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Project Publications: University of Kentucky: Activation of PCBs to Genotoxins in vivo

Superfund Research Program

Activation of PCBs to Genotoxins in vivo

Project Leader: Larry W. Robertson (University of Iowa)
Grant Number: P42ES007380
Funding Period: 1997 - 2005

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Publications

2006

  • Feliciano JS, Xu S, Guan X, Lehmler H, Bachas LG, Daunert S. 2006. ClcR-based biosensing system in the detection of cis-dihydroxylated (chloro-)biphenyls. Anal Bioanal Chem 385(5):807-813. PMID:16791559
  • Kunz S, Schwarz M, Schilling B, Papke O, Lehmler H, Robertson LW, Schrenk D, Schmitz H. 2006. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicol Lett 164(2):133-143. PMID:16426774
  • Ptak A, Ludewig G, Robertson LW, Lehmler H, Gregoraszczuk EL. 2006. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: Effects on sex hormone levels and aromatase activity. Toxicol Lett 164(2):113-122. PMID:16412591

2005

  • Espandiari P, Robertson LW, Srinivasan C, Glauert HP. 2005. Comparison of different initiation protocols in the resistant hepatocyte model. Toxicology 206(3):373-381. PMID:15588927
  • Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler H, Lee EY, Robertson LW, Spear BT. 2005. Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats. J Nutr 135(2):283-286. PMID:15671227
  • Hennig B, Toborek M, Ramadass P, Ludewig G, Robertson LW, Arif JM. 2005. Polychlorinated biphenyls, oxidative stress and diet. Chapter Vol. 3 in: Reviews in Food and Nutrition Toxicity. CRC Press, Inc., Boca Raton, DE. pp.93-128.

2004

  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2004. Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model. Toxicol Sci 79(1):41-46. PMID:14976334
  • Gauger KJ, Kato Y, Haraguchi K, Lehmler H, Robertson LW, Bansal R, Zoeller RT. 2004. Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environ Health Perspect 112(5):516-523. PMID:15064154
  • Hennig B, Reiterer G, Toborek M, Daugherty A, Smart EJ, Matveev SV, Robertson LW. 2004. Dietary fat interacts with PCBs to induce changes in lipid metabolism in LDL receptor deficient mice. Organohalogen Compounds 66:2903-2906.
  • Hennig B, Toborek M, Robertson LW. 2004. Proinflammatory mechanisms of PCB toxicity in the vascular endothelium. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Lu Z, Lee EY, Robertson LW, Glauert HP, Spear BT. 2004. Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-B. Toxicol Sci 81(1):35-42.

2003

  • Arif JM, Lehmler H, Robertson LW, Gupta RC. 2003. Interaction of benzoquinone- and hydroquinone-derivatives of lower chlorinated biphenyls with DNA and nucleotides in vitro. Chem Biol Interact 142(3):307-316. PMID:12453668
  • Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. 2003. PCB 104 induces oxidative stress and stimulates proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis. FASEB J 17:A272.
  • Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. 2003. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol Appl Pharmacol 189(1):1-10. PMID:12758055
  • Lehmler H, Price DJ, Garrison AW, Birge WJ, Robertson LW. 2003. Distribution of PCB 84 Enantiomers in C57BL/6 Mice. Fresenius Environmental Bulletin 12(2):254-260.
  • Lehmler H, Price DJ, Garrison AW, Birge WJ, Robertson LW. 2003. Distribution of PCB 84 atropisomers in female C57BL/6 mice. Presented at the 42nd Annual Meeting of the Society of Toxicology in Salt Lake City, Utah, March 9-13, 2003. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Lu Z, Robertson LW, Spear BT, Glauert HP. 2003. Effect of 2,2', 4,4', 5,5' -hexachlorobiphenyl (PCB153) on gene expression in mice deficient in the P50 subunit of NF-kappa B. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Ludewig G, Tampal N, Robertson LW. 2003. Comparative study of PCB, Pbb and PBDE mixtures on serum parameters in the rat. Presented at the 42nd Annual Meeting of the Cociety of Toxicology in Salt Lake City, Utan, March 9-13, 2003. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Sulkowski WW, Kania-Korwel I, Robertson LW. 2003. Polychlorinated biphenyls production in Poland. Fresenius Environmental Bulletin 12:152-157.
  • Sulkowski WW, Kania-Korwel I, Robertson LW, Szafran B, Lulek J. 2003. Post-production polychlorinated biphenyls levels in soil. Fresenius Environmental Bulletin 12:158-164.
  • Tampal N, Myers S, Robertson LW. 2003. Binding of polychlorinated biphenyls/metabolites to hemoglobin. Toxicol Lett 142(1-2):53-60. PMID:12765239
  • Tampal N, Robertson LW, Srinivasan C, Ludewig G. 2003. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicol Appl Pharmacol 187(3):168-177. PMID:12662900
  • Wlodarczyk-Makula M, Sulkowski WW, Popenda A, Robertson LW. 2003. The influence of sewage and sludge treatment processes on concentrations of polycyclic aromatic hydrocarbons. Fresenius Environmental Bulletin 12:338-342.

