Superfund Research Program

Vascular Mechanisms of PCB-Induced Brain Metastases

Project Leader: Michal Toborek (University of Miami)
Grant Number: P42ES007380
Funding Period: 2000-2014

Project-Specific Links

Publications

2015

• Eum SY, Jaraki D, Andras IE, Toborek M. 2015. Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2. Toxicol Appl Pharmacol 287(3):258-266. doi:10.1016/j.taap.2015.06.011 PMID:26080028 PMCID:PMC4574485

2014

• Rownicka-Zubik J, Sulkowski L, Toborek M. 2014. Interactions of PCBs with human serum albumin: in vitro spectroscopic study. Spectrochim Acta A Mol Biomol Spectrosc 124c:632-637. doi:10.1016/j.saa.2014.01.069 PMID:24513710 PMCID:PMC4033824

2013

• Chen L, Zhang B, Toborek M. 2013. Autophagy is involved in nanoalumina-induced cerebrovascular toxicity. Nanomedicine-Nanotechnology Biology and Medicine 9:212-221. doi:10.1016/j.nano.2012.05.017 PMID:22687898 PMCID:PMC3482418
• Choi J, Eum SY, Rampersaud E, Daunert S, Abreu MT, Toborek M. 2013. Exercise attenuates PCB-induced changes in the mouse gut microbiome. Environ Health Perspect 121(6):725-730. doi:10.1289/ehp.1306534 PMID:23632211 PMCID:PMC3672930
• Wrobel JK, Seelbach MJ, Chen L, Power RF, Toborek M. 2013. Supplementation with selenium-enriched yeast attenuates brain metastatic growth. Nutr Cancer 65(4):563-570. doi:10.1080/01635581.2013.775315 PMID:23659448
• Zhang B, Choi J, Eum SY, Daunert S, Toborek M. 2013. TLR4 signaling is invovled in brain vascular toxicity of PCB153 bound to nanoparticles. PLoS One 8(5):e63159. doi:10.1371/journal.pone.0063159 PMID:23690990 PMCID:PMC3653967

2012

• Chen L, Choi J, Choi Y, Hennig B, Toborek M. 2012. HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits. Neurobiol Aging 33:1579-1590. doi:10.1016/j.neurobiolaging.2011.06.004 PMID:21764480 PMCID:PMC3206197
• Nakagawa S, Castro V, Toborek M. 2012. Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier. J Cell Mol Med 16(12):2950-2957. doi:10.1111/j.1582-4934.2012.01622.x PMID:22947176 PMCID:PMC3524391
• Sipos E, Chen L, Andras IE, Wrobel JK, Zhang B, Pu H, Park M, Eum SY, Toborek M. 2012. Proinflammatory adhesion molecules facilitate polychlorinated biphenyl–mediated enhancement of brain metastasis formation. Toxicol Sci 126(2):362-371. doi:10.1093/toxsci/kfr349 PMID:22240979 PMCID:PMC3307603
• Zhang B, Chen L, Choi J, Hennig B, Toborek M. 2012. Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles. J Neuroimmune Pharmacol 7(4):991-1001. doi:10.1007/s11481-012-9403-y PMID:23081707 PMCID:PMC3518694
• Zheng Y, Morris AJ, Sunkara M, Layne J, Toborek M, Hennig B. 2012. Epigallocatechin-gallate stimulates NF-E2-related factor and heme oxygenase-1 via caveolin-1 displacement. J Nutr Biochem 23(2):163-168. doi:10.1016/j.jnutbio.2010.12.002 PMID:21447442 PMCID:PMC4309924
• Zhong Y, Zhang B, Eum SY, Toborek M. 2012. HIV-1 tat triggers nuclear localization of ZO-1 via Rho signaling and cAMP response element-binding protein activation. J Neurosci 32(1):143-150. doi:10.1523/JNEUROSCI.4266-11.2012 PMID:22219277 PMCID:PMC3566645
• Zhu H, Zhao J, Zhu B, Collazo J, Gal J, Shi P, Liu L, Strom A, Lu X, McCann RO, Toborek M, Kyprianou N. 2012. EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer. Prostate 72(1):72-81. doi:10.1002/pros.21408 PMID:21563192 PMCID:PMC3158271

