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Program Publications: Columbia University: Columbia University and Northern Plains Partnership for the Superfund Research Program

Superfund Research Program

Columbia University and Northern Plains Partnership for the Superfund Research Program

Center Director: Ana Navas-Acien
Grant Number: P42ES033719
Funding Period: 2022-2027
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Domingo-Relloso A, Tellez-Plaza M, Valeri L. 2024. Methods for the analysis of multiple epigenomic mediators in environmental epidemiology. Curr Environ Health Rep doi:10.1007/s40572-024-00436-9 PMID:38386268
  • George C, Zacher T, Endres K, Richards F, Bear Robe L, Harvey D, Best LG, Red Cloud R, Black Bear A, Skinner L, Cuny C, Rule A, Schwab KJ, Gittelsohn J, Glabonjat R, Schilling K, O'Leary M, Thomas ED, Umans JG, Zhu J, Moulton LH, Navas-Acien A. 2024. Effect of an arsenic mitigation program on arsenic exposure in American Indian communities: A cluster randomized controlled trial of the community-led Strong Heart Water Study Program. Environ Health Perspect 132(3):37007. doi:10.1289/ehp12548 PMID:38534131 PMCID:10967367
  • Lieberman-Cribbin W, Li Z, Lewin M, Ruiz P, Jarrett J, Cole SA, Kupsco A, O'Leary M, Pichler G, Shimbo D, Devereux RB, Umans JG, Navas-Acien A, Nigra AE. 2024. The contribution of declines in blood lead levels to reductions in blood pressure levels: Longitudinal evidence in the Strong Heart Family Study. J Am Heart Assoc 13(2):doi:10.1161/jaha.123.031256 PMID:38205795
  • Schilling K, Glabonjat RA, Balac O, Galvez-Fernandez M, Domingo-Relloso A, Slavkovich VN, Goldsmith J, Jones MR, Sanchez TR, Navas-Acien A. 2024. Method validation for (ultra)-trace element concentrations in urine for small sample volumes in large epidemiological studies: application to the population-based epidemiological multi-ethnic study of atherosclerosis (MESA). Analytical Methods 16(2):214-226. doi:10.1039/d3ay01605f PMID:38099473
  • Spaur M, Glabonjat RA, Schilling K, Lombard M, Galvez-Fernandez M, Lieberman-Cribbin W, Hayek C, Ilievski V, Balac O, Izuchukwu C, Patterson KP, Basu A, Bostick BC, Chen Q, Sanchez TR, Navas-Acien A, Nigra AE. 2024. Contribution of arsenic and uranium in private wells and community water systems to urinary biomarkers in US adults: The Strong Heart Study and the Multi-Ethnic Study of Atherosclerosis. J Expo Sci Environ Epidemiol 34(1):77-89. doi:10.1038/s41370-023-00586-2 PMID:37558699 PMCID:10853483


  • Anderson DM, Bear AB, Zacher T, Endres K, Saxton R, Richards F, Robe LB, Harvey D, Best LG, Cloud RR, Thomas ED, Gittelsohn J, O'Leary M, Navas-Acien A, George CM. 2023. Implementing a community-led arsenic mitigation intervention for private well users in American Indian communities: a qualitative evaluation of the Strong Heart Water Study Program. Int J Environ Res Public Health 20(3):2681. doi:10.3390/ijerph20032681 PMID:36768048 PMCID:PMC9915175
  • Boyer K, Domingo-Relloso A, Jiang E, Haack K, Goessler W, Zhang Y, Umans JG, Belsky DW, Cole SA, Navas-Acien A, Kupsco A. 2023. Metal mixtures and DNA methylation measures of biological aging in American Indian populations. Environ Int 178:108064. doi:10.1016/j.envint.2023.108064 PMID:37364305
  • Chernoff M, Delgado DA, Tong L, Chen LS, Oliva M, Tamayo LI, Best LG, Cole SA, Jasmine F, Kibriya MG, Nelson H, Huang L, Haack K, Kent J, Umans JG, Graziano JH, Navas-Acien A, Karagas MR, Ahsan H, Pierce BL. 2023. Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations. PLoS Genet 19(1):e1010588. doi:10.1371/journal.pgen.1010588 PMID:36668670 PMCID:PMC9891528