2002

  • Espandiari P, Glauert HP, Robertson LW. 2002. Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. Toxicol Sci 66:310.
  • Hansen LA, Machala M, James MO, Hennig B, Glauert HP, Narbonne J, van Bree L, Schultz T, Grevatt P, Suk WA, Holoubek I, Robertson LW. 2002. Research needs identified. In: Proceedings of the 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2002. Brno, Czech Republic.
  • Hansen LG, Machala M, Fischer L, James MO, Hennig B, Glauert HP, Narbonne J, van Bree L, Schultz T, Grevett P, Suk WA, Holoubek I, Robertson LW. 2002. Research needs identified at the second PCB Workshop in Brno, Czech Republic. Toxicol Sci 87(3):261-265. doi:10.1080/02772240500079011
  • Hennig B, Hammock BD, Slim RM, Toborek M, Viswanathan S, Robertson LW. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int J Hyg Environ Health 205(1-2):95-102. PMID:12018021
  • Hennig B, Meerarani P, Slim RM, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 181(3):174-183. PMID:12079426
  • Hennig B, Meerarani P, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs. Organohalogen Compounds 55:355-358.
  • Lehmler H, Robertson LW, Parkin S. 2002. 2-(3,5-Dichlorophenyl)-1,4-benzoquinone. Acta Crystallogr B E58:o366-o367.
  • Lehmler H, Robertson LW, Parkin S, Brock CP. 2002. Z'=4 structure without obvious pseudosymmetry: implications for the formation of solid-state compounds. Acta Crystallogr B 58(Pt1):140-147. PMID:11818662
  • Machala M, Blaha L, Pliskova M, Vondracek J, Lehmler H, Malmberg T, Robertson LW. 2002. Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines. Organohalogen Compounds 56:25-28.
  • Pereg D, Robertson LW, Gupta RC. 2002. DNA adduction by polychlorinated biphenyls: adducts derived from hepatic microsomal activation and from synthetic metabolites. Chem Biol Interact 139(2):129-144. PMID:11823002
  • Srinivasan A, Robertson LW, Ludewig G. 2002. Sulfhydryl binding and topoisomerase inhibition by PCB Metabolites. Chem Res Toxicol 15(4):497-505. PMID:11952335
  • Tampal N, Lehmler H, Espandiari P, Malmberg T, Robertson LW. 2002. Glucuronidation of hydroxylated polychlorinated biphenyls (PCBs). Chem Res Toxicol 15(10):1259-1266. doi:10.1021/tx0200212 PMID:12387623
  • Tampal N, Robertson LW, Ludewig G. 2002. In vivo MDR1 transport studies with PCB 77. Organohalogen Compounds 55:457-459.
  • Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2002. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by Polychlorinated Biphenyls. Toxicol Appl Pharmacol 179(3):172-184. PMID:11906247
  • Toborek M, Lee YW, Kaiser S, Hennig B. 2002. Measurement of inflammatory properties of fatty acids in human endothelial cells. Chapter 352 in: Methods in Enzymology, Redox Cell Biology and Genetics. Academic Press, New York, NY. pp.198-219.

