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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of Arizona: Detoxification of Metals: In Vitro and In Vivo Studies

Superfund Research Program

Detoxification of Metals: In Vitro and In Vivo Studies

Project Leader: H. Vasken Aposhian
Grant Number: P42ES004940
Funding Period: 1995 - 2000

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Publications

2000

  • Aposhian HV, Zheng B, Aposhian MM, Le X, Cebrian ME, Cullen WR, Zakharyan RA, Ma M, Dart RC, Cheng Z, Andrewes P, Yip L, O'Malley GF, Maiorino RM, Van Voorhies W, Healy SM, Titcomb A. 2000. DMPS-arsenic challenge test: II. Modulation of arsenic species, including monomethylarsonous acid (MMAIII ), excreted in human urine. Toxicol Appl Pharmacol 165(1):74-83. PMID:10814555

1999

  • Aposhian HV, Zakharyan RA, Wildfang E, Healy SM, Radabaugh TR, Bogdan GM, Powell LA, Aposhian MM. 1999. How is inorganic arsenic detoxified?. In: Proceedings of the San Diego Arsenic Symposium. San Diego, CA.
  • Healy SM, Wildfang E, Zakharyan RA, Aposhian HV. 1999. Diversity of inorganic arsenite biotransformation. Biol Trace Elem Res 68(3):249-266. PMID:10328340
  • Zakharyan RA, Aposhian HV. 1999. Arsenite methylation by methylvitamin B12 and glutathione does not require an enzyme. Toxicol Appl Pharmacol 154(30):287-291. PMID:9931288

1998

  • Aposhian HV. 1998. Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS). Environ Health Perspect 106(Suppl.4):1017-1025. PMID:9703487
  • Aposhian HV, Zakharyan RA, Healy SM, Wildfang E, Radabaugh TR, Badghisi H, Aposhian MM. 1998. Biodiversity of inorganic arsenite methyltransferases. Environ Health Perspect 42(1-S):353.
  • Healy SM, Casarez EA, Ayala-Fierro F, Aposhian HV. 1998. Enzymatic methylation of arsenic compounds: V. Arsenite methyltransferase activity in tissues of mice. Toxicol Appl Pharmacol 148(1):65-70. PMID:9465265
  • Healy SM, Wildfang E, Radabaugh TR, Badghisi H, Aposhian MM. 1998. Do arsenite and its methyltransferases have evolutionary significance?. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
  • Wildfang E, Zakharyan RA, Aposhian HV. 1998. Enzymatic methylation of arsenic compounds: VI. Characterization of hamster liver arsenite and monomethylarsonic acid methyltransferase activities in vitro. Toxicol Appl Pharmacol 152(2):366-375. PMID:9853005
  • Wildfang E, Zakharyan RA, Aposhian HV. 1998. Hamster and rabbit arsenite and MMA methyltransferase kinetics. In: Proceedings of the Symposium on Risk Considerations for Environmental Health and Safety. The University of Arizona, Tucson, AZ.
  • Wildfang E, Zakharyan RA, Aposhian HV. 1998. Hamster and rabbit arsenite and MMA methyltransferase kinetics: comparisons of in vitro properties. Environ Health Perspect 42(1-S):283.
  • Zakharyan RA, Healy SM, Chaga G, Aposhian HV. 1998. Purification and properties of the arsenite methylating isoenzymes of rabbit liver. Environ Health Perspect 42:332.

1997

  • Aposhian HV. 1997. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu Rev Pharmacol Toxicol 37:397-419. PMID:9131259
  • Aposhian HV, Arroyo AP, Cebrian ME, Del Razo LM, Hurlbut KM, Dart RC, Gonzalez-Ramirez D, Kreppel H, Smith AH, Gonsebatt ME, Ostrosky-Wegman P, Aposhian MM. 1997. Increased urinary excretion of monomethylarsonic acid in humans given DMPS. Environ Health Perspect 36(1,2):5.
  • Aposhian HV, Zakharyan RA, Healy SM, Wildfang E, Radabaugh TR, Clayton DB, Badghisi H, Aposhian MM. 1997. Species and structural diversity of arsenite methyltransferases. In: Proceedings of Arsenic: Health Effects, Mechanisms of Actions, and Research Issues. Hunt Valley, MD.
  • Aposhian HV, Zakharyan RA, Wu Y, Healy SM, Aposhian MM. 1997. Enzymatic methylation of arsenic compounds: II. An overview. In: Arsenic Exposure and Human Health, Vol. 2. Chapman & Hall, London, United Kingdom.
  • Cianciola ME, Echeverria D, Martin MD, Aposhian HV, Woods JS. 1997. Epidemiologic assessment of measures used to indicate low level exposure to mercury vapor (Hg). J Toxicol Environ Health A 52(1):19-33. doi:10.1080/00984109708984050 PMID:9269320
  • Cianciola ME, Echeverria D, Martin MD, Aposhian HV, Woods JS. 1997. Epidemiologic assessment of measures used to indicate low level exposure to mercury vapor (Hg0). Environ Health Perspect 36(1,2):6.
  • Healy SM, Casarez EA, Aposhian HV. 1997. Arsenite methyltransferase activity in various tissues of B6C3F1 mice administered subchronic doses of sodium arsenate. Environ Health Perspect 36(1,2):313.
  • Healy SM, Radabaugh TR, Badghisi H, Wildfang E, Zakharyan RA, Aposhian MM, Aposhian HV. 1997. A challenge to the putative route of arsenic detoxification. In: Proceedings of Arsenic: Health Effects, Mechanisms of Actions, and Research Issues. Hunt Valley, MD.
  • Healy SM, Zakharyan RA, Aposhian HV. 1997. Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig. Mutat Res Rev Mutat Res 386(3):229-239. PMID:9219561
  • Keith RL, Setiarahardjo I, Fernando Q, Aposhian HV, Gandolfi A. 1997. Utilization of renal slices to evaluate the efficacy of chelators to remove mercury from the kidney. Toxicology 116:67-75. PMID:9020508
  • Radabaugh TR, Aposhian HV. 1997. Enzymatic reduction of arsenate to arsenite in mammalian liver. Environ Health Perspect 36(1,2):293.
  • Wildfang E, Zakharyan RA, Aposhian HV. 1997. Hamster and rabbit arsenite and MMA methyltransferase kinetics: Comparisons of in vitro properties. In: Proceedings of Arsenic: Health Effects, Mechanisms of Actions, and Research Issues. Hunt Valley, MD.
  • Wildfang E, Zakharyan RA, Aposhian HV. 1997. Lack of in vitro arsenite and monomethylarsonic acid methyltransferase activity in the chimpanzee and squirrel monkey. Environ Health Perspect 36(1,2):293.
  • Zakharyan RA, Healy SM, Chaga G, Aposhian HV. 1997. Purification and properties of the arsenite methylating isoenzymes of rabbit liver. In: Proceedings of Arsenic: Health Effects, Mechanisms of Actions, and Research Issues. Hunt Valley, MD.

