Superfund Research Program

The Human Genetics of Arsenic Biotransformation

Project Leader: H. Vasken Aposhian
Grant Number: P42ES004940
Funding Period: 2000-2010

Project-Specific Links

Publications

2008

• Chowdhury UK, Aposhian HV. 2008. Protein expression in the livers and urinary bladders of hamsters exposed to sodium arsenite. Ann N Y Acad Sci 1140:325-334. doi:10.1196/annals.1454.019 PMID:18991932

2006

• Aposhian HV, Aposhian MM. 2006. Arsenic toxicology: five questions (review). Chem Res Toxicol 19(1):1-15. PMID:16411650
• Chowdhury UK, Zakharyan RA, Hernandez A, Avram MD, Kopplin MJ, Aposhian HV. 2006. Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: enzyme and arsenic species concentrations in tissues after arsenate administration. Toxicol Appl Pharmacol 216(3):446-457. doi:10.1016/j.taap.2006.06.014 PMID:16930657

2005

• Kirkpatrick DS, Weldon SF, Tsaprailis G, Liebler DC, Gandolfi A. 2005. Proteomic identification of ubiquitinated proteins from human cells expressing His-tagged ubiquitin. Proteomics 5(8):2104-2111. PMID:15852347
• Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi A, Klimecki WT. 2005. Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Environ Health Perspect 113(6):775-781. PMID:15929903
• Zakharyan RA, Tsaprailis G, Chowdhury UK, Hernandez A, Aposhian HV. 2005. Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase. Chem Res Toxicol 18(8):1287-1295. doi:10.1021/tx0500530 PMID:16097802

2004

• Bredfeldt TG, Kopplin MJ, Gandolfi A. 2004. Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Toxicol Appl Pharmacol 198(3):412-418. PMID:15276421

2003

• Aposhian HV, Zakharyan RA, Avram MD, Kopplin MJ, Wollenberg ML. 2003. Oxidation and detoxification of trivalent arsenic species. Toxicol Appl Pharmacol 193(1):1-8. PMID:14613711
• Aposhian HV, Zakharyan RA, Healy SM, Wildfang E, Petrick JS, Sampayo-Reyes A, Board PG, Carter DE, Mazumder G, Aposhian MM. 2003. Enzymology and Toxicity of Inorganic Arsenic. In: Arsenic Exposure and Health Effects: Proceedings of the Fifth International Conference on Arsenic Exposure and Health Effects, San Diego, California. Elsiever Science Ltd., Oxford, United Kingdom. pp.225-240.
• Carter DE, Aposhian HV, Gandolfi A. 2003. The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. Toxicol Appl Pharmacol 193(3):309-334. PMID:14678742
• Chowdhury UK, Rahman MM, Sengupta MK, Lodh D, Chanda CR, Roy S, Quamruzzaman Q, Tokunaga H, Ando M, Chakraborti DK. 2003. Pattern of excretion of arsenic compounds [arsenite, arsenate, MMA(V), DMA(V)] in urine of children compared to adults from an arsenic exposed area in Bangladesh. J Environ Sci Health A Tox Hazard Subst Environ Eng 38(1):87-113. PMID:12635821
• Yu L, Kalla K, Guthrie E, Vidrine A, Klimecki WT. 2003. Genetic variation in genes associated with arsenic metabolism: GST-Omega and Purine Nucleoside Phosphorylase polymorphisms in European and Indigenous Americans. EHP Toxicogenomics 111(11):1421-1428.

2002

• Gong Z, Jiang G, Cullen WR, Aposhian HV. 2002. Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. Chem Res Toxicol 15(10):1318-1323. PMID:12387631
• Mukhopadhyay R, Rosen BP. 2002. Arsenate reductases in prokaryotes and eukaryotes. Environ Health Perspect 110(5):745-748. PMID:12426124
• Radabaugh TR, Sampayo-Reyes A, Zakharyan RA, Aposhian HV. 2002. Arsenate reductase II. Purine nucleoside phophorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. Chem Res Toxicol 15(5):692-698.
• Rosen BP. 2002. Biochemistry of arsenic detoxification. FEBS Lett 529(1):86-97. PMID:12354618

