Superfund Research Program

Novel Approaches to Studying the in situ Bioremediation of Complex Mixtures

Project Leader: Rolf Ulrich Halden
Grant Number: R01ES015445
Funding Period: 2006-2012

Program Links

Publications

2022

• Driver E, Gushgari AJ, Steele JC, Bowes DA, Halden RU. 2022. Assessing population-level stress through glucocorticoid hormone monitoring in wastewater. Sci Total Environ 838(2):155961. doi:10.1016/j.scitotenv.2022.155961 PMID:35588803

2019

• Kalinowski T, McClellan K, Bruton TA, Krajmalnik-Brown R, Driver E, Halden RU. 2019. Autonomous screening of groundwater remediation technologies in the subsurface using the In Situ Microcosm Array (ISMA). J Hazard Mater 367:668-675. doi:10.1016/j.jhazmat.2018.12.054 PMID:30654284

2018

• Magee HY, Maurer MM, Cobos A, Pycke BF, Venkatesan AK, Magee D, Scotch M, Halden RU. 2018. US nationwide reconnaissance of ten infrequently monitored antibiotics in municipal biosolids. Sci Total Environ 643:460-467. doi:10.1016/j.scitotenv.2018.06.206 PMID:29945081

2017

• Driver E, Roberts J, Dollar P, Charles M, Hurst P, Halden RU. 2017. Comparative meta-analysis and experimental kinetic investigation of column and batch bottle microcosm treatability studies informing in situ groundwater remedial design. J Hazard Mater 323(PtA):377-385. doi:10.1016/j.jhazmat.2016.05.008 PMID:27207379 PMCID:PMC5097027
• Geer LA, Pycke BF, Waxenbaum J, Sherer DM, Abulafia O, Halden RU. 2017. Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York. J Hazard Mater 323(PtA):177-183. doi:10.1016/j.jhazmat.2016.03.028 PMID:27156397 PMCID:PMC5018415
• Wells EM, Herbstman JB, Lin YH, Hibbeln JR, Halden RU, Witter FR, Goldman LR. 2017. Methyl mercury, but not inorganic mercury, associated with higher blood pressure during pregnancy. Environ Res 154:247-252. doi:10.1016/j.envres.2017.01.013 PMID:28110211 PMCID:PMC532883

2016

• Halden RU. 2016. Lessons learned from probing for impacts of triclosan and triclocarban on human microbiomes. mSphere 1(3):e00056-15. doi:10.1128/mSphere.00089-16 PMID:27306705 PMCID:PMC4888884
• Heckenbach ME, Romero FN, Green MD, Halden RU. 2016. Meta-analysis of ionic liquid literature and toxicology. Chemosphere 150:266-274. doi:10.1016/j.chemosphere.2016.02.029 PMID:26907595 PMCID:PMC4789176
• Lee W, Morris JS. 2016. Identification of differentially methylated loci using wavelet-based functional mixed models. Bioinformatics 32:664-672. doi:10.1093/bioinformatics/btv659 PMID:26559505 PMCID:PMC4907398
• Roll IB, Driver E, Halden RU. 2016. Apparatus and method for time-integrated, active sampling of contaminants in fluids demonstrated by monitoring of hexavalent chromium in groundwater. Sci Total Environ 556:45-52. doi:10.1016/j.scitotenv.2016.03.011 PMID:26971208 PMCID:PMC4826302
• Roll IB, Halden RU. 2016. Critical review of factors governing data quality of integrative samplers employed in environmental water monitoring. Water Res 94:200-207. doi:10.1016/j.watres.2016.02.048 PMID:26945963 PMCID:PMC4822337
• Supowit SD, Roll IB, Dang VD, Kroll KJ, Denslow ND, Halden RU. 2016. Active sampling device for determining pollutants in surface and pore water - the in situ sampler for biphasic water monitoring. Sci Rep 6:21886. doi:10.1038/srep21886 PMID:26905924 PMCID:PMC4764808
• Venkatesan AK, Halden RU. 2016. Modeling the pH-mediated extraction of ionizable organic contaminants to improve the quality of municipal sewage sludge destined for land application. Sci Total Environ 550:736-741. doi:10.1016/j.scitotenv.2016.01.119 PMID:26849337 PMCID:PMC4769932

