ehp.1308015 PMID:24659601 PMCID:PMC4123034
• Skibola CF, Berndt SI, Vijai J, Conde L, Wang Z, Yeager M, de Bakker PI, Birmann BM, Vajdic CM, Lightfoot TJ, Foo J, Bracci PM, Vermeulen R, Slager SL, de Sanjose S, Wang SS, Linet MS, Salles G, Lan Q, Severi G, Hjalgrim H, Melbye M, Gu J, Ghesquieres H, Link BK, Morton LM, Holly EA, Smith A, Tinker LF, Teras LR, Kricker A, Becker N, Purdue MP, Spinelli JJ, Zhang Y, Giles GG, Vineis P, Monnereau A, Bertrand KA, Albanes D, Zeleniuch-Jacquotte A, Gabbas A, Chung CC, Burdett L, Hutchinson A, Lawrence C, Montalvan R, Liang L, Huang J, Ma B, Liu J, Adami H, Glimelius B, Ye Y, Nowakowski GS, Dogan A, Thompson CA, Habermann TM, Novak AJ, Liebow M, Witzig TE, Weiner GJ, Schenker MB, Hartge P, De Roos AJ, Cozen W, Zhi D, Akers NK, Riby J, Smith MT, Lacher M, Villano DJ, Maria A, Roman E, Kane E, Jackson RD, North KE, Diver WR, Turner J, Armstrong BK, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, McKay J, Brooks-Wilson AR, Zheng T, Holford TR, Kaaks R, Kelly RS, Ohlsson B, Travis RC, Weiderpass E, Clavel J, Giovannucci E, Kraft P, Virtamo J, Mazza P, Cocco P, Ennas M, Chiu BC, Fraumeni JF, Nieters A, Offit K, Wu X, Cerhan JR, Smedby KE, Chanock SJ, Rothman N. 2014. Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Am J Hum Genet 95(4):462-471. doi:10.1016/j.ajhg.2014.09.004 PMID:25279986 PMCID:PMC4185120
• Smith AH, Marshall G, Yuan Y, Steinmaus CM, Liaw J, Smith MT, Wood L, Heirich M, Fritzemeier R, Pegram M, Ferreccio Readi C. 2014. Rapid reduction in breast cancer mortality with inorganic arsenic in drinking water. EBioMedicine 1(1):58-63. doi:10.1016/j.ebiom.2014.10.005 PMID:25580451 PMCID:PMC4286879
• Thomas R, Hubbard AE, McHale CM, Zhang L, Rappaport SM, Lan Q, Rothman N, Vermeulen R, Guyton KZ, Jinot J, Sonawane B, Smith MT. 2014. Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure. PLoS One 9(5):e91828. doi:10.1371/journal.pone.0091828 PMID:24786086 PMCID:PMC4006721
• Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. 2014. Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect 122(10):1110-1116. doi:10.1289/ehp.1307602 PMID:24911217 PMCID:PMC4181922
• Whitehead T, Brown F, Metayer C, Park J, Does MB, Dhaliwal J, Petreas MX, Buffler PA, Rappaport SM. 2014. Polychlorinated biphenyls in residential dust: sources of variability. Environ Sci Technol 48:157-164. doi:10.1021/es403863m PMID:24313682 PMCID:PMC3941978
• Xiao J, Lee S, Xiao Y, Ma X, Houseman EA, Hsu L, Roy R, Wrensch MR, de Smith AJ, Chokkalingam AP, Buffler PA, Wiencke JK, Wiemels JL. 2014. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer 135(5):1101-1109. doi:10.1002/ijc.28759 PMID:24496747 PMCID:PMC4776754

