Superfund Research Program

Genetic Stress and Toxicant-Induced Pregnancy Disruption

Project Leader: Surendra Sharma (Women & Infants Hospital of Rhode Island)
Grant Number: P42ES013660
Funding Period: 2005-2014

Project-Specific Links

Publications

2017

• Blois SM, Freitag N, Tirado-Gonzalez I, Cheng S, Heimesaat MM, Rose M, Conrad ML, Barrientos G, Sharma S, Bereswill S. 2017. NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface. Sci Rep 7(1):2189. doi:10.1038/s41598-017-02333-8 PMID:28526846 PMCID:PMC5438353
• Kalkunte S, Huang Z, Lippe EO, Robertson LW, Sharma S, Kumar S. 2017. Polychlorinated biphenyls target Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Sci Rep 7:39885. doi:10.1038/srep39885 PMID:28071720 PMCID:PMC5223111

2014

• Lin Y, Liu X, Shan B, Wu J, Sharma S, Sun Y. 2014. Prevention of CpG-induced pregnancy disruption by adoptive transfer of in vitro-induced regulatory T cells. PLoS One 9(4):e94702. doi:10.1371/journal.pone.0094702 PMID:24714634 PMCID:PMC3979847
• Qin X, Liu X, Shan B, Shi L, Sharma S, Wu J, Lin Y. 2014. Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice. Am J Reprod Immunol 71(3):229-240. doi:10.1111/aji.12194 PMID:24382123 PMCID:PMC4030494
• Sharma S. 2014. Natural killer cells and regulatory T cells in early pregnancy loss. Int J Dev Biol 58(2-4):219-229. doi:10.1387/ijdb.140109ss PMID:25023688 PMCID:PMC4306453

2013

• Sun Y, Qin X, Shan B, Wang W, Zhu Q, Sharma S, Wu J, Lin Y. 2013. Differential effects of the CpG-Toll-like receptor 9 axis on pregnancy outcome in non-obese diabetic mice and wild-type controls. Fertil Steril 99:1759-1767. doi:10.1016/j.fertnstert.2013.01.121 PMID:23414919 PMCID:PMC3756663
• Thaxton JE, Nevers TA, Lippe EO, Blois SM, Saito S, Sharma S. 2013. NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice. J Immunol 190(7):3639-3647. doi:10.4049/jimmunol.1203488 PMID:23455498 PMCID:PMC3608719

2010

• Kalkunte S, Boij R, Norris WE, Friedman J, Lai Z, Kurtis J, Lim K, Padbury J, Matthiesen L, Sharma S. 2010. Sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay. Am J Pathol 177(5):2387-2398. doi:10.2353/ajpath.2010.100475 PMID:20889559 PMCID:PMC2966797
• Sharma S, Norris WE, Kalkunte S. 2010. Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia. J Reprod Immunol 85(1):112-116. doi:10.1016/j.jri.2010.01.002 PMID:20236707 PMCID:PMC3621111
• Sharma S, Stabila J, Pietras L, Singh A, McGonnigal B, Ernerudh J, Matthiesen L, Padbury J. 2010. Haplotype-dependent differential activation of the human IL-10 gene promoter in macrophages and trophoblasts: implications for placental IL-10 deficiency and pregnancy complications. Am J Reprod Immunol 64(3):179-187. doi:10.1111/j.1600-0897.2010.00854.x PMID:20482524 PMCID:PMC3634123
• Thaxton JE, Nevers TA, Sharma S. 2010. TLR-mediated preterm birth in response to pathogenic agents. Infect Dis Obstet Gynecol 2010:doi:10.1155/2010/378472 PMID:20827416 PMCID:PMC2933901
• Thaxton JE, Sharma S. 2010. Interleukin-10: a multi-faceted agent of pregnancy. Am J Reprod Immunol 63(6):482-491. doi:10.1111/j.1600-0897.2010.00810.x PMID:20163400 PMCID:PMC3628686

2009

• Bayraktar M, Peltier M, Vetrano A, Arita Y, Gurzenda E, Joseph A, Kazzaz J, Sharma S, Hanna N. 2009. IL-10 Modulates Placental Responses to TLR Ligands. Am J Reprod Immunol 62(6):390-399. doi:10.1111/j.1600-0897.2009.00756.x PMID:19821803 PMCID:PMC3756675
• Kalkunte S, Lai Z, Norris WE, Pietras LA, Tewari N, Boij R, Neubeck S, Markert UR, Sharma S. 2009. Novel approaches for mechanistic understanding and predicting preeclampsia. J Reprod Immunol 83(1-2):134-138. doi:10.1016/j.jri.2009.08.006 PMID:19836839 PMCID:PMC2790420
• Kalkunte S, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. 2009. Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol 182(7):4085-4092. doi:10.4049/jimmunol.0803769 PMID:19299706 PMCID:PMC3616376
• McGowan EC, Kostadinov S, McLean K, Gotsch F, Venturini D, Romero R, Laptook AR, Sharma S. 2009. Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk. Pediatric Research 66(4):455-460. doi:10.1203/PDR.0b013e3181b3b0fa PMID:19581835 PMCID:PMC2795791
• Murphy S, Hanna N, Fast L, Shaw S, Berg G, Padbury J, Romero R, Sharma S. 2009. Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery. J Clin Invest 200(3):308.e1-308.e9. doi:10.1016/j.ajog.2008.10.043 PMID:19114277 PMCID:PMC3893044
• Tewari N, Kalkunte S, Murray DW, Sharma S. 2009. The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies. J Biol Chem 284(22):15224-15232. doi:10.1074/jbc.M808892200 PMID:19332547 PMCID:PMC2685703
• Thaxton JE, Romero R, Sharma S. 2009. TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J Immunol 183(2):1144-1154. doi:10.4049/jimmunol.0900788 PMID:19561095 PMCID:PMC2785500

2008

• Bryant BH, Yamasaki H, Sandrof MA, Boekelheide K. 2008. Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. Toxicol Pathol 36(4):552-559. doi:10.1177/0192623308317426 PMID:18467684 PMCID:PMC2574707
• Kalkunte S, Chichester CO, Sentman CL, Romero R, Sharma S, Gotsch F. 2008. Evolution of non-cytotoxic uterine natural killer cells. Am J Reprod Immunol 59(5):425-432. doi:10.1111/j.1600-0897.2008.00595.x PMID:18405313 PMCID:PMC3042548

2007

• Bryant BH, Boekelheide K. 2007. Time-dependent changes in post-mortem testis histopathology in the rat. Toxicol Pathol 35:665-71. PMID:17676525
• Moffit JS, Bryant BH, Hall SJ, Boekelheide K. 2007. Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. Toxicol Pathol 35(5):719-727. doi:10.1080/01926230701481931 PMID:17763286