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Your Environment. Your Health.

Program Publications: University of Iowa: Airborne PCBs: Sources, Exposures, Toxicities, Remediation

Superfund Research Program

Airborne PCBs: Sources, Exposures, Toxicities, Remediation

Center Director: Keri C. Hornbuckle
Grant Number: P42ES013661
Funding Period: 2006-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2021

  • Bako CM, Mattes TE, Marek RF, Hornbuckle KC, Schnoor JL. 2021. Biodegradation of PCB congeners by Paraburkholderia xenovorans LB400 in presence and absence of sediment during lab bioreactor experiments. Environ Pollut 271:116364. doi:10.1016/j.envpol.2020.116364 PMID:33412450
  • Bako CM, Mattes TE, Marek RF, Hornbuckle KC, Schnoor JL. 2021. Dataset describing biodegradation of individual polychlorinated biphenyl congeners (PCBs) by Paraburkholderia xenovorans LB400 in presence and absence of sediment slurry. Data Brief 35:106821. doi:10.1016/j.dib.2021.106821 PMID:33604434 PMCID:PMC7873373
  • Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo D, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. 2021. Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab doi:10.1152/ajpendo.00119.2021 PMID:33843283
  • Haque E, Moran ME, Thorne PS. 2021. Retrospective blood lead assessment from archived clotted erythrocyte fraction in a cohort of lead-exposed mother-child dyads. Sci Total Environ 754:142166. doi:10.1016/j.scitotenv.2020.142166 PMID:32920407 PMCID:PMC7686297
  • Li X, Liu Y, Martin JW, Cui JY, Lehmler H. 2021. Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice. Environ Pollut doi:10.1016/j.envpol.2020.115726 PMID:33032095 PMCID:PMC7746632
  • McCarthy RA, Gupta AS. 2021. Employing and interpreting a machine learning target-cognizant technique for analysis of unknown signals in multiple reaction monitoring. IEEE Access 9:24727-24737. doi:10.1109/ACCESS.2021.3056955
  • Zhang D, Saktrakulkla P, Tuttle K, Marek RF, Lehmler H, Wang K, Hornbuckle KC, Duffel MW. 2021. Detection and quantification of polychlorinated biphenyl sulfates in human serum. Environ Sci Technol 55:2473-2481. doi:10.1021/acs.est.0c06983 PMID:33502843 PMCID:PMC7924310
  • Zhang Q, Kong W, Wei L, Hou X, Ma Q, Liu Y, Luo Y, Liao C, Liu J, Schnoor JL, Jiang G. 2021. Compartmentalization and excretion of 2,4,6-tribromophenol sulfation and glycosylation conjugates in rice plants. Environ Sci Technol 55:2980-2990. doi:10.1021/acs.est.0c07184 PMID:33544574

2020

  • Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo D, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. 2020. Exposure to static magnetic and electric fields treats type 2 diabetes. Cell Metab 32:561-574. doi:10.1016/j.cmet.2020.09.012 PMID:33027675
  • Chen W, Yu M, Zhang Q, Hou X, Kong W, Wei L, Mao X, Liu J, Schnoor JL, Jiang G. 2020. Metabolism of SCCPs and MCCPs in suspension rice cells based on paired mass distance (PMD) analysis. Environ Sci Technol 54:9990-9999. doi:10.1021/acs.est.0c01830 PMID:32600037
  • Deng P, Hoffman JB, Petriello MC, Wang C, Li X, Kraemer MP, Morris AJ, Hennig B. 2020. Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice. J Lipid Res 61:45-53. doi:10.1194/jlr.RA119000346 PMID:31604806 PMCID:PMC6939596
  • Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B. 2020. Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol Appl Pharmacol 409:115301. doi:10.1016/j.taap.2020.115301 PMID:33096110 PMCID:PMC7725976
  • Dhakal RC, Li X, Parkin S, Lehmler H. 2020. Synthesis of mono- and dimethoxylated polychlorinated biphenyl derivatives starting from fluoroarene derivatives. Environ Sci Pollut Res Int 27:8905-8925. doi:10.1007/s11356-019-07133-3
  • Egusquiza RJ, Ambrosio ME, Wang SG, Kay KM, Zhang C, Lehmler H, Blumberg B. 2020. Evaluating the role of the steroid and xenobiotic receptor (SXR/PXR) in PCB-153 metabolism and protection against associated adverse effects during perinatal and chronic exposure in mice. Environ Health Perspect 128:16. doi:10.1289/EHP6262 PMID:32352317 PMCID:PMC7228131
  • Grimm FA, Klaren WD, Li X, Lehmler H, Karmakar M, Robertson LW, Chiu WA, Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Perspect 128:77008. doi:10.1289/EHP7030 PMID:32701041 PMCID:PMC7377239
  • Heiger-Bernays WJ, Tomsho KS, Basra K, Petropoulos ZE, Crawford KA, Martinez A, Hornbuckle KC, Scammell MK. 2020. Human health risks due to airborne polychlorinated biphenyls are highest in New Bedford Harbor communities living closest to the harbor. Sci Total Environ 710:doi:10.1016/j.scitotenv.2019.135576 PMID:31785914 PMCID:PMC7015809
  • Hennig B, Deng P. 2020. Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks. Food Front 1:13-14. doi:10.1002/fft2.6 PMID:33073239 PMCID:PMC7566652
  • Li X, Zhang C, Wang K, Lehmler H. 2020. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut 266:115233. doi:10.1016/j.envpol.2020.115233 PMID:32712482 PMCID:PMC7492420
  • Li Y, Chen W, Kong W, Liu J, Schnoor JL, Jiang G. 2020. Transformation of 1,1,1,3,8,10,10,10-octachlorodecane in air phase increased by phytogenic volatile organic compounds of pumpkin seedlings. Sci Total Environ 74:doi:10.1016/j.scitotenv.2019.135455 PMID:31791777 PMCID:PMC7029796
  • Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
  • Mattes TE, Ingalls AE, Burke S, Morris RM. 2020. Metabolic flexibility of SUP05 under low DO growth condition. Environ Microbiol 11:doi:10.1111/1462-2920.15226
  • McCarthy RA, Gupta AS, Kubicek B, Awad AM, Martinez A, Marek RF, Hornbuckle KC. 2020. Signal processing methods to interpret polychlorinated biphenyls in airborne samples. IEEE Access 8:147738-147755. doi:10.1109/access.2020.3013108 PMID:33335823 PMCID:PMC7742762
  • Qian J, Martinez A, Marek RF, Nagorzanski MR, Zhi H, Furlong ET, Kolpin DW, LeFevre G, Cwiertny DM. 2020. Polymeric nanofiber-carbon nanotube composite mats as fast-equilibrium passive samplers for polar organic contaminants. Environ Sci Technol 54:6703-6712. doi:10.1021/acs.est.0c00609 PMID:32343558 PMCID:PMC7665838
  • Roy MA, Duche PR, Timme-Laragy AR. 2020. The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepatic neutral lipids in zebrafish larvae (Danio rerio). Chemosphere 260:doi:10.1016/j.chemosphere.2020.127609 PMID:32693259 PMCID:PMC7530052
  • Saktrakulkla P, Lan T, Hua J, Marek RF, Thorne PS, Hornbuckle KC. 2020. Polychlorinated biphenyls in food. Environ Sci Technol 54:11443-11452. doi:10.1021/acs.est.0c03632 PMID:32816464 PMCID:PMC7759298
  • Stolwijk J, Falls-Hubert KC, Searby CC, Wagner BA, Buettner GR. 2020. Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments. Redox Biol 32:15. doi:10.1016/j.redox.2020.101518 PMID:32278283 PMCID:PMC7150527
  • Stolwijk J, Garje R, Sieren JC, Buettner GR, Zakharia Y. 2020. Understanding the redox biology of selenium in the search of targeted cancer therapies. Antioxidants (Basel) 9:doi:10.3390/antiox9050420 PMID:32414091 PMCID:PMC7278812
  • Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
  • Williams AE, Watt J, Robertson LW, Gadupudi GS, Osborn ML, Soares M, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti N, Suva LJ, Ronis M. 2020. Skeletal toxicity of coplanar polychlorinated biphenyl congener 126 in the rat is aryl hydrocarbon receptor dependent. Toxicol Sci 175:113-125. doi:10.1093/toxsci/kfaa030 PMID:32119087 PMCID:PMC7197949
  • Wu X, Zhai G, Schnoor JL, Lehmler H. 2020. Atropselective disposition of 2,2 ,3,4 ,6-Pentachlorobiphenyl (PCB 91) and identification of its metabolites in mice with liver-specific deletion of Cytochrome P450 Reductase. Chem Res Toxicol 33:1328-1338. doi:10.1021/acs.chemrestox.9b00255 PMID:31403789 PMCID:PMC7042073
  • Zhang C, Flor S, Ludewig G, Lehmler H. 2020. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: Experimental and modeling results. Environ Sci Technol 54:13817-13827. doi:10.1021/acs.est.0c02508 PMID:33059451 PMCID:PMC7642102
  • Zhang C, Flor S, Ruiz P, Dhakal RC, Hu X, Teesch LM, Ludewig G, Lehmler H. 2020. 3,3'-dichlorobiphenyl is metabolized to a complex mixture of oxidative metabolites, including novel methoxylated metabolites, by HepG2 cells. Environ Sci Technol 54:12345-12357. doi:10.1021/acs.est.0c03476 PMID:32910851 PMCID:PMC7544623
  • Zhang Q, Kong W, Wei L, Wang Y, Luo Y, Wang P, Liu J, Schnoor JL, Jiang G. 2020. Uptake, phytovolatilization, and interconversion of 2,4-dibromophenol and 2,4-dibromoanisole in rice plants. Environ Int 142:105888. doi:10.1016/j.envint.2020.105888 PMID:32593840 PMCID:PMC7670850

