Superfund Research Program

Data Management and Analysis Core

Project Leader: David Kaeli
Co-Investigators: Akram N. Alshawabkeh, Jennifer Dy, Justin Manjourides, Bhramar Mukherjee (University of Michigan)
Grant Number: P42ES017198
Funding Period: 2010-2025

Project-Specific Links

Publications

2023

• Eick SM, Geiger SD, Alshawabkeh AN, Aung MT, Barrett ES, Bush NR, Carroll KN, Cordero JF, Goin DE, Ferguson KK, Kahn LG, Liang D, Meeker JD, Milne GL, Nguyen RH, Padula AM, Sathyanarayana S, Taibl KR, Schantz SL, Woodruff TJ, Morello-Frosch R. 2023. Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study. Am J Obstet Gynecol 228(5):576.e1-576.e22. doi:10.1016/j.ajog.2022.11.1282 PMID:36400174 PMCID:PMC1014953
• Kim C, Cathey A, Watkins DJ, Mukherjee B, Rosario-Pabon Z, Velez-Vega C, Alshawabkeh AN, Cordero JF, Meeker JD. 2023. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico. J Reprod Immunol 159:103991. doi:10.1016/j.jri.2023.103991 PMID:37454540
• Park S, Cathey A, Hao W, Zeng L, Pennathur S, Aung MT, Rosario-Pabon Z, Velez-Vega C, Cordero JF, Alshawabkeh AN, Watkins DJ, Meeker JD. 2023. Associations of phthalates, phthalate replacements, and their mixtures with eicosanoid biomarkers during pregnancy. Environ Int 178:108101. doi:10.1016/j.envint.2023.108101 PMID:37487376
• Welch BM, Keil AP, Buckley JP, Engel SM, James-Todd T, Zota AR, Alshawabkeh AN, Barrett ES, Bloom MS, Bush NR, Cordero JF, Dabelea D, Eskenazi B, Lanphear BP, Padmanabhan V, Sathyanarayana S, Swan SH, Aalborg J, Baird DD, Binder AM, Bradman A, Braun JM, Calafat AM, Cantonwine DE, Christenbury KE, Factor-Litvak P, Harley K, Hauser R, Herbstman JB, Hertz-Picciotto I, Holland NT, Jukic AM, McElrath TF, Meeker JD, Messerlian C, Michels KB, Newman RB, Nguyen RH, O'Brien KM, Rauh VA, Redmon B, Rich DQ, Rosen EM, Schmidt RJ, Sparks AE, Starling AP, Wang C, Watkins DJ, Weinberg CR, Weinberger B, Wenzel AG, Wilcox A, Yolton K, Zhang Y, Ferguson KK. 2023. Racial and ethnic disparities in phthalate exposure and preterm birth: A pooled study of sixteen U.S. cohorts. Environ Health Perspect 131(12):127015. doi:10.1289/ehp12831 PMID:38117586 PMCID:10732302
• Zimmerman E, Aguiar A, Aung MT, Geiger SD, Hines M, Woodbury ML, Martens A, Huerta-Montanez G, Cordero JF, Meeker JD, Schantz SL, Alshawabkeh AN. 2023. Examining the association between prenatal maternal stress and infant non-nutritive suck. Pediatric Research 93(5):1285-1293. doi:10.1038/s41390-021-01894-9 PMID:34916626 PMCID:PMC9200902

