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Your Environment. Your Health.

Program Publications: Colorado State University: Integrated Research on Hazardous Waste Chemical Mixtures

Superfund Research Program

Integrated Research on Hazardous Waste Chemical Mixtures

Center Director: Raymond S H. Yang
Grant Number: P42ES005949
Funding Period: 1992-2000

Publications

2020

  • Cadmus P, Kotalik CJ, Jefferson AL, Wheeler S, McMahon A, Clements WH. 2020. Size dependent sensitivity of aquatic insects to metals. Environ Sci Technol doi:10.1021/acs.est.9b04089

2005

  • Zimbron JA, Reardon KF. 2005. Hydroxyl free radical reactivity toward aqueous chlorinated phenols. Water Res 39(5):865-869. PMID:15743632

2004

  • Chubb LS, Andersen ME, Broccardo CJ, Legare ME, Billings RE, Dean CE, Hanneman WH. 2004. Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicol Pathol 32(4):467-473. PMID:15223772

2003

  • Andersen ME, Ou YC, Yang RH, Conolly RB, Thomas RS, Gustafson DL, Long ME, Dobrev ID, Chubb LS, Xu Y, Lapidot SA. 2003. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci 73(2):301-314. PMID:12700395
  • Bae D, Handa RJ, Yang RH, Campain JA. 2003. Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. Toxicol Sci 74(1):32-42. PMID:12773770

2002

  • Andersen ME, Yang RH, French CT, Chubb LS, Dennison JE. 2002. Molecular circuits, biological switches, and nonlinear dose-response relationships. Environ Health Perspect 110(suppl.6):971-978. PMID:12634127
  • Bae D, Hanneman WH, Yang RH, Campain JA. 2002. Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. Environ Health Perspect 110(suppl.6):931-941. PMID:12634122
  • Beaty BJ, Mackie RS, Mattingly KS, Carlson JO, Rayms-Keller A. 2002. The midgut epithelium of aquatic arthropods: a critical target organ in environmental toxicology. Environ Health Perspect 110(suppl.6):911-914. PMID:12634118
  • Dean, Jr. CE, Benjamin SA, Chubb LS, Tessari JD, Keefe TJ. 2002. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Toxicol Sci 66(1):54-61. PMID:11861972
  • Dobrev ID, Andersen ME, Yang RH. 2002. In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. Environ Health Perspect 110(10):1031-1039. PMID:12361929
  • Klein MT, Hou G, Quann RJ, Wei W, Liao KH, Yang RH, Campain JA, Mazurek MA, Broadbelt LJ. 2002. BioMOL: a computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level. Environ Health Perspect 110(suppl.6):1025-1029. PMID:12634134
  • Liao KH, Dobrev ID, Dennison, Jr. JE, Andersen ME, Reisfeld B, Reardon KF, Campain JA, Wei W, Klein MT, Quann RJ, Yang RH. 2002. Application of biologically based computer modeling to simple or complex mixtures. Environ Health Perspect 110(suppl.6):957-963. PMID:12634125
  • Reardon KF, Kim K. 2002. Two-dimensional electrophoresis analysis of protein production during growth of Pseudomonas putida F1 on toluene, phenol, and their mixture. Electrophoresis 23(14):2233-2241. PMID:12210227
  • Reardon KF, Mosteller DC, Bull Rogers JD, DuTeau NM, Kim K. 2002. Biodegradation kinetics of aromatic hydrocarbon mixtures by pure and mixed bacterial cultures. Environ Health Perspect 110(suppl.6):1005-1011. PMID:12634132
  • Suk WA, Olden K, Yang RH. 2002. Chemical mixtures research: significance and future perspectives. Environ Health Perspect 110(suppl.6):891-892. PMID:12634115

2001

  • Bae D, Gennings C, Carter, Jr. WH, Yang RH, Campain JA. 2001. Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes. Toxicol Sci 63(1):132-142. PMID:11509753
  • Black IV WC, Baer CF, Antolin MF, DuTeau NM. 2001. Population genomics: genome-wide sampling of insect populations. Annual Review of Entomology 46:441-469. PMID:11112176
  • Dobrev ID, Andersen ME, Yang RH. 2001. Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling. Arch Toxicol 75(3):134-144. PMID:11409535
  • Liao KH, Gustafson DL, Fox MH, Chubb LS, Reardon KF, Yang RH. 2001. A biologically based model of growth and senescence of Syrian Hamster Embryo (SHE) cells after exposure to arsenic. Environ Health Perspect 109(12):1207-1213. PMID:11748027
  • Ou YC, Conolly RB, Thomas RS, Xu Y, Andersen ME, Chubb LS, Pitot HC, Yang RH. 2001. A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res 61(5):1879-1889. PMID:11280742
  • Pott WA, Benjamin SA, Yang RH. 2001. Pharmacokinetics, metabolism, and carcinogenicity of arsenic. Rev Environ Contam Toxicol 169:165-214. PMID:11330077