2019

  • Boesen A, Martinez A, Hornbuckle KC. 2019. Air-water PCB fluxes from southwestern Lake Michigan revisited. Environ Sci Pollut Res Int doi:10.1007/s11356-019-05159-1 PMID:31062242 PMCID:PMC6834886
  • Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer S, Cullen JJ, Buettner GR. 2019. Pharmacologic ascorbate primes pancreatic cancer cells for death by rewiring cellular energetics and inducing DNA damage. Mol Cancer Res 17:2102-14. doi:10.1158/1541-7786.MCR-19-0381 PMID:31337671 PMCID:PMC6774825
  • Deng P, Li X, Petriello MC, Wang C, Morris AJ, Hennig B. 2019. Application of metabolomics to characterize environmental pollutant toxicity and disease risks. Rev Environ Health 34(3):251-259. doi:10.1515/reveh-2019-0030 PMID:31408434 PMCID:PMC6915040
  • Dhakal RC, Parkin S, Lehmler H. 2019. 3,5-Dichloro-3 ,4 -dimethoxybiphenyl. IUCrData 4:doi:10.1107/S2414314619005182
  • Ewald JM, Humes SV, Martinez A, Schnoor JL, Mattes TE. 2019. Growth of dehalococcoides spp. and increased abundance of reductive dehalogenase genes in anaerobic PCB-contaminated sediment microcosms. Environ Sci Pollut Res Int doi:10.1007/s11356-019-05571-7 PMID:31209752 PMCID:PMC6918016
  • Gourronc FA, Perdew GH, Robertson LW, Klingelhutz AJ. 2019. PCB126 blocks the thermogenic beiging response of adipocytes. Environ Sci Pollut Res Int 27:doi:10.1007/s11356-019-06663-0 PMID:31721030 PMCID:PMC7098842
  • Hou X, Kong W, Wang X, Liu Y, Chen W, Liu J, Schnoor JL, Jiang G. 2019. Abiotic methylation of tetrabromobisphenol A (TBBPA) with the occurrence of methyl iodide in aqueous environments. Environ Sci Technol Lett 6:558-564. doi:10.1021/acs.estlett.9b00445
  • Hou X, Yu M, Liu A, Wang X, Li Y, Liu J, Schnoor JL, Jiang G. 2019. Glycosylation of tetrabromobisphenol A in pumpkin. Environ Sci Technol 53:8805-8812. doi:10.1021/acs.est.9b02122 PMID:31283198
  • Jahnke JC, Hornbuckle KC. 2019. PCB Emissions from Paint Colorants. Environ Sci Technol 53-9:5187-5194. doi:10.1021/acs.est.9b01087 PMID:30997998 PMCID:PMC6519452
  • Janechek N, Marek RF, Bryngelson N, Singh A, Bullard RL, Brune WH, Stanier CO. 2019. Physical properties of secondary photochemical aerosol from OH oxidation of a cyclic siloxane. Atmos Chem Phys 19:1649-1664. doi:10.5194/acp-19-1649-2019 PMID:31889955 PMCID:PMC6936766
  • Klenov V, Flor S, Adur M, Ganesan S, Eti N, Iqbal K, Soares M, Ludewig G, Ross J, Keating A, Robertson LW. 2019. Uterine toxicity following exposure to polychlorinated biphenyl 126 is mediated by the aryl hydrocarbon receptor. Fertil Steril 111(4):e4. doi:10.1016/j.fertnstert.2019.02.038
  • Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
  • Li Y, Chiou CT, Li H, Schnoor JL. 2019. Improved prediction of the bioconcentration factors of organic contaminants from soils into plant/crop roots by related physicochemical parameters. Environ Int 126:46-53. doi:10.1016/j.envint.2019.02.020 PMID:30776749
  • Li Y, Hou X, Chen W, Liu J, Zhou Q, Schnoor JL, Jiang G. 2019. Carbon chain decomposition of short chain chlorinated paraffins mediated by pumpkin and soybean seedlings. Environ Sci Technol 53(12):6765-6772. doi:10.1021/acs.est.9b01215 PMID:31099560
  • Liu B, Sun Y, Xu G, Snetselaar LG, Ludewig G, Wallace RB, Bao W. 2019. Association between Body Iron Status and Leukocyte Telomere Length, a Biomarker of Biological Aging, in a Nationally Representative Sample of US Adults. J Acad Nutr Diet 119(4):617-625. doi:10.1016/j.jand.2018.09.007 PMCID:PMC6548326
  • Martinez A, Awad AM, Herkert N, Hornbuckle KC. 2019. Determination of PCB fluxes from Indiana Harbor and Ship Canal using dual-deployed air and water passive samplers. Environ Pollut 244:469-476. doi:10.1016/j.envpol.2018.10.048 PMID:30366294 PMCID:PMC6277018
  • Ronis M, Watts J, Pulliam CF, Williams AE, Alund AW, Haque E, Gadupudi GS, Robertson LW. 2019. Skeletal toxicity resulting from exposure of growing male rats to coplanar PCB 126 is associated with disruption of calcium homeostasis and the GH-IGF-1 axis and direct effects on bone formation. Arch Toxicol doi:10.1007/s00204-019-02645-w PMID:31820026
  • Roy MA, Sant KE, Venezia OL, Shipman AB, McCormick SD, Saktrakulkla P, Hornbuckle KC, Timme-Laragy AR. 2019. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environ Pollut 254:113027. doi:10.1016/j.envpol.2019.113027 PMID:31421573 PMCID:PMC7027435
  • Saktrakulkla P, Dhakal RC, Lehmler H, Hornbuckle KC. 2019. A semi-target analytical method for quantification of OH-PCBs in environmental samples. Environ Sci Pollut Res Int 1-13. doi:10.1007/s11356-019-05775-x PMID:31359319 PMCID:PMC6986979
  • Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. doi:10.1021/acs.est.9b00535 PMID:30821444 PMCID:PMC6457253
  • Subramanian S, Tehrani R, Van Aken B. 2019. Transcriptomic response of Arabidopsis thaliana exposed to hydroxylated polychlorinated biphenyls (OH-PCBs). Int J Phytoremediation 21(1):52-59. doi:10.1080/15226514.2018.1523872 PMID:30648423 PMCID:PMC6548195
  • Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler H. 2019. Atropselective oxidation of 2,2 ,3,3 ,4,6 -hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for pcb 132 neurotoxicity. Toxicology 171:406-420. doi:10.1093/toxsci/kfz150 PMID:31268529 PMCID:PMC6760323
  • Uwimana E, Ruiz P, Li X, Lehmler H. 2019. Human CYP2A6, CYP2B6, and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environ Sci Technol 53(4):2114-2123. doi:10.1021/acs.est.8b05250 PMID:30576102 PMCID:PMC6380921
  • Zhang Q, Liu Y, Lin Y, Kong W, Zhao X, Ruan T, Liu J, Schnoor JL, Jiang G. 2019. Multiple metabolic pathways of 2,4,6-tribromophenol in rice plants. Environ Sci Technol 53:7473-7482. doi:10.1021/acs.est.9b01514 PMID:31244074

