Superfund Research Program

Mechanism of Environmental Stress-Induced Developmental Abnormalities

Project Leaders: Dennis Thiele, Richard T. Di Giulio
Grant Number: P42ES010356
Funding Period: 2000-2011

Project-Specific Links

Publications

2010

• Clark BW, Matson CW, Jung D, Di Giulio RT. 2010. AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 99(2):232-240. doi:10.1016/j.aquatox.2010.05.004 PMID:20605646 PMCID:PMC2901414
• Kim B, Turski ML, Nose Y, Casad M, Rockman HA, Thiele D. 2010. Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Cell Metab 11(5):353-63. doi:10.1016/j.cmet.2010.04.003 PMID:20444417 PMCID:PMC2901851

2009

• Song MO, Li J, Freedman JH. 2009. Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics 38(3):386-401. doi:10.1152/physiolgenomics.00083.2009 PMID:19549813 PMCID:PMC3774564

2008

• Mattie MD, McElwee MK, Freedman JH. 2008. Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J Mol Biol 383(5):1008-1018. doi:10.1016/j.jmb.2008.08.080 PMID:18793645 PMCID:PMC2662727

2007

• Turski ML, Thiele D. 2007. Drosophila ctrl A functions as a copper transporter essential for development. J Biol Chem 282:24017-24026. PMID:17573340

2005

• Song MO, Freedman JH. 2005. Activation of mitogen activated protein kinases by PCB126 (3,3',4,4',5-pentachlorobiphenyl) in HepG2 cells. Toxicol Sci 84(2):308-318. doi:10.1093/toxsci/kfi084 PMID:15647597
• Song MO, Freedman JH. 2005. Expression of copper-responsive genes in HepG2 cells. Mol Cell Biochem 279(1-2):141-147. doi:10.1007/s11010-005-8286-0 PMID:16283523

2004

• Levin ED, Swain HA, Donerly S, Linney EA. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicol Teratol 26(6):719-723. PMID:15451035
• Mattie MD, Freedman JH. 2004. Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways. Am J Physiol Cell Physiol 286(2):C293-C301. doi:10.1152/ajpcell.00293.2003 PMID:14576086

2003

• Levin ED, Chrysanthis E, Yacsin K, Linney EA. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicol Teratol 25(1):51-57. PMID:12633736

2002

• Adams TK, Saydam N, Steiner F, Schaffner W, Freedman JH. 2002. Activation of gene expression by metal-responsive signal transduction pathways. Environ Health Perspect 110(5):813-817. PMID:12426137
• Kimura Y, Corcoran EE, Eto K, Gengyo-Ando K, Muramatsu M, Kobayashi R, Freedman JH, Mitani S, Hagiwara M, Means AR, Tokumitsu H. 2002. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO J 3:962-966. PMID:12231504
• Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol Teratol 24(6):733-741. PMID:12460655
• Liao VH, Dong J, Freedman JH. 2002. Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity. J Biol Chem 277(44):42049-42059. doi:10.1074/jbc.M206740200 PMID:12189149
• Liao VH, Freedman JH. 2002. Differential display analysis of gene expression in invertebrates. Cellular and Molecular Life Sciences 59:1256-1263. PMID:12363029
• Mattie MD, Freedman JH. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. In: Metal Ions in Biology and Medicine: Proceedings of the Seventh International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Reims, France. pp.108-112.
• Mattie MD, Freedman JH. 2002. Copper inducible gene expression regulated by metals and oxidative stress responsive pathways. Trace Elem Med 3:46.
• Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH. 2002. Regulation of metallothionein transcription by the metal responsive transcription factor MTF-1. Identification of signal transduction cascades that control metal-inducible transcription. J Biol Chem 277:20438-20445. PMID:11923282

2001

• Mattie MD, Freedman JH. 2001. Protective effects of aspirin and Vitamin E (a-tocopherol) against copper- and cadmium-induced toxicity. Biochem Biophys Res Commun 285(4):921-925. PMID:11467839