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Project Publications: University of California-Berkeley: Exposomics of Endocrine Disruption

Superfund Research Program

Exposomics of Endocrine Disruption

Project Leader: Martyn T. Smith
Co-Investigator: Jen-Chywan Wang
Grant Number: P42ES004705
Funding Period: 2017-2022

Project-Specific Links



  • Phillips RV, Wei L, Cardenas A, Hubbard AE, McHale CM, Vermeulen R, Wei H, Smith MT, Zhang L, Lan Q, Rothman N. 2022. Epigenome-wide association studies of occupational exposure to benzene and formaldehyde. Epigenetics 1-19. doi:10.1080/15592294.2022.2115604 PMID:36017556
  • Ramaprasad AS, Smith MT, McCoy D, Hubbard AE, La Merrill MA, Durkin KA. 2022. Predicting the binding of small molecules to nuclear receptors using machine learning. Brief Bioinform 23(3):doi:10.1093/bib/bbac114 PMID:35383362 PMCID:PMC9116378
  • Tachachartvanich P, Singam ER, Durkin KA, Furlow JD, Smith MT, La Merrill MA. 2022. In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor. J Hazard Mater 429:doi:10.1016/j.jhazmat.2022.128243 PMID:35093747


  • de la Rosa R, Vasquez S, Tachachartvanich P, Daniels SI, Sille F, Smith MT. 2021. Cell-based bioassay to screen environmental chemicals and human serum for total glucocorticogenic activity. Environ Toxicol Chem 40(1):177-186. doi:10.1002/etc.4903 PMID:33085113 PMCID:PMC7793542
  • Nwanaji-Enwerem JC, Chung FF, van der Laan L, Novoloaca A, Cuenin C, Johansson H, Bonanni B, Hubbard AE, Smith MT, Hartman SJ, Cardenas A, Sears DD, Herceg Z. 2021. An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. Clin Epigenetics 13(1):224. doi:10.1186/s13148-021-01218-y PMID:34920739 PMCID:PMC8684118
  • van der Laan L, Cardenas A, Vermeulen R, Fadadu RP, Hubbard AE, Phillips RV, Zhang L, Breeze C, Hu W, Wen C, Huang Y, Tang X, Smith MT, Rothman N, Lan Q. 2021. Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde. Environ Int 158:106871. doi:10.1016/j.envint.2021.106871 PMID:34560324


  • Castriota F, Rieswijk L, Dahlberg S, La Merrill MA, Steinmaus CM, Smith MT, Wang J. 2020. A state-of-the-science review of arsenics effects on glucose homeostasis in experimental models. Environ Health Perspect 128(1):doi:10.1289/EHP4517 PMID:31898917 PMCID:PMC7015542
  • Castriota F, Zushin PH, Sanchez SS, Phillips RV, Hubbard AE, Stahl A, Smith MT, Wang J, La Merrill MA. 2020. Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice. Am J Physiol Endocrinol Metab 318:E667-E677. doi:10.1152/ajpendo.00282.2019 PMID:32045263
  • de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. 2020. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicol Vitro 69(7):104975. doi:10.1016/j.tiv.2020.104975 PMID:32858110 PMCID:PMC7594746
  • La Merrill MA, Vandenberg LN, Smith MT, Goodson III WH, Browne P, Patisaul HB, Guyton KZ, Kortenkamp A, Cogliano VJ, Woodruff TJ, Rieswijk L, Sone H, Korach KS, Gore AC, Zeise L, Zoeller RT. 2020. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol 16:45-57. doi:10.1038/s41574-019-0273-8 PMID:31719706 PMCID:PMC6902641
  • Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev 29(10):doi:10.1158/1055-9965.EPI-19-1346 PMID:32152214 PMCID:PMC7483401