2000

  • Bull Rogers JD, DuTeau NM, Reardon KF. 2000. Use of 16S-rRNA to investigate microbial population dynamics during biodegradation of toluene and phenol by binary culture. Biotechnol Bioeng 70(4):436-445. PMID:11005926
  • Bull Rogers JD, Reardon KF. 2000. Modeling substrate interactions during the biodegradation of mixtures of toluene and phenol by Burkholderia species JS150. Biotechnol Bioeng 70(4):429-435. PMID:11005925
  • Gustafson DL, Long ME, Thomas RS, Benjamin SA, Yang RH. 2000. Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: application of a medium-term liver focus bioassay and molecular and cellular indices. Toxicol Sci 53(2):245-252. PMID:10696772
  • Reardon KF, Mosteller DC, Bull Rogers JD. 2000. Biodegradation kinetics of benzene, toluene, and phenol as single and mixed substrates for Pseudomonas putida F1. Biotechnol Bioeng 69(4):385-400. PMID:10862677
  • Thomas RS, Conolly RB, Gustafson DL, Long ME, Benjamin SA, Yang RH. 2000. A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator. Toxicol Appl Pharmacol 166(2):128-137. PMID:10896854

1999

  • Benjamin SA, Yang RH, Tessari JD, Chubb LS, Brown MD, Dean CE, Keefe TJ. 1999. Lack of promotional effects of groundwater contaminant mixtures on the induction of preneoplastic foci in rat liver. Toxicology 137(3):137-149. PMID:10522494
  • Carlisle DM, Clements WH. 1999. Sensitivity and variability of metrics used in biological assessments of running waters. Environ Toxicol Chem 18(2):285-291.
  • Conuel JC, Reardon KF. 1999. Comparison of Operating Strategies in an Immobilized-Cell Bioreactor Based on Cometabolism. In: Proceedings of the International In Situ and On-site Bioreclamation Symposium. San Diego, CA.
  • Mosteller DC, Reardon KF. 1999. Biodegradation Kinetics of Pseudomonas putida F1 for Aromatic Hydrocarbon Mixtures. In: Proceedings of the International In Situ and On-site Bioreclamation Symposium. San Diego, CA.

1998

  • Beaty BJ, Black IV WC, Carlson JE, Clements WH, DuTeau NM, Harrahy E, Nuckols JR, Olson KE, Rayms-Keller A. 1998. Molecular and genetic ecotoxicological approaches to aquatic environmental bioreporting. Environ Health Perspect 106(Suppl.6):1395-1407.
  • Courtney LA, Clements WH. 1998. Effects of acidic pH on benthic macroinvertebrate communities in stream microcosms. Hydrobiologia 379:135-145.
  • DuTeau NM, Bull Rogers JD, Bartholomay CT, Reardon KF. 1998. Species-specific oligonucleotides for enumeration of Pseudomonas putida F1, Burkholderia sp strain JS150, and Bacillus subtilis ATCC 7003 in biodegradation experiments. Appl Environ Microbiol 64(12):4994-4999. PMID:9835594 PMCID:PMC90954
  • Gustafson DL, Coulson AL, Feng L, Pott WA, Thomas RS, Chubb LS, Saghir SA, Benjamin SA, Yang RH. 1998. Use of a medium-term liver focus bioassay to assess the hepatocarcinogenicity of 1,2,4,5-tetrachlorobenzene and 1,4-dichlorobenzene. Cancer Lett 129(1):39-44. PMID:9714333
  • Medley CN, Clements WH. 1998. Responses of diatom communities to heavy metals in Rocky Mountain streams: the influence of longitudinal variation. Ecol Appl 8(3):631-644.
  • Perkins C, Winn DT, Tessari JD, Chubb LS, Cady TA, Clements WH, Benjamin SA, Yang RH. 1998. Analytical chemistry determinations of complex chemical mixtures. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
  • Pott WA, Benjamin SA, Yang RH. 1998. Antagonistic interactions of arsenic-containing mixtures in a multiple organ carcinogenicity bioassay. Cancer Lett 133(2):185-190. PMID:10072168
  • Rayms-Keller A, Olson KE, McGaw M, Oray CL, Carlson JE, Beaty BJ. 1998. Effect of heavy metals on Aedes aegypti larvae (Diptera: Culicidae). Ecotoxicol Environ Saf 39:41-47. PMID:9515074
  • Thomas RS, Gustafson DL, Pott WA, Long ME, Benjamin SA, Yang RH. 1998. Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence. Carcinogenesis 19(10):1855-1862. PMID:9806169
  • Thomas RS, Gustafson DL, Ramsdell HS, El-Masri HA, Benjamin SA, Yang RH. 1998. Enhanced regional expression of glutathioneS-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria. Toxicol Appl Pharmacol 150(1):22-31. PMID:9630449
  • Yang RH. 1998. Some critical issues and concerns related to research advances on the toxicology of chemical mixtures. Environ Health Perspect 106(Suppl.6):1595. PMID:9703493
  • Yang RH, Thomas RS, El-Masri HA. 1998. Integrating computer modeling and mechanistic toxicology for the development of a predictive and alternative toxicology approach for chemicals and chemical mixtures. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
  • Yang RH, Thomas RS, Gustafson DL, Campain JA, Benjamin SA, Verhaar HJ, Mumtaz MM. 1998. Approaches to developing alternative and predictive toxicology based on PBPK/PD and QSAR modeling. Environ Health Perspect 106(suppl.6):1385-1393. PMID:9860897

