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Your Environment. Your Health.

Project Publications: University of Florida: Dichloroacetate Kinetics, Metabolism and Human Toxicology

Superfund Research Program

Dichloroacetate Kinetics, Metabolism and Human Toxicology

Project Leader: Peter W. Stacpoole
Grant Number: P42ES007375
Funding Period: 1995 - 2000

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Publications

2000

  • Cornett-Mueller R, James MO, Ally A, Henderson GN, Cheung J, Ammini CV, Stacpoole PW, Shroads AL. 2000. Involvement of the tyrosine catabolic pathway in the inhibition of DCA metabolism. Society of Toxicology
  • James MO, Cornett R, Henderson GN, Shroads AL, Stacpoole PW. 2000. Destruction of glutathione S-transferase zeta protein by dichloroacetic acid treatment. British Pharmacological Society 131(Suppl.5):104P.

1999

  • Cornett R, James MO, Henderson GN, Cheung J, Shroads AL, Stacpoole PW. 1999. Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity. Biochem Biophys Res Commun 262(3):752-756. PMID:10471397

1998

  • Cornett R, James MO, Rocca J, Yan Z. 1998. In vivo metabolism of dichloroacetate (DCA) to the glycine in hippuric acid. Environ Health Perspect 42:328.
  • James MO, Yan Z, Cornett R, Jayanti VK, Henderson GN, Davydova N, Katovich MK, Pollock B, Stacpoole PW. 1998. Pharmacokinetics and metabolism of [14C] dichloroacetate (DCA) in the male Sprague-Dawley rat: identification of the glycine conjugates, including hippuric, as urinary metabolites of DCA. Drug Metab Dispos 26(11):1134-1143.
  • Pavlakis SG, Kingsley PB, Kaplan GP, Stacpoole PW, O'Shea M, Lustbader D. 1998. Magnetic resonance spectroscopy use in monitoring MELAS treatment. Arch Neurol 55:849-852. PMID:9626777
  • Stacpoole PW. 1998. Dichloroacetate treatment of congenital lactic acidosis: pros and cons. Japanese Journal for Inherited Metabolic Diseases 14:9-14.
  • Stacpoole PW, Henderson GN, Yan Z, Cornett R, James MO. 1998. Pharmokinetics, metabolism and toxicology of dichloroacetate. J Mol Biol 30(3):499-539. PMID:9710704
  • Stacpoole PW, Henderson GN, Yan Z, James MO. 1998. Clinical pharmacology and toxicology of dichloroacetate. Environ Health Perspect 106(4):989-994. PMID:9703483

1997

  • Henderson GN, Yan Z, James MO, Davydova N, Stacpoole PW. 1997. Kinetics and metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite. Biochem Biophys Res Commun 235(3):695-698. PMID:9207222
  • Stacpoole PW, Barnes CL, Hurbanis MD, Cannon SL, Kerr DS. 1997. Treatment of congenital lactic acidosis with dichloroacetate. Archives of Disease in Childhood 77(6):535-541. PMID:9496194
  • Yan Z, Henderson GN, James MO, Stacpoole PW. 1997. Determination of dichloroacetate and its metabolites in human plasma by gas chromatography-mass spectrometry. Journal of Chromatographic Science 703(1-2):75-84. PMID:9448064

1995

  • James MO, Jayanti VK, Henderson GN, Stacpoole PW. 1995. In vivo and in vitro metabolism of [14C]-dichloroacetic acid (DCA) in the male Sprague-Dawley rat. Environ Health Perspect 15:261.
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