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Your Environment. Your Health.

Program Publications: University of Florida: Molecular Mechanisms of Endocrine Disruption in Largemouth Bass

Superfund Research Program

Molecular Mechanisms of Endocrine Disruption in Largemouth Bass

Project Leader: Nancy D. Denslow
Grant Number: R01ES015449
Funding Period: 2006-2009

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  • Colli-Dula RC, Martyniuk CJ, Kroll KJ, Prucha MS, Kozuch M, Barber DS, Denslow ND. 2014. Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides). Aquat Toxicol 156:148-160. doi:10.1016/j.aquatox.2014.08.008 PMID:25203422 PMCID:PMC4252624
  • Mehinto AC, Prucha MS, Colli-Dula RC, Kroll KJ, Lavelle CM, Barber DS, Vulpe CD, Denslow ND. 2014. Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides). Aquat Toxicol 152:186-194. doi:10.1016/j.aquatox.2014.04.004 PMID:24794047





  • Chu B, Chang CY, Kroll KJ, Denslow ND, Wang Y, Pearton SJ, Lin J, Dabiran AM, Wowchak AM, Cui B, Chow PP, Johnson JW, Rajagopal P, Roberts JC, Piner EL, Linthicum KJ, Ren F. 2010. Detection of vitellogenin, an endocrine disrupter biomarker, using AlGaN/GaN high electron mobility transistors. Physica Status Solidi 8(7-8):2486-2488. doi:10.1002/pssc.201001171
  • Martyniuk CJ, Feswick A, Spade DJ, Kroll KJ, Barber DS, Denslow ND. 2010. Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus. Neurotoxicology 31(4):356-366. doi:10.1016/j.neuro.2010.04.008 PMID:20438755 PMCID:PMC2882520
  • Martyniuk CJ, Kroll KJ, Doperalski NJ, Barber DS, Denslow ND. 2010. Genomic and proteomic responses to environmentally relevant exposures to dieldrin: Indicators of neurodegeneration?. Toxicol Sci 117(1):190-199. doi:10.1093/toxsci/kfq192 PMID:20584760 PMCID:PMC2923291 (Completed with ARRA Funds)
  • Popesku J, Martyniuk CJ, Denslow ND, Trudeau V. 2010. Rapid dopaminergic modulation of the fish hypothalamic transcriptome and proteome. PLoS One 5:E12338. doi:10.1371/journal.pone.0012338 PMID:20808832 PMCID:PMC2924890 (Completed with ARRA Funds)


  • Martyniuk CJ, Alvarez S, McClung S, Villeneuve DL, Ankley GT, Denslow ND. 2009. Quantitative proteomic profiles of androgen receptor signaling in the liver of fathead minnows (Pimephales promelas). J Proteome Res 8(5):2186-2200. doi:10.1021/pr800627n PMID:19267455 (Completed with ARRA Funds)
  • Martyniuk CJ, Denslow ND. 2009. Towards functional genomics in fish using quantitative proteomics. Gen Comp Endocrinol 164:135-141. doi:10.1016/j.ygcen.2009.01.023 PMID:19523377
  • Martyniuk CJ, Sanchez BC, Szabo N, Denslow ND, Sepulveda MS. 2009. Aquatic contaminants alter genes involved in neurotransmitter synthesis and gonadotropin release in largemouth bass. Aquat Toxicol 95(1):1-9. doi:10.1016/j.aquatox.2009.06.009 PMID:19781795 (Completed with ARRA Funds)