1997

  • Archibeque-Engle S, Tessari JD, Winn DT, Keefe TJ, Nett TM, Zheng T. 1997. Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum. J Toxicol Environ Health A 52:285-293. PMID:9354175
  • Arguello J, Kinonen C, Miller C, Palmer J, Dowell C, Cao JQ, Spink D, Tessari JD, Veeramachaneni D, Cosma G. 1997. Comparative reproductive toxicities of p,p-DDT vs. p,p-DDE following perinatal exposures in male rabbits. In: Proceedings of the 36th Society of Toxicology (SOT) Annual Meeting, March 9-13, 1997. Cincinnati, OH.
  • Benjamin SA, Chubb LS, Dean, Jr. CE, Tessari JD, Yang RH, Brown MD. 1997. Lack of preneoplastic foci in rats exposed to a hazardous waste groundwater mixture in a medium-term hepatic initiation/promotion assay. Environ Health Perspect 36:153.
  • Black IV WC, DuTeau NM. 1997. RAPD-PCR and SSCP Analysis for Insect Population Genetic Studies. In: Molecular Biology of Insect Disease Vectors. Chapman and Hall, London, United Kingdom. pp.361-373.
  • Clements WH. 1997. Ecological significance of endpoints used to assess sediment quality. In: Ecological Risk Assessment of Contaminated Sediments. SETAC Foundation for Environmental Education, SETAC Press, Pensacola, FL.
  • Clements WH. 1997. Effects of contaminants at higher levels of biological organization in aquatic systems. Reviews in Toxicology 1:269-308.
  • Clements WH, Day KE, DeWitt T, Landis WG, Landrigan PJ, Morrisey D, Reiley M, Rosenbers DM, Suter G. 1997. Critical issues of ecological relevance in sediment risk assessment. In: Ecological Risk Assessment of Contaminated Sediments. SETAC Foundation for Environmental Education, SETAC Press, Pensacola, FL.
  • Clements WH, Rees DE. 1997. Indirect effects of heavy metals on brown trout (Salmo trutta) feeding habits and bioaccumulation in the Arkansas River, CO. Trans Am Fish Soc 126:774-785.
  • DuTeau NM, Rayms-Keller A, Black IV WC, Beaty BJ, Carlson JE, Olson KE, Harrahy E, Clements WH. 1997. Genetic Diversity in Neutral and Metal-Responsive Genes as Ecological Indicators of Heavy Metal Contaminants in the Arkansas River. In: Proceedings of the Current Issues in Chemical Mixtures Conference. Colorado State University, Ft. Collins, CO.
  • El-Masri HA, Reardon KF, Yang RH. 1997. Integrated approaches for the analysis of toxicologic interactions of chemical mixtures. Crit Rev Toxicol 27(2):175-197. PMID:9099518
  • Harrahy E, Clements WH. 1997. Toxicity and bioaccumulation of a mixture of heavy metals in Chironomus tentans (Chironomidae: Diptera) in synthetic sediment. Environ Toxicol Chem 16:317-327.
  • Kiffney PM, Clements WH, Cady TA. 1997. Influence of ultraviolet radiation on the colonization dynamics of a Rocky mountain stream benthic community. Journal of the North American Benthological Society 16:520-530.
  • Kiffney PM, Little EE, Clements WH. 1997. Influence of ultraviolet-B radiation on the drift response of stream invertebrates. Freshwater Biology 37:485-492.
  • Reardon KF, Rogers JD, Mosteller DC, Kim K, Brown DE, DuTeau NM. 1997. Chemical and Microbial Interactions during Biodegradation of Pollutant Mixtures. In: Proceedings of the Current Issues in Chemical Mixtures Conference. Colorado State University, Ft. Collins, CO.
  • Reichard JF, Hallahan T, Billings RE. 1997. Metals inhibit induction of nitric oxide synthase in cultured rat hepatocytes. Environ Health Perspect 36:39.
  • Saghir SA, Feng L, El-Masri HA, Benjamin SA, Yang RH. 1997. Toxicologic interactions involving three chemicals: Kepone, carbon tetrachloride, and 1,1,2,2-tetrachloroethane. Environ Health Perspect 36:151.
  • Sieg DJ, Billings RE. 1997. Lead/cytokine-mediated DNA damage in cultured mousehepatocytes. Toxicol Appl Pharmacol 142:106-115. PMID:9007039
  • Smith TB, Reardon KF, Yang RH. 1997. Assessment of the carcinogenic potential of arsenic and arsenic-containing chemical mixtures using the Syrian Hamster Embryo (SHE) cell assay. Environ Health Perspect 36:89.
  • Verhaar HJ, Morroni JS, Reardon KF, Hays SM, Gaver DP, Carpenter RL, Yang RH. 1997. A proposed approach to study the toxicology of complex mixtures of petroleum products: The integrated use of QSAR, lumping analysis, and PBPK/PD modeling. Environ Health Perspect 105(supp.5):179-195. PMID:9114286
  • Yang RH. 1997. Some current approaches for studying combination toxicology in chemical mixtures. Food Chem Toxicol 34(11-12):1173-1174. PMID:9119313
  • Yang RH. 1997. Toxicologic Interactions of Chemical Mixtures. In: Comprehensive Toxicology, Vol. 1, General Principles, Toxicokinetics, and Mechanisms of Toxicity. Elsevier Science, Ltd., Oxford, United Kingdom. pp.189-203.