2018

  • Alam S, Carter GS, Krager KJ, Li X, Lehmler H, Aykin-Burns N. 2018. PCB11 metabolite, 3,3-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. Antioxidants (Basel) 7(9):121. doi:10.3390/antiox7090121 PMID:30223548
  • Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
  • Das S, Oldham E, Lehmler H, Knutson BL, Rankin S. 2018. Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants. Journal of Colloid and Interface Science 517:428-438. doi:10.1016/j.jcis.2017.10.066 PMID:29096103
  • Dhakal K, Gadupudi GS, Lehmler H, Ludewig G, Duffel MW, Robertson LW. 2018. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290. doi:10.1007/s11356-017-9694-x PMID:28744683 PMCID:PMC5785587
  • Enayah SH, Vanle BC, Fuortes LJ, Doorn JA, Ludewig G. 2018. PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology 394:93-101. doi:10.1016/j.tox.2017.12.003 PMID:29233657 PMCID:PMC5756734
  • Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. 2018. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci 163:440-453. doi:10.1093/toxsci/kfy041 PMID:29474705 PMCID:PMC5974782
  • Garje R, An JJ, Sanchez K, Greco A, Stolwijk J, Devor E, Rustum Y, Zakharia Y. 2018. Current Landscape and the Potential Role of Hypoxia-Inducible Factors and Selenium in Clear Cell Renal Cell Carcinoma Treatment. Int J Mol Sci 19(12):3834. doi:10.3390/ijms19123834 PMID:30513765 PMCID:PMC6321165
  • Gourronc FA, Robertson LW, Klingelhutz AJ. 2018. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492. doi:10.1007/s11356-017-9676-z PMID:28699004 PMCID:PMC5764822
  • Herkert N, Hornbuckle KC. 2018. Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environ Sci Process Impacts 20:757-766. doi:10.1039/c8em00082d PMID:29611590 PMCID:PMC5966328
  • Herkert N, Jahnke JC, Hornbuckle KC. 2018. Emissions of tetrachlorobiphenyls (PCBs 47, 51, and 68) from polymer resin on kitchen cabinets as a non-aroclor source to residential air. Environ Sci Technol 52(9):5154-5160. doi:10.1021/acs.est.8b00966 PMID:29667399
  • Herkert N, Spak SN, Smith A, Schuster JK, Harner T, Martinez A, Hornbuckle KC. 2018. Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20(1):210-219. doi:10.1039/c7em00360a PMID:29094747 PMCID:PMC5783774
  • Hou X, Yu M, Liu A, Li Y, Ruan T, Liu J, Schnoor JL, Jiang G. 2018. Biotransformation of tetrabromobisphenol A dimethyl ether back to tetrabromobisphenol A in whole pumpkin plants. Environ Pollut 241:331-338. doi:10.1016/j.envpol.2018.05.075 PMID:29843015 PMCID:PMC6351071
  • Jones MP. 2018. Linear regression with left-censored covariates and outcome using a pseudolikelihood approach. Environmetrics 29:16. doi:10.1002/env.2536 PMID:30686916 PMCID:PMC6344928
  • Klaren WD, Vine D, Vogt S, Robertson LW. 2018. Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25(17):16427-16433. doi:10.1007/s11356-017-0202-0 PMID:28940161 PMCID:PMC5866157
  • Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler H. 2018. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25(17):1-14. doi:10.1007/s11356-017-1162-0 PMID:29322390 PMCID:PMC6015536
  • Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
  • Liu Y, Richardson ES, Derocher AE, Lunn NJ, Lehmler H, Li X, Zhang Y, Cui JY, Cheng L, Martin JW. 2018. Hundreds of unrecognized halogenated contaminants discovered in polar bear serum. Angew Chem Int Ed Engl 57:16401-16406. doi:10.1002/anie.201809906 PMID:30376612
  • Mattes TE, Ewald JM, Liang Y, Martinez A, Awad AM, Richards P, Hornbuckle KC, Schnoor JL. 2018. PCB dechlorination hotspots and reductive dehalogenase genes in sediments from a contaminated wastewater lagoon. Environ Sci Pollut Res Int 25(17):16376-16388. doi:10.1007/s11356-017-9872-x PMID:28803405 PMCID:PMC6206866
  • Parker VS, Squirewell EJ, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201. doi:10.1016/j.etap.2018.01.010 PMID:29408762 PMCID:PMC6078096
  • Pencikova K, Svrzkova L, Strapacova S, Neca J, Bartonkova I, Dvorak Z, Hyzdalova M, Pivnicka J, Palkova L, Lehmler H, Li X, Vondracek J, Machala M. 2018. In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486. doi:10.1016/j.envpol.2018.02.067 PMID:29518658 PMCID:PMC5908724
  • Robertson LW, Weber R, Nakano T, Johansson N. 2018. PCBs risk evaluation, environmental protection, and management: 50-year research and counting for elimination by 2028. Environ Sci Pollut Res Int 25:16269-16276. doi:10.1007/s11356-018-2467-3 PMID:29934860 PMCID:PMC6033322
  • Rodriguez EA, Vanle BC, Doorn JA, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78. doi:10.1016/j.etap.2018.06.010 PMID:29986280 PMCID:PMC609219
  • Sethi S, Keil KP, Lein PJ. 2018. 3,3-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 1-9. doi:10.1007/s00204-018-2307-8 PMID:30225637 PMCID:PMC6196112
  • Tomsho KS, Basra K, Rubin SM, Miller CB, Juang R, Broude S, Martinez A, Hornbuckle KC, Heiger-Bernays WJ, Scammell MK. 2018. Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25(17):16389-16400. doi:10.1007/s11356-017-0286-6 PMID:29079973 PMCID:PMC6015112
  • Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832
  • Xiao X, Chen B, Chen Z, Zhu L, Schnoor JL. 2018. Insight into Multiple and Multilevel Structures of Biochars and Their Potential Environmental Applications: A Critical Review. Environ Sci Technol 52(9):5027-5047. doi:10.1021/acs.est.7b06487 PMID:29634904 PMCID:PMC6402350