  • Blum JL, James MO, Stuchal L, Denslow ND. 2008. Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells. Psychiatr Pol 108(1-2):55-63. PMID:17949972 (Completed with ARRA Funds)
  • Blum JL, Nyagode BA, James MO, Denslow ND. 2008. Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides). Aquat Toxicol 86(4):459-469. doi:10.1016/j.aquatox.2007.12.008 PMID:18279978 PMCID:PMC3004021 (Completed with ARRA Funds)
  • Blum JL, Prucha MS, Patel V, Denslow ND. 2008. Use of cDNA macroarrays and gene profiling for detection of effects by environmental toxicants. Chapter 4 in: Methods in Molecular Biology: Environmental Genomics. Humana Press, pp.43-53.
  • Blum JL, Prucha MS, Patel V, Denslow ND. 2008. Use of cDNA macroarrays and gene profiling for detection of effects of environmental toxicants. Methods Mol Biol 410:43-53. PMID:18642594
  • Garcia-Reyero N, Griffitt RJ, Liu L, Kroll KJ, Farmerie WG, Barber DS, Denslow ND. 2008. Construction of a robust microarray from a non-model species (largemouth bass) using pyrosequencing technology. J Fish Biol 72(9):2354-2376. doi:10.1111/j.1095-8649.2008.01904.x PMID:19936325 PMCID:PMC2779536 (Completed with ARRA Funds)
  • Perkins EJ, Denslow ND, Chipman K, Guiney PD, Oris JT, Poynton H, Yves Robidoux P, Scroggins R, Van Der Kraak G. 2008. Application of genomics to environmental monitoring. In: Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology. pp.87-121.


  • Denslow ND, Garcia-Reyero N, Barber DS. 2007. Fish 'n' chips: the use of microarrays for aquatic toxicology. Mol Biosyst 3(3):172-177. doi:10.1039/b612802p PMID:17308663 PMCID:PMC2259425 (Completed with ARRA Funds)
  • Denslow ND, Sepulveda MS. 2007. Ecotoxicological effects of endocrine disrupting compounds on fish. Chapter 10 in: The Fish Oocyte: From Basic Studies to Biotechnological Applications. pp.255-322.
  • Sabo-Attwood TL, Blum JL, Kroll KJ, Patel V, Birkholz D, Szabo N, Fisher SZ, McKenna R, Campbell-Thompson M, Denslow ND. 2007. Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol. J Mol Endocrinol 39(4):223-237. doi:10.1677/JME-07-0038 PMID:17909263 (Completed with ARRA Funds)


  • Ankley GT, Daston GP, Degitz SJ, Denslow ND, Hoke RA, Kennedy SW, Miracle AL, Perkins EJ, Snape J, Tillitt DE, Tyler DE, Versteeg D. 2006. Toxicogenomics in regulatory ecotoxicology. Environ Sci Technol 40(13):4055-4065. PMID:16856717 (Completed with ARRA Funds)
  • Cook J, Denslow ND, Iguchi T, Linney EA, Miracle AL, Shaw JR, Viant MR, Zacharewski TR. 2006. "Omics" approaches in the context of human and environmental toxicology. Chapter 1 in: Genomic Approaches for Cross-Species Extrapolation in Toxicology. pp.1-25.
  • Denslow ND, Colbourne JK, Dix DJ, Freedman JH, Helbing CC, Kennedy SW, Williams PL. 2006. Selection of surrogate animal species for comparative toxicogenomics. Chapter 2 in: Genomic Approaches for Cross-Species Extrapolation in Toxicology. pp.33-75.
  • Garcia-Reyero N, Barber DS, Gross TS, Denslow ND. 2006. Modeling of gene expression pattern alteration by p,p′-DDE and dieldrin in largemouth bass. Mar Environ Res 62:S415-S419. doi:10.1016/j.marenvres.2006.04.049 PMID:16707152 PMCID:PMC1810567
  • Garcia-Reyero N, Barber DS, Gross TS, Johnson KG, Sepúlveda MS, Szabo N, Denslow ND. 2006. Dietary exposure of largemouth bass to OCPs changes expression of genes important for reproduction. Aquat Toxicol 78(4):358-369. doi:10.1016/j.aquatox.2006.05.003 PMID:16765462 PMCID:PMC1892580 (Completed with ARRA Funds)
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