2015

• Bruton TA, Pycke BF, Halden RU. 2015. Effect of nanoscale zero-valent iron treatment on biological reductive dechlorination: A review of current understanding and research needs. Crit Rev Environ Sci Technol 45(11):1148-1175. doi:10.1080/10643389.2014.924185
• Done HY, Halden RU. 2015. Reconnaissance of 47 antibiotics and associated microbial risks in seafood sold in the United States. J Hazard Mater 282:10-17. doi:10.1016/j.jhazmat.2014.08.075 PMID:25449970 PMCID:PMC4254636
• Hartmann EM, Colquhoun DR, Schwab KJ, Halden RU. 2015. Absolute quantification of norovirus capsid protein in food, water, and soil using synthetic peptides with electrospray and MALDI mass spectrometry. J Hazard Mater 286:525-532. doi:10.1016/j.jhazmat.2014.12.055 PMID:25603302 PMCID:PMC4369174
• Venkatesan AK, Halden RU. 2015. Effective strategies for monitoring and regulating chemical mixtures and contaminants sharing pathways of toxicity. Int J Environ Res Public Health 12(9):10549-10557. doi:10.3390/ijerph120910549 PMID:26343697 PMCID:PMC4586627

2014

• Pycke BF, Geer LA, Dalloul M, Abulafia O, Jenck AM, Halden RU. 2014. Human fetal exposure to triclosan and triclocarban in an urban population from Brooklyn, New York. Environ Sci Technol 48(15):8831-8838. doi:10.1021/es501100w PMID:24971846 PMCID:PMC4123932
• Pycke BF, Roll IB, Brownawell B, Kinney CA, Furlong ET, Kolpin DW, Halden RU. 2014. Transformation products and human metabolites of triclocarban and triclosan in sewage sludge across the United States. Environ Sci Technol 48:7881-7890. doi:10.1021/es5006362 PMID:24932693 PMCID:PMC4215897
• Venkatesan AK, Halden RU. 2014. Brominated flame retardants in U.S. biosolids from the EPA national sewage sludge survey and chemical persistence in outdoor soil mesocosms. Water Res 55:133–142. doi:10.1016/j.watres.2014.02.021 PMID:24607311 PMCID:PMC4013270
• Venkatesan AK, Halden RU. 2014. Loss and in situ production of perfluoroalkyl chemicals in outdoor biosolids-soil mesocosms. Environ Res 132:321-327. doi:10.1016/j.envres.2014.04.024 PMID:24834828 PMCID:PMC4122524
• Wells EM, Navas-Acien A, Apelberg BJ, Herbstman JB, Jarrett JM, Lin YH, Verdon CP, Ward C, Caldwell KL, Hibbeln JR, Halden RU, Witter FR, Goldman LR. 2014. Association of selenium and copper with lipids in umbilical cord blood. J Dev Orig Health Dis 5(4):281-287. doi:10.1017/S2040174414000233 PMID:24965134 PMCID:PMC4135310

2013

• North EJ, Halden RU. 2013. Plastics and environmental health: the road ahead. Rev Environ Health 28:1-8. doi:10.1515/reveh-2012-0030 PMID:23337043 PMCID:PMC3791860
• Venkatesan AK, Halden RU. 2013. National inventory of alkylphenol ethoxylate compounds in U.S. sewage sludges and chemical fate in outdoor soil mesocosms. Environ Pollut 174:189-193. doi:10.1016/j.envpol.2012.11.012 PMID:23274446 PMCID:PMC3552055
• Venkatesan AK, Halden RU. 2013. National inventory of perfluoroalkyl substances in archived U.S. biosolids from the 2001 EPA National Sewage Sludge Survey. J Hazard Mater 252-253:413-418. doi:10.1016/j.jhazmat.2013.03.016 PMID:23562984 PMCID:PMC3776589
• Ziv-El M, Kalinowski T, Krajmalnik-Brown R, Halden RU. 2013. Simultaneous determination of chlorinated ethenes and ethene in groundwater using headspace solid-phase microextraction with gas chromatography. Journal of Chromatographic Science doi:10.1093/chromsci/bms258 PMID:23377651