  • Domingo-Relloso A, Joehanes R, Rodriguez-Hernandez Z, Lahousse L, Haack K, Fallin MD, Herreros-Martinez M, Umans JG, Best LG, Huan T, Liu C, Ma J, Yao C, Jerolon A, Bermundez JD, Cole SA, Rhoades DA, Levy D, Navas-Acien A, Tellez-Plaza M. 2023. Smoking, blood DNA methylation sites and lung cancer risk. Environ Pollut 334:122153. doi:10.1016/j.envpol.2023.122153 PMID:37442331
  • Dye CK, Domingo-Relloso A, Kupsco A, Tinkelman NE, Spratlen MJ, Bozack AK, Tellez-Plaza M, Goessler W, Haack K, Umans JG, Baccarelli A, Cole SA, Navas-Acien A. 2023. Maternal DNA methylation signatures of arsenic exposure is associated with adult offspring insulin resistance in the Strong Heart Study. Environ Int 173:107774. doi:10.1016/j.envint.2023.107774 PMID:36805808 PMCID:PMC10166110
  • Galvez-Fernandez M, Navas-Acien A. 2023. Response to comment on Galvez-Fernandez et al. urinary zinc and incident type 2 diabetes: prospective evidence from the Strong Heart Study. Diabetes Care 2022;45:2561-2569. Diabetes Care 46(5):e109. doi:10.2337/dci22-0060 PMID:37185677 PMCID:PMC10154660
  • Hefferon R, Goin DE, Sarnat JA, Nigra AE. 2023. Regional and racial/ethnic inequalities in public drinking water fluoride concentrations across the US. J Expo Sci Environ Epidemiol doi:10.1038/s41370-023-00570-w PMID:37391608
  • Jiang E, Domingo-Relloso A, Abuawad A, Haack K, Tellez-Plaza M, Fallin M, Umans JG, Best LG, Zhang Y, Kupsco A, Belsky DW, Cole SA, Navas-Acien A. 2023. Arsenic exposure and epigenetic aging: The association with cardiovascular disease and all-cause mortality in the Strong Heart Study. Environ Health Perspect 131(12):127016. doi:10.1289/ehp11981 PMID:38133959 PMCID:10743589
  • Khan KM, Zimpfer MJ, Sultana R, Parvez TM, Navas-Acien A, Parvez F. 2023. Role of metals on SARS-CoV-2 infection: a review of recent epidemiological studies. Curr Environ Health Rep doi:10.1007/s40572-023-00409-4 PMID:37665544
  • Li M, Do V, Brooks JL, Hilpert M, Goldsmith J, Chillrud SN, Ali T, Best LG, Yracheta J, Umans JG, van Donkelaar A, Martin RV, Navas-Acien A, Kioumourtzoglou M. 2023. Fine particulate matter composition in American Indian vs. Non-American Indian communities. Environ Res 237(Pt2):117091. doi:10.1016/j.envres.2023.117091 PMID:37683786 PMCID:PMC10591960
  • Martinez-Morata I, Sobel MH, Tellez-Plaza M, Navas-Acien A, Howe CG, Sanchez TR. 2023. A state-of-the-science review on mental biomarkers. Curr Environ Health Rep doi:10.1007/s40572-023-00402-x PMID:37337116
  • Nghiem AA, Prommer H, Mozumder R, Siade AJ, Jamieson J, Ahmed KM, van Geen AF, Bostick BC. 2023. Sulfate reduction accelerates groundwater arsenic contamination even in aquifers with abundant iron oxides. Nat Water 1(2):151-165. doi:10.1038/s44221-022-00022-z PMID:37034542 PMCID:PMC1007439
  • Shen Y, Kioumourtzoglou M, Wu H, Vokonas PS, Spiro, III A, Navas-Acien A, Baccarelli A, Gao F. 2023. Cohort network: A knowledge graph toward data dissemination and knowledge-driven discovery for cohort studies. Environ Sci Technol 57(22):8236-8244. doi:10.1021/acs.est.2c08174 PMID:37224396
  • Slowly M, Domingo-Relloso A, Santella RM, Haack K, Fallin MD, Terry MB, Rhoades DA, Herreros-Martinez M, Garcia-Esquinas E, Cole SA, Tellez-Plaza M, Navas-Acien A, Wu H. 2023. Blood DNA methylation and liver cancer in American Indians: evidence from the Strong Heart Study. Cancer Causes Control doi:10.1007/s10552-023-01822-8 PMID:38010586