1996

  • Archibeque-Engle S, Tessari JD, Winn DT. 1996. Quality assurance/quality control procedures for chlorinated hydrocarbons in human breast adipose tissue. J Toxicol Environ Health A 49:589-598. PMID:8977626
  • Carlisle DM, Clements WH. 1996. Effects of population density on the response of macroinvertebrates to heavy metals. Bulletin of the North American Benthology Society 13:144.
  • Chubb LS, El-Masri HA, Saghir SA, Yang RH. 1996. A physiologically based pharmacokinetic model predicting liver dosimetry of kepone. Environ Health Perspect 30:252.
  • Clements WH, Cady TA, Kiffney PM. 1996. Metal-tolerant mayflies are more susceptible to stonefly predation than intolerant mayflies. Bulletin of the North American Benthology Society 13:144.
  • Clements WH, Kiffney PM. 1996. Validation of whole effluent toxicity tests: integrated studies using field biomonitoring and microcosm experiments. In: Whole effluent toxicity testing: an evaluation of methods and predictability of receiving responses. SETAC (Society of Environmental Toxicology and Chemistry) Foundation for Environmental Education. SETAC Press, Pensacola, FL.
  • Constan AA, Benjamin SA, Chubb LS, Tessari JD, Baker DC, Yang RH. 1996. Concurrent apoptosis and hepatocellular proliferation prevent increased formation of enzyme-altered foci in F344 rats exposed to a mixture of groundwater contaminants. Environ Health Perspect 30:160.
  • Constan AA, Benjamin SA, Tessari JD, Baker DC, Yang RH. 1996. Increased rate of apoptosis correlates with hepatocellular proliferation in Fischer-344 rats following long-term exposure to a mixture of groundwater contaminants. Toxicol Pathol 24(3):315-322. doi:10.1177/019262339602400307 PMID:8736387
  • Dean, Jr. CE, Benjamin SA, Yang RH, Chubb LS, Tessari JD. 1996. Cell proliferation, apoptosis, and promotion of preneoplastic foci in rat liver after exposure to a model hazardous waste groundwater mixture. In: Proceedings of the FASEB (Federation of American Societies for Experimental Biology) Summer Research Conference: Cellular and Molecular Mechanisms for Liver Growth Regulation. Snowmass, CO.
  • El-Masri HA, Constan AA, Ramsdell HS, Yang RH. 1996. Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats. Toxicol Appl Pharmacol 141(1):124-132. PMID:8917684
  • El-Masri HA, Thomas RS, Mumtaz MM, Andersen ME, Yang RH. 1996. A biologically based mathematical model of the effects of partial hepatectomy on cell cycle kinetics. Environ Health Perspect 30:131.
  • El-Masri HA, Thomas RS, Sabados G, Phillips JK, Constan AA, Benjamin SA, Mehendale HM, Yang RH, Andersen ME. 1996. Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and kepone. Arch Toxicol 70:704-713. PMID:8896716
  • Harrahy E, Clements WH. 1996. Influence of previous exposure to a mixture of metals in Baetis tricaudatus: a comparison of populations. Bulletin of the North American Benthology Society 13:247.
  • Hwang IY, Reardon KF, Tessari JD, Yang RH. 1996. A gas-liquid system for enzyme kinetic studies of volatile organic chemicals: Determination of enzyme kinetic constants and partition coefficients of trichloroethylene. Drug Metab Dispos 24:377-382. PMID:8801050
  • Kiffney PM, Clements WH. 1996. Drift responses of stream insects to ultraviolet radiation. Bulletin of the North American Benthology Society 13:111.
  • Kiffney PM, Clements WH. 1996. Effects of heavy metals on stream macroinvertebrate assemblages from different elevations. Ecol Appl 6:472-481.
  • Kiffney PM, Clements WH. 1996. Size-dependent response of macro-invertebrates to metals in experimental streams. Environ Toxicol Chem 15:1352-1356.