2012

• Chari BP, Halden RU. 2012. Predicting the concentration range of unmonitored chemicals in wastewater-dominated streams and in run-off from biosolids-amended soils. Sci Total Environ 440:314-320. doi:10.1016/j.scitotenv.2012.05.042 PMID:22682556 PMCID:PMC3496017
• Chari BP, Halden RU. 2012. Validation of mega composite sampling and nationwide mass inventories for 26 previously unmonitored contaminants in archived biosolids from the U.S National Biosolids Repository. Water Res 46:4814-4824. doi:10.1016/j.watres.2012.06.017 PMID:22789759 PMCID:PMC3579625
• Colquhoun DR, Hartmann EM, Halden RU. 2012. Proteomic profiling of the dioxin-degrading bacterium sphingomonas wittichii RWI. J Biomed Biotechnol 2012:doi:10.1155/2012/408690 PMID:23091346 PMCID:PMC3468919
• Hansmeier N, Chao T, Goldman LR, Witter FR, Halden RU. 2012. Prioritization of biomarker targets in human umbilical cord blood: identification of proteins in infant blood serving as validated biomarkers in adults. Environ Health Perspect 120(5):764-769. doi:10.1289/ehp.1104190 PMID:22538116 PMCID:PMC3346780
• Hartmann EM, Badalamenti JP, Krajmalnik-Brown R, Halden RU. 2012. Quantitative PCR for tracking the megaplasmid-borne biodegredation potential of a model sphingomonad. Appl Environ Microbiol 78:4493-4496. doi:10.1128/aem.00715-12 PMID:22492441 PMCID:PMC3370553
• Kalinowski T, Halden RU. 2012. Can stress enhance phytoremediation of polychlorinated biphenyls?. Environ Eng Sci 29:1047-1052. doi:10.1089/ees.2012.0089 PMID:23236249 PMCID:PMC3516413
• Venkatesan AK, Pycke BF, Barber LB, Lee KE, Halden RU. 2012. Occurrence of triclosan, triclocarban, and its lesser chlorinated congeners in Minnesota freshwater sediments collected near wastewater treatment plants. J Hazard Mater 30:29-35. doi:10.1016/j.jhazmat.2012.05.049 PMID:22742731 PMCID:PMC3401314