2011

• Huang W, Andras IE, Rha GB, Hennig B, Toborek M. 2011. PPAR alpha and PPAR gamma protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. FASEB J 25:3979-3988. doi:10.1096/fj.11-188607 PMID:21840940 PMCID:PMC3205841
• Layne J, Majkova Z, Smart EJ, Toborek M, Hennig B. 2011. Caveolae: A regulatory platform for nutritional modulation of inflammatory diseases. J Nutr Biochem 22(9):807-811. doi:10.1016/j.jnutbio.2010.09.013 PMID:21292468 PMCID:PMC3139026
• Majkova Z, Layne J, Sunkara M, Morris AJ, Toborek M, Hennig B. 2011. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Toxicol Appl Pharmacol 251(1):41-49. doi:10.1016/j.taap.2010.11.013 PMID:21130106 PMCID:PMC3026064
• Shang Y, Chen L, Toborek M, Yu G. 2011. Diffuse optical monitoring of repeated cerebral ischemia in mice. Opt Express 19(21):20301-20315. doi:10.1364/OE.19.020301 PMID:21997041 PMCID:PMC3495871

2010

• Choi Y, Arzuaga X, Kluemper CT, Caraballo A, Toborek M, Hennig B. 2010. Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs. Environ Int 36(8):931-934. doi:10.1016/j.envint.2009.06.009 PMID:19608276 PMCID:PMC2889233
• Choi Y, Seelbach MJ, Pu H, Eum SY, Chen L, Zhang B, Hennig B, Toborek M. 2010. Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression. Environ Health Perspect 118(7):976-981. doi:10.1289/ehp.0901751 PMID:20299304 PMCID:PMC2920918
• Eum SY, Andras IE, Choi Y, Hennig B, Toborek M. 2010. Caveolae/lipid raft modulates TNF-alpha-induced upregulation of cell adhesion molecules in human brain endothelial cells. FASEB J 24:604.1.
• Eum SY, Choi Y, Andras IE, Hennig B, Toborek M. 2010. Lipid raft-dependent NADPH oxidase regulates polychlorinated biphenyls-induced expression of cell adhesion molecules in human brain endothelial cells. FASEB J 24:750.9.
• Han S, Eum SY, Toborek M, Smart EJ, Hennig B. 2010. Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice. Toxicol Appl Pharmacol 246(1-2):74-82. doi:10.1016/j.taap.2010.04.009 PMID:20406653 PMCID:PMC2895770
• Majkova Z, Toborek M, Hennig B. 2010. The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants. J Cell Mol Med 14(10):2359-2370. doi:10.1111/j.1582-4934.2010.01064.x PMID:20406324 PMCID:PMC2965309
• Seelbach MJ, Chen L, Powell A, Choi Y, Zhang B, Hennig B, Toborek M. 2010. Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation. Environ Health Perspect 118(4):479-484. doi:10.1289/ehp.0901334 PMID:20064788 PMCID:PMC2854723
• Zhang B, Chen L, Swartz KR, Bruemmer D, Eum SY, Huang W, Seelbach MJ, Choi Y, Hennig B, Toborek M. 2010. Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. J Neurosci Res 88(13):2859-2868. doi:10.1002/jnr.22450 PMID:20564349 PMCID:PMC2919635
• Zheng Y, Layne J, Toborek M, Hennig B. 2010. The roles of caveolin-1 and heme oxygenase-1 in EGCG-mediated protection against TNF-alpha-induced endothelial inflammation. FASEB J 24:541.10.
• Zheng Y, Toborek M, Hennig B. 2010. Epigallocatechin gallate mediated protection against tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent. Metabolism-Clinical and Experimental 59(10):1528-1535. doi:10.1016/j.metabol.2010.01.018 PMID:20580034
• Zhong Y, Hennig B, Toborek M. 2010. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. J Cereb Blood Flow Metab 30(3):522-533. doi:10.1038/jcbfm.2009.214 PMID:19794400 PMCID:PMC2949153