2017

  • Buettner GR, Buranasudja V, Doskey CM, Wagner BA. 2017. Estimating and partitioning the flux of ATP in cells in culture using mol cell(-1) s(-1) and the stoichiometries of metabolism. Free Radic Biol Med 112:161-161. doi:10.1016/j.freeradbiomed.2017.10.248
  • Buranasudja V, Doskey CM, Wagner BA, Du J, Gordon DJ, Koppenhafer S, Cullen JJ, Buettner GR. 2017. DNA damage and energy crisis are central in the mechanism for the cytotoxicity of pharmacological ascorbate in cancer treatment. Free Radic Biol Med 112:162-162. doi:10.1016/j.freeradbiomed.2017.10.249
  • Das S, Xu W, Lehmler H, Miller A, Knutson BL, Rankin S. 2017. Inverted micelle-in-micelle configuration in cationic/carbohydrate surfactant mixtures. Chemphyschem 18(1):79-86. doi:10.1002/cphc.201600908 PMID:27788284
  • Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
  • Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
  • Janechek N, Hansen K, Stanier CO. 2017. Comprehensive atmospheric modeling of reactive cyclic siloxanes and their oxidation products. Atmos Chem Phys 17:8357-8370. doi:10.5194/acp-17-8357-2017 PMCID:PMC6368090
  • Joshi S, Lehmler H, Knutson BL, Rankin S. 2017. Imprinting of Stöber particles for chirally-resolved adsorption of target monosaccharides and disaccharides. New J Chem 20(41):11525-11532. doi:10.1039/C7NJ01938F
  • Kalkunte S, Huang Z, Lippe EO, Robertson LW, Sharma S, Kumar S. 2017. Polychlorinated biphenyls target Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Sci Rep 7:39885. doi:10.1038/srep39885 PMID:28071720 PMCID:PMC5223111
  • Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
  • Kania-Korwel I, Wu X, Wang K, Lehmler H. 2017. Identification of lipidomic markers of chronic 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134. doi:10.1016/j.tox.2017.09.005 PMID:28890136 PMCID:PMC5633524
  • Klinefelter K, Hoover MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler H, Lopez-Juarez A, Ludwig CP, Curran CP. 2017. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 1-16. doi:10.1007/s00335-017-9728-1 PMID:29197979
  • Li Y, Hou X, Yu M, Zhou Q, Liu J, Schnoor JL, Jiang G. 2017. Dechlorination and chlorine rearrangement of 1,2,5,5,6,9,10-heptachlorodecane mediated by the whole pumpkin seedlings. Environ Pollut 224:524-531. doi:10.1016/j.envpol.2017.02.035 PMID:28242253
  • Liu B, Lehmler H, Sun Y, Xu G, Sun Q, Hu F, Wallace RB, Boa W, Hu FB, Zhong G, Liu Y. 2017. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health 1(3):e114-e122. doi:10.1016/S2542-5196(17)30049-9 PMID:29308453 PMCID:PMC5751959
  • Lynch CF, Kelly KM, Ludewig G, Wang K, Roh T, Weyer P. 2017. Low-level arsenic exposure from drinking water is associated with prostate cancer in Iowa. Environ Res 159:338-343. doi:10.1016/j.envres.2017.08.026 PMID:28841521 PMCID:PMC5623650
  • Marek RF, Thorne PS, Herkert N, Awad AM, Hornbuckle KC. 2017. Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. schools. Environ Sci Technol 51(14):7853-7860. doi:10.1021/acs.est.7b01910 PMID:28656752 PMCID:PMC5777175
  • Martinez A, Hadnott BN, Awad AM, Herkert N, Tomsho KS, Basra K, Scammell MK, Heiger-Bernays WJ, Hornbuckle KC. 2017. Release of airborne polychlorinated biphenyls from New Bedford Harbor results in elevated concentrations in the surrounding air. Environ Sci Technol Lett 4(4):127-131. doi:10.1021/acs.estlett.7b00047 PMID:28413805 PMCID:PMC5390305
  • Qian J, Jennings B, Cwiertny DM, Martinez A. 2017. Emerging investigator series: development and application of polymeric electrospun nanofiber mats as equilibrium-passive sampler media for organic compounds. Environ Sci Process Impacts 19:1445-1456. doi:10.1039/c7em00289k PMID:29086783 PMCID:PMC5687983
  • Schnoor JL, Van Aken B, Subramanian S. 2017. Effects of Polychlorinated Biphenyls (PCBs) and Their Hydroxylated Metabolites (OH-PCBs) on Arabidopsis thaliana. Environ Sci Technol 51(12):7263-7270. doi:10.1021/acs.est.7b01538 PMID:28541669 PMCID:PMC5772893
  • Schon P, Ctistis G, Bakker W, Luthe G. 2017. Nanoparticular surface-bound PCBs, PCDDs, and PCDFs-a novel class of potentially higher toxic POPs. Environ Sci Pollut Res Int 24(14):12758-12766. doi:10.1007/s11356-016-6211-6 PMID:26939687
  • Schroer HW, Langenfeld KL, Li X, Lehmler H, Just CL. 2017. Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 28(1):95-109. doi:10.1007/s10532-016-9780-7 PMID:27913891
  • Schroer HW, Li X, Lehmler H, Just CL. 2017. Metabolism and photolysis of 2,4-Dinitroanisole in Arabidopsis. Environ Sci Technol 51:13714-13722. doi:10.1021/acs.est.7b04220 PMID:29131608
  • Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364
  • Uwimana E, Maiers A, Li X, Lehmler H. 2017. Microsomal metabolism of prochiral polychlorinated biphenyls results in the enantioselective formation of chiral metabolites. Environ Sci Technol 51(3):1820-1829. doi:10.1021/acs.est.6b05387 PMID:28038482 PMCID:PMC5300040
  • Wagner BA, Buranasudja V. 2017. Quantitative differences in physical size, H2O2-removal, and cellular bioenergetics in the human pancreatic cancer cell lines MIA PaCa-2 and Panc-1: Impact on susceptibilities to ascorbate/H2O. Free Radic Biol Med 112:178-178. doi:10.1016/j.freeradbiomed.2017.10.279
  • Zhao H, Lehmler H, Chen J, Liu S, Cai X. 2017. Antibiotic pollution in marine food webs in laizhou bay, north China: trophodynamics and human exposure implication. Environ Sci Technol 51(4):doi:10.1021/acs.est.6b04556 PMID:28106989 PMCID:PMC5618103
  • . 2017. Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25(17):1-9. doi:10.1007/s11356-017-0683-x PMID:29124635 PMCID:PMC5943194

