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Project Publications: Harvard School of Public Health: Genetic Epidemiology of Neurodevelopmental Metal Toxicity

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Superfund Research Program

Genetic Epidemiology of Neurodevelopmental Metal Toxicity

Project Leader: David C. Christiani
Grant Number: P42ES016454
Funding Period: 2010-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2022

  • Andrews FV, Branscum A, Hystad P, Smit E, Afroz S, Golam M, Sharif OI, Rahman M, Quamruzzaman Q, Christiani DC, Kile ML. 2022. A prospective study of arsenic and manganese exposures and maternal blood pressure during gestation. Environ Res 214(1):113845. doi:10.1016/j.envres.2022.113845 PMID:35830911
  • Andrews FV, Branscum A, Hystad P, Smit E, Afroz S, Golam M, Sharif OI, Rahman M, Quamruzzaman Q, Christiani DC, Kile ML. 2022. Testing the limit: evaluating drinking water arsenic regulatory levels based on adverse pregnancy outcomes in Bandladesh. Toxics 10(10):600. doi:10.3390/toxics10100600 PMID:36287880 PMCID:PMC9609177
  • Devick K, Bobb JF, Mazumdar M, Claus Henn B, Bellinger DC, Wright RO, Williams PL, Coull BA, Valeri L, Christiani DC. 2022. Bayesian kernel machine regression-causal mediation analysis. Stat Med doi:10.1002/sim.9255 PMID:34993981
  • Liu J, Deng W, Lee JJ, Lin PD, Valeri L, Christiani DC, Bellinger DC, Wright RO, Mazumdar M, Coull BA. 2022. A cross-validated ensemble approach to robust hypothesis testing of continuous nonlinear interactions: applications of nutrition-environment studies. J Am Stat Assoc 117(538):561-573. doi:10.1080/01621459.2021.1962889 PMID:36310839 PMCID:PMC9611147

2021

  • Liu J, Lee JJ, Lin PD, Valeri L, Christiani DC, Bellinger DC, Wright RO, Mazumdar M, Coull BA. 2021. A cross-validated Ensemble Approach to Robust Hypothesis Testing of Continuous Nonlinear Interactions: Application to Nutrition-Environment Studies. J Am Stat Assoc 13:

2020

  • Gleason K, Valeri L, Shankar AH, Obrycki JF, Sharif OI, Mostofa G, Quamruzzaman Q, Wright RO, Christiani DC, Bellinger DC, Mazumdar M. 2020. Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children. J Neurodev Disord 12:39. doi:10.1186/s11689-020-09346-x PMID:33327931
  • Welch B, Branscum A, Geldhof J, Ahmed S, Hystad P, Smit E, Afroz S, Megowan M, Golam M, Sharif OI, Rahman M, Quamruzzaman Q, Christiani DC, Kile ML. 2020. Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: A prospective birth cohort study. Environmental Health 19:doi:10.1186/s12940-020-00592-z PMID:32276596

2019

2018

  • Sun R, Wang Z, Henn BC, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. 2018. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry PMID:30120420

2017

  • Henn BC, Bellinger DC, Hopkins MR, Coull BA, Ettinger AS, Jim R, Hatley EL, Christiani DC, Wright RO. 2017. Maternal and cord blood manganese concentrations and early childhood neurodevelopment among residents near a mining-impacted superfund site. Environ Health Perspect 125:9. doi:10.1289/ehp925 PMID:28665786
  • Sun R, Carroll RJ, Christiani DC, Lin X. 2017. Testing for gene-environment interaction under exposure misspecification. Biometrics doi:10.1111/biom.12813 PMID:29120492
  • Valeri L, Mazumdar M, Bobb JF, Henn BC, Rodrigues EG, Sharif OI, Kile ML, Quamruzzaman Q, Afroz S, Golam M, Amarasiriwardena C, Bellinger DC, Christiani DC, Coull BA, Wright RO. 2017. Effect of prenatal exposure to metal mixtures on neurodevelopmental outcomes at 20-40 months of age: Evidence from Rural Bangladesh. Environ Health Perspect 125:11. doi:10.1289/ehp614 PMID:28669934
  • Wagner PJ, Park H, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. 2017. In vitro effects of lead on gene expression in neural stem cells and associations between up-regulated genes and cognitive scores in children. Environ Health Perspect 125(4):721-729. doi:10.1289/ehp265 PMID:27562236
  • Wang Z, Henn BC, Wang C, Wei Y, Li S, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo M, Schnaas L, Christiani DC. 2017. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health 16:81. doi:10.1186/s12940-017-0288-3 PMID:28754176 PMCID:PMC5534076

2016

  • Claus Henn B, Ettinger AS, Hopkins MR, Jim R, Amarasiriwardena CJ, Christiani DC, Coull BA, Bellinger DC, Wright RO. 2016. Prenatal arsenic exposure and birth outcomes among a population residing near a mining-related Superfund site. Environ Health Perspect 124(8):1308-1315. doi:10.1289/ehp.1510070 PMID:26859631 PMCID:PMC4977047
  • Kile ML, Cardenas A, Rodrigues EG, Mazumdar M, Dobson CB, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. 2016. Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort. Epidemiology 27(2):173-181. doi:10.1097/EDE.0000000000000416 PMID:26583609 PMCID:PMC4733817
  • Rodrigues EG, Bellinger DC, Valeri L, Hasan OS, Quamruzzaman Q, Golam M, Kile ML, Christiani DC, Wright RO, Mazumdar M. 2016. Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water. Environ Health 15:44. doi:10.1186/s12940-016-0127-y PMID:26968381 PMCID:PMC4788832

