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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of Florida: Molecular Mechanisms of Endocrine Disruption

Superfund Research Program

Molecular Mechanisms of Endocrine Disruption

Project Leader: Nancy D. Denslow
Co-Investigator: Patrick Larkin
Grant Number: P42ES007375
Funding Period: 2000-2006

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Publications

2020

2016

  • Martyniuk CJ, Doperalski NJ, Feswick A, Prucha MS, Kroll KJ, Barber DS, Denslow ND. 2016. Transcriptional networks associated with the immune system are disrupted by organochlorine pesticides in largemouth bass (Micropterus salmoides) ovary. Aquat Toxicol 177:405-416. doi:10.1016/j.aquatox.2016.06.009 PMID:27391359
  • Martyniuk CJ, Doperalski NJ, Prucha MS, Zhang J, Kroll KJ, Conrow R, Barber DS, Denslow ND. 2016. High contaminant loads in Lake Apopka's riparian wetland disrupt gene networks involved in reproduction and immune function in largemouth bass. Comp Biochem Physiol Part D Genomics Proteomics 19:140-150. doi:10.1016/j.cbd.2016.06.003 PMID:27397556

2014

  • Dominguez GA, Bisesi JH, Kroll KJ, Denslow ND, Sabo-Attwood TL. 2014. Control of transcriptional repression of the vitellogenin receptor gene in largemouth bass (Micropterus salmoides) by select estrogen receptors isotypes. Toxicol Sci 141(2):423-431. doi:10.1093/toxsci/kfu145 PMID:25061109 PMCID:PMC4271047

2013

2011

  • Doperalski NJ, Martyniuk CJ, Prucha MS, Kroll KJ, Denslow ND, Barber DS. 2011. Cloning and expression of the translocator protein (18 kDa), voltage-dependent anion channel, and diazepam binding inhibitor in the gonad of largemouth bass (Micropterus salmoides) across the reproductive cycle. Gen Comp Endocrinol 173(1):86-95. doi:10.1016/j.ygcen.2011.04.027 PMID:21600210 PMCID:PMC3144257 (Completed with ARRA Funds)

2010

  • Kocerha RJ, Prucha MS, Kroll KJ, Steinhilber D, Denslow ND. 2010. Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways. Endocrinology 151(1):341-349. doi:10.1210/en.2009-0551 PMID:19906818 PMCID:PMC2803149 (Completed with ARRA Funds)
  • Martyniuk CJ, Kroll KJ, Doperalski NJ, Barber DS, Denslow ND. 2010. Environmentally relevant exposure to 17 alpha-ethinylestradiol affects the telencephalic proteome of male fathead minnows. Aquat Toxicol 98(4):344-353. doi:10.1016/j.aquatox.2010.03.007 PMID:20381887 PMCID:PMC2874657 (Completed with ARRA Funds)

2009

  • Martyniuk CJ, Kroll KJ, Porak WF, Steward C, Grier HJ, Denslow ND. 2009. Seasonal relationship between gonadotropin, growth hormone, and estrogen receptor mRNA expression in the pituitary gland of largemouth bass. Gen Comp Endocrinol 163(3):306-317. doi:10.1016/j.ygcen.2009.04.028 PMID:19416730 PMCID:PMC4188826 (Completed with ARRA Funds)

2008

2007

  • Barber DS, McNally AJ, Garcia-Reyero N, Denslow ND. 2007. Exposure to p,p'-DDE or dieldrin during the reproductive season alters hepatic CYP expression in largemouth bass (Micropterus salmoides). Aquat Toxicol 81(1):27-35. doi:10.1016/j.aquatox.2006.10.008 PMID:17145087 PMCID:PMC1847780 (Completed with ARRA Funds)