2016

  • Anderson DG, Florang V, Schamp J, Buettner GR, Doorn JA. 2016. Antioxidant-mediated modulation of protein reactivity for 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Chem Res Toxicol 29(7):1098-1107. doi:10.1021/acs.chemrestox.5b00528 PMID:27268734 PMCID:PMC5248556
  • Awad AM, Martinez A, Marek RF, Hornbuckle KC. 2016. Occurrence and distribution of two hydroxylated polychlorinated biphenyl congeners in Chicago air. Environ Sci Technol Lett 3:47-51. doi:10.1021/acs.estlett.5b00337
  • Bhalla R, Tehrani R, Van Aken B. 2016. Toxicity of hydroxylated polychlorinated biphenyls (HO-PCBs) using the bioluminescent assay Microtox(®). Ecotoxicology 25(7):1438-1444. doi:10.1007/s10646-016-1693-z PMID:27411941 PMCID:PMC5131519
  • Ctistis G, Schon P, Bakker W, Luthe G. 2016. PCDDs, PCDFs, and PCBs co-occurrence in TiO2 nanoparticles. Environ Sci Pollut Res Int 23(5):4837-4843. doi:10.1007/s11356-015-5628-7 PMID:26545886
  • Doskey CM, Buranasudja V, Wagner BA, Wilkes JG, Du J, Cullen JJ, Buettner GR. 2016. Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biol 10:274-284. doi:10.1016/j.redox.2016.10.010 PMID:27833040 PMCID:PMC5106370
  • Ekuase EJ, van't Erve TJ, Rahaman A, Robertson LW, Duffel MW, Luthe G. 2016. Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes. Environ Sci Pollut Res Int 23(3):2119-2127. doi:10.1007/s11356-015-4886-8 PMID:26165989 PMCID:PMC4713379
  • Flor S, He X, Lehmler H, Ludewig G. 2016. Estrogenicity and androgenicity screening of PCB sulfate monoesters in human breast cancer MCF-7 cells. Environ Sci Pollut Res Int 23(3):2186-2200. doi:10.1007/s11356-015-5142-y PMID:26300354 PMCID:PMC4718780
  • Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. 2016. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci 149(1):98-110. doi:10.1093/toxsci/kfv215 PMID:26396156 PMCID:PMC4731404
  • Gadupudi GS, Klingelhutz AJ, Robertson LW. 2016. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol 29(9):1504-1509. doi:10.1021/acs.chemrestox.6b00172 PMID:27509375
  • Herkert N, Martinez A, Hornbuckle KC. 2016. A model using local weather data to determine the effective sampling volume for PCB congeners collected on passive air samplers. Environ Sci Technol 50(13):6690-6697. doi:10.1021/acs.est.6b00319 PMID:26963482 PMCID:PMC4935961
  • Hunt G, Stegeman JJ, Robertson LW. 2016. PCBs: exposures, effects, remediation, and regulation with special emphasis on PCBs in schools. Environ Sci Pollut Res Int 23(3):1971-1974. doi:10.1007/s11356-015-5774-y PMID:26620856 PMCID:PMC4718839
  • Kania-Korwel I, Lehmler H. 2016. Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review. Environ Sci Pollut Res Int 23(3):2042-2057. doi:10.1007/s11356-015-4150-2 PMID:25651810 PMCID:PMC4527964
  • Kania-Korwel I, Lehmler H. 2016. Toxicokinetics of chiral polychlorinated biphenyls across different species--a review. Environ Sci Pollut Res Int 23(3):2058-2080. doi:10.1007/s11356-015-4383-0 PMID:25824003 PMCID:PMC4591098
  • Klaren WD, Flor S, Gibson-Corley KN, Ludewig G, Robertson LW. 2016. Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicol Rep 3:21-28. doi:10.1016/j.toxrep.2015.12.001 PMID:26770886 PMCID:PMC4710377
  • Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851-859. doi:10.1021/acs.chemrestox.6b00022 PMID:26967026 PMCID:PMC5100827
  • Koh W, Hornbuckle KC, Wang K, Thorne PS. 2016. Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers. Environ Int 94:538-545. doi:10.1016/j.envint.2016.06.014 PMID:27352881 PMCID:PMC4980156
  • Koh WX, Hornbuckle KC, Marek RF, Wang K, Thorne PS. 2016. Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two US Midwestern communities. Chemosphere 147:389-395. doi:10.1016/j.chemosphere.2015.12.113 PMID:26774304 PMCID:PMC4747419
  • Li M, Teesch LM, Murry DJ, Pope RM, Li Y, Robertson LW, Ludewig G. 2016. Cytochrome c adducts with PCB quinoid metabolites. Environ Sci Pollut Res Int 23(3):2148-2159. doi:10.1007/s11356-015-4801-3 PMID:26062463 PMCID:PMC4676959
  • Ma C, Zhai G, Wu H, Kania-Korwel I, Lehmler H, Schnoor JL. 2016. Identification of a novel hydroxylated metabolite of 2,2',3,5',6-pentachlorobiphenyl formed in whole poplar plants. Environ Sci Pollut Res Int 23(3):2089-2098. doi:10.1007/s11356-015-5939-8 PMID:26676542 PMCID:PMC4718877
  • Martinez A, Schnoebelen DJ, Hornbuckle KC. 2016. Polychlorinated biphenyl congeners in sediment cores from the Upper Mississippi River. Chemosphere 144:1943-1949. doi:10.1016/j.chemosphere.2015.10.090 PMID:26547030 PMCID:PMC4695299
  • Osterberg D, Scammell MK. 2016. PCBs in schools--where communities and science come together. Environ Sci Pollut Res Int 23(3):1998-2002. doi:10.1007/s11356-015-5009-2 PMID:26194237 PMCID:PMC4770789
  • Portier CJ, Armstrong BK, Baguley B, Baur X, Belyaev I, Belle R, Belpoggi F, Biggeri A, Bosland MC, Bruzzi P, Budnik L, Bugge M, Burns K, Calaf GM, Carpenter DO, Carpenter H, Lopez-Carillo L, Clapp R, Cocco P, Consonni D, Comba P, Craft ES, Dalvie M, Davis D, Demers PA, De Roos AJ, DeWitt JC, Forastiere F, Freedman JH, Fritschi L, Gaus C, Gohlke J, Goldberg M, Greiser E, Hansen J, Hardell L, Hauptmann M, Huang W, Huff J, James MO, Jameson C, Kortenkamp A, Kopp-Schneider A, Kromhout H, Larramendy M, Landrigan PJ, Lash LH, Leszczynski D, Lynch CF, Magnani C, Mandrioli D, Martin FL, Merler E, Michelozzi P, Miligi L, Miller A, Mirabelli D, Mirer F, Naidoo S, Perry MJ, Petronio M, Pirastu R, Portier R, Ramos KS, Robertson LW, Rodriguez T, Roosli M, Ross M, Roy D, Rusyn I, Saldiva P, Sass J, Savolainen K, Scheepers P, Sergi C, Silbergeld EK, Smith MT, Stewart BW, Sutton P, Tateo F, Terracini B, Thielmann H, Thomas DB, Vainio H, Vena J, Vineis P, Weiderpass E, Weisenburger DD, Woodruff TJ, Yorifuji T, Yu I, Zambon P, Zeeb H, Zhou SF. 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health 70(8):741-745. doi:10.1136/jech-2015-207005 PMID:26941213 PMCID:PMC4975799
  • Rodriguez EA, Li X, Lehmler H, Robertson LW, Duffel MW. 2016. Sulfation of lower chlorinated polychlorinated biphenyls increases their affinity for the major drug-binding sites of human serum albumin. Environ Sci Technol 50(10):5320-5327. doi:10.1021/acs.est.6b00484 PMID:27116425 PMCID:PMC4883002
  • Schnoor JL. 2016. Recognizing drinking water pipes as community health hazards. J Chem Educ 93(4):581-582. doi:10.1021/acs.jchemed.6b00218
  • Shen H, Robertson LW, Ludewig G. 2016. Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3. Environ Sci Pollut Res Int 23(3):2108-2118. doi:10.1007/s11356-015-4722-1 PMID:26006071 PMCID:PMC4662644
  • Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371 PMID:27989147 PMCID:PMC5175585
  • Wang B, Klaren WD, Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status, and MnSOD in the rat. Toxicol Sci 150(1):15-26. doi:10.1093/toxsci/kfv312 PMID:26660635 PMCID:PMC5009614
  • Wangpradit O, Adamcakova-Dodd A, Heitz K, Robertson LW, Thorne PS, Luthe G. 2016. PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats. Environ Sci Pollut Res Int 23(3):2128-2137. doi:10.1007/s11356-015-5022-5 PMID:26400242 PMCID:PMC4803647
  • Wangpradit O, Rahaman A, Mariappan S, Buettner GR, Robertson LW, Luthe G. 2016. Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids. Environ Sci Pollut Res Int 23(3):2138-2147. doi:10.1007/s11356-015-5007-4 PMID:26396011 PMCID:PMC4767158
  • Weisenhorn EM, van't Erve TJ, Riley NM, Hess JR, Raife TJ, Coon JJ. 2016. Multi-omics evidence for inheritance of energy pathways in red blood cells. Mol Cell Proteomics 15(12):3614-3623. doi:10.1074/mcp.M116.062349 PMID:27777340 PMCID:PMC5141275
  • Wu X, Lehmler H. 2016. Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes. Environ Sci Pollut Res Int 23(3):2081-2088. doi:10.1007/s11356-015-4987-4 PMID:26155892 PMCID:PMC4706823
  • Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084 PMID:27208083 PMCID:PMC4960907
  • Xiao W, Sarsour EH, Wagner BA, Doskey CM, Buettner GR, Domann FE, Goswami PC. 2016. Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Arch Toxicol 90(2):319-332. doi:10.1007/s00204-014-1407-3 PMID:25417049 PMCID:PMC4441874
  • Xin X, Senthilkumar PK, Schnoor JL, Ludewig G. 2016. Effects of PCB126 and PCB153 on telomerase activity and telomere length in undifferentiated and differentiated HL-60 cells. Environ Sci Pollut Res Int 23(3):2173-2185. doi:10.1007/s11356-015-5187-y PMID:26330309 PMCID:PMC4718801