  • Ahearn A. 2019. Key characteristics: a new approach to identifying potential toxicants, with Martyn Smith. The Researcher's Perspective 2019(1):doi:10.1289/EHP5776
  • Arzuaga X, Smith MT, Gibbons CF, Skakkelmek NE, Yost EE, Beverly BE, Hotchkiss AK, Hauser R, Pagani RL, Schrader SM, Zeise L, Prins GS. 2019. Proposed key characteristics of male reproductive toxicants as an approach for organizing and evaluating mechanistic evidence in human health hazard assessments. Environ Health Perspect 127(6):65001. doi:10.1289/ehp5045 PMID:31199676 PMCID:PMC6792367
  • Chen T, Lee RA, Tsai SL, Kanamaluru D, Gray NE, Yiv N, Cheang R, Tan JH, Lee JY, Fitch MD, Hellerstein MK, Wang J. 2019. An ANGPTL4 ceramide protein kinase C axis mediates chronic glucocorticoid exposure induced hepatic steatosis and hypertriglyceridemia in mice. J Biol Chem 294(23):9213-9224. doi:10.1074/jbc.RA118.006259 PMID:31053639 PMCID:PMC6556567
  • Eick SM, Ferreccio Readi C, Acevedo J, Castriota F, Cordero JF, Roh T, Smith AH, Smith MT, Steinmaus CM. 2019. Socioeconomic status and the association between arsenic exposure and type 2 diabetes. Environ Res 172:578-585. doi:10.1016/j.envres.2019.03.013 PMID:30875511 PMCID:PMC7003534
  • La Merrill MA, Johnson CL, Smith MT, Kandula NR, Macherone A, Pennell KD, Kanaya AM. 2019. Exposure to persistent organic pollutants (POPs) and their relationship to hepatic fat and insulin insensitivity among Asian Indian immigrants in the United States. Environ Sci Technol 53:13906-13918. doi:10.1021/acs.est.9b03373 PMID:31746186
  • Lee KM, Bassig BA, Zhang L, Vermeulen R, Hu W, Wong JJ, Wen C, Huang Y, Purdue MP, Ji B, Li L, Tang X, Rothman N, Smith MT, Lan Q. 2019. Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China. Int Arch Occup Environ Health 92(8):1077-1085. doi:10.1007/s00420-019-01448-x PMID:31161417 PMCID:PMC6953905
  • Lee KM, Zhang L, Vermeulen R, Hu W, Bassig BA, Wong JJ, Qiu C, Purdue MP, Wen C, Walker DI, Jones DP, Li L, Huang Y, Rothman N, Smith MT, Lan Q. 2019. Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards. Occup Environ Med 76(6):376-381. doi:10.1136/oemed-2018-105583 PMID:30971425 PMCID:PMC6953904
  • Luderer U, Eskenazi B, Hauser R, Korach KS, McHale CM, Moran-Messen FM, Rieswijk L, Solomon G, Udagawa O, Zhang L, Zlatnik M, Zeise L, Smith MT. 2019. Proposed key characteristics of female reproductive toxicants as an approach for organizing and evaluating mechanistic data in hazard assessment. Environ Health Perspect 127:75001. doi:10.1289/ehp4971 PMID:31322437 PMCID:PMC6791466
  • Phillips RV, Rieswijk L, Hubbard AE, Vermeulen R, Zhang J, Hu W, Li L, Bassig BA, Wong JJ, Reiss B, Huang Y, Wen C, Purdue MP, Tang X, Smith MT, Rothman N, Lan Q. 2019. Human exposure to trichloroethylene is associated with increased variability of blood DNA methylation that is enriched in genes and pathways related to autoimmune disease and cancer. Epigenetics 14(11):1112-1124. doi:10.1080/15592294.2019.1633866 PMID:31241004 PMCID:PMC6773405


  • Daniels SI, Chambers JC, Sanchez SS, La Merrill MA, Hubbard AE, Macherone A, McMullin M, Zhang L, Elliott P, Smith MT, Kooner JS. 2018. Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes. J Endocr Soc 2(8):832-841. doi:10.1210/js.2017-00480 PMID:30019022 PMCID:PMC6041775
  • Grigoryan H, Edmands WM, Lan Q, Carlsson H, Vermeulen R, Zhang L, Yin S, Li G, Smith MT, Rothman N, Rappaport SM. 2018. Adductomic signatures of benzene exposure provide insights into cancer induction. Carcinogenesis 39:661-668. doi:10.1093/carcin/bgy042 PMID:29538615 PMCID:PMC5932554
  • Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. 2018. Key characteristics approach to carcinogenic hazard identification. Chem Res Toxicol 31(12):1290-1292. doi:10.1021/acs.chemrestox.8b00321 PMID:30521319 PMCID:PMC6424613
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • McHale CM, Osborne G, Morello-Frosch R, Salmon AG, Sandy MS, Solomon G, Zhang L, Smith MT, Zeise L. 2018. Assessing health risks from multiple environmental stressors: moving from G x E to I x E. Mutat Res Rev Mutat Res 775:11-20. doi:10.1016/j.mrrev.2017.11.003 PMID:29555026 PMCID:PMC5863617
  • Rothman N, Zhang L, Smith MT, Vermeulen R, Lan Q. 2018. Formaldehyde, hematotoxicity, and chromosomal changes-response. Cancer Epidemiol Biomarkers Prev 27:120-121. doi:10.1158/1055-9965.epi-17-0804 PMID:29311167
  • Tachachartvanich P, Sangsuwan R, Ruiz HS, Sanchez SS, Durkin KA, Zhang L, Smith MT. 2018. Assessment of the endocrine-disrupting effects of trichloroethylene and its metabolites using in vitro and in silico approaches. Environ Sci Technol 52(3):1542-1550. doi:10.1021/acs.est.7b04832 PMID:29294279 PMCID:PMC6290898


  • De La Rosa VY, Asfaha J, Fasullo M, Loguinov AV, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD. 2017. Editor's highlight: High-throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes. Toxicol Sci 160:111-120. doi:10.1093/toxsci/kfx159 PMID:28973557 PMCID:PMC5837773
  • Rothman N, Lan Q, Smith MT, Vermeulen R, Zhang L. 2017. Response to letter to the editor of Carcinogenesis by Pira et al., 2017. Carcinogenesis 38:1253-1255. doi:10.1093/carcin/bgx111 PMID:29040449
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