2001

  • Espandiari P, Twaroski TP, Festag M, Lee EY, Glauert HP, Robertson LW. 2001. Effect of 4-chlorobiphenyl as an initiator of rat liver carcinogenisis. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.399-401.
  • Festag M, Ludewig G, Srinivasan A, Robertson LW, Steinberg P. 2001. PCB-3, PCB-77 und verschiedene PCB Metabolite verursachen keine Einselstrangbruche in DNA in vitro und/oder in vivo. In: Proceedings of the 42nd Fruhjahrstagung of the German Society for Experimental and Clinical Pharmacology and Toxicology, March 13-15, 2001. Mainz, Germany.
  • Ludewig G, Srinivasan A, Robertson LW. 2001. Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion. Cent Eur J Public Health 8:15-17. PMID:10943438
  • Oakley GG, Roe AL, Blouin RA, Twaroski TP, Ganguly TC, Vore M, Lehmler H, Robertson LW. 2001. 2,4,4'-trichlorobiphenyl increases STAT5 transcriptional activity. Mol Carcinog 30(4):199-208. PMID:11346882
  • Pereg D, Tampal N, Espandiari P, Robertson LW. 2001. Distribution and macromolecular binding of benzo[a]pyrene and two polychlorinated biphenyl congeners in female mice. Chem Biol Interact 137(3):243-258. PMID:11566292
  • Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
  • Srinivasan A, Espandiari P, Robertson LW, Ludewig G. 2001. Intracellular oxidative stress produced by PCB metabolites. Environ Health Perspect 60(1):1127.
  • Tampal N, Robertson LW, Lehmler H, Srinivasan C, Ludewig G. 2001. PCBs as Substrates for the MDR Transporter. Environ Health Perspect 60(1):1118.
  • Twaroski TP, O'Brien ML, Larmonier N, Glauert HP, Robertson LW. 2001. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E and oxidative stress in the rat liver. Toxicol Appl Pharmacol 171(2):85-93. PMID:11222084
  • Twaroski TP, O'Brien ML, Robertson LW. 2001. Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes and selenium status: implications for oxidative stress. Biochem Pharmacol 62(3):273-281. PMID:11434900

2000

  • Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. Toxicol Sci 54(1):76.
  • McLean MR, Twaroski TP, Robertson LW. 2000. Redox cycling of 2-(x'-mono, -di, -trichlorophenyl)- 1, 4-benzoquinones, oxidation products of polychlorinated biphenyls. Arch Biochem Biophys 376(2):449-455. doi:10.1006/abbi.2000.1754 PMID:10775433
  • Robertson LW, Espandiari P, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Ludewig G, Glauert HP, Arif JM, Gupta RC. 2000. Metabolism and activation of polychlorinated biphenyls (PCBs). Cent Eur J Public Health 8Suppl:14-15. PMID:10943437
  • Robertson LW, Gupta RC. 2000. Chapter 2: Metabolism of polychlorinated biphenyls (PCBs) generates electrophiles and reactive oxygen species that damage DNA. In: Molecular Drug Metabolism and Toxicology. OICA International Limited, London, United Kingdom. pp.16-32.
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates Polychlorinated Biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol 166(1):36-42. PMID:10873716
  • Srinivasan A, Robertson LW, Ludewig G. 2000. PCB metabolites: cytotoxicity, glutathione depletion and inhibition of topoisomerase II. Toxicol Sci 54(1):78.

1999

  • Arif JM, Robertson LW, Gupta RC. 1999. Artificial production of 8-oxodeoxyguanosine (8-oxodG) during tissue DNA processing and its inhibition. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.4251.
  • Espandiari P, Robertson LW, Ludewig G. 1999. Dihydroxybiphenyls: A structure-activity comparison. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.328.
  • Espandiari P, Srinivasan A, Robertson LW, Ludewig G. 1999. Structure activity relationships for strand break induction and toxicity of lower halogenated dihydroxy-biphenyls. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.2259.
  • Lu Z, Spear BT, Lee EY, Robertson LW, Glauert HP. 1999. Activation of hepatic NF-ÇB by a single dose of Polychlorinated Biphenyls (PCBs). FASEB J 13:681.10.
  • Slim RM, Toborek M, Malecki A, Robertson LW, Hennig B. 1999. Protective role of vitamin E on PCB-induced dysfunction of vascular endothelial cells. FASEB J 13:651.17.
  • Srinivasan A, Espandiari P, Robertson LW, Ludewig G. 1999. DNA strand break induction by the PCB metabolite 4-chloro-2',5'-dihydroxybiphenyl. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.2258.
  • Srinivasan A, Lehmler H, Shaw JR, Robertson LW, Ludewig G. 1999. Superoxide production and glutathione binding by hydroquinone and p-quinone metabolites of Polychlorinated Biphenyls (PCBs). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.4261.
  • Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 1999. Effect of the PCBs 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 3,3',4,4'-tetrachlorobiphenyl (PCB-77) on cell proliferation and the activation of the transcription factors NF-ÇB and AP-1 in rats treated with diethylnitrosamine (DEN). FASEB J 13:162.3.
  • Twaroski TP, Arif JM, Gupta RC, Robertson LW. 1999. Antioxidant enzyme levels and oxidative damage in rats exposed to selected Polychlorinated Biphenyls (PCBs) after maximal cytochrome P450 induction. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.4269.
  • Twaroski TP, Espandiari P, Robertson LW. 1999. Effects of selected PCB congeners on drug- and glutathione-metabolizing enzymes in the rat. Toxicol Sci 48(1-S):