2009

• Arzuaga X, Ren N, Stromberg AJ, Black EP, Arsenescu V, Cassis LA, Majkova Z, Toborek M, Hennig B. 2009. Induction of gene pattern changes associated with dysfunctional lipid metabolism induced by dietary fat and exposure to a persistent organic pollutant. Toxicol Lett 189(2):96-101. doi:10.1016/j.toxlet.2009.05.008 PMID:19467301 PMCID:PMC2729430
• Chen L, Swartz KR, Toborek M. 2009. Novel surgical technique for direct substance or cell delivery into the cerebral vasculature. FASEB J 23:832.6.
• Chen L, Swartz KR, Toborek M. 2009. Vessel microport technique for applications in cerebrovascular research. J Neurosci Res 87(7):1718-1727. doi:10.1002/jnr.21973 PMID:19115415 PMCID:PMC2713928
• Choi Y, Eum SY, Hennig B, Toborek M. 2009. NADPH oxidase is involved in polychlorinated biphenylmediated alterations of tight junction proteins in cells ofthe gastrointestinal tract. FASEB J 23:570.7.
• Eum SY, Andras IE, Hennig B, Toborek M. 2009. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicol Appl Pharmacol 240(2):299-305. doi:10.1016/j.taap.2009.07.022 PMID:19632255 PMCID:PMC2760772
• Eum SY, Choi Y, Radakovic M, Andras IE, Hennig B, Toborek M. 2009. Polychlorinated biphenyls induce adhesion of breast cancer cells to human brain endothelium through lipid raft-dependent upregulation of cell adhesion molecules. FASEB J 23:739.22.
• Eum SY, Choi Y, Radakovic M, Andras IE, Toborek M. 2009. Lipid raft-associated signaling pathways are involved in polychlorinated biphenyl-induced disruption of tight junction in human brain endothelium. FASEB J 23:637.6.
• Majkova Z, Smart EJ, Hennig B. 2009. Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol Appl Pharmacol 237(1):1-7. doi:10.1016/j.taap.2009.02.016 PMID:19265715 PMCID:PMC2680936
• Seelbach MJ, Chen L, Choi Y, Yinan W, Layne J, Hennig B, Toborek M. 2009. Novel model of brain metastasis formation: the influence of polychlorinated biphenyls on blood-brain barrier integrity and brain metastasis. FASEB J 23:1020.9.
• Zheng Y, Lim EJ, Wang L, Smart EJ, Toborek M, Hennig B. 2009. Role of caveolin-1 in EGCG-mediated protection against linoleic-acid-induced endothelial cell activation. J Nutr Biochem 20:202-209. doi:10.1016/j.jnutbio.2008.02.004 PMID:18656337 PMCID:PMC2655117
• Zheng Y, Oesterling EG, Toborek M, Hennig B. 2009. Flavonoids protect against endothelial dysfunction by induction of hemeoxygenase-1. FASEB J 23:717.11.

2008

• Chen L, Yokel R, Hennig B, Toborek M. 2008. Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. J Neuroimmune Pharmacol 3(4):286-295. doi:10.1007/s11481-008-9131-5 PMID:18830698 PMCID:PMC2771674
• Eum SY, András IE, Couraud P, Hennig B, Toborek M. 2008. Pcbs and tight junction expression. Environ Toxicol Pharmacol 25(2):234-240. doi:10.1016/j.etap.2007.10.019 PMID:18438464 PMCID:PMC2346445
• Lim EJ, Májková Z, Xu S, Bachas LG, Arzuaga X, Smart EJ, Tseng M, Toborek M, Hennig B. 2008. Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chem Biol Interact 176(2-3):71-78. doi:10.1016/j.cbi.2008.08.007 PMID:18786521 PMCID:PMC2603293
• Majkova Z, Oesterling EG, Toborek M, Hennig B. 2008. Impact of nutrition on PCB toxicity. Environ Toxicol Pharmacol 25:192-196. doi:10.1016/j.etap.2007.10.015 PMID:21783859
• Shen H, Arzuaga X, Toborek M, Hennig B. 2008. Zinc nutritional status modulates expression of ahr-responsive p450 enzymes in vascular endothelial cells. Environ Toxicol Pharmacol 25(2):197-201. doi:10.1016/j.etap.2007.10.016 PMID:19255596 PMCID:PMC2346446
• Sipka SM, Eum SY, Son KW, Xu S, Gavalas VG, Hennig B, Toborek M. 2008. Oral administration of PCBs induces proinflammatory and prometastatic responses. Environ Toxicol Pharmacol 25(2):251-259. doi:10.1016/j.etap.2007.10.020 PMID:18438459 PMCID:PMC2346434
• Venkatachalam K, Arzuaga X, Chopra N, Gavalas VG, Xu J, Bhattacharyya D, Hennig B, Bachas LG. 2008. Reductive dechlorination of 3,3',4,4'-tetrachlorobiphenyl (PCB77) using palladium or palladium/iron nanoparticles and assessment of the reduction in toxic potency in vascular endothelial cells. J Hazard Mater 159(2-3):483-491. doi:10.1016/j.jhazmat.2008.02.109 PMID:18423858 PMCID:PMC3247144
• Wang L, Reiterer G, Toborek M, Hennig B. 2008. Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. Chem Biol Interact 172(1):27-38. doi:10.1016/j.cbi.2007.11.003 PMID:18155686 PMCID:PMC2277485
• Zhong Y, Smart EJ, Couraud P, Hennig B, Toborek M. 2008. Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling. J Neurosci 28(31):7788-7796. doi:10.1523/JNEUROSCI.0061-08.2008 PMID:18667611 PMCID:PMC2635104