2015

  • Agudo A, Aronson KJ, Bonefeld-Jørgensen EC, Cocco P, Cogliano VJ, Cravedi J, Esch HL, Fiedler H, Glauret HP, Guo YL, Herbert RA, Hopf NB, James MO, Johansson N, Le Bizec B, Ludewig G, Machala M, Merletti F, Narbonne J, Robertson LW, Ruder AM, Tryphonas H, Vermeulen R, Vorkamp K, Walker N. 2015. IARC monographs on the evaluation of carcinogenic risks to humans, volume 107, Polychlorinated biphenyls and polybrominated biphenyls. https://monographs.iarc.fr/ENG/Monographs/vol107/mono107.pdf
  • Ampleman MD, Martinez A, DeWall J, Rawn DF, Hornbuckle KC, Thorne PS. 2015. Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol 49(2):1156-1164. doi:10.1021/es5048039 PMID:25510359 PMCID:PMC4303332
  • Cieslak JA, Strother RK, Rawal M, Du J, Doskey CM, Schroeder SR, Button AM, Wagner BA, Buettner GR, Cullen JJ. 2015. Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer. Free Radic Biol Med 83:227-237. doi:10.1016/j.freeradbiomed.2015.02.018 PMID:25725418 PMCID:PMC4441864
  • Doskey CM, van't Erve TJ, Wagner BA, Buettner GR. 2015. Moles of a substance per cell is a highly informative dosing metric in cell culture. PLoS One 10(7):e0132572. doi:10.1371/journal.pone.0132572 PMID:26172833 PMCID:PMC4501792
  • Gadupudi GS, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. 2015. PCB126 inhibits adipogenesis of human preadipocytes. Toxicol In Vitro 29(1):132-141. doi:10.1016/j.tiv.2014.09.015 PMID:25304490 PMCID:PMC4250299
  • Grimm FA, He X, Teesch LM, Lehmler H, Robertson LW, Duffel MW. 2015. Tissue distribution, metabolism, and excretion of 3,3'-dichloro-4'-sulfooxy-biphenyl in the rat. Environ Sci Technol 49(13):8087-8095. doi:10.1021/acs.est.5b01499 PMID:26046945 PMCID:PMC4496304
  • Grimm FA, Hu D, Kania-Korwel I, Lehmler H, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW. 2015. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45(3):245-272. doi:10.3109/10408444.2014.999365 PMID:25629923 PMCID:PMC4383295
  • Grimm FA, Lehmler H, He X, Robertson LW, Duffel MW. 2015. Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models. Chem Biol Interact 228:1-8. doi:10.1016/j.cbi.2015.01.002 PMID:25595224 PMCID:PMC4327905
  • Hu X, Adamcakova-Dodd A, Lehmler H, Gibson-Corley KN, Thorne PS. 2015. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ Sci Technol 49(19):11875-11883. doi:10.1021/acs.est.5b02865 PMID:26348937 PMCID:PMC4711378
  • Jones MP, Perry SS, Thorne PS. 2015. Maximum pairwise psuedo-likelihood estimation of the covariance matrix from left-censored data. J Agric Biol Environ Stat 20(1):83-99. doi:10.1007/s13253-014-0185-y
  • Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
  • Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Robertson LW. 2015. Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure. Toxicology 338:1-7. doi:10.1016/j.tox.2015.09.004 PMID:26410179 PMCID:PMC4658301
  • Koh WX, Hornbuckle KC, Thorne PS. 2015. Human serum from urban and rural adolescents and their mothers shows exposure to polychlorinated biphenyls not found in commercial mixtures. Environ Sci Technol 49(13):8105-8112. doi:10.1021/acs.est.5b01854 PMID:26053216 PMCID:PMC4774248
  • Liang Y, Meggo RE, Hu D, Schnoor JL, Mattes TE. 2015. Microbial community analysis of switchgrass planted and unplanted soil microcosms displaying PCB dechlorination. Appl Microbiol Biotechnol 99(15):6515-6526. doi:10.1007/s00253-015-6545-x PMID:25820643 PMCID:PMC4498989
  • Martinez A, Spak SN, Petrich NT, Hu D, Carmichael G, Hornbuckle KC. 2015. Atmospheric dispersion of PCB from a contaminated Lake Michigan harbor. Atmos Environ (1994) 122:791-798. doi:10.1016/j.atmosenv.2015.10.040 PMID:26594127 PMCID:PMC4649934
  • Oldham E, Nunes LM, Varela-Ramirez A, Rankin S, Knutson BL, Aguilera RJ, Lehmler H. 2015. Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line. Chem Cent J 9:3. doi:10.1186/s13065-014-0072-1 PMID:25705252 PMCID:PMC4333309
  • Peverly A, Ma Y, Vinier M, Rodenburg ZL, Spak SN, Hornbuckle KC, Hites RA. 2015. Variations of flame retardant, polycyclic aromatic hydrocarbon, and pesticide concentrations in Chicago's atmosphere measured using passive sampling. Environ Sci Technol 49(9):5371-5379. doi:10.1021/acs.est.5b00216 PMID:25874663
  • Peverly A, O'Sullivan C, Liu L, Venier M, Martinez A, Hornbuckle KC, Hites RA. 2015. Chicago's sanitary and ship canal sediment: polycyclic aromatic hydrocarbons, polychlorinated biphenyls, brominated flame retardants, and organophosphate esters. Chemosphere 134:380-386. doi:10.1016/j.chemosphere.2015.04.065 PMID:25981316
  • Shanahan CE, Spak SN, Martinez A, Hornbuckle KC. 2015. Inventory of PCBs in Chicago and opportunities for reduction in airborne emissions and human exposure. Environ Sci Technol 49(23):13878-13888. doi:10.1021/acs.est.5b00906 PMID:26440379
  • Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler H, Lein PJ. 2015. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology 338:59-68. doi:10.1016/j.tox.2015.10.002 PMID:26463278 PMCID:PMC4658283
  • van't Erve TJ, Wagner BA, Martin SM, Knudson C, Blendowski R, Keaton M, Holt T, Hess JR, Buettner GR, Ryckman KK, Darbro BW, Murray JC, Raife TJ. 2015. The heritability of hemolysis in stored human red blood cells. Transfusion 55(6):1178-1185. doi:10.1111/trf.12992 PMID:25644965 PMCID:PMC4469565
  • Wu X, Barnhart CD, Lein PJ, Lehmler H. 2015. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol 49(1):616-625. doi:10.1021/es504766p PMID:25420130 PMCID:PMC4291784
  • Xiao W, Goswami PC. 2015. Down-regulation of peroxisome proliferator activated receptor γ coactivator 1α induces oxidative stress and toxicity of 1-(4-Chlorophenyl)-benzo-2,5-quinone in HaCaT human keratinocytes. Toxicol In Vitro 29(7):1332-1338. doi:10.1016/j.tiv.2015.05.009 PMID:26004620 PMCID:PMC4553100
  • Xiao W, Son J, Vorrink SU, Domann FE, Goswami PC. 2015. Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes. Toxicol Lett 233(3):258-266. doi:10.1016/j.toxlet.2015.02.005 PMID:25668756 PMCID:PMC4341842
  • Zhai G, Gutowski SM, Walters KS, Yan B, Schnoor JL. 2015. Charge, size, and cellular selectivity for multiwall carbon nanotubes by maize and soybean. Environ Sci Technol 49(12):7380-7390. doi:10.1021/acs.est.5b01145 PMID:26010305
  • Zhao H, Jiang J, Wang Y, Lehmler H, Buettner GR, Quan X, Chen J. 2015. Monohydroxylated polybrominated diphenyl ethers (OH-PBDEs) and dihydroxylated polybrominated biphenyls (Di-OH-PBBs): novel photoproducts of 2,6-dibromophenol. Environ Sci Technol 49(24):14120-14128. doi:10.1021/acs.est.5b03637 PMID:26545041 PMCID:PMC4717839

2014

2013

2012

  • Ambati J, Song Y, Rankin S, Lehmler H. 2012. Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation. J Phys Chem A 116:1586-1595. doi:10.1021/jp2077193 PMID:22257259 PMCID:PMC3417754
  • Chaudhuri L, Nicholson AM, Kalen AL, Goswami PC. 2012. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene 31:1207-1216. doi:10.1038/onc.2011.325 PMID:21804600 PMCID:PMC3208126
  • Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396
  • Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Hornbuckle KC, Thorne PS. 2012. Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile. Environ Sci Technol 46(17):9653-9662. doi:10.1021/es301129h PMID:22846166 PMCID:PMC3573703
  • Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler H. 2012. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393-11401. doi:10.1021/es302810t PMID:22974126 PMCID:PMC3475189
  • Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, Olivier AK. 2012. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology 302(1):25-33. doi:10.1016/j.tox.2012.07.007 PMID:22824115 PMCID:PMC3438370
  • Martinez A, Erdman NR, Rodenburg ZL, Eastling PM, Hornbuckle KC. 2012. Spatial distribution of chlordanes and PCB congeners in soil in Cedar Rapids, Iowa, USA. Environ Pollut 161:222-228. doi:10.1016/j.envpol.2011.10.028 PMID:22230089 PMCID:PMC3255082
  • Oldham E, Xie W, Farnoud AM, Fiegel J, Lehmler H. 2012. Disruption of phosphatidylcholine mono layers and bilayers by perfluorobutane sulfonate. Journal of Physical Chemistry B 116:9999-10007. doi:10.1021/jp304412p PMID:22834732 PMCID:PMC3464004
  • Sarsour EH, Kalen AL, Xiao Z, Veenstra TD, Chaudhuri L, Venkataraman S, Reigan P, Buettner GR, Goswami PC. 2012. Manganese superoxide dismutase regulates a metabolic switch during the Mammalian Cell Cycle. Cancer Res 72:3807-3816. doi:10.1158/0008-5472.CAN-11-1063 PMID:22710435 PMCID:PMC3429130
  • Senthilkumar PK, Robertson LW, Ludewig G. 2012. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicol Appl Pharmacol 259(1):115-123. doi:10.1016/j.taap.2011.12.015 PMID:22210444 PMCID:PMC3288560
  • Shen H, Robertson LW, Ludewig G. 2012. Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats. Toxicol Lett 209(3):291-298. doi:10.1016/j.toxlet.2012.01.003 PMID:22266287 PMCID:PMC3288253
  • Tehrani R, Lyv MM, Kaveh R, Schnoor JL, Van Aken B. 2012. Biodegradation of mono-hydroxylated PCBs by Burkholderia xenovorans. Biotechnol J 34:2247-2252. doi:10.1007/s10529-012-1037-x PMID:22918793 PMCID:PMC3592572
  • Xin X, Kuppusamy SP, Schnoor JL, Ludewig G. 2012. Downregulation of Telomerase Activity and Shortening of Telomere Length by Polychlorinated Biphenyls (PCBs) in HL-60 Cells. Environ Mol Mutagen 53:S66.