2004

  • Doi AM, Pham RT, Hughes EM, Barber DS, Gallagher EP. 2004. Molecular cloning and characterization of a glutathione S-transferase from largemouth bass (Micropterus salmoides) liver that is involved in the detoxification of 4-hydroxynonenal. Biochem Pharmacol 67(11):2129-2139. doi:10.1016/j.bcp.2004.01.024 PMID:15135309
  • Henson KL, Gallagher EP. 2004. Glutathione S-transferase expression in pollution-associated hepatic lesions of brown bullheads (Ameiurus nebulosus) from the Cuyahoga River, Cleveland, Ohio. Toxicol Sci 80(1):26-33. PMID:15071171
  • Hughes EM, Gallagher EP. 2004. Effects of 4-nonylphenol and 17 Beta-estradiol on phase two antioxidant gene expression in largemouth bass liver. Comp Biochem Physiol C Toxicol Pharmacol 137(3):237-247.
  • Hughes EM, Gallagher EP. 2004. Effects of beta-naphthoflavone on hepatic biotransformation and glutathione biosynthesis in largemouth bass (Micropterus salmoides). Mar Environ Res 58(2-5):675-679. doi:10.1016/j.marenvres.2004.03.061 PMID:15178098
  • Pham RT, Barber DS, Gallagher EP. 2004. GSTA is the major gene responsible for 4-hydroxynonenal metabolism in largemouth bass liver. Mar Environ Res 58(2-5):485-488. PMID:15178070
  • Sabo-Attwood TL, Kroll KJ, Denslow ND. 2004. Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol. Mol Cell Endocrinol 218(1-2):107-118. doi:10.1016/j.mce.2003.12.007 PMID:15130515
  • Sepulveda MS, Gallagher EP, Gross TS. 2004. Effects of pulp mill effluents on health and reproductive parameters and in largemouth bass. Environ Sci Technol 13:291-301.
  • Sepulveda MS, Gallagher EP, Wieser CM, Gross TS. 2004. Reproductive and biochemical biomarkers in largemouth bass sampled downstream of a pulp and paper mill in Florida. Ecotoxicol Environ Saf 57(3):431-440. doi:10.1016/j.ecoenv.2003.08.020 PMID:15041266

2003

  • Denslow ND, Knoebl I, Larkin P. 2003. Approaches in proteomics and genomics for eco-toxicology. Chapter Vol. 6 in: Biochemistry and Molecular Biology of Fishes-Environmental Toxicology. Elsevier, Amsterdam, Netherlands.
  • Kocerha RJ, Kroll KJ, Denslow ND. 2003. Steroidogenic Acute Regulatory Protein (StAR Protein) activity in fish. In: Society of Toxicology, 42nd Annual Meeting, March. Salt Lake City, UT.
  • Larkin P, Folmar LC, Hemmer MJ, Poston AJ, Denslow ND. 2003. Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray. EHP Toxicogenomics 111(1T):29-36. PMID:12735107
  • Larkin P, Knoebl I, Denslow ND. 2003. Differential gene expression analysis in fish exposed to endocrine disrupting compounds. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 136(2):149-161. PMID:14529741
  • Larkin P, Sabo-Attwood TL, Kelso J, Denslow ND. 2003. Analysis of gene expression patterns in largemouth bass throughout their reproductive cycle and with exposure to p, p ' DDE using gene arrays. Ecotoxicology 72(1):738Suppl.S.
  • Larkin P, Sabo-Attwood TL, Kelso J, Denslow ND. 2003. Analysis of gene expression patterns in largemouth bass throughout their reproductive cycle and with exposure to p, p ' DDE using gene arrays. In: Society of Toxicology, 42nd Annual Meeting, March. Salt Lake City, UT.
  • Larkin P, Sabo-Attwood TL, Kelso J, Denslow ND. 2003. Analysis of gene expression profiles in largemouth bass exposed to 17-beta-estradiol and to anthropogenic contaminants that behave as estrogens. Ecotoxicology 12(6):463-468. PMID:14680325
  • Sabo-Attwood TL, Denslow ND. 2003. Estrogen Receptor Alpha, but not Beta or Gamma Expression is induced by Estradiol and Xenoestrogens in Largemouth Bass (Micropterus salmoides) liver Tissue. In: Society of Toxicology, 42nd Annual Meeting, March. Salt Lake City, UT.

