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Project Publications: University of Arizona: Arsenic-Induced Pseudohypoxia Drives Malignant Transformation in Lung Cancer

Superfund Research Program

Arsenic-Induced Pseudohypoxia Drives Malignant Transformation in Lung Cancer

Project Leader: Walter T. Klimecki
Grant Number: P42ES004940
Funding Period: 2010-2017
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Malm SW, Zmouzougan EA, Klimecki WT. 2018. Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line. Toxicol In Vitro 50:383-390. doi:10.1016/j.tiv.2018.04.008 PMID:29678786


  • Gamboa-Loira B, Cebrian ME, Salinas-Rodriguez A, Lopez-Carillo L. 2017. Genetic susceptibility to breast cancer risk associated with inorganic arsenic exposure. Environ Toxicol Pharmacol 56:106-113. doi:10.1016/j.etap.2017.08.032 PMID:28889078


  • Beamer P, Klimecki WT, Loh M, Van Horne YO, Sugeng AJ, Lothrop N, Billheimer D, Guerra S, Lantz RC, Canales RA, Martinez FD. 2016. Association of children's urinary CC16 levels with arsenic concentrations in multiple environmental media. Int J Environ Res Public Health 13(5):521. doi:10.3390/ijerph13050521 PMID:27223295 PMCID:PMC4881146
  • Loh M, Sugeng AJ, Lothrop N, Klimecki WT, Cox M, Wilkinson S, Lu Z, Beamer P. 2016. Multimedia exposures to arsenic and lead for children near an inactive mine tailings and smelter site. Environ Res 146:331-339. doi:10.1016/j.envres.2015.12.011 PMID:26803211
  • Ramirez-Andreotta M, Lothrop N, Wilkinson S, Root RA, Artiola JF, Klimecki WT, Loh M. 2016. Analyzing patterns of community interest at a legacy mining waste site to assess and inform environmental health literacy efforts. J Environ Stud Sci 6(3):543-555. doi:10.1007/s13412-015-0297-x PMID:27595054 PMCID:PMC5007004




  • Diaz-Villasenor A, Cruz L, Cebrian A, Hernandez-Ramirez RU, Hiriart M, Garcia-Vargas GG, Bassol S, Sordo M, Gandolfi A, Klimecki WT, Cebrian ME, Ostrosky-Wegman P, Lopez-Carillo L. 2013. Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: A pilot study of risk factors for T2DM. PLoS One 8:doi:10.1371/journal.pone.0051642 PMID:23349674 PMCID:PMC3551951
  • Zhao F, Severson PL, Pacheco S, Futscher BW, Klimecki WT. 2013. Arsenic exposure induces the Warburg effect in cultured human cells. Toxicol Appl Pharmacol 271(1):72-77. doi:10.1016/j.taap.2013.04.020 PMID:23648393 PMCID:PMC3714307



  • Gomez-Rubio P, Roberge J, Arendell L, Harris RB, O'Rourke MK, Chen Z, Cantu-Soto E, Meza-Montenegro MM, Billheimer D, Lu Z, Klimecki WT. 2011. Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico. Toxicol Appl Pharmacol 252:176-182. doi:10.1016/j.taap.2011.02.007 PMID:21320519 PMCID:PMC3075343


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