1998

  • Arif JM, Gairola CG, Glauert HP, Kelloff GJ, Lubet RA, Gupta RC. 1998. Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz. Carcinogenesis 19(8):1515-1517. PMID:9744551
  • Bachas LG, Daunert S, Robertson LW. 1998. Information dissemination and outreach activities at the University of Kentucky. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.69.
  • de Boer J, Robertson LW, Dettmer F, Wichmann H, Bahadir M. 1998. Polybrominated diphenyl- ethers in human adipose tissue and relation with watching television - a case study. Organohalogen Compounds 35:407-410.
  • Espandiari P, Ludewig G, Glauert HP, Robertson LW. 1998. Activation of hepatic NF-ÇB by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats. J Biochem Mol Toxicol 12:339-344. PMID:9736482
  • Glauert HP, Lu Z, Al-bayati Z, Lee EY, Robertson LW. 1998. Effects of PCBs on hepatic lipid peroxidation and transcription factor activation in rats. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.9.
  • Ludewig G, Espandiari P, Srinivasan A, Robertson LW. 1998. Reactive oxygen species (ROS) and genotoxicity associated with PCB metabolism. Pol J Pharmacol 50(83):
  • Ludewig G, Srinivasan A, Espandiari P, Robertson LW. 1998. Generation of reactive oxygen species (ROS) and genotoxicity by metabolites of polychlorinated biphenyls (PCBs). Organohalogen Compounds 37:143-146.
  • McLean MR, Twaroski TP, Robertson LW. 1998. A new mechanism of toxicity for polychlorinated biphenyls (PCBs): Redox cycling and superoxide generation. Organohalogen Compounds 37:59-62.
  • Oakley GG, Roe AL, Blouin RA, Ganguly TC, Vore M, Robertson LW. 1998. Activation of AP-1 and STAT transcription factors by non-coplanar Polychlorinated Biphenyls (PCBs). Toxicol Sci 42:133.
  • Robertson LW, Amaro AR, Bauer U, Lehmler H, Shaw JR, McLean MR, Twaroski TP, Oakley GG, Arif JM, Gupta RC. 1998. A new mechanism of toxicity for Polychlorinated Biphenyls (PCBs). Pol J Pharmacol 50(84):
  • Slim RM, Toborek M, Robertson LW, Hennig B. 1998. Linoleic acid amplifies PCB-mediated dysfunction of endothelial cells. FASEB J 12(5):A1008.
  • Toborek M, Slim RM, Robertson LW, Hennig B. 1998. Linoleic acid amplifies PCB-mediated dysfunction of endothelial cells. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.11.
  • Twaroski TP, Robertson LW. 1998. PCB-induced oxidative stress and effects on glutathione, glutathione peroxidase and catalase. Toxicol Sci 42:153.

