Superfund Research Program

Heavy Metal Induced Airway Remodeling and COPD

Project Leader: Veena Antony
Co-Investigators: Mohammad Athar, Ranu Surolia, Hitesh Batra, Pooja Singh
Grant Number: P42ES027723
Funding Period: 2020-2025

Project-Specific Links

Publications

2024

• Singh P, Li FJ, Dsouza K, Stephens CT, Zheng H, Kumar A, Dransfield MT, Antony V. 2024. Low dose cadmium exposure regulates miR-381-ANO1 interaction in airway epithelial cells. Sci Rep 14(1):246. doi:10.1038/s41598-023-50471-z PMID:38168913 PMCID:PMC10762153

2023

• Dsouza K, Surolia R, Kulkarni T, Li FJ, Singh P, Zeng H, Stephens CT, Kumar A, Wang Z, Antony V. 2023. Use of a pulmosphere model to evaluate drug antifibrotic responses in interstitial lung diseases. Respir Res 24(1):96. doi:10.1186/s12931-023-02404-7 PMID:36978076 PMCID:10045174
• Guo T, Jiang C, Yang S, Zhu Y, He C, Carter AB, Antony V, Peng H, Zhou Y. 2023. Mitochondrial fission and bioenergetics mediate human lung fibroblast durotaxis. JCI Insight 8(1):doi:10.1172/jci.insight.157348 PMID:36422990 PMCID:9870082
• Jin L, Kashyap M, Chen Y, Khan J, Guo Y, Chen JQ, Lee MB, Weng Z, Oak A, Patcha P, Mayo T, Sinha R, Atigadda V, Mukhtar MS, Deshane J, Raman C, Elston C, Elewski BE, Elmets CA, Athar M. 2023. Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa. iScience 26(6):106896. doi:10.1016/j.isci.2023.106896 PMID:37332597 PMCID:PMC10275975
• Larson-Casey JL, Liu S, Pyles JM, Lapi SE, Saleem K, Antony V, Gonzalez ML, Crossman DK, Carter AB. 2023. Impaired PPARy activation by cadmium exacerbates infection-induced lung injury. JCI Insight 8(9):e166608. doi:10.1172/jci.insight.166608 PMID:36928191 PMCID:PMC10243824
• Larson-Casey JL, Saleem K, Surolia R, Pandey J, Mack M, Antony V, Bodduluri S, Bhatt S, Duncan SR, Carter AB. 2023. Myeloid heterogeneity mediates acute exacerbations of pulmonary fibrosis. J Immunol 211(11):1714-1724. doi:10.4049/jimmunol.2300053 PMID:37782053
• Surolia R, Li FJ, Dsouza K, Zeng H, Singh P, Stephens CT, Guo Y, Wang Z, Kashyap M, Srivastava RK, Gonzalez ML, Benson P, Kumar A, Kim H, Kim Y, Ahmad A, Athar M, Antony V. 2023. Cutaneous exposure to arsenicals is associated with development of constrictive bronchitis in mice. Am J Respir Cell Mol Biol 68(5):485-497. doi:10.1165/rcmb.2022-0321MA PMID:36780670 PMCID:PMC10174172

2022

• Cui H, Xie N, Banerjee S, Dey T, Liu R, Antony V, Sanders YY, Adams TS, Gomez JL, Thannickal V, Kaminski N. 2022. CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging. Am J Respir Crit Care Med 206(4):459-475. doi:10.1164/rccm.202109-2151OC PMID:35687485
• Li FJ, Surolia R, Singh P, Dsouza K, Stephens CT, Wang Z, Liu R, Bae S, Kim Y, Athar M, Dransfield MT, Antony V. 2022. Fibrinogen mediates cadmium-induced macrophage activation and serves as a predictor of cadmium exposure in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol doi:10.1152/ajplung.00475.2021 PMID:35200041
• Stephens CT, Kim Y, Ramachandran R, Baskin ML, Antony V, Bae S. 2022. Disparities in healthcare utilization: Superfund site vs. neighboring comparison site. Int J Environ Res Public Health 19(15):9271. doi:10.3390/ijerph19159271 PMID:35954629 PMCID:PMC9367949
• Surolia R, Antony V. 2022. Pathophysiological role of vimentin intermediate filaments in lung diseases. Front Cell Dev Biol doi:10.3389/fcell.2022.872759 PMID:35573702 PMCID:PMC9096236

2021

• Gu L, Surolia R, Larson-Casey JL, He C, Davis D, Kang J, Antony V, Carter AB. 2021. Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death Differ 29(1):doi:10.1038/s41418-021-00840-w PMID:34413485 (ahead of print)
• Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AV, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal V, Carter AB, Antony V. 2021. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med 13(585):doi:10.1126/scitranslmed.aba2927 PMID:33731433
• Surolia R, Li FJ, Wang Z, Kashyap M, Srivastava RK, Traylor AM, Singh P, Dsouza K, Kim H, Pittet J, Zmijewski J, Agarwal A, Athar M, Ahmad A, Antony V. 2021. NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns. JCI Insight 6(10):e147564. doi:10.1172/jci.insight.147564 PMID:34027893 PMCID:PMC826236

2020

• Rana T, Jiang C, Liu G, Miyata T, Antony V, Thannickal V, Liu R. 2020. PAI-1 regulation of TGF-B1-induced alveolar type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages. Am J Respir Cell Mol Biol 62:319-330. doi:10.1165/rcmb.2019-0071OC PMID:31513752 PMCID:PMC7055702
• Srivastava RK, Muzaffar S, Khan J, Traylor AM, Zmijewski J, Curtis L, George JF, Ahmad A, Antony V, Agarwal A, Athar M. 2020. Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals. Ann N Y Acad Sci 1480(1):155-169. doi:10.1111/nyas.14475 PMID:32885420 PMCID:PMC9109234

2019

• Larson-Casey JL, Vaid M, Gu L, He C, Cai G, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini AF, Hanumanthu VS, Surolia R, Antony V, Carter AB. 2019. Increased flux through the mevalonate pathway mediates fibrotic repair without injury. J Clin Invest 129:4962-4978. doi:10.1172/JCI127959 PMID:31609245 PMCID:PMC6819144
• Surolia R, Li FJ, Wang Z, Li H, Dsouza K, Thomas V, Mirov S, Perez-Sala D, Athar M, Thannickal V, Antony V. 2019. Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury. JCI Insight 4:doi:10.1172/jci.insight.123253 PMID:30944258 PMCID:PMC6483650