2011

  • Anderson DG, Mariappan S, Buettner GR, Doorn JA. 2011. Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone. J Biol Chem 286:26978-26986. doi:10.1074/jbc.M111.249532 PMID:21642436 PMCID:PMC3143656
  • Buettner GR. 2011. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem 11(4):341-346. PMID:21453242 PMCID:PMC3131414
  • Bunaciu RP, Tharappel JC, Lehmler H, Lee EY, Robertson LW, Bruckner GG, Spear BT, Glauert HP. 2011. Role of oil vehicle on hepatic cell proliferation in PCB-treated rats. J Environ Pathol Toxicol Oncol 30(4):273-282. PMID:22181977 PMCID:PMC3522147
  • Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260h PMID:21913674 PMCID:PMC3196794
  • Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Toward identifying the next generation of superfund and hazardous waste site contaminants. Environ Health Perspect 119(1):6-10. doi:10.1289/ehp.1002497 PMID:21205582 PMCID:PMC3018501
  • Gulcan HO, Duffel MW. 2011. Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes. Arch Biochem Biophys 507:232-240. doi:10.1016/j.abb.2010.12.027 PMID:21187059 PMCID:PMC3058861
  • Hu D, Martinez A, Hornbuckle KC. 2011. Sedimentary records of non-Aroclor and Aroclor PCB mixtures in the Great Lakes. Journal of Great Lakes Research 37:359-364. doi:10.1016/j.jglr.2011.03.001 PMID:23538476 PMCID:PMC3607302
  • Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler H. 2011. Synthesis of sterically hindered polychlorinated biphenyl derivatives. Synthesis 7:1045-1054. doi:10.1055/s-0030-1258454 PMID:21516177 PMCID:PMC3080045
  • Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler H. 2011. Regioselective iodination of chlorinated aromatic compounds using silver salts. Tetrahedron 67(39):7461-7469. doi:10.1016/j.tet.2011.07.064 PMID:21918585 PMCID:PMC3170769
  • Kania-Korwel I, Duffel MW, Lehmler H. 2011. Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes. Environ Sci Technol 45:9590-9596. doi:10.1021/es2014727 PMID:21966948 PMCID:PMC3216237
  • Lai IK, Chai Y, Simmons DL, Watson WH, Tan R, Haschek-Hock WM, Wang K, Wang B, Ludewig G, Robertson LW. 2011. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci 124:202-214. doi:10.1093/toxsci/kfr215 PMID:21865291 PMCID:PMC3196656
  • Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chem Biol Interact 189:153-160. doi:10.1016/j.cbi.2010.11.009 PMID:21130751 PMCID:PMC3032042
  • Martinez A, Hornbuckle KC. 2011. Record of PCB congeners, sorbents and potential toxicity in core samples in Indiana Harbor and Ship Canal. Chemosphere 85:542-547. doi:10.1016/j.chemosphere.2011.08.018 PMID:21899876 PMCID:PMC3222236
  • Moo -Young M, Butler M, Webb C, Moreira A, Grodzinski B, Cui ZF, Agathos SN. 2011. Microbial degradation of polychlorinated biphenyls. In: Comprehensive Biotechnology.
  • Moo -Young M, Butler M, Webb C, Moreira A, Grodzinski B, Cui ZF, Agathos SN. 2011. Transgenic Plants and Associated bacteria for phytoremediation of organic pollutants. In: Comprehensive Biotechnology.
  • Robertson LW, Ludewig G. 2011. Polychlorinated biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrst Reinhalt Luft 71(1-2):25-32. PMID:21686028 PMCID:PMC3113507
  • Sarsour EH, Kumar MG, Kalen AL, Goswami M, Buettner GR, Goswami PC. 2011. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr) 34(1):95-109. doi:10.1007/s11357-011-9223-7 PMID:21384152 PMCID:PMC3260369
  • Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. 2011. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett 204:64-70. doi:10.1016/j.toxlet.2011.04.012 PMID:21530622 PMCID:PMC3109099
  • Song Y, Ambati J, Parkin S, Rankin S, Robertson LW, Lehmler H. 2011. Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. Chemosphere 85:386-392. doi:10.1016/j.chemosphere.2011.07.004 PMID:21824639 PMCID:PMC3206982
  • Wagner BA, Venkataraman S, Buettner GR. 2011. The rate of oxygen utilization by cells. Free Radic Biol Med 51(3):700-712. doi:10.1016/j.freeradbiomed.2011.05.024 PMID:21664270 PMCID:PMC3147247
  • Wang B, Robertson LW, Wang K, Ludewig G. 2011. Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126. Xenobiotica 41:1031-1043. doi:10.3109/00498254.2011.603763 PMID:21970748 PMCID:PMC3564674
  • Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360m PMID:22026639 PMCID:PMC3243785
  • Zhai G, Lehmler H, Schnoor JL. 2011. New hydroxylated metabolites of 4-monochlorobiphenyl in whole poplar plants. Chem Cent J 5:87. doi:10.1186/1752-153X-5-87 PMID:22185578 PMCID:PMC3260099
  • Zhai G, Lehmler H, Schnoor JL, Hu D. 2011. Enantioselective biotransformation of chiral PCBs in whole poplar plants. Environ Sci Technol 45(6):2308-2316. doi:10.1021/es1033662 PMID:21329345 PMCID:PMC3066656

2010

2009

  • Klosener J, Peters TM, Adamcakova-Dodd A, Teesch LM, Thorne PS, Robertson LW, Luthe G. 2009. Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures. Chem Res Toxicol 22(1):179-186. doi:10.1021/tx8003032 PMID:19111055 PMCID:PMC3120107
  • Liu J, Hu D, Jiang G, Schnoor JL. 2009. In vivo biotransformation of 3,3',4,4'-tetrachlorobiphenyl by whole plants-poplars and switchgrass. Environ Sci Technol 43(19):7503-7509. PMID:19848168 PMCID:PMC2754666
  • Persoon C, Hornbuckle KC. 2009. Calculation of passive sampling rates from both native PCBs and depuration compounds in indoor and outdoor environments. Chemosphere 74(7):917-923. doi:10.1016/j.chemosphere.2008.10.011 PMID:19068264 PMCID:PMC2657292
  • Pessah IN, Lehmler H, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. 2009. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol 22(1):201-207. doi:10.1021/tx800328u PMID:18954145 PMCID:PMC2662366
  • Song Y, Wagner BA, Witmer JR, Lehmler H, Buettner GR. 2009. Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones. Proc Natl Acad Sci U S A 106(24):9725-9730. doi:10.1073/pnas.0810352106 PMID:19497881 PMCID:PMC2689812
  • Spencer W, Lehmler H, Robertson LW, Gupta RC. 2009. Oxidative DNA adducts following Cu2+-mediated activation of dihydroxy PCBs: role of reactive oxygen species. Free Radic Biol Med 46(10):1346-1352. doi:10.1016/j.freeradbiomed.2009.02.005 PMID:19233261 PMCID:PMC2744390
  • Wangpradit O, Teesch LM, Mariappan S, Duffel MW, Norstrom K, Robertson LW, Luthe G. 2009. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Toxicol 22(1):64-71. doi:10.1021/tx800300t PMID:19105592 PMCID:PMC2637223
  • Yang-won S, Buettner GR, Venkataraman S, Treimer S, Robertson LW, Ludewig G. 2009. UVA/B-induced formation of free radicals from decabromodiphenyl ether. Environ Sci Technol 43(7):2581-2588. PMID:19452920 PMCID:PMC2685467