2007

• Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. 2007. PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis. Cardiovasc Toxicol 7(4):264-272. doi:10.1007/s12012-007-9005-8 PMID:17955387
• Hennig B, Oesterling EG, Toborek M. 2007. Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis. Nutrition, Metabolism & Cardiovascular Diseases 17(2):162-9. PMID:17306736
• Lehmann L, Esch HL, Kirby PA, Robertson LW, Ludewig G. 2007. 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28(2):471-478. doi:10.1093/carcin/bgl157 PMID:16950798
• Lim EJ, Smart EJ, Toborek M, Hennig B. 2007. The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells. Am J Physiol Heart Circ Physiol 293:doi:10.1152/ajpheart.00921.2007 PMID:17933968

2006

• Arzuaga X, Reiterer G, Majkova Z, Toborek M, Hennig B. 2006. PPARg agonists protect against PCB-induced vascular endothelial cell activation. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Eum SY, Lee YW, Hennig B, Toborek M. 2006. Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells. Mol Cancer Res 4(6):361-70. PMID:16778083
• Eum SY, Rha GB, Hennig B, Toborek M. 2006. c-Src-mediated interleukin-8 overexpression and migration of endothelial cells: implications in PCB-mediated tumor metastasis. FASEB J 20:A1147.
• Eum SY, Rha GB, Hennig B, Toborek M. 2006. cSRC-mediated interleukin-8 overexpression and migration of endothelial cells: implications in PCB-mediated tumor metastasis. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Feliciano JS, Pasini P, Deo SK, Daunert S. 2006. Photoproteins as reporters in whole cell sensing systems. Chapter 8 in: Photoproteins in Bioanalysis. Wiley-VCH, New York, NY. pp.131-154.
• Hayashi K, Pu H, Andras IE, Eum SY, Yamauchi A, Hennig B, Toborek M. 2006. HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. J Cereb Blood Flow Metab 26(8):1052-65. PMID:16395283
• Hennig B, Arzuaga X, Majkova Z, Smart EJ, Toborek M. 2006. Endothelial cell dysfunction: environmental contaminants and nutritional implications. Atherosclerosis 7(3):444.
• Hennig B, Lei W, Arzuaga X, Das Ghosh D, Viswanathan S, Toborek M. 2006. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling. J Nutr Biochem 17(11):766-772. PMID:16563718
• Hennig B, Toborek M. 2006. Impact of nutrition on PCB toxicity. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Huang Z, Eum SY, Hennig B, Toborek M, Zhu H. 2006. Proteomic characterization of endothelial cell surface proteins upon PCB exposure. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Majkova Z, Lim EJ, Smart EJ, Toborek M, Hennig B. 2006. Role of caveolin-1 in PCB-induced vascular endothelial cell activation. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Rha GB, Eum SY, Hennig B, Toborek M. 2006. c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line. Toxicol Sci 92(1):311-20. PMID:16611624
• Shen H, Arzuaga X, Toborek M, Hennig B. 2006. Zinc nutritional status modulates PCB 77-induced proinflammatory responses in vascular endothelial cells. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Sipka SM, Eum SY, Pu H, Hennig B, Toborek M. 2006. Structure-function relationship of PCB-mediated induction of proinflammatory mediators in vivo. FASEB J 20:A641.
• Sipka SM, Eum SY, Xu S, Gavalas VG, Hennig B, Toborek M. 2006. Oral administration of PCBs induces proinflammatory and prometastatic responses. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
• Toborek M, Hennig B. 2006. PCBs and cancer metastasis. In: PCB Workshop, 4th, 2006. Zakopane, Poland.

