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Project Publications: New York University School of Medicine: Metal-Induced Inflammatory Factors, Oxidative Stress and Suppression of their Effects

Superfund Research Program

Metal-Induced Inflammatory Factors, Oxidative Stress and Suppression of their Effects

Project Leader: Krystyna Frenkel
Grant Number: P42ES010344
Funding Period: 2000 - 2006

Project-Specific Links




  • Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X. 2006. Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med 40(3):444-452. PMID:16443159


  • Yang C, Wu J, Zhang R, Zhang P, Eckard J, Yusuf R, Huang X, Rossman TG, Frenkel K. 2005. Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. Toxicology 213(1-2):81-96. PMID:16085347


  • Wu J, Eckard J, Rossman TG, Yang C, Frenkel K. 2003. p53 Signaling pathway involved in arsenite-induced HOS cell transformation and its prevention by caffeic acid phenethyl ester (CAPE). Toxicol Sci 72(1):1307Suppl.S.
  • Wu J, Yang C, Eckard J, Rossman TG, Frenkel K. 2003. Arsenite-induced human cell tranformation and down-regulation of stress and toxicity-related genes: Reversal by caffeic acid phenethyl ester (CAPE). In: Proceedings of the Ninety Fourth (AACR) American Association for Cancer Researcht, April 5-9, 2003, Toronto. Toronto, Canada.
  • Yang C, Frenkel K. 2003. Caffeic acid phenethyl ester (CAPE) inhibits arsenite-induced human cell transformation and induces G2/M phase arrest of arsenite-transformed human cells. Toxicol Sci 72(1):1029Suppl.S.


  • Frenkel K. 2002. Carcinogenesis: Role of reactive oxygen and nitrogen species. In: Encyclopedia of Cancer, 2nd Edition. pp.359-367.
  • Frenkel K, Rossman TG, Yang C. 2002. Caffeic acid phenethyl ester (CAPE) prevents arsenic-mediated transformation of human cells and down-regulation of inflammatory cytokines. Cancer Detect Prev 67.
  • Huang X, Dai J, Fournier J, Ali AM, Zhang Q, Frenkel K. 2002. Ferrous ion autoxidation and its chelation in iron-loaded human liver HepG2 cells. Free Radic Biol Med 32(1):84-92. PMID:11755320
  • Li X, Eckard J, Shah R, Malluck C, Frenkel K. 2002. Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses. Cancer Res 62(2):417-423. PMID:11809690
  • Yang C, Frenkel K. 2002. Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis. J Environ Pathol Toxicol Oncol 21(4):331-342. PMID:12510962
  • Yang C, Zhang RH, Eckard J, Yusuf R, Rossman TG, Frenkel K. 2002. Critical role of inflammatory cytokines in the inhibition of arsenic-induced cell transformation by caffeic acid phenethyl ester (CAPE). In: Proceedings of Ninety Third Annual Meeting of the (AACR) American Association of Cancer Research, April 6-10, 2002, San Francisco. pp.1034.


  • Cooney RV, Maskarinec G, Frank AA, Okinaka L, Karkoszka J, Wilkens LR, Frenkel K. 2001. Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans. Free Radic Biol Med 31:460-468. PMID:11498279
  • Huang X, Powell J, Mooney LA, Li CL, Frenkel K. 2001. Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses. Free Radic Biol Med 31:1341-1351. PMID:11728805
  • Mahabir S, Frenkel K, Brady MS, Coit D, Lewis JJ, Leibes L, Roush G, Berwick M. 2001. Antibodies against 5-hydroxymethyl-2-deoxyuridine: a pilot trial. FASEB J 15:A282.
  • Mooney LA, Perera F, Van Bennekum AM, Blaner WS, Karkoszka J, Covey L, Hsu YZ, Cooper TB, Frenkel K. 2001. Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers. Cancer Epidemiol Biomarkers Prev 10:641-648. PMID:11401914
  • Yusuf R, Frenkel K. 2001. Oxidative stress-mediated transformation of MCF-10 human mammary cells: roles of hydrocortisone (HC), 17beta-estradiol (E2), and 7,12-dimethylbenz[a]anthracene (DMBA). Free Radic Biol Med 31:427.
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