2022

• Carpenito T, Manjourides J. 2022. MISL: Multiple imputation by super learning. Stat Methods Med Res 12:doi:10.1177/09622802221104238 PMID:35658622
• Cathey A, Watkins DJ, Rosario Z, Velez-Vega C, Mukherjee B, Alshawabkeh AN, Cordero JF, Meeker JD. 2022. Biomarkers of exposure to phthalate mixtures and adverse birth outcomes in a Puerto Rico birth cohort. Environ Health Perspect 130(3):doi:10.1289/EHP8990 PMID:35333099 PMCID:PMC8953418
• Eick SM, Geiger SD, Alshawabkeh AN, Aung M, Barrett ES, Bush NR, Cordero JF, Ferguson KK, Meeker JD, Milne GL, Nguyen RH, Padula AM, Sathyanarayana S, Welch BM, Schantz SL, Woodruff TJ, Morello-Frosch R. 2022. Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts. Sci Total Environ 835:doi:10.1016/j.scitotenv.2022.155596 PMID:35490822 PMCID:PMC9177811
• Howe CG, Nozadi S, Garcia E, O'Connor TG, Starling AP, Farzan SF, Jackson BP, Madan J, Alshawabkeh AN, Cordero JF, Bastain TM, Meeker JD, Breton CV, Karagas MR. 2022. Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program. Environ Int 161:doi:10.1016/j.envint.2022.107102 PMID:35081493 PMCID:PMC8891091
• Kim C, Cathey A, Watkins DJ, Mukherjee B, Rosario-Pabon Z, Velez Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD. 2022. Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico. Environ Res 209:doi:10.1016/j.envres.2022.112874 PMID:35123972
• Kim C, Cathey A, Watkins DJ, Mukherjee B, Rosario-Pabon Z, Velez-Vega C, Alshawabkeh AN, Cordero JF, Meeker JD. 2022. Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico. Environ Epidemiol 6(4):e214. doi:10.1097/EE9.0000000000000214
• Previdi IL, Welton M, Rivera JD, Watkins DJ, Diaz Z, Torres H, Galan C, Guilloty NI, Agosto LD, Cordero JF, Alshawabkeh AN, Velez Vega CM. 2022. The impact of natural disasters on maternal health: Hurricanes Irma and Maria in Puerto Rico. Children (Basel) 9(7):940. doi:10.3390/children9070940 PMID:35883924 PMCID:PMC9315789
• Rahman SM, Lan J, Kaeli D, Dy J, Alshawabkeh AN, Gu AZ. 2022. Machine learning-based biomarkers identification from toxicogenomics - bridging to regulatory relevant phenotypic endpoints. J Hazard Mater 423:doi:10.1016/j.jhazmat.2021.127141 PMID:34560480
• Rivera-Nunez Z, Ashrap P, Barrett ES, Llanos AA, Watkins DJ, Cathey A, Velez-Vega C, Rosario Z, Cordero JF, Alshawabkeh AN, Meeker JD. 2022. Personal care products: Demographic characteristics and maternal hormones in pregnant women from Puerto Rico. Environ Res 206:doi:10.1016/j.envres.2021.112376 PMID:34798118 PMCID:PMC8810700
• Welch BM, Keil AP, Buckley JP, Calafat AM, Christenbury KE, Engel SM, O'Brien KM, Rosen EM, James-Todd T, Zota AR, Ferguson KK, Alshawabkeh AN, Cordero JF, Meeker JD, Barrett ES, Bush NR, Nguyen RH, Sathyanarayana S, Swan SH, Cantonwine DE, Aalborg J, Dabelea D, Starling AP, Hauser R, Messerlian C, Zhang Y, Bradman A, Eskenazi B, Charley PH, Holland NT, Bloom MS, Newman RB, Wenzel AG, Braun JM, Lanphear BP, Yolton K, Factor-Litvak P, Herbstman JB, Rauh VA, Drobnis EZ, Sparks AE, Redmon JB, Wang C, Binder AM, Michels KB, Baird DD, Jukic AM, Weinberg CR, Wilcox AJ, Rich DQ, Weinberger B, Padmanabhan V, Watkins DJ, Hertz-Picciotto I, Schmidt RJ. 2022. Associations between prenatal urinary biomarkers of phthalate exposure and preterm birth: A pooled study at 16 US cohorts. JAMA Pediatr doi:10.1001/jamapediatrics.2022.2252 PMID:35816333 PMCID:PMC9274448

2021

• Boss J, Rix A, Chen Y, Narisetty NN, Wu Z, Ferguson KK, McElrath TF, Meeker JD, Mukherjee B. 2021. A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures. Environmetrics 32(8):doi:10.1002/env.2698 (ahead of print)
• Cathey A, Eaton JL, Ashrap P, Watkins DJ, Rosario Z, Velez-Vega C, Alshawabkeh AN, Cordero JF, Mukherjee B, Meeker JD. 2021. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environ Int 154:doi:10.1016/j.envint.2021.106565 PMID:33882432

2020

• Aung MT, Song Y, Ferguson KK, Cantonwine DE, Zeng L, McElrath TF, Pennathur S, Meeker JD, Mukherjee B. 2020. Application of an analytical framework for multivariate mediation analysis of environmental data. Nat Commun 11:5624. doi:10.1038/s41467-020-19335-2 PMID:33159049 PMCID:PMC7648785