2015

  • Bobb JF, Valeri L, Henn BC, Wright RO, Mazumdar M, Godleski J, Coull BA, Christiani DC. 2015. Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostatistics 16(3):493-508. doi:10.1093/biostatistics/kxu058 PMID:25532525
  • Mazumdar M, Hasan OS, Hamid R, Valeri L, Paul L, Selhub J, Rodrigues EG, Silva F, Mia S, Mostofa G, Quamruzzaman Q, Rahman M, Christiani DC. 2015. Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Environ Health 14:34. doi:10.1186/s12940-015-0020-0 PMID:25885259 PMCID:PMC4404044
  • Mazumdar M, Valeri L, Rodrigues EG, Hasan OS, Hamid R, Paul L, Selhub J, Silva F, Mostofa G, Quamruzzaman Q, Rahman M, Christiani DC. 2015. Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele. Birth Defects Res A Clin Mol Teratol 103(9):754-762. doi:10.1002/bdra.23399 PMID:26250961 PMCID:PMC4565773

2014

  • Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun H, Lin X, Baccarelli A, Christiani DC. 2014. Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study. BMC Public Health 14:1279. doi:10.1186/1471-2458-14-1279 PMID:25512264 PMCID:PMC4302115
  • Gleason K, Shine JP, Shobnam N, Rokoff LB, Suchanda HS, Hasan OS, Mostofa G, Amarasiriwardena CJ, Quamruzzaman Q, Rahman M, Kile ML, Bellinger DC, Christiani DC, Wright RO, Mazumdar M. 2014. Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health 2014:730636. doi:10.1155/2014/730636 PMID:25214856 PMCID:PMC4158309
  • Grashow R, Zhang J, Fang SC, Weisskopf MG, Christiani DC, Kile ML, Cavallari JM. 2014. Inverse association between toenail arsenic and body mass index in a population of welders. Environ Res 131:131-133. doi:10.1016/j.envres.2014.03.010 PMID:24721130 PMCID:PMC4035809
  • Kile ML, Houseman EA, Baccarelli A, Quamruzzaman Q, Rahman M, Mostofa G, Cardenas A, Wright RO, Christiani DC. 2014. Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics 9(5):774-782. doi:10.4161/epi.28153 PMID:24525453 PMCID:PMC4063836
  • Kile ML, Rodrigues EG, Mazumdar M, Dobson CB, Diao N, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. 2014. A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health 13(1):29. doi:10.1186/1476-069X-13-29 PMID:24735908 PMCID:PMC4021291
  • Seow W, Kile ML, Baccarelli A, Pan W, Byun H, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC. 2014. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen 55(6):449-456. doi:10.1002/em.21860 PMID:24677489 PMCID:PMC4082746

2013

2012

  • Ciesielski T, Weuve J, Bellinger DC, Schwartz J, Lanphear BP, Wright RO. 2012. Cadmium exposure and neurodevelopmental outcomes in U.S. children. Environ Health Perspect 120(5):758-763. doi:10.1289/ehp.1104152 PMID:22289429 PMCID:PMC3346779
  • Fleisch AF, Wright RO, Baccarelli A. 2012. Environmental epigenetics: a role in endocrine disease?. J Mol Endocrinol 49:R61-67. doi:10.1530/jme-12-0066 PMID:22798698 PMCID:PMC3752847
  • Kile ML, Baccarelli A, Hoffman E, Tarantini L, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Hsueh Y, Wright RO, Christiani DC. 2012. Prenatal arsenic exposure and DNA methylation in maternal and umbilical cord blood leukocytes. Environ Health Perspect 120:1061-6. doi:10.1289/ehp.1104173 PMID:22466225 PMCID:PMC3404653
  • Seow W, Pan W, Kile ML, Baccarelli A, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lin X, Christiani DC. 2012. Arsenic reduction in drinking water and improvement in skin lesions: A follow-up study in Bangladesh. Environ Health Perspect 121:1733-1738. doi:10.1289/ehp.1205381 PMID:23060367 PMCID:PMC3548283

2011

  • Claus Henn B, Kim J, Wessling-Resnick M, Tellez-Rojo MM, Jayawardene I, Ettinger AS, Hernandez-Avila M, Schwartz J, Christiani DC, Hu H, Wright RO. 2011. Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models. Environ Health 10(1):97. doi:10.1186/1476-069X-10-97 PMID:22074419 PMCID:PMC3248860
  • Lin X, Cai T, Wu MC, Zhou Q, Liu G, Christiani DC, Lin X. 2011. Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol 35:620-631. doi:10.1002/gepi.20610 PMID:21818772 PMCID:PMC3373190
  • Peters J, Kubzansky LD, Ikeda A, Spiro, III A, Wright RO, Weisskopf MG, Kim D, Sparrow D, Nie LH, Hu H, Schwartz J. 2011. Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. Am J Epidemiol 174:1345-1353. doi:10.1093/aje/kwr269 PMID:22071587 PMCID:PMC3276297
  • Peters JL, Kubzansky LD, Ikeda A, Fang SC, Sparrow D, Weisskopf MG, Wright RO, Vokonas PS, Hu H, Schwartz J. 2011. Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study. Environ Health Perspect 120:361-366. doi:10.1289/ehp.1103467 PMID:22142875 PMCID:PMC3295335
  • Roy A, Hu H, Bellinger DC, Mukherjee B, Modali R, Nasaruddin K, Schwartz J, Wright RO, Ettinger AS, Palaniapan K, Balakrishnan K. 2011. Hemoglobin, lead exposure, and intelligence quotient: effect modification by the DRD2 Taq IA polymorphism. Environ Health Perspect 119(1):144-149. doi:10.1289/ehp.0901878 PMID:21205584 PMCID:PMC3018494

2010

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