2011

• Benn T, Herckes P, Westerhoff P, Pycke B, Halden RU. 2011. Evaluation of extraction methods for the quantification of aqueous fullerenes in urine. Anal Bioanal Chem 399(4):1631-9. doi:10.1007/s00216-010-4465-2 PMID:21153587 PMCID:PMC3711233
• Chao T, Song G, Hansmeier N, Westerhoff P, Herckes P, Halden RU. 2011. Characterization and liquid chromatography-MS/MS based quantification of hydroxylated fullerenes. Anal Chem 83:1777-1783. doi:10.1021/ac1031379 PMID:21294534 PMCID:PMC3118260
• Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Toward identifying the next generation of superfund and hazardous waste site contaminants. Environ Health Perspect 119(1):6-10. doi:10.1289/ehp.1002497 PMID:21205582 PMCID:PMC3018501
• Higgins CP, Paesani ZJ, Chalew TE, Halden RU, Hundal L. 2011. Persistence of triclocarban and triclosan in soils after land application of biosolids and bioaccumulation in Eisenia foetida. Environ Toxicol Chem 30(3):556-563. doi:10.1002/etc.416 PMID:21128266 PMCID:PMC3034821
• Neta G, Goldman LR, Barr DB, Apelberg BJ, Witter FR, Halden RU. 2011. Fetal exposure to chlordane and permethrin mixtures in relation to inflammatory cytokines and birth outcomes. Environ Sci Technol 45(4):1680-1687. doi:10.1021/es103417j PMID:21235202 PMCID:PMC3085719
• Pycke B, Benn T, Westerhoff P, Halden RU. 2011. Strategies for quantifying C60 fullerenes in environmental and biological samples and implications for toxicological studies in environmental health and ecotoxicology. Trends in Analytical Chemistry 30(1):44-57. doi:10.1016/j.trac.2010.08.005 PMID:21359100 PMCID:PMC3045199
• Wells EM, Goldman LR, Jarrett JM, Apelberg BJ, Herbstman JB, Caldwell KL, Halden RU, Witter FR. 2011. Selenium and maternal blood pressure during childbirth. J Expo Sci Environ Epidemiol 22:191-197. doi:10.1038/jes.2011.42 PMID:22108761 PMCID:PMC3661205
• Wells EM, Navas-Acien A, Herbstman JB, Apelberg BJ, Silbergeld EK, Caldwell KL, Jones RL, Halden RU, Witter FR, Goldman LR. 2011. Low-level lead exposure and elevations in blood pressure during pregnancy. Environ Health Perspect 119:664-669. doi:10.1289/ehp.1002666 PMID:21292600 PMCID:PMC3094418
• Ziv-El M, Delgado AG, Yao Y, Kang D, Nelson KG, Halden RU, Krajmalnik-Brown R. 2011. Development and characterization of DehaloR^2, a novel anaerobic microbial consortium performing rapid dechlorination of TCE to ethene. Appl Microbiol Biotechnol 92(5):1063-1071. doi:10.1007/s00253-011-3388-y PMID:21667274

2010

• Chao T, Hansmeier C, Halden RU. 2010. Towards proteome standards: the use of absolute quantitation in high-throughput biomarker discovery. J Proteomics 73(8):1641-1646. doi:10.1016/j.jprot.2010.04.004 PMID:20399287 PMCID:PMC2885480
• Deo RP, Halden RU. 2010. Comment on "The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res 44:2685-2687. doi:10.1016/j.watres.2009.11.040 PMID:20022620
• Deo RP, Halden RU. 2010. Effect of sample filtration on the quality of monitoring data reported for organic compounds during wastewater treatment. J Environ Monit 12:478-483. doi:10.1039/b919076g PMID:20145890
• Deo RP, Halden RU. 2010. In silico screening for unmonitored, potentially problematic high production volume (HPV) chemicals prone to accumulate in biosolids. J Environ Monit 12(10):1840-1845. doi:10.1039/c001559h PMID:20721409
• Guerrero-Preston R, Goldman LR, Brebi-Mieville L, Ili-Gangas C, LeBron C, Hernández-Arroyo M, Witter FR, Apelberg BJ, Roystacher M, Jaffe A, Halden RU, Sidransky D. 2010. Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds. Epigenetics 5(6):539-546. PMID:20523118 PMCID:PMC3322495
• Halden RU. 2010. Plastics and health risks. Annu Rev Public Health 31:179-194. doi:10.1146/annurev.publhealth.012809.103714 PMID:20070188
• Hartmann EM, Colquhoun DR, Halden RU. 2010. Identification of putative biomarkers for toluene-degrading Burkholderia and Pseudomonads using matrix-assisted laser desorption/Ionization time-of-flight mass spectrometry and peptide mass fingerprinting. Bioscience, Biotechnology, Biochemistry 74(7):1470-1472. doi:10.1271/bbb.100064 PMID:20622441
• McClellan K, Halden RU. 2010. Pharmaceuticals and personal care products in archived U.S. biosolids from the 2001 EPA national sewage sludge survey. Water Res 44(22):658-668. doi:10.1016/j.watres.2009.12.032 PMID:20106500 PMCID:PMC2827628
• Miller T, Colquhoun DR, Halden RU. 2010. Identification of wastewater bacteria involved in the degradation of triclocarban and its non-chlorinated congener. J Hazard Mater 183(1-3):766-772. doi:10.1016/j.jhazmat.2010.07.092 PMID:20727675 PMCID:PMC2939305
• Miller T, Delcher A, Salzberg S, Saunders E, Detter JC, Halden RU. 2010. Genome sequence of the dioxin-mineralizing bacterium Sphingomonas wittichii RW1. J Bacteriol 192(22):6101-6102. doi:10.1128/JB.01030-10 PMID:20833805 PMCID:PMC2976435
• Neta G, Goldman LR, Barr DB, Sjodin A, Apelberg BJ, Witter FR, Halden RU. 2010. Distribution and determinants of pesticide mixtures in cord serum using principal component analysis. Environ Sci Technol 44(14):5641-5648. doi:10.1021/es1009778 PMID:20550184
• Walters E, McClellan K, Halden RU. 2010. Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids-soil mixtures in outdoor mesocosms. Water Res 44:6011-6020. doi:10.1016/j.watres.2010.07.051 PMID:20728197 PMCID:PMC2991390