2005

• Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. 2005. 3,3'4,4'-tetrachlorobiphenyl disrupts PPAR signaling in vascular endothelial cells. In: Proceedings of the DIOXIN 2005 Conference, August 21-26. Toronto, Canada.
• Eum SY, Lee YW, Hennig B, Toborek M. 2005. Role of EGF receptor/MAP kinases in activation of human microvascular endothelial cells by exposure to polychlorinated biphenyls. FASEB J 19:A1067.
• Gosh DG, Viswanathan S, Toborek M, Hennig B. 2005. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3/AKT and ERK1/2 MARK signaling. FASEB J 19:A1006.
• Hennig B, Majkova Z, Oesterling EG, Arzuaga X, Reiterer G, Toborek M. 2005. Proinflammatory mechanisms induced by PCBs: implications in vascular diseases. In: Proceedings of the DIOXIN 2005 Conference, August 21-26. Toronto, Canada.
• Hennig B, Reiterer G, Majkova Z, Oesterling EG, Meerarani P, Toborek M. 2005. Modification of environmental toxicity by nutrients: implications in atherosclerosis. Cardiovasc Toxicol 5(2):153-160. PMID:16046791
• Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart EJ, Robertson LW. 2005. Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor. Environ Health Perspect 113(1):83-87. PMID:15626652 PMCID:PMC1253714
• Hennig B, Toborek M, Ramadass P, Ludewig G, Robertson LW, Arif JM. 2005. Polychlorinated biphenyls, oxidative stress and diet. Chapter Vol. 3 in: Reviews in Food and Nutrition Toxicity. CRC Press, Inc., Boca Raton, DE. pp.93-128.
• Majkova Z, Smart EJ, Daugherty A, Toborek M, Hennig B. 2005. PCB-induced inflammatory response in caveolin-1 deficient mice. In: Society of Toxicology, 44th Annual Meeting, 2005. New Orleans, LA.
• Majkova Z, Smart EJ, Daugherty A, Toborek M, Hennig B. 2005. PCB-induced inflammatory response in caveolin-1 deficient mice. In: Proceedings of the 44^th Annual Meeting of the Society of Toxicology (SOT), March 6-10, 2005. New Orleans, LA.
• Reiterer G, MacDonald R, Browning JD, Marrow J, Matveev SV, Daugherty A, Smart EJ, Toborek M, Hennig B. 2005. Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. J Nutr 135(9):2114-2118. PMID:16140885
• Preedy VR, Watson RR, eds. 2005. Reviews in Food and Nutrition Toxicity CRC Press, Inc., Boca Raton, DE.

2004

• Eum SY, Lee YW, Hennig B, Toborek M. 2004. Specific non-coplanar PCBs disrupts barrier function and increase transendothelial migration of breast cancer cells. FASEB J 18:A187.
• Eum SY, Lee YW, Hennig B, Toborek M. 2004. VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells. Exp Cell Res 296(2):231-244. PMID:15149853
• Hennig B, Toborek M, Bachas LG, Suk WA. 2004. Emerging issues: nutritional awareness in environmental toxicology. J Nutr Biochem 15(4):194-195. PMID:15068811
• Lee YW, Eum SY, Hennig B, Toborek M. 2004. Potential role of cytochrome P450 3A4 (CYP3A4) in the PC104-mediated barrier dysfunction of human microvascular endothelial cells. FASEB J 18:A991.
• Reiterer G, Toborek M, Hennig B. 2004. Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells. J Nutr 134(7):1711-1715. PMID:15226458
• Toborek M, Hennig B. 2004. Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. J Nutr 134(4):771-775. PMID:15051824
• Wu G, Toborek M, Hennig B, Saraswathi V. 2004. Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling. J Lipid Res 45(5):794-804. doi:10.1194/jlr.M300497-JLR200 PMID:14993245