2013

• Dangleben NL, Skibola CF, Smith MT. 2013. Arsenic immunotoxicity: a review. Environ Health 12(1):73. doi:10.1186/1476-069x-12-73 PMID:24004508 PMCID:PMC3848751
• Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Panico S, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA. 2013. Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research. Environ Health Perspect 121(4):480-487. doi:10.1289/ehp.1205657 PMID:23384616 PMCID:PMC3620742
• Herceg Z, Lambert MP, van Veldhoven K, Demetriou C, Vineis P, Smith MT, Straif K, Wild CP. 2013. Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis 34(9):1955-1967. doi:10.1093/carcin/bgt212 PMID:23749751 PMCID:PMC3765050
• Hosgood H, Zhang L, Tang X, Vermeulen R, Hao Z, Shen M, Qiu C, Ge Y, Hua M, Ji Z, Li S, Xiong J, Reiss B, Liu S, Xin KX, Azuma M, Xie Y, Freeman LB, Ruan X, Guo W, Galvan N, Blair AE, Li L, Huang H, Smith MT, Rothman N, Lan Q. 2013. Occupational exposure to formaldehyde and alterations in lymphocyte subsets. Am J Ind Med 56:252-257. doi:10.1002/ajim.22088 PMID:22767408 PMCID:PMC3493854
• Howcroft TK, Campisi J, Louis GB, Smith MT, Wise B, Wyss-Coray T, Augustine AD, McElhaney JE, Kohanski R, Sierra F. 2013. The role of inflammation in age-related disease. Aging-US 5(1):84-93. doi:10.18632/aging.100531 PMID:23474627 PMCID:PMC3616233
• Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. 2013. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and Myeloid Leukemias by cytogenetic subtype. Cancer Epidemiol Biomarkers Prev 22(9):1600. doi:10.1158/1055-9965.epi-13-0350 PMID:23853208 PMCID:PMC3769478
• Rappaport SM, Johnson BA, Bois FY, Kupper LL, Kim S, Thomas R. 2013. Ignoring and adding errors do not improve the science. Carcinogenesis 34(7):1689-1691. doi:10.1093/carcin/bgt100 PMID:23528242 PMCID:PMC3697890
• Rappaport SM, Kim S, Thomas R, Johnson BA, Bois FY, Kupper LL. 2013. Low-dose metabolism of benzene in humans: science and obfuscation. Carcinogenesis 34(1):2-9. doi:10.1093/carcin/bgs382 PMID:23222815 PMCID:PMC3584950
• Shuga J, Zeng Y, Novak R, Lan Q, Tang X, Rothman N, Vermeulen R, Li L, Hubbard AE, Zhang L, Mathies RA, Smith MT. 2013. Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR. Nucleic Acids Res 41(16):e159. doi:10.1093/nar/gkt613 PMID:23873959 PMCID:PMC3763562

2012

• Fromowitz M, Shuga J, Wlassowsky AY, Ji Z, North M, Vulpe CD, Smith MT, Zhang L. 2012. Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate. Environ Mol Mutagen 53:488-491. doi:10.1002/em.21707 PMID:22730236
• Ji Z, Weldon RH, Marchetti F, Chen H, Li G, Xing C, Kurtovich E, Young SS, Schmid TE, Waidyanatha S, Rappaport SM, Zhang L, Eskenazi B. 2012. Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene. Environ Mol Mutagen 53(3):218-26. doi:10.1002/em.21683 PMID:22351378
• Marchetti F, Eskenazi B, Weldon RH, Li G, Zhang L, Rappaport SM, Schmid TE, Xing C, Kurtovich E, Wyrobek AJ. 2012. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect 120(2):229-234. doi:10.1289/ehp.1103921 PMID:22086566 PMCID:PMC3279447
• McHale CM, Zhang L, Smith MT. 2012. Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis doi:10.1093/carcin/bgr297 PMID:22166497 PMCID:PMC3271273

2011

• McHale CM, Zhang L, Hubbard AE, Smith MT. 2011. Transcriptomic studies in human populations. Chapter 9 in: Applications of toxicogenomics in safety evaluation and risk assessment. John Wiley & Sons, Hoboken, NJ. pp.177-206.
• McHale CM, Zhang L, Lan Q, Vermeulen R, Li G, Hubbard AE, Porter KE, Thomas R, Portier CJ, Shen M, Rappaport SM, Yin S, Rothman N, Smith MT. 2011. Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect 119:628-634. doi:10.1289/ehp.1002546 PMID:21147609 PMCID:PMC3094412
• Shen M, Zhang L, Lee KM, Vermeulen R, Hosgood H, Yin S, Rothman N, Chanock SJ, Smith MT, Lan Q, Li G. 2011. Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity. Exp Mol Med 43:374-378. doi:10.3858/emm.2011.43.6.041 PMID:21540635 PMCID:PMC3128916
• Smith MT, Zhang L, McHale CM, Skibola CF, Rappaport SM. 2011. Benzene, the exposome and future investigations of leukemia etiology. Chem Biol Interact 192(1-2):155-159. doi:10.1016/j.cbi.2011.02.010 PMID:21333640 PMCID:PMC3461963