1997

  • Arif JM, Gairola CG, Glauert HP, Kelloff GJ, Lubet RA, Gupta RC. 1997. Effects of dietary supplementation of N-acetylcysteine on cigarette smoke-related DNA adducts in rat tissues. Int J Oncol 11:1227-1233. PMID:21528327
  • Gierthy JF, Yang Y, Robertson LW, Oakley GG, Arcaro KF, Vakharia D. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. Environ Health Perspect 36(1):159.
  • Leung LK, Glauert HP. 1997. Lack of correlation between hepatic prostaglandin concentrations and DNA synthesis after the administration of phenobarbital and the peroxisome proliferator ciprofibrate in rats. Toxicology 123:101-109. PMID:9347925
  • Leung LK, Johnson M, Glauert HP. 1997. Effect of gadolinium chloride-induced Kupffer cell inactivation on liver regeneration in rats. Environment & Nutrition Interactions 1:13-22.
  • McLean MR, Twaroski TP, Robertson LW. 1997. Redox-cycling of catechol and hydroquinone metabolites of polychlorinated biphenyls (PCBs). Fundam Appl Toxicol 36:159.
  • Peebles RS, Glauert HP. 1997. Effect of phenobarbital on hepatic eicosanoid concentrations in rats. Arch Toxicol 71(10):646-650. PMID:9332702
  • Robertson LW, Amaro AR, Bauer U, Espandiari P, Ludewig G, McLean MR, Oakley GG, Twaroski TP, Gupta RC. 1997. Oxidative DNA Damage Induced by Polychlorinated Biphenyls (PCBs). New Activation Mechanisms. In: Proceedings of the DOD (Department of Defense ) Breast Cancer Research Program Meeting. Washington, DC. pp.211.

1996

  • Amaro AR, Oakley GG, Bauer U, Spielmann HP, Robertson LW. 1996. Metabolic activation of PCBs to quinones: reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase. Chem Res Toxicol 9:623-629. PMID:8728508
  • Hong JT, Glauert HP. 1996. Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. Journal of Cellular Physiology 169:309-319. PMID:8908198
  • Leung LK, Glauert HP. 1996. Reduction of the concentrations of prostaglandins E2 and F, and thromboxane b2 in cultured rat hepatocytes treated with the peroxisome proliferator ciprofibrate. Toxicol Lett 85(3):143-149.
  • Li Y, Leung LK, Glauert HP, Spear BT. 1996. Activation of hepatic NF-ÇB by phenobarbital in rats. Biochem Biophys Res Commun 229(3):982-989.
  • Li Y, Leung LK, Glauert HP, Spear BT. 1996. Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-ÇB activity. Carcinogenesis 17(11):2305-2309. PMID:8968042
  • Ludewig G, Oakley GG, Espandiari P, Robertson LW. 1996. Production of superoxide and DNA strand breaks by diol metabolites of lower chlorinated biphenyls (PCBs). In: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.989.
  • McLean MR, Bauer U, Amaro AR, Robertson LW. 1996. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem Res Toxicol 9:158-164. PMID:8924585
  • McLean MR, Robertson LW, Gupta RC. 1996. Detection of PCB-adducts by the 32P- postlabeling technique. Chem Res Toxicol 9:165-171. PMID:8924587
  • Nilakantan V, Li Y, Glauert HP, Spear BT. 1996. Increased liver-specific catalase activity in transgenic mice. DNA Cell Biol 15:625-630. PMID:8769564
  • Oakley GG, Devanaboyina U, Robertson LW, Gupta RC. 1996. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs). In: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.996.
  • Oakley GG, Devanaboyina U, Robertson LW, Gupta RC. 1996. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): Implications for PCB induced oxidative stress in breast cancer. Chem Res Toxicol 9:1285-1292. PMID:8951230
  • Oakley GG, Robertson LW, Gupta RC. 1996. Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling. Carcinogenesis 17:109-114. PMID:8565118
  • Silberhorn EM, Birge WJ, Robertson LW. 1996. SARs and mechanisms of action for PCB congeners: Fathead minnow developmental toxicity. In: Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting 1996. Washington, DC. pp.P0936.

1995

  • Bauer U, Amaro AR, Robertson LW. 1995. A new strategy for the synthesis of polychlorinated biphenyl metabolites. Chem Res Toxicol 8:92-95. PMID:7703372
  • Espandiari P, Thomas VA, Glauert HP, O'Brien ML, Noonan D, Robertson LW. 1995. The herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a peroxisome proliferator in rats. Fundam Appl Toxicol 26(1):85-90. PMID:7657066
  • Hong JT, Wilson MW, Glauert HP. 1995. Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. J Biochem Toxicol 10(5):239-243. PMID:8847705
  • Wilson MW, Lay LT, Chow CK, Tai H, Robertson LW, Glauert HP. 1995. Altered hepatic eicosanoid concentrations in rats treated with the peroxisome proliferators ciprofibrate and perfluorodecanoic acid. Arch Toxicol 69(7):491-497. PMID:8526745
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