1996

  • Aposhian HV. 1996. Arsenic toxicology: Does methylation of arsenic species have an evolutionary significance?. In: Metals Ions in Biology and Medicine: Proceedings of the Fourth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext, Montrouge, France. pp.399-401.
  • Aposhian HV, Zakharyan RA, Wu Y, Healy SM, Wildfang E, Radabaugh TR, Badghisi H, Aposhian MM. 1996. Does methylation of arsenite have evolutionary significance? The diversity of the reductase and methyltransferases of arsenic metabolism. In: Proceedings of Modulation of Chemical Toxicity and Risk Assessment. The University of Arizona, Tucson, AZ.
  • Aposhian MM. 1996. Sodium 2,3-dimercapto-1-propanesulfonate treatment does not redistribute mercury or lead to the brain of rats. In: Metals Ions in Biology and Medicine: Proceedings of the Fourth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext, Montrouge, France. pp.363-365.
  • Aposhian MM, Maiorino RM, Xu Z, Aposhian HV. 1996. Sodium 2,3-dimercapto-1-propanesulfonate (DMPS) treatment does not redistribute lead or mercury to the brain of rats. Toxicology 109(1):49-55. PMID:8619252
  • Healy SM, Zakharyan RA, Aposhian HV. 1996. Does the guinea pig methylate arsenite and MMA?. Environ Health Perspect 30(1,2):89.
  • Maiorino RM, Gonzalez-Ramirez D, Zuniga-Charles M, Xu Z, Hurlbut KM, Aposhian MM, Dart RC, Woods JS, Ostrosky-Wegman P, Gonsebatt ME, Aposhian HV. 1996. Sodium 2,3-dimercaptopropane-1-sulfonate challenge test for mercury in humans. III. Urinary mercury after exposure to mercurous chloride. J Pharmacol Exp Ther 277(2):938-944. PMID:8627576
  • Maiorino RM, Xu Z, Aposhian HV. 1996. Determination and metabolism of dithiol chelating agents XVII In humans, sodium 2,3-dimercapto-1-propanesulfonate is bound to plasma albumin via mixed disulfide formation and is found in the urine as cyclic polymeric disulfides. J Pharmacol Exp Ther 277(1):375-384. PMID:8613944
  • Zakharyan RA, Wildfang E, Aposhian HV. 1996. Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. Toxicol Appl Pharmacol 140(1):77-84. PMID:8806872

1995

  • Aposhian HV, Gonzalez-Ramirez D, Maiorino RM, Zuniga-Charles M, Hurlbut KM, Aposhian MM, Dart RC. 1995. DMPS (DIMAVAL) as a challenge test to assess the mercury and arsenic body/kidney load in humans and as a treatment of mercury toxicity. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, Edmonton, Alberta, Canada, 7-12 May, 1995. Edmonton, Alberta, Canada.
  • Aposhian HV, Maiorino RM, Gonzalez-Ramirez D, Zuniga-Charles M, Xu Z, Hurlbut KM, Junco-Munoz P, Dart RC, Aposhian MM. 1995. Mobilization of heavy metals by newer, therapeutically useful chelating agents. Toxicology 97(1-3):23-38. PMID:7716789
  • Aposhian HV, Zakharyan RA, Wu Y, Bogdan GM, Healy SM. 1995. Purification and properties of the arsenite methylating enzymes of rabbit liver. In: Proceedings of the Vth COMTOX Symposium on Toxicology and Clinical Chemistry of Metals. pp.25.
  • Aposhian HV, Zakharyan RA, Wu Y, Bogdan GM, Healy SM. 1995. Purification and properties of the arsenite methylating enzymes of rabbit liver. International Congenital Toxicology 7:86-88.
  • Hasal SJ, Aposhian HV, Gandolfi A, Brendel K. 1995. Human and rabbit renal cortical slices in aerated submersion culture as a model to evaluate heavy metal chelators. Environ Health Perspect 15:310.
  • Zakharyan RA, Wu Y, Aposhian HV. 1995. Enzymatic assay and purification of arsenic methyltransferase from rabbit liver. Environ Health Perspect 15:308.
  • Zakharyan RA, Wu Y, Bogdan GM, Aposhian HV. 1995. Enzymatic methylation of arsenic compounds: I. Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem Res Toxicol 8(8):1029-1038. PMID:8605285
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