2009

• Chalew TE, Halden RU. 2009. Environmental exposure of aquatic and terrestrial biota to triclosan and triclocarban. J Am Water Works Assoc 45(1):4-13. doi:10.1111/j.1752-1688.2008.00284.x PMID:20046971 PMCID:PMC2684649
• Colquhoun DR, Goldman LR, Cole RN, Gucek M, Mansharamani M, Witter FR, Apelberg BJ, Halden RU. 2009. Global screening of human cord blood proteomes for biomarkers of toxic exposure and effect. Environ Health Perspect 117(5):832-838. doi:10.1289/ehp.11816 PMID:19478969 PMCID:PMC2685849
• Deo RP, Halden RU. 2009. Empirical model for predicting concentrations of refractory hydrophobic organic compounds in digested sludge from municipal wastewater treatment plants. Environ Chem 6(6):544. doi:10.1071/EN09063 PMID:20161626 PMCID:PMC2813041
• Halden RU. 2009. Book Review: Pharma-Ecology: The occurrence and fate of pharmaceuticals and personal care products in the environment by Patrick K. Jjimba. Environ Health Perspect 117(4):A172.
• Heidler J, Halden RU. 2009. Fate of organohalogens in U.S. wastewater treatment plants and estimated chemical releases to soils nationwide from biosolids recycling. J Environ Monit 11:2207-2215. doi:10.1039/B914324F PMID:20024018 PMCID:PMC2802102
• Higgins CP, Paesani ZJ, Chalew TE, Halden RU. 2009. Bioaccumulation of triclocarban in Lumbriculus variegatus. Environ Toxicol Chem 28(12):2580-2586. PMID:19655999
• Von Seggern C, Halden RU. 2009. Detection of bioterrorism agents and related public health threats utilising matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS). International Journal of Health Science 2(2):197-203.