2008

  • Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
  • Glauert HP, Tharappel JC, Lu Z, Stemm DN, Banerjee S, Chan L, Lee EY, Lehmler H, Robertson LW, Spear BT. 2008. Role of oxidative stress in the promoting activities of pcbs. Environ Toxicol Pharmacol 25(2):247-250. doi:10.1016/j.etap.2007.10.025 PMID:19122744 PMCID:PMC2836878
  • Gulcan HO, Duffel MW. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 21(8):1503-1508. doi:10.1021/tx800133d PMID:18656962 PMCID:PMC2548291
  • Hu D, Hornbuckle KC, Martinez A. 2008. Discovery of non-aroclor PCB (3,3'-dichlorobiphenyl) in Chicago air. Environ Sci Technol 42(21):7873-7877. PMID:19031874 PMCID:PMC2646757
  • Jacobus JA, Flor S, Klingelhutz AJ, Robertson LW, Ludewig G. 2008. 2-(4'-Chlorophenyl)-1,4-benxoquinone increases the frequency of micronuclei and shortens telomeres. Environ Toxicol Pharmacol 25(2):267-272. doi:10.1016/j.etap.2007.10.022 PMID:18438462 PMCID:PMC2346440
  • Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Dose-dependent enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl in female mice. Environ Toxicol Chem 27(2):299-305. doi:10.1897/07-359R.1 PMID:18348647
  • Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food Chem Toxicol 46(2):637-644. doi:10.1016/j.fct.2007.09.072 PMID:17950514 PMCID:PMC2289907
  • Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H. 2008. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21(6):1295-1303. doi:10.1021/tx800059j PMID:18494506 PMCID:PMC2574739
  • Kania-Korwel I, Vyas SM, Song Y, Lehmler H. 2008. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J Chromatogr A 1207:146-154. PMID:18760792
  • Kania-Korwel I, Xie W, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice after induction of CYP enzymes. Arch Environ Contam Toxicol 55(3):510-517. doi:10.1007/s00244-007-9111-4 PMID:18437444
  • Kania-Korwel I, Zhao H, Norstrom K, Li X, Hornbuckle KC, Lehmler H. 2008. Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J Chromatogr A 1214(1-2):37-46. doi:10.1016/j.chroma.2008.10.089 PMID:19019378 PMCID:PMC2648864
  • Klosener J, Swenson DC, Robertson LW, Luthe G. 2008. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Crystallogr B 64(Pt1):108-119. doi:10.1107/S0108768107067079 PMID:18204217 PMCID:PMC3120100
  • Liu J, Schnoor JL. 2008. Uptake and translocation of lesser-chlorinated polychlorinated biphenyls (PCBs) in whole hybrid poplar plants after hydroponic exposure. Chemosphere 73(10):1608-1616. doi:10.1016/j.chemosphere.2008.08.009 PMID:18793792 PMCID:PMC2668963
  • Ludewig G, Lehmann L, Esch HL, Robertson LW. 2008. Metabolic activation of PCBs to carcinogens in vivo - a review. Environ Toxicol Pharmacol 25(2):241-246. doi:10.1016/j.etap.2007.10.029 PMID:18452002 PMCID:PMC2364599
  • Luthe G, Boy R, Jacobus JA, Smith B, Rahaman A, Robertson LW, Ludewig G. 2008. Xenobiotic geometry and media pH determine cytotoxicity through solubility. Chem Res Toxicol 21(5):1017-1027. doi:10.1021/tx700214p PMID:18402468
  • Luthe G, Jacobus JA, Robertson LW. 2008. Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: a theoretical Structure-activity assessment. Environ Toxicol Pharmacol 25(2):202-210. doi:10.1016/j.etap.2007.10.017 PMID:19768137 PMCID:PMC2746664
  • Ravoori S, Ayotte P, Srinivasan C, Pereg D, Robertson LW, Gupta RC, Jeyabalan J. 2008. DNA damage associated with PCBs in the whole blood cells of Inuit. Environ Toxicol Pharmacol 25(2):273-276. PMID:21783863
  • Sacco JC, Lehmler H, Robertson LW, Li W, James MO. 2008. Glucuronidation of polychlorinated biphenylols and UDP-glucuronic acid concentrations in channel catfish liver and intestine. Drug Metab Dispos 36(4):623-630. doi:10.1124/dmd.107.019596 PMID:18180271
  • Song Y, Buettner GR, Parkin S, Wagner BA, Robertson LW, Lehmler H. 2008. Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones. J Org Chem 73(21):8296-8304. doi:10.1021/jo801397g PMID:18839991 PMCID:PMC2629131
  • Stemm DN, Tharappel JC, Lehmler H, Srinivasan C, Morris J, Spate VL, Robertson LW, Spear BT, Glauert HP. 2008. Effect of dietary selenium on the promotion of hepatocarcinogenesis by 3,3', 4,4'-tetrachlorobiphenyl and 2,2', 4,4', 5,5'-hexachlorobiphenyl. Exp Biol Med (Maywood) 233(3):366-376. doi:10.3181/0708-RM-211 PMID:18296742
  • Tharappel JC, Lehmler H, Srinivasan C, Robertson LW, Spear BT, Glauert HP. 2008. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol 46(11):3467-3474. doi:10.1016/j.fct.2008.08.023 PMID:18796325 PMCID:PMC2597727
  • Venkatesha VA, Venkataraman S, Sarsour EH, Kalen AL, Buettner GR, Robertson LW, Lehmler H, Goswami PC. 2008. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med 45(8):1094-1102. doi:10.1016/j.freeradbiomed.2008.07.007 PMID:18691649 PMCID:PMC2614346

2007

  • Bunaciu RP, Tharappel JC, Lehmler H, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP. 2007. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 239(3):147-55. PMID:17703865
  • Kania-Korwel I, Shaikh NS, Hornbuckle KC, Robertson LW, Lehmler H. 2007. Enantioselective disposition of PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality 19(1):56-66. doi:10.1002/chir.20342 PMID:17089340
  • Lehmann L, Esch HL, Kirby PA, Robertson LW, Ludewig G. 2007. 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28(2):471-478. doi:10.1093/carcin/bgl157 PMID:16950798
  • Ludewig G, Esch HL, Robertson LW. 2007. Polyhalogenierte Bi- und Terphenyle. Chapter 20 in: Handbuch der Lebensmitteltoxikologie. Wiley-VCH Weinheim, Germany. pp.1031-1094.
  • Luthe G, Swenson DC, Robertson LW. 2007. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3). Acta Crystallogr B 63:319-327. PMID:17374943
  • Norstrom K, Czub B, McLachlan M, Thorne PS, Hornbuckle KC. 2007. Serum PCBs in five men from Chicago: consideration of current exposures. Discernment of dietary and inhalation exposure to PCBs from congener profiles in blood. Chapter 47(2)in: American Chemical Society Division of Environmental Chemistry Annual Meefing. Boston, MA. pp.433-436.
  • Sadeghi-aliabadi H, Chan K, Lehmler H, Robertson LW, O-Brian PJ. 2007. Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem Biol Interact 167:184-192. PMID:17408604
  • Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. 2007. Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 Cells. Toxicol Sci 100:88-98. PMID:17686921

2006

  • Bender RP, Lehmler H, Robertson LW, Ludewig G, Osheroff N. 2006. Polychlorinated biphenyl quinone mtabolites Poison human topoisomerase II: Altering enzyme function by blocking the N-terminal protein gate. Biochemistry 45(33):10140-10152. PMID:16906772
  • Kania-Korwel I, Garrison AW, Avants JK, Hornbuckle KC, Robertson LW, Sulkowski WW, Lehmler H. 2006. Distribution of chiral PCBs in selected tissues in the laboratory rat. Environ Sci Technol 40(12):3704-3710. PMID:16830530
  • Kunz S, Schwarz M, Schilling B, Papke O, Lehmler H, Robertson LW, Schrenk D, Schmitz H. 2006. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicol Lett 164(2):133-143. PMID:16426774
  • Liu Y, Apak TI, Lehmler H, Robertson LW, Duffel MW. 2006. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 19(11):1420-1425. PMID:17112228
  • Luthe G, Leonards PE, Reijerink GS, Liu H, Johansen JS, Robertson LW. 2006. Monofluorinated analogues of polybrominated diphenyl ethers as analytical standards: synthesis, NMR, and GC-MS characterization and molecular orbital studies. Environ Sci Technol 40(9):3023-3029. PMID:16719106
  • Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler H, Robertson LW, Gregoraszczuk EL. 2006. Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicol Lett 166(3):200-211. PMID:16949219
  • Ptak A, Ludewig G, Robertson LW, Lehmler H, Gregoraszczuk EL. 2006. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: Effects on sex hormone levels and aromatase activity. Toxicol Lett 164(2):113-122. PMID:16412591
  • Shaikh NS, Swenson DC, Lehmler H. 2006. 2,3,6-Trichloroiodobenzene. Acta Crystallogr B E62,Part10:o4672-o4673.
  • Strathmann J, Schwarz M, Tharappel JC, Glauert HP, Spear BT, Robertson LW, Appel KE, Buchmann A. 2006. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol Sci 93(1):34-40. doi:10.1093/toxsci/kfl041 PMID:16782779
  • Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 2,5-Dichloro-4'-methoxybiphenyl. Acta Crystallogr B E62,Part9:o4162-o4163.
  • Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 4-Chloro-2',3'-dimethoxybiphenyl. Acta Crystallogr B E62,Part9:o3639-o3640.
  • Wang L, Lehmler H, Robertson LW, James MO. 2006. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem Biol Interact 159(3):235-246. PMID:16413005

1997

  • Duffel MW. 1997. Sulfotransferases. Chapter 18 in: Comprehensive Toxicology, 3rd Edition. Vol. 10. Elsevier, NY. pp.407-428.
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