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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Dartmouth College: Induction of Oxidative Stress and Activation of Transcription Factors by Toxic Metals

Superfund Research Program

Induction of Oxidative Stress and Activation of Transcription Factors by Toxic Metals

Project Leader: Aaron Barchowsky (University of Pittsburgh)
Grant Number: P42ES007373
Funding Period: 1995 - 2000

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Publications

2020

1999

  • Barchowsky A, Klei LR, Dudek EJ, Swartz HM, James PE. 1999. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite. Free Radic Biol Med 27(11-12):1405-1412. PMID:10641735
  • Barchowsky A, Roussel RR, Klei LR, James PE, Ganju N, Smith KR, Dudek EJ. 1999. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol Appl Pharmacol 159(1):65-75. PMID:10448126
  • Chen CY, Sillett KS, Folt CL, Whittemore S, Barchowsky A. 1999. Molecular and demographic measures of arsenic stress in D. pulex. Hydrobiologia 410:229-238.
  • Shumilla JA, Barchowsky A. 1999. Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. Toxicol Appl Pharmacol 158(3):288-295. PMID:10438662
  • Shumilla JA, Broderick RJ, Wang Y, Barchowsky A. 1999. Chromium(VI) inhibits the transciptional activity of Nuclear Factor-kB by decreasing the interaction of p65 with cAMP-responsive element-binding protein-binding protein. J Biol Chem 274(51):36207-36212. PMID:10593907

1998

  • Shumilla JA, Wetterhahn KE, Barchowsky A. 1998. Inhibition of NF-kB binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism. Arch Biochem Biophys 349(2):356-362. PMID:9448725

1997

  • Barchowsky A, Lannon BM, Elmore LC, Treadwell MD. 1997. Increased focal adhesion kinase- and urokinase-type plasminogen activator receptor-associated cell signaling in endothelial cells exposed to asbestos. Toxicol Appl Pharmacol 105(Suppl.5):1131-1137. PMID:9400712
  • Kaltreider RC, Ihnat MA, Pesce CA, Nemeth MJ, Lariviere JP, Hamilton JW. 1997. Arsenic and chromium induce metal-, dose-, time-, and cell factor-dependent alterations in transcription factor binding. Environ Health Perspect 36:116.
  • Kaltreider RC, Warren AJ, Ihnat MA, Rowell EE, Hamilton JW. 1997. The DNA crosslinking agents mitomycin C and chromium(VI) alter transcription factor binding principally through DNA damage-dependent mechanisms. Proc Am Assoc Cancer Res

1996

  • Barchowsky A, Dudek EJ, Treadwell MD, Wetterhahn KE. 1996. Arsenic induces oxidant stress and NF-ÇB activation in cultured aortic endothelial cells. Free Radic Biol Med 21(6):783-790. PMID:8902524
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