2008

• Halden RU. 2008. PCPs persist for decades. Trends in Analytical Chemistry 27(6):VI.
• Heidler J, Halden RU. 2008. Meta-analysis of mass balances examining chemical fate during wastewater treatment. Environ Sci Technol 42(17):6324-6332. doi:10.1021/es703008y PMID:18800497
• Herbstman JB, Sjödin A, Apelberg BJ, Witter FR, Halden RU, Patterson DG, Panny SR, Needham LL, Goldman LR. 2008. Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels. Environ Health Perspect 116(10):1376-1382. doi:10.1289/ehp.11379 PMID:18941581 PMCID:PMC2569098
• Kim SR, Halden RU, Buckley TJ. 2008. Polycyclic aromatic hydrocarbons in human milk of nonsmoking US women. Environ Sci Technol 42(7):2663-2667. PMID:18505013
• Miller T, Heidler J, Chillrud SN, DeLaquil A, Ritchie JC, Bopp RF, Halden RU, Mihalic JN. 2008. Fate of triclosan and evidence for reductive dechlorination of triclocarban in estuarine sediments. Environ Sci Technol 42(12):4570-6. doi:10.1021/es702882g PMID:18605588
• Rittmann BE, Krajmalnik-Brown R, Halden RU. 2008. Pre-genomic, genomic and post-genomic study of microbial communities involved in bioenergy. Nat Rev Microbiol 6(8):604-612. doi:10.1038/nrmicro1939 PMID:18604223
• Young TA, Heidler J, Matos-Pérez CR, Toler T, Gibson KE, Schwab KJ, Halden RU. 2008. Ab initio and in situ comparison of caffeine, triclosan, and triclocarban as indicators of sewage-derived microbes in surface waters. Environ Sci Technol 42(9):3335-3340. PMID:18522115

2007

• Apelberg BJ, Goldman LR, Calafat AM, Herbstman JB, Kuklenyik Z, Heidler J, Needham LL, Halden RU, Witter FR. 2007. Determinants of fetal exposure to perfluorinated compounds. Environ Sci Technol 41(11):3891-3897. doi:10.1021/es0700911
• Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, Goldman LR. 2007. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relationship to weight and size at birth. Environ Health Perspect 115(11):1670-1676. doi:10.1289/ehp.10334 PMID:18008002 PMCID:PMC2072847
• Heidler J, Halden RU. 2007. Mass balance assessment of triclosan removal during conventional sewage treatment. Chemosphere 66(2):362-369. PMID:16766013
• Herbstman JB, Sjödin A, Apelberg BJ, Witter FR, Patterson DG, Halden RU, Jones RS, Park A, Zhang Y, Heidler J, Needham LL, Goldman LR. 2007. Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population. Environ Health Perspect 115(12):1794-1800. PMID:18087602
• Kim SR, Halden RU, Buckley TJ. 2007. Volatile organic compounds in human milk: Methods and measurements. Environ Sci Technol 41(5):1662-1667. doi:10.1021/es062362y PMID:17396657
• Miller T, Franklin MP, Halden RU. 2007. Bacterial community analysis of shallow groundwater undergoing sequential anaerobic and aerobic chloroethene biotransformation. FEMS Microbiol Ecol 60(2):299-311. PMID:17386036
• Sapkota A, Heidler J, Halden RU. 2007. Detection of triclocarban and two co-contaminating chlorocarbanilides in U.S. aquatic environments using isotope dilution liquid chromatography tandem mass spectrometry. Environ Res 103(1):21-29. PMID:16678153

2006

• Colquhoun DR, Schwab KJ, Cole RN, Halden RU. 2006. Detection of norovirus capsid protein in authentic standards and in stool extracts by matrix-assisted laser desorption ionization and nanospray mass spectrometry. Appl Environ Microbiol 72(4):2749-2755.
• Halden RU. 2006. Comment on "biological removal of polychlorinated dibenzo-p-dioxins from incinerator fly ash by Sphingomonas wittichii RW1" by I-H Nam, Y-M Kim, B-H Kim, K Murugesan, and Y-S Chang. Water Res 40(9):1918-1920. doi:10.1016/j.watres.2006.02.034 PMID:16620903
• Halden RU. 2006. Commentary on "Accumulation of contaminants in fish from wastewater treatment wetlands.". Environ Sci Technol 40(11):3437. PMID:16749718
• Heidler J, Sapkota A, Halden RU. 2006. Partitioning, persistence, and accumulation in digested sludge of the topical antiseptic triclocarban during wastewater treatment. Environ Sci Technol 40(11):3634-3639. PMID:16786704 PMCID:PMC2768036