  • Kim K, Reardon KF. 1996. Two-Dimensional Protein Electrophoresis Analysis of the Adaptation of Pseudomonas putida F1 to Toluene and Phenol as Growth Substrates. In: Proceedings of the Ninth Annual Colorado Biotechnology Symposium. Fort Collins, CO.
  • Klimowski LK, Rayms-Keller A, Olson KE, Yang RH, Carlson JE, Beaty BJ. 1996. Inducibility of a molecular bioreporter system by heavy metals. Environ Toxicol Chem 15:85-91.
  • La Point TW, Barbour M, Borton DL, Cherry D, Clements WH, Diamond J, Grothe D, Lewis M, Reed D, Saalfield J. 1996. Field assessments. In: Whole effluent toxicity testing: an evaluation of methods and predictability of receiving responses. SETAC (Society of Environmental Toxicology and Chemistry) Foundation for Environmental Education. SETAC Press, Pensacola, FL.
  • Rogers JD, DuTeau NM, Mosteller DC, Reardon KF. 1996. Kinetics and Population Dynamics in the Biodegradation of Aromatic Hydrocarbon Mixtures. In: Proceedings of the 3rd Symposium of the International Society for Environmental Biotechnology. Boston, MA.
  • Rogers JD, DuTeau NM, Reardon KF. 1996. Microbial Population Dynamics and Biodegradation Kinetics of Organic Pollutant Mixtures. In: Proceedings of the Annual Meeting of the American Institute of Chemical Engineers. Chicago,, IL.
  • Rogers JD, DuTeau NM, Reardon KF. 1996. Use of Species-Specific Genetic Markers for Determining the Relationship between Microbial Population Dynamics and the Biodegradation of Pollutant Mixtures. In: Proceedings of the 96th General Meeting of the American Society of Microbiology. New Orleans, LA.
  • Rogers JD, Reardon KF, DuTeau NM. 1996. Microbial Population Dynamics and Biodegradation Kinetics of Aromatic Hydrocarbon Mixtures. In: Proceedings of the Ninth Annual Colorado Biotechnology Symposium. Fort Collins, CO.
  • Tessari JD. 1996. Analytical chemistry quality control/quality assurance. In: Proceedings of the Northeast/MidAtlantic Breast Cancer Programs: Timing of Environmental Exposures in Breast Cancer, (National Institute of Environmental Health Sciences). NIEHS, Research Triangle Park, NC.
  • Thomas RS, Bigelow PL, Keefe TJ, Yang RH. 1996. Variability in biological exposure indices using physiologically based pharmacokinetic modeling and Monte Carlo simulation. Am Ind Hyg Assoc J 57(1):23-32. PMID:8588550
  • Thomas RS, Chubb LS, Constan AA, Benjamin SA, El-Masri HA, Veeramachaneni D, Tessari JD, Nett TM, Palmer J, Miller C, Kinonen C, Arguello J, Cosma G. 1996. Male reproductive toxicity following perinatal exposures to the anti-androgen p,p-DDT. In: Proceedings of the 35thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
  • Thomas RS, Lytle WE, Keefe TJ, Constan AA, Yang RH. 1996. Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using Advanced Continuous Simulation Language (ACSL): a computational method. Fundam Appl Toxicol 31(1):19-28. PMID:8998950
  • Thomas RS, Yang RH, Morgan DG, Moorman MP, Kermani HR, Sloane RA, O'Connor RW, Adkins, Jr. B, Gargas ML, Andersen ME. 1996. PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure. Environ Health Perspect 104(8):858-865. PMID:8875160
  • Yang RH. 1996. A comparison of quantitative, immunohistochemical markers for cell-cycle specific changes in F344 rats. Environ Health Perspect 30:130.
  • Yang RH. 1996. The application of computer modeling to health effects research. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia.
  • Yang RH. 1996. Toxicology of representative superfund mixtures. In: Proceedings of the 1996 Annual Meeting of the International Life Sciences Institute. Cancun, Mexico.