  • Smith TJ, Navas-Acien A, Baker S, Kok C, Kruczynski K, Avolio LN, Pisanic N, Randad PR, Fry RC, Goessler W, van Green A, Buckley JP, Rahman MH, Ali H, Haque R, Shaikh S, Siddiqua TJ, Schulze KJ, West KP, Labrique AB, Heaney C. 2023. Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh. Environ Res 234:116453. doi:10.1016/j.envres.2023.116453 PMID:37343752
  • Spaur M, Lombard M, Ayotte JD, Bostick BC, Chillrud SN, Navas-Acien A, Nigra AE. 2023. Cross-sectional associations between drinking water arsenic and urinary inorganic arsenic in the United States: NHANES 2003-2014. Environ Res 227:115741. doi:10.1016/j.envres.2023.115741 PMID:36963713 PMCID:PMC1016594
  • Valeri L. 2023. Invited perspective: a multivariate disease process perspective for environmental epidemiology. Environ Health Perspect 131(1):11302. doi:10.1289/EHP12509 PMID:36696107 PMCID:PMC9875848
  • Zacher T, Endres K, Richards F, Robe LB, Powers M, Yracheta J, Harvey D, Best LG, Cloud RR, Bear AB, Ristau S, Aurand D, Skinner L, Cuny C, Gross M, Thomas ED, Rule A, Schwab KJ, O'Leary M, Moulton LH, Navas-Acien A, George CM. 2023. Evaluation of a water arsenic filter in a participatory intervention to reduce arsenic exposure in American Indian communities: The Strong Heart Water Study. Sci Total Environ 862:160217. doi:10.1016/j.scitotenv.2022.160217 PMID:36410482 PMCID:PMC10373100
  • Zhao Z, Pang X, Zou C, Dickson AJ, Basu A, Guo Z, Pan S, Nielsen AT, Schovsbo NH, Jing Z, Dahl TW. 2023. Dynamic oceanic redox conditions across the late Cambrian SPICE event constrained by molybdenum and uranium isotopes. Earth Planet Sci Lett 604:118013. doi:10.1016/j.epsl.2023.118013


  • Baneras J, Iglesies-Grau J, Tellez-Plaza M, Arrarte V, Baez-Ferrer N, Benito B, Ruiz RC, Cecconi A, Dominguez-Rodriguez A, Rodriguez-Sinovas A, Ujueta F, Vozzi C, Lamas GA, Navas-Acien A. 2022. Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment. Rev Esp Cardiol 75(12):1050-1058. doi:10.1016/j.rec.2022.05.030 PMID:35931285
  • Basu A, Schilling K, Halliday A, Wasserman N, Johnson TM. 2022. Te(IV) immobilization by siderite: reaction kinetics, mechanism, and Te isotopic fractionation. Chemical Geology 612:121123. doi:10.1016/j.chemgeo.2022.121123
  • Bradley PM, Romanok KM, Smalling KL, Focazio MJ, Charboneau R, George CM, Navas-Acien A, O'Leary M, Cloud RR, Zacher T, Breitmeyer SE, Cardon MC, Cuny C, Ducheneaux G, Enright K, Evans N, Gray JL, Harvey DE, Hladik ML, Kanagy LK, Loftin KA, McCleskey RB, Medlock-Kakaley E, Meppelink S, Valder JF, Weis CP. 2022. Tapwater exposures, effects potential, and residential risk management in Northern Plains Nation. ACS ES&T Wat 2(10):1772-1788. doi:10.1021/acsestwater.2c00293 PMID:36277121
  • Domingo-Relloso A, Gribble MO, Riffo-Campos AL, Haack K, Cole SA, Tellez-Plaza M, Umans JG, Fretts A, Zhang Y, Fallin MD, Navas-Acien A, Everson TM. 2022. Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study. Clin Epigenetics 14(1):177. doi:10.1186/s13148-022-01392-7 PMID:36529747 PMCID:PMC9759920
  • Domingo-Relloso A, Makhani K, Riffo-Campos AL, Tellez-Plaza M, Klein KO, Subedi P, Zhao J, Moon KA, Bozack AK, Haack K, Goessler W, Umans JG, Best LG, Zhang Y, Herreros-Martinez M, Glabonjat RA, Schilling K, Galvez-Fernandez M, Kent JW, Sanchez TR, Taylor K, Johnson WC, Durda P, Tracy RP, Rotter JI, Rich SS, Berg DV, Kasela S, Lappalainen T, Vasan RS, Joehanes R, Howard AG, Levy D, Lohman K, Liu Y, Fallin MD, Cole SA, Mann KK, Navas-Acien A. 2022. Arsenic exposure, blood DNA methylation, and cardiovascular disease. Circ Res 131(2):e51-e69. doi:10.1161/CIRCRESAHA.122.320991 PMID:35658476