2002

  • Bowman CJ, Kroll KJ, Gross TS, Denslow ND. 2002. Estradiol-induced gene expression in largemouth bass (Micropterus salmoides). Mol Cell Endocrinol 196(1-2):67-77. PMID:12385826
  • Doi AM, Gallagher EP. 2002. Isolation and cloning of a major glutathione S-transferase from largemouth bass (Micropterus salmoides). In: Proceedings of the 41st Annual Meeting of the Society of Toxicology (SOT), March 17-21, 2002. Nashville, TN.
  • Gallagher EP. 2002. Cloning and expression of a novel glutathione S-transferase that provides protection against oxidative injury in largemouth bass liver. In: Proceedings of the Aquatic Toxicology Workshop. Whistler, British Columbia.
  • Gallagher EP. 2002. Conservation of a glutathione S-transferase that provides protection against oxidative injury in largemouth bass. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC), 23rd Annual Meeting, Salt Lake City, Utah. November 16 - 20.
  • Hughes EM, Gallagher EP. 2002. Effects of natural and synthetic extrogens on largemouth bass hepatic oxidant defense pathways. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC), 23rd Annual Meeting, Salt Lake City, Utah. November 16 - 20.
  • Kocerha RJ, Sabo-Attwood TL, Upp JJ, Nelson MS, Denslow ND. 2002. The regulation of the steroidogenic acute regulatory protein (Star Protein) in largemouth bass (Micropterus salmoides). In: Proceedings of the 41st Annual Meeting of the Society of Toxicology (SOT), March 17-21, 2002. Nashville, TN.
  • Larkin P, Folmar LC, Hemmer MJ, Poston AJ, Lee HS, Denslow ND. 2002. Array Technology as a tool to monitor exposure of fish to xenoestrogens. Mar Environ Res 54(3-5):395-399. PMID:12408593
  • Larkin P, Sabo-Attwood TL, Kelso J, Denslow ND. 2002. Expression profiling of largemouth bass (Micropterus salmoides) exposed to estradiol, nonylphenol, and p,p'-DDE. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC), 23rd Annual Meeting, Salt Lake City, Utah. November 16 - 20.
  • Larkin P, Sabo-Attwood TL, Kelso J, Denslow ND. 2002. Gene expression analysis of largemouth bass exposed to estradiol, nonylphenol, and p,p'-DDE. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 133(4):543-557. PMID:12470818
  • Pham RT, Gardner JL, Gallagher EP. 2002. Conjugation of 4-hydroxynonenal by largemouth bass (Micropterus salmoides) glutathione S-transferases. Mar Environ Res 54(3-5):291-295. PMID:12408579
  • Sabo-Attwood TL, Larkin P, Kelso J, Denslow ND. 2002. Changes in largemouth bass gene expression following acute exposure to nonylphenol. In: Proceedings of the Society of Toxicology and Chemistry, November. Salt Lake City, UT.
  • Sabo-Attwood TL, Larkin P, Kelso J, Denslow ND. 2002. Gene Expression Profiles of Largemouth Bass Exposed to Nonylphenol and ICI 182,780. In: Proceedings of the International Congress on the Biology of Fish, July 21-26. Vancouver, Canada.
  • Sabo-Attwood TL, Nelson MS, Upp JJ, Denslow ND. 2002. Differential expression of three estrogen receptor isotypes during largemouth bass (micropterus salmoides) reproduction and following exposure to nonylphenol. In: Proceedings of the 41st Annual Meeting of the Society of Toxicology (SOT), March 17-21, 2002. Nashville, TN.

2001

  • Denslow ND, Bowman CJ, Ferguson RJ, Lee HS, Hemmer MJ, Folmar LC. 2001. Induction of gene expression in sheepshead minnows (Cyprinodon varigatus) treated with 17-p-estradiol, diethylstilbestrol or ethinylestradiol: the use of mRNA fingerprint as an indicator of gene regulation. Gen Comp Endocrinol 121:250-260. PMID:11254367
  • Denslow ND, Lee HS, Bowman CJ, Hemmer MJ, Folmar LC. 2001. Multiple responses in gene expression in fish treated with estrogen. Comp Biochem Physiol 129(2-3):277-282. doi:10.1016/S1096-4959(01)00322-0 PMID:11399460
  • Gallagher EP, Gross TS, Sheehy KM. 2001. Decreased glutathione S-transferase expression and activity and altered sex steroids in Lake Apopka brown bullheads (Ameriurus nebulosus). Aquat Toxicol 55(3-4):223-237. PMID:11595311
  • Henson KL, Stauffer G, Gallagher EP. 2001. Induction of glutathione S-transferase activity and protein expression in brown bullhead (Ameriurus nebulosus) liver by ethoxyquin. Toxicol Sci 62(1):54-60. PMID:11399793

2000

  • Bowman CJ, Kroll KJ, Hemmer MJ, Folmar LC, Denslow ND. 2000. Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus). Gen Comp Endocrinol 120(3):300-313. PMID:11121295

1999

  • Bowman CJ, Denslow ND. 1999. Development and validation of a species- and gene-specific molecular biomarker: Vitellogenin mRNA in largemouth bass (Micropterus salmoides). Ecotoxicology 8:399-416.
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