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Project Publications: Dartmouth College: Mechanism of Arsenic-Induced Vascular Disease

Superfund Research Program

Mechanism of Arsenic-Induced Vascular Disease

Project Leader: Aaron Barchowsky (University of Pittsburgh)
Grant Number: P42ES007373
Funding Period: 2000-2005

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Publications

2007

  • Straub AC, Stolz DB, Ross MA, Hernandez-Zavala A, Soucy NV, Klei LR, Barchowsky A. 2007. Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology 45(1):205-12. PMID:17187425
  • Straub AC, Stolz DB, Vin H, Ross MA, Soucy NV, Klei LR, Barchowsky A. 2007. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl Pharmacol 222(3):327-36. PMID:17123562

2005

  • Soucy NV, Mayka DD, Klei LR, Nemec AA, Bauer JA, Barchowsky A. 2005. Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice. Cardiovasc Toxicol 5(1):29-42. PMID:15738583

2003

  • Barchowsky A, O'Hara KA. 2003. Metal-induced cell signaling and gene activation in lung diseases. Free Radic Biol Med 34(9):1130-1135. PMID:12706493
  • James PE, Madhani M, Ross CR, Klei LR, Swartz HM. 2003. Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide. Advances in Experimental Medicine and Biology 530:645-652. PMID:14562762
  • O'Hara KA, Klei LR, Barchowsky A. 2003. Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol 190(3):214-223. PMID:12902192

2002

  • Barchowsky A, Soucy NV, O'Hara KA, Hwa J, Noreault-Conti TL, Andrew AS. 2002. A novel pathway for nickel-induced interleukin-8 expression. J Biol Chem 277(27):24225-24231. PMID:11978798

2001

  • Andrew AS, Klei LR, Barchowsky A. 2001. AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. Am J Physiol 281(3):L616-L623. PMID:11504688
  • Andrew AS, Klei LR, Barchowsky A. 2001. Nickel requires hypoxia inducible factor-1a, not redox signaling to induce plasminogen activator inhibitor-1. Am J Physiol 281(3):L607-L615. PMID:11504687
  • Andrew AS, Klei LR, Barchowsky A. 2001. Role of oxidative, AP-1, and hypoxia-responsive signaling pathways in induction of plasminogen activator inhibitor-1 (PAI-1) by nickel. Environ Health Perspect 60:212.
  • Smith KR, Klei LR, Barchowsky A. 2001. Arsenite stimulates plasma membrane NADPH oxidase activity in vascular endothelial cells. Am J Physiol 280(3):L442-L449. PMID:11159027
  • Soucy NV, Andrew AS, Barchowsky A. 2001. Nickel induces IL-8 expression in human airway epithelial cells. Environ Health Perspect 60:317.
  • Soucy NV, Klei LR, Barchowsky A. 2001. Mechanisms for arsenite-stimulated vascular cell angiogenic and profibrotic gene expression. Free Radic Biol Med 31:S62.

2000

  • Andrew AS, Barchowsky A. 2000. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Toxicol Appl Pharmacol 168(1):50-57. PMID:11000099
  • Andrew AS, Klei LR, Barchowsky A. 2000. Role of oxidative, AP-1, and hypoxia-responsive signaling pathways in induction of plasminogen activator inhibitor-1 (PAI-1) by nickel. Free Radic Biol Med 29:S53.
  • Barchowsky A, Frleta D, Vincenti MP. 2000. Integration of the NF-kB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 12(10):1469-1479. PMID:11023661
  • Barchowsky A, Klei LR, Smith KR, Ross CR. 2000. Oxidant signaling mechanisms initiated by low levels of arsenic in vascular cells. In: Metal Ions in Biology and Medicine. Vol. 6. John Libbey Eurotext, Paris, France. pp.47-49.
  • Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. 2000. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-jun N-terminal kinase, and nuclear factor B: Differential regulation of collagenase 1 and collagenase 3. Arthritis & Rheumatism 43(4):801-811. PMID:10765924
  • Roussel RR, Barchowsky A. 2000. Arsenic inhibits NF-kB-mediated gene transcription by blocking IkB kinase activity and IkBa phosphorylation and degradation. Arch Biochem Biophys 377(1):204-212.
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