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Your Environment. Your Health.

Project Publications: Duke University: Mechanism of Environmental Stress-Induced Developmental Abnormalities

Superfund Research Program

Mechanism of Environmental Stress-Induced Developmental Abnormalities

Project Leaders: Dennis Thiele, Richard T. Di Giulio
Grant Number: P42ES010356
Funding Period: 2000-2011

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  • Turski ML, Thiele D. 2007. Drosophila ctrl A functions as a copper transporter essential for development. J Biol Chem 282:24017-24026. PMID:17573340



  • Levin ED, Swain HA, Donerly S, Linney EA. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicol Teratol 26(6):719-723. PMID:15451035
  • Mattie MD, Freedman JH. 2004. Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways. Am J Physiol Cell Physiol 286(2):C293-C301. doi:10.1152/ajpcell.00293.2003 PMID:14576086


  • Levin ED, Chrysanthis E, Yacsin K, Linney EA. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicol Teratol 25(1):51-57. PMID:12633736


  • Adams TK, Saydam N, Steiner F, Schaffner W, Freedman JH. 2002. Activation of gene expression by metal-responsive signal transduction pathways. Environ Health Perspect 110(5):813-817. PMID:12426137
  • Kimura Y, Corcoran EE, Eto K, Gengyo-Ando K, Muramatsu M, Kobayashi R, Freedman JH, Mitani S, Hagiwara M, Means AR, Tokumitsu H. 2002. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO J 3:962-966. PMID:12231504
  • Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol Teratol 24(6):733-741. PMID:12460655
  • Liao VH, Dong J, Freedman JH. 2002. Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity. J Biol Chem 277(44):42049-42059. doi:10.1074/jbc.M206740200 PMID:12189149
  • Liao VH, Freedman JH. 2002. Differential display analysis of gene expression in invertebrates. Cellular and Molecular Life Sciences 59:1256-1263. PMID:12363029
  • Mattie MD, Freedman JH. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. In: Metal Ions in Biology and Medicine: Proceedings of the Seventh International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Reims, France. pp.108-112.
  • Mattie MD, Freedman JH. 2002. Copper inducible gene expression regulated by metals and oxidative stress responsive pathways. Trace Elem Med 3:46.
  • Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH. 2002. Regulation of metallothionein transcription by the metal responsive transcription factor MTF-1. Identification of signal transduction cascades that control metal-inducible transcription. J Biol Chem 277:20438-20445. PMID:11923282


  • Mattie MD, Freedman JH. 2001. Protective effects of aspirin and Vitamin E (a-tocopherol) against copper- and cadmium-induced toxicity. Biochem Biophys Res Commun 285(4):921-925. PMID:11467839
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