2003

• Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. 2003. PCB 104 induces oxidative stress and stimulates proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis. FASEB J 17:A272.
• Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. 2003. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol Appl Pharmacol 189(1):1-10. PMID:12758055

2002

• Choi W, Lee YW, Hennig B, Robertson LW, Toborek M. 2002. PCB-induced inflammatory reactions in human endothelial cells: implication in cancer metastasis. FASEB J 16:A961.
• Hennig B, Hammock BD, Slim RM, Toborek M, Viswanathan S, Robertson LW. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int J Hyg Environ Health 205(1-2):95-102. PMID:12018021
• Hennig B, Meerarani P, Slim RM, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 181(3):174-183. PMID:12079426
• Hennig B, Viswanathan S, Toborek M. 2002. Fatty acid-induced endothelial cell activation. Atherosclerosis Supplements 3(2):123.
• Park HJ, Lee YW, Hennig B, Toborek M. 2002. Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-ºB-dependent pathway. Nutr Cancer 41:126-134. PMID:12094615
• Toborek M, Lee YW, Garrido R, Kaiser S, Hennig B. 2002. Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am J Clin Nutr 75(1):119-125. PMID:11756069
• Viswanathan S, Hammock BD, Meerarani P, Toborek M, Hennig B. 2002. Mechanisms of linoleic acid-induced endothelial activation: possible involvement of epoxide metabolites in mediating the inflammatory response. FASEB J 16:A157.

2001

• Hennig B, Slim RM, Toborek M, Hammock BD, Robertson LW. 2001. Cardiovascular disease: endothelial cells as a target for PCB toxicity. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.211-220.
• Hennig B, Toborek M. 2001. Fatty acid-induced endothelial cell activation: implications in atherosclerosis. Pol J Pharmacol 53(Suppl.):36.
• Hennig B, Toborek M, McClain CJ. 2001. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll Nutr 20(2):97-105. PMID:11349944
• Hennig B, Toborek M, Reiterer G, Majkova Z, Oesterling EG, Meerarani P, Robertson LW. 2001. Nutrition Modulates PCB Toxicity: Implications in Atherosclerosis. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY.
• Hennig B, Viswanathan S, Toborek M, Hammock BD. 2001. Mechanisms of fatty-acid mediated endothelial cell activation. J Am Coll Nutr 20:574.
• Lee YW, Park HJ, Hennig B, Toborek M. 2001. Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism. J Nutr Biochem 12(11):648-654. PMID:12031258
• Slim RM, Hammock BD, Toborek M, Robertson LW. 2001. The role of methyl linoleic acid epoxide and diol metabolites in the synergistic toxicity of linoleic acid and PCBs to vascular endothelial cells. Toxicol Sci 60:13.
• Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
• Viswanathan S, Narayan P, Hammock BD, Meerarani P, Toborek M, Hennig B. 2001. Linoleic acid-derived epoxides alter calcium and nitric oxide metabolism in endothelial cells. FASEB J 15:A190.

2000

• Hennig B, Meerarani P, Kaiser S, Toborek M. 2000. Inflammatory events and fatty acid-induced activation of vascular endothelial cells. FASEB J 14:A199.
• Hennig B, Meerarani P, Ramadass P, Watkins BA, Toborek M. 2000. Fatty acid-mediated activation of vascular endothelial cells. Metabolism 49(8):1006-1013. PMID:10954018
• Hennig B, Slim RM, Toborek M, Malecki A, Robertson LW. 2000. Effects of lipids and antioxidants on PCB-mediated dysfunction of vascular endothelial cells. Cent Eur J Public Health 8(supp):18-19. PMID:10943440
• Hennig B, Slim RM, Toborek M, Watkins BA, Robertson LW. 2000. Modulation of PCB-induced endothelial activation by fatty acids and antioxidants. In: Proceedings of the 1^st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY.
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