  • Domingo-Relloso A, Riffo-Campos AL, Powers M, Tellez-Plaza M, Haack K, Brown RH, Umans JG, Fallin MD, Cole SA, Navas-Acien A, Sanchez TR. 2022. An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study. Clin Epigenetics doi:10.1186/s13148-022-01294-8 PMID:35681244 PMCID:PMC9185990
  • Dwivedi P, Schilling K, Wasserman N, Johnson TM, Pallud C. 2022. Oxidation of dissolved tetravalent selenium by birnessite: Se isotope fractionation and the effects of pH and birnessite structure. Front Earth Sci doi:10.3389/feart.2022.909900
  • Galvez-Fernandez M, Powers M, Grau-Perez M, Domingo-Relloso A, Lolacono NJ, Goessler W, Zhang Y, Fretts A, Umans JG, Maruthur N, Navas-Acien A. 2022. Urinary zinc and incident type 2 diabetes: prospective evidence from the Strong Heart Study. Diabetes Care 45(11):2561-2569. doi:10.2337/dc22-1152 PMID:36134919 PMCID:PMC9679259
  • Huang J, El-Kersh K, Mann KK, James KA, Cai L. 2022. Overview of the cardiovascular effects of environmental metals: New preclinical and clinical insights. Toxicol Appl Pharmacol 454:116247. doi:10.1016/j.taap.2022.116247 PMID:36122736
  • Li M, Hilpert M, Goldsmith A, Brooks JL, Shearston JG, Chillrud SN, Ali T, Umans JG, Best LG, Yracheta J, van Donkelaar A, Martin RV, Navas-Acien A, Kioumourtzoglou M. 2022. Air pollution in American Indian versus Non-American Indian communities, 2000-2018. Am J Public Health 112:615-623. doi:10.2105/ajph.2021.306650 PMID:35319962 PMCID:PMC8961849
  • Li Z, Lewin M, Ruiz P, Nigra AE, Henderson NB, Jarrett JM, Ward C, Zhu J, Umans JG, O'Leary M, Zhang Y, Ragin-Wilson A, Navas-Acien A. 2022. Blood cadmium, lead, manganese, mercury, and selenium levels in American Indian populations: The Strong Heart Study. Environ Res 215(Pt3):114101. doi:10.1016/j.envres.2022.114101 PMID:35977585 PMCID:PMC9644284
  • Lieberman-Cribbin W, Domingo-Relloso A, Navas-Acien A, Cole SA, Haack K, Umans JG, Tellez-Plaza M, Colicino E, Baccarelli A, Gao X, Kupsco A. 2022. Epigenetic biomarkers of lead exposure and cardiovascular disease: prospective evidence in the Strong Heart Study. J Am Heart Assoc 11(23):e026934. doi:10.1161/JAHA.122.026934 PMID:36382957
  • Martinez-Morata I, Bostick BC, Conroy-Ben O, Duncan DT, Jones MR, Spaur M, Patterson KP, Prins SJ, Navas-Acien A, Nigra AE. 2022. Nationwide geospatial analysis of county racial and ethnic composition and public drinking water arsenic and uranium. Nat Commun 13(1):7461. doi:10.1038/s41467-022-35185-6 PMID:36460659 PMCID:PMC9718774
  • Nigra AE, Luca AC, Navas-Acien A. 2022. Socioeconomic vulnerability and public water arsenic concentrations across the US. Environ Pollut (Tor) 313:120113. doi:10.1016/j.envpol.2022.120113 PMID:36084737
  • Spaur M, Nigra AE, Sanchez TR, Navas-Acien A, Lazo M, Wu H. 2022. Association of blood manganese, selenium with steatosis, fibrosis in the National Health and Nutrition Examination Survey, 2017-18. Environ Res 213:doi:10.1016/j.envres.2022.113647 PMID:35691383
  • Zhao D, Domingo-Relloso A, Tellez-Plaza M, Nigra AE, Valeri L, Moon KA, Goessler W, Best LG, Ali T, Umans JG, Fretts A, Cole SA, Navas-Acien A. 2022. High level of selenium exposure in the Strong Heart Study: a cause for incident cardiovascular disease?. Antioxid Redox Signal 37(13-15):990-997. doi:10.1089/ars.2022.0029 PMID:35350849 PMCID:PMC9689768
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