2001

• Aposhian HV, Aposhian MM. 2001. Arsenic mobilization by DMPS. In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.397-406.
• Aposhian HV, Gurzau ES, Le X, Gurzau A, Zakharyan RA, Cullen WR, Healy SM, Gonzalez-Ramirez D, Morgan DL, Sampayo-Reyes A, Wildfang E, Radabaugh TR, Petrick JS, Mash EA, Aavula RB, Aposhian MM. 2001. The discovery, importance and siginificance of monomethyl-arsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. In: Arsenic Exposure and Health Effects IV. Elsevier, New York, NY. pp.305-314.
• Petrick JS, Jagadish B, Mash EA, Aposhian HV. 2001. Monomethylarsonous acid (MMAIII) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem Res Toxicol 14(6):651-656. PMID:11409934
• Wildfang E, Radabaugh TR, Aposhian HV. 2001. Enzymatic methylation of arsenic compounds. IX. Liver arsenite methyltransferase and arsenate reductase activities in primates. Toxicology 168(3):213-221. PMID:11684318
• Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV. 2001. Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione-S-transferase superfamily. Chem Res Toxicol 14(8):1051-1057. PMID:11511179

2000

• Aposhian HV, Aposhian MM. 2000. Arsenic mobilization by DMPS. In: Proceedings of the Fourth International Conference on Arsenic Exposure and Health Effects. San Diego, CA.
• Aposhian HV, Gurzau ES, Le X, Gurzau A, Healy SM, Lu X, Ma M, Yip L, Zakharyan RA, Maiorino RM, Dart RC, Tircus MG, Gonzalez-Ramirez D, Morgan DL, Avram D, Aposhian MM. 2000. Occurrence of monomethylarsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. Chem Res Toxicol 13(8):693-697. PMID:10956055
• Aposhian HV, Gurzau ES, Le X, Gurzau A, Zakharyan RA, Cullen WR, Healy SM, Gonzalez-Ramirez D, Morgan DL, Sampayo-Reyes A, Wildfang E, Radabaugh TR, Petrick JS, Mash EA, Aavula RB, Aposhian MM. 2000. The discovery, importance and significance of monomethyl- arsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. In: Proceedings of the Fourth International Conference on Arsenic Exposure and Health Effects. San Diego, CA.
• Gailer J, George GN, Pickering IJ, Prince RC, Ringwald SC, Pemberton JE, Glass RS, Younis HS, DeYoung DW, Aposhian HV. 2000. A metabolic link between arsenite and selenite: The seleno-bis(S-glutathionyl) arsinium ion. J Am Chem Soc 122(19):4637-4639.
• Le X, Lu X, Ma M, Cullen WR, Aposhian HV, Zheng B. 2000. Speciation of key arsenic metabolic intermediates in human urine. Anal Chem 72(21):5172-5177. PMID:11080860
• Le X, Ma M, Lu X, Cullen WR, Aposhian HV, Zheng B. 2000. Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ Health Perspect 108(11):1015-1018. PMID:11102289
• Petrick JS, Ayala-Fierro F, Cullen WR, Carter DE, Aposhian HV. 2000. The most toxic arsenical in the inorganic arsenic biotransformation pathway. In: Proceedings of the Fourth International Conference on Arsenic Exposure and Health Effects. San Diego, CA.
• Radabaugh TR, Aposhian HV. 2000. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem Res Toxicol 13(1):26-30. PMID:10649963
• Sampayo-Reyes A, Zakharyan RA, Aposhian HV. 2000. Monomethylarsonic acid MMA (V) reductase activity in hamster tissues. In: Proceedings of the Fourth International Conference on Arsenic Exposure and Health Effects. San Diego, CA.
• Sampayo-Reyes A, Zakharyan RA, Healy SM, Aposhian HV. 2000. Monomethylarsonic acid (MMAV) reductase and monomethylarsonous acid (MMAIII) in hamster tissue. Chem Res Toxicol 13(11):1181-1186.
• Wildfang E, Healy SM, Aposhian HV. 2000. Arsenic. In: Molecular Biology and Toxicology of Metals. Taylor and Francis Inc., London, United Kingdom. pp.75-112.

1999

• Zakharyan RA, Aposhian HV. 1999. Enzymatic reduction of arsenic compounds in mammalian systems: the rate limiting enzyme of rabbit liver arsenic biotransformation is MMAV reductase. Chem Res Toxicol 12(12):1278-1283. PMID:10604879
• Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DE, Aposhian HV. 1999. Enzymatic methylation of arsenic compounds: VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes. Toxicol Appl Pharmacol 158(1):9-15. PMID:10387927

1998

• Echeverria D, Aposhian HV, Woods JS, Heyer NJ, Aposhian MM, Bittner AC, Mahurin RK, Cianciola ME. 1998. Neurobehavioral effects from exposure to dental amalgam Hgo: new distinctions between recent exposure and Hg body burden. FASEB J 12(11):971-980. PMID:9707169