Superfund Research Program

Arsenic-Induced Pseudohypoxia Drives Malignant Transformation in Lung Cancer

Project Leader: Walter T. Klimecki
Grant Number: P42ES004940
Funding Period: 2010-2017

Project-Specific Links

Publications

2018

• Malm SW, Zmouzougan EA, Klimecki WT. 2018. Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line. Toxicol In Vitro 50:383-390. doi:10.1016/j.tiv.2018.04.008 PMID:29678786

2017

• Gamboa-Loira B, Cebrian ME, Salinas-Rodriguez A, Lopez-Carillo L. 2017. Genetic susceptibility to breast cancer risk associated with inorganic arsenic exposure. Environ Toxicol Pharmacol 56:106-113. doi:10.1016/j.etap.2017.08.032 PMID:28889078

2016

• Beamer P, Klimecki WT, Loh M, Van Horne YO, Sugeng AJ, Lothrop N, Billheimer D, Guerra S, Lantz RC, Canales RA, Martinez FD. 2016. Association of children's urinary CC16 levels with arsenic concentrations in multiple environmental media. Int J Environ Res Public Health 13(5):521. doi:10.3390/ijerph13050521 PMID:27223295 PMCID:PMC4881146
• Loh M, Sugeng AJ, Lothrop N, Klimecki WT, Cox M, Wilkinson S, Lu Z, Beamer P. 2016. Multimedia exposures to arsenic and lead for children near an inactive mine tailings and smelter site. Environ Res 146:331-339. doi:10.1016/j.envres.2015.12.011 PMID:26803211
• Ramirez-Andreotta M, Lothrop N, Wilkinson S, Root RA, Artiola JF, Klimecki WT, Loh M. 2016. Analyzing patterns of community interest at a legacy mining waste site to assess and inform environmental health literacy efforts. J Environ Stud Sci 6(3):543-555. doi:10.1007/s13412-015-0297-x PMID:27595054 PMCID:PMC5007004

2015

• Zhao F, Klimecki WT. 2015. Culture conditions profoundly impact phenotype in BEAS-2B, a human pulmonary epithelial model. J Appl Toxicol 35(8):945-951. doi:10.1002/jat.3094 PMID:25524072 PMCID:PMC4474793

2014

• Zhao F, Malm SW, Hinchman AN, Li H, Beeks CG, Klimecki WT. 2014. Arsenite-induced pseudo-hypoxia results in loss of anchorage-dependent growth in BEAS-2B pulmonary epithelial cells. PLoS One 9(12):e114549. doi:10.1371/journal.pone.0114549 PMID:25513814 PMCID:PMC4267735

2013

• Diaz-Villasenor A, Cruz L, Cebrian A, Hernandez-Ramirez RU, Hiriart M, Garcia-Vargas GG, Bassol S, Sordo M, Gandolfi A, Klimecki WT, Cebrian ME, Ostrosky-Wegman P, Lopez-Carillo L. 2013. Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: A pilot study of risk factors for T2DM. PLoS One 8:doi:10.1371/journal.pone.0051642 PMID:23349674 PMCID:PMC3551951
• Zhao F, Severson PL, Pacheco S, Futscher BW, Klimecki WT. 2013. Arsenic exposure induces the Warburg effect in cultured human cells. Toxicol Appl Pharmacol 271(1):72-77. doi:10.1016/j.taap.2013.04.020 PMID:23648393 PMCID:PMC3714307

2012

• Bolt AM, Klimecki WT. 2012. Autophagy in toxicology: self-consumption in times of stress and plenty. J Appl Toxicol doi:10.1002/jat.1787 PMID:22334383 PMCID:PMC3572937
• Bolt AM, Zhao F, Pacheco S, Klimecki WT. 2012. Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells. Toxicol Appl Pharmacol 264(2):255-261. doi:10.1016/j.taap.2012.08.006 PMID:22959463 PMCID:PMC3462290
• Canet MJ, Hardwick RN, Lake AD, Kopplin MJ, Scheffer GL, Klimecki WT, Gandolfi A, Cherrington NJ. 2012. Altered arsenic disposition in experimental nonalcoholic fatty liver disease. Drug Metab Dispos 40(9):1817-1824. doi:10.1124/dmd.112.046177 PMID:22699396 PMCID:PMC3422539
• Gomez-Rubio P, Klimentidis YC, Cantu-Soto E, Meza-Montenegro MM, Billheimer D, Lu Z, Chen Z, Klimecki WT. 2012. Indigenous American ancestry is associated with arsenic methylation efficiency in an admixed population of northwest Mexico. Toxicol Appl Pharmacol 75(1):36-49. doi:10.1080/15287394.2011.615107 PMID:22047162 PMCID:PMC3572940

2011

• Gomez-Rubio P, Roberge J, Arendell L, Harris RB, O'Rourke MK, Chen Z, Cantu-Soto E, Meza-Montenegro MM, Billheimer D, Lu Z, Klimecki WT. 2011. Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico. Toxicol Appl Pharmacol 252:176-182. doi:10.1016/j.taap.2011.02.007 PMID:21320519 PMCID:PMC3075343

2010

• Bolt AM, Byrd RM, Klimecki WT. 2010. Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. Toxicol Appl Pharmacol 244(3):366-373. doi:10.1016/j.taap.2010.01.019 PMID:20153345 PMCID:PMC2849852
• Bolt AM, Douglas R, Klimecki WT. 2010. Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. Toxicol Lett 199(2):153-159. doi:10.1016/j.toxlet.2010.08.017 PMID:20816728 PMCID:PMC2956852
• Gomez-Rubio P, Meza-Montenegro MM, Cantu-Soto E, Klimecki WT. 2010. Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10. J Appl Toxicol 30(3):260-270. doi:10.1002/jat.1492 PMID:20014157 PMCID:PMC2862143