1995

  • Benjamin SA, Constan AA, Yang RH, Tessari JD, Baker DC. 1995. Lack of correlation between liver cell proliferation and preneoplastic foci in rats exposed to a mixture of groundwater contaminants. Toxicol Pathol 23:756.
  • Clements WH. 1995. The influence of heavy metals and predation on benthic macroinvertebrate communities from polluted and unpolluted streams. Environ Toxicol Chem 16thAnnualMeetingAbstracts,p.87.
  • Clements WH. 1995. Tolerance of benthic macroinvertebrate populations and communities to metals: the influence of previous exposure. Bulletin of the Ecological Society of America 76:49.
  • Constan AA, Yang RH, Baker DC, Benjamin SA. 1995. A unique pattern of hepatocyte proliferation in F344 rats following long-term exposures to low-levels of a chemical mixture of groundwater contaminants. Carcinogenesis 16(2):303-310. PMID:7859362
  • El-Masri HA, Thomas RS, Benjamin SA, Yang RH. 1995. Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment. Toxicology 105(2-3):275-282. PMID:8571364
  • Mosteller DC, Reardon KF. 1995. Biodegradation Kinetics of Aromatic Hydrocarbon Mixtures. In: Proceedings of the Tenth Conference on Hazardous Waste Remediation. Manhattan, KS.
  • Mosteller DC, Rogers JD, Kim K, Griffith CR, Reardon KF. 1995. Biodegradation of Aromatic Hydrocarbon Mixtures: Kinetics and Enzyme Levels. In: Proceedings of the Eighth Annual Colorado Biotechnology Symposium. Boulder, CO.
  • Reardon KF, Mosteller DC, Rogers JD, Kim K, DuTeau NM. 1995. Biodegradation of Aromatic Hydrocarbon Mixtures: Kinetics, Enzyme Levels, and Population Dynamics. In: Proceedings of the Annual Meeting of the American Institute of Chemical Engineers. Miami Beach, FL.
  • Veeramachaneni D, Palmer J, Amann RP. 1995. Infantile exposure of rabbits to a chemical mixture alters pituitary and testicular function as adults. J Androl 16(supp.):80.
  • Veeramachaneni D, Palmer J, Amann RP. 1995. Sexual dysfunction and abnormal acrosomes in rabbits following infantile exposure to a mixture of chemicals in drinking water. Biol Reprod 52:171.
  • Yang RH, El-Masri HA, Thomas RS, Constan AA. 1995. The use of physiologically based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures. Toxicol Lett 82/83:497-504. PMID:8597101
  • Yang RH, El-Masri HA, Thomas RS, Constan AA, Tessari JD. 1995. The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures. Toxicol Lett 79(1-3):193-200. PMID:7570656
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