2019

• Aker AM, Ferguson KK, Rosario Z, Mukherjee B, Alshawabkeh AN, Cordero JF, Meeker JD. 2019. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environ Res 169:41-51. doi:10.1016/j.envres.2018.10.030 PMID:30412856 PMCID:PMC6347499
• Boss J, Mukherjee B, Ferguson KK, Aker AM, Alshawabkeh AN, Cordero JF, Meeker JD, Kim S. 2019. Estimating outcome-exposure associations when exposure biomarker detection limits vary across batches. Epidemiology 30(5):746-755. doi:10.1097/EDE.0000000000001052 PMID:31299670 PMCID:PMC6677587
• Torres NI, Rivera VL, Padilla IY, Macchiavelli R, Kaeli D, Alshawabkeh AN. 2019. Effect of hydrogeological and anthropogenic factors on the spatial and temporal distribution of CVOCs in the karst system of northern Puerto Rico. Environ Earth Sci 78:594. doi:10.1007/s12665-019-8611-7 PMID:31929835 PMCID:PMC6953914 (in press)

2018

• Dong S, Feric Z, Li X, Rahman SM, Li G, Wu C, Gu AZ, Dy J, Kaeli D. 2018. A hybrid approach to identify key indicators of PROTECT (Puerto Rico Testsite for Exploring Contamination Threats) dataset with an end-to-end toolchain. In: 2018 IEEE International Conference on Big Data (Big Data). (). IEEE, New York, NY.
• Dong S, Feric Z, Yu L, Kaeli D, Meeker JD, Padilla IY, Cordero JF, Velez Vega CM, Rosario Z, Alshawabkeh AN. 2018. An efficient data management framework for Puerto Rico Testsite for Exploring Contamination Threats (PROTECT). In: 2018 IEEE International Conference on Big Data (Big Data). (). IEEE, New York, NY.
• Torres NI, Yu X, Padilla IY, Macchiavelli R, Ghasemizadeh R, Kaeli D, Cordero JF, Meeker JD, Alshawabkeh AN. 2018. The influence of hydrogeological and anthropogenic variables on phthalate contamination in eogenetic karst groundwater systems. Environ Pollut 237:298-307. doi:10.1016/j.envpol.2018.01.106 PMID:29494923 PMCID:PMC5915304
• Yu X, Feric Z, Cordero JF, Meeker JD, Alshawabkeh AN. 2018. Potential influence of temperature and precipitation on preterm birth rate in Puerto Rico. Sci Rep 8:16106. doi:10.1038/s41598-018-34179-z PMID:30382121 PMCID:PMC6208375

2017

• Cordero JF, Meeker JD, Loch-Caruso R, Giese RW, Padilla IY, Vesper D, Kaeli D, Sheahan TC, Brown P, Velez Vega CM, Alshawabkeh AN. 2017. Team science applied to environmental health research: karst hydrogeology and preterm birth in Puerto Rico. In: Karst Groundwater Contamination and Public Health: Beyond Case Studies. Springer, New York, NY. pp.17-25.

2016

• Li X, Yu L, Kaeli D, Yao Y, Wang P, Giese RW, Yusa V, Alshawabkeh AN. 2016. A framework for big metabolomic data management and analysis. IJAS 9(1-2):50-61.
• Yu X, Ghasemizadeh R, Padilla IY, Kaeli D, Alshawabkeh AN. 2016. Patterns of temporal scaling of groundwater level fluctuation. J Hydrol 536:485-495. doi:10.1016/j.jhydrol.2016.03.018

2015

• Yu X, Ghasemizadeh R, Padilla IY, Irizarry C, Kaeli D, Alshawabkeh AN. 2015. Spatiotemporal changes of CVOC concentrations in karst aquifers: analysis of three decades of data from Puerto Rico. Sci Total Environ 511:1-10. doi:10.1016/j.scitotenv.2014.12.031 PMID:25522355 PMCID:PMC4330126

2012

• Cordero JF, Meeker JD, Sheahan TC, Padilla IY, Giese RW, Silevitch M, Loch-Caruso R, Kaeli D, Alshawabkeh AN. 2012. Case Study - Puerto Rico Test Site for Exploring Contamination Threats. In: GeoCongress 2012: State of the Art and Practice in Geotechnical Engineering. American Society of Civil Engineers, Reston, VA.
• Yu X, Ghasemizadeh R, Padilla IY, Kaeli D. 2012. Temporal scaling of groundwater level fluctuations near a stream. Ground Water 50(1):59-67. doi:10.1111/j.1745-6